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Product Substitutes
Drug-Drug Interactions
Severe
CefpodoximeCholera, live attenuated
Severe
Drug-Drug Interactions
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Severe
How does the drug interact with Pencital 100mg Tablet:
Co-administration of Pencital 100mg Tablet with Heparin may enhance the levels or effects of heparin by anticoagulation (preventing blood from clotting).
How to manage the interaction:
Although there is an interaction, Pencital 100mg Tablet can be taken with Heparin if prescribed by the doctor. Do not stop using any medications without a doctor's advice. Do not discontinue the medication without consulting a doctor.
Co-administration of Pencital 100mg Tablet with Heparin may enhance the levels or effects of heparin by anticoagulation (preventing blood from clotting).
How to manage the interaction:
Although there is an interaction, Pencital 100mg Tablet can be taken with Heparin if prescribed by the doctor. Do not stop using any medications without a doctor's advice. Do not discontinue the medication without consulting a doctor.
CefpodoximeCholera, live attenuated
Severe
How does the drug interact with Pencital 100mg Tablet:
Co-administration of Pencital 100mg Tablet with the Cholera vaccine may reduce the effectiveness of the vaccine.
How to manage the interaction:
Talk to your doctor before receiving the Cholera vaccine if you are currently being treated with Pencital 100mg Tablet or have been treated within the last 14 days. To ensure adequate vaccine response, you should not receive cholera vaccine until at least 14 days after you complete your antibiotic therapy. Do not discontinue the medication without consulting a doctor.
Co-administration of Pencital 100mg Tablet with the Cholera vaccine may reduce the effectiveness of the vaccine.
How to manage the interaction:
Talk to your doctor before receiving the Cholera vaccine if you are currently being treated with Pencital 100mg Tablet or have been treated within the last 14 days. To ensure adequate vaccine response, you should not receive cholera vaccine until at least 14 days after you complete your antibiotic therapy. Do not discontinue the medication without consulting a doctor.
Drug-Food Interactions
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.
Drug-Food Interactions
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Drug-Diseases Interactions
CEFPODOXIME PROXETIL-100MGOther bacterial intestinal infections
Severe
CEFPODOXIME PROXETIL-100MGDisorders resulting from impaired renal tubular function
Moderate
Drug-Diseases Interactions
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CEFPODOXIME PROXETIL-100MGOther bacterial intestinal infections
Severe
How does the disease interact with Pencital 100mg Tablet:
Almost all antibacterial medications have been associated to reports of Clostridioides difficile-associated diarrhoea (CDAD), formerly known as pseudomembranous colitis. It can vary from mild diarrhoea to deadly colitis. Clindamycin and lincomycin are two of the most frequent offenders.
How to manage the interaction:
Antibiotics may cause Clostridioides difficile-associated diarrhoea (CDAD), which may range from mild diarrhoea to fatal colitis. Appropriate fluid and electrolyte management, protein supplementation, antibacterial treatment of C difficile, and surgical evaluation is advised.
Almost all antibacterial medications have been associated to reports of Clostridioides difficile-associated diarrhoea (CDAD), formerly known as pseudomembranous colitis. It can vary from mild diarrhoea to deadly colitis. Clindamycin and lincomycin are two of the most frequent offenders.
How to manage the interaction:
Antibiotics may cause Clostridioides difficile-associated diarrhoea (CDAD), which may range from mild diarrhoea to fatal colitis. Appropriate fluid and electrolyte management, protein supplementation, antibacterial treatment of C difficile, and surgical evaluation is advised.
CEFPODOXIME PROXETIL-100MGDisorders resulting from impaired renal tubular function
Moderate
How does the disease interact with Pencital 100mg Tablet:
The kidneys remove the majority of beta-lactam antibiotics as unaltered drugs and, in certain situations, as metabolites as well. In individuals with poor renal function, the blood concentrations of beta-lactam antibiotics and their metabolites may rise and their half-lives may be prolonged. According to the particular product package labelling, dosage modifications may be required. These alterations should be based on the severity of the infection as well as the degree of renal impairment. Renal function tests should be carried out on a regular basis during extended and/or high-dose therapy since these medicines have occasionally been linked to nephrotoxicity and changes in renal function.
How to manage the interaction:
The serum concentration may be increased in patients with impaired kidney function. Dose adjustment may be necessary for patients with kidney dysfunction. Regular renal function tests are advised.
The kidneys remove the majority of beta-lactam antibiotics as unaltered drugs and, in certain situations, as metabolites as well. In individuals with poor renal function, the blood concentrations of beta-lactam antibiotics and their metabolites may rise and their half-lives may be prolonged. According to the particular product package labelling, dosage modifications may be required. These alterations should be based on the severity of the infection as well as the degree of renal impairment. Renal function tests should be carried out on a regular basis during extended and/or high-dose therapy since these medicines have occasionally been linked to nephrotoxicity and changes in renal function.
How to manage the interaction:
The serum concentration may be increased in patients with impaired kidney function. Dose adjustment may be necessary for patients with kidney dysfunction. Regular renal function tests are advised.
CEFPODOXIME PROXETIL-100MGAbnormal serum enzyme levels
Moderate
How does the disease interact with Pencital 100mg Tablet:
Certain cephalosporins have been associated with cases of hepatitis. There has also been a brief increase in the levels of AST, ALT, and alkaline phosphatase. Patients with hepatic problems should be treated with caution and under close observation when using these medications.
How to manage the interaction:
Caution and monitoring is recommended in patients with liver disorders.
Certain cephalosporins have been associated with cases of hepatitis. There has also been a brief increase in the levels of AST, ALT, and alkaline phosphatase. Patients with hepatic problems should be treated with caution and under close observation when using these medications.
How to manage the interaction:
Caution and monitoring is recommended in patients with liver disorders.
CEFPODOXIME PROXETIL-100MGEpilepsy
Moderate
How does the disease interact with Pencital 100mg Tablet:
It has been suggested that cephalosporins can cause seizures. In particular in patients with a history of epilepsy and/or where prescribed doses of cephalosporins were exceeded because of renal impairment, cephalosporins have been associated with nonconvulsive status epilepticus (NCSE), encephalopathy, coma, asterixis, neuromuscular excitability, and myoclonia. Depending on the creatinine clearance, change the dosage. In individuals with known seizure disorders, anticonvulsant medication should be maintained. Patients should get a neurological exam to see if medication should be stopped if CNS side effects like seizures happen.
How to manage the interaction:
Cephalosporin antibiotics may trigger seizures. Dose adjustment may be needed.
It has been suggested that cephalosporins can cause seizures. In particular in patients with a history of epilepsy and/or where prescribed doses of cephalosporins were exceeded because of renal impairment, cephalosporins have been associated with nonconvulsive status epilepticus (NCSE), encephalopathy, coma, asterixis, neuromuscular excitability, and myoclonia. Depending on the creatinine clearance, change the dosage. In individuals with known seizure disorders, anticonvulsant medication should be maintained. Patients should get a neurological exam to see if medication should be stopped if CNS side effects like seizures happen.
How to manage the interaction:
Cephalosporin antibiotics may trigger seizures. Dose adjustment may be needed.
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