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Reviewed By Sureshvarma D , MPharma
48 Hrs returnable
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Whats That

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Composition :

EVEROLIMUS-5MG

Manufacturer/Marketer :

Novartis India Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

Therapeutic Class

ANTINEOPLASTIC

Country of origin

India

Manufacturer/Marketer address

Sandoz House, Shiv Sagar Estate, Worli Mumbai -400 018, India
Other Info - AFI0013

FAQs

Afinitor 5 mg Tablet is an anticancer medicine. It belongs to a group of medicines known as a kinase inhibitor. It works by lowering the blood supply to the tumor, which reduces the growth and spread of cancer cells.

There is no specific duration of treatment with Afinitor 5 mg Tablet . Afinitor 5 mg Tablet is continued till benefit is seen or undesirable toxicity or side effects occur.

You should prevent grapefruit or grapefruit juice while taking Afinitor 5 mg Tablet . This is because taking them together may rise the levels of Afinitor 5 mg Tablet in your blood to toxic levels. Avoid the use of live vaccinations and any probable contact with people who have received live vaccinations.

Afinitor 5 mg Tablet can lead to serious side effects that consist of severe allergic reactions, angioedema (painless swelling under the skin) and kidney failure which can be dangerous and can lead to death. It is possible that you may develop an infection or problems associated to lungs like breathing problems.

It usually takes three to six months for most types of lung cancer to double their size. It will take a long time for lung cancer to reach a size that could be diagnosed in X-Ray.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Caution

You are recommended to avoid alcohol consumption while taking Afinitor 5 mg Tablet to avoid unpleasant side-effects.

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Pregnancy

Unsafe

Afinitor 5 mg Tablet is belonging to pregnancy C category. It is not safe in pregnancy as it may causes harm to the unborn baby. Do not conceive a baby while taking Afinitor 5 mg Tablet .

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Breast Feeding

Unsafe

Afinitor 5 mg Tablet should not be taken by breastfeeding mothers as it may harm to the new-born baby.

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Driving

Caution

Afinitor 5 mg Tablet may cause tiredness (fatigue), do not drive or operate heavy machinery if you feel dizzy.

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Liver

Caution

Afinitor 5 mg Tablet should be taken with caution in patients dealing with liver disease. The doctor may adjust the dose according to the medical condition of the patient.

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Kidney

Caution

Afinitor 5 mg Tablet is likely unsafe in patients with severe kidney disease as it may cause kidney failure which can be dangerous, use Afinitor 5 mg Tablet only when prescribed by a doctor.

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Children

Unsafe

Afinitor 5 mg Tablet is not recommended for children below 18 years as the safety and effectiveness were not established.

About Afinitor 5 mg Tablet

Afinitor 5 mg Tablet belongs to the group of medicine called ‘anti-cancer’. It is primarily used to treat breast cancer, pancreatic cancer, lung cancer and kidney cancer. Breast cancer is a type of cancer that develops in breast cells stimulated by the female sex hormone known as estrogen. Pancreatic cancer is described as a cancerous growth in the pancreas which normally begins in the cells that generate the juices that help break down food and the hormones which help in controlling blood sugar levels. Lung cancer is the uncontrolled growth of abnormal cells in one or both lungs. 

Afinitor 5 mg Tablet contains 'Everolimus' which belongs to the group of medicines known as 'kinase inhibitors'. It works by decreases the activity of the immune system of the body and prevents rejection of the transplanted organ. It works by stopping the action of an abnormal protein that causes the multiplication of cancerous cells. In this way, it stops the spread of cancerous cells.

Take Afinitor 5 mg Tablet as prescribed by your doctor. You are advised to take Afinitor 5 mg Tablet for as long as your doctor has prescribed it for you depending on your medical conditions. You may experience weakness, infection, sinus inflammation, cough, diarrhea, fever, fatigue, otitis media (infection of the ear), stomatitis (Inflammation of the mouth) and upper respiratory tract infection. Most of these side effects of Afinitor 5 mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

To treat your condition effectually, continue taking Afinitor 5 mg Tablet for as long as your doctor has prescribed. If you are known to be allergic to Afinitor 5 mg Tablet or any other medicines, please tell your doctor. Do not take Afinitor 5 mg Tablet if you are pregnant or planning for pregnancy as Afinitor 5 mg Tablet may harm the unborn baby. Afinitor 5 mg Tablet should not be taken by breastfeeding mothers as it may cause harm to the newborn baby. Afinitor 5 mg Tablet causes tiredness, thus, it is advisable not to drive unless you are alert. Elderly people are more sensitive to medicine so they may adjust the dosage according to their condition.

Uses of Afinitor 5 mg Tablet

Breast cancer, pancreatic cancer, lung cancer and kidney cancer.

Medicinal Benefits Mweb

Medicinal Benefits

Afinitor 5 mg Tablet is indicated to the patients dealing with breast cancer, pancreatic cancer, lung cancer, kidney cancer and stomach/ intestinal cancer. Cancer of this type tends to spread quickly in other parts of the body. Afinitor 5 mg Tablet travels through the bloodstream and effectively destroys cancerous cells and other parts of the body. It works by decreases the activity of the immune system of the body and prevents rejection of the transplanted organ. It works by stopping the action of an abnormal protein that causes the multiplication of cancerous cells. In this way, it stops the spread of cancerous cells. Besides this, it is also effective in people with genetic disorders to treat some types of tumors in the brain or kidney.

Directions for Use

Take Afinitor 5 mg Tablet with or without food as advised by the doctor. Swallow it as a whole with water; do not crush, break or chew it.

Side Effects of Afinitor 5 mg Tablet

  • Tiredness
  • Breathlessness
  • Dizziness
  • Headache
  • Loss of appetite
  • Infection
  • Mouth ulcers 
  • Sinus inflammation
  • Cough
  • Diarrhea
  • Fever
  • High level of sugar in the blood (hyperglycemia)
  • Signs of low level of red blood cells (anemia) 
  • Otitis media (infection of the ear)
  • Stomatitis (Inflammation of the mouth)
  • Upper respiratory tract infection.
  • Swelling of arms, hands, feet, and ankles

Drug Warnings

If you are known to be allergic to Afinitor 5 mg Tablet or any other medicines, please tell your doctor. Afinitor 5 mg Tablet should not be taken in the conditions like liver disease, diabetes and high level of cholesterol. Do not take Afinitor 5 mg Tablet if you have recent surgery, infection and hepatitis B. Afinitor 5 mg Tablet may weaken your immune system, inform your doctor before taking Afinitor 5 mg Tablet . Afinitor 5 mg Tablet may also impair your kidney function. Therefore, monitor your kidney function regularly while taking Afinitor 5 mg Tablet . Afinitor 5 mg Tablet may cause cough, fever and shortness of breathing, thereby inform your doctor while taking your Afinitor 5 mg Tablet . Afinitor 5 mg Tablet may cause skin cancer, if you observe night sweating, weight loss, or change in color and size of the mole inform your doctor. Do not take Afinitor 5 mg Tablet if you are pregnant or planning for pregnancy as Afinitor 5 mg Tablet may harm the unborn baby. Afinitor 5 mg Tablet should not be taken by breastfeeding mothers as it may cause harm to the newborn baby. Afinitor 5 mg Tablet causes tiredness, thus, it is advisable not to drive unless you are alert. Elderly people are more sensitive to medicine so they may adjust the dosage according to their condition.

Drug-Drug Interactions

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EverolimusPolymyxin b
Severe
EverolimusSaquinavir
Severe

Drug-Drug Interactions

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EverolimusPolymyxin b
Severe
How does the drug interact with Afinitor 5 mg Tablet:
Taking Afinitor 5 mg Tablet and Polymyxin b together may increase the risk of kidney problems.

How to manage the interaction:
There may be a possibility of interaction between Afinitor 5 mg Tablet and Polymyxin b, but it can be taken if prescribed by a doctor. However, if you experience nausea, vomiting, a decrease in hunger, increased or decreased urine, weight gain or loss that occurs suddenly, swelling, difficulty breathing, bone pain, muscle pain, fatigue, weakness, dizziness, confusion, and irregular heartbeat, consult a doctor. Do not discontinue any medications without a doctor's advice.
EverolimusSaquinavir
Severe
How does the drug interact with Afinitor 5 mg Tablet:
Taking Afinitor 5 mg Tablet with saquinavir can considerably raise blood levels of Afinitor 5 mg Tablet, increasing the risk of serious side effects (pneumonitis - lung inflammation, infection, mouth ulcers, anemia, or bleeding).

How to manage the interaction:
Taking Afinitor 5 mg Tablet with Saquinavir together can result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without a doctor's advice.
EverolimusAmikacin
Severe
How does the drug interact with Afinitor 5 mg Tablet:
Coadministration of Amikacin and Afinitor 5 mg Tablet can increase the risk of developing kidney problems.

How to manage the interaction:
Although taking amikacin and Afinitor 5 mg Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. Consult the doctor if you experience vomiting, increased or decreased urination, swelling, shortness of breath, muscle cramps, weakness, or palpitation. Do not discontinue any medications without a doctor's advice.
EverolimusAprepitant
Severe
How does the drug interact with Afinitor 5 mg Tablet:
Coadministration of Afinitor 5 mg Tablet with Aprepitant blood levels may considerably increase the blood level of the aprepitant, which increases the severity of serious side effects (pneumonitis - inflammation of the lungs, infection, mouth ulcers, anemia, or bleeding).

How to manage the interaction:
Although co-administration of Aprepitant and Afinitor 5 mg Tablet can lead to an interaction, it can be taken if prescribed by a doctor. Consult a doctor if you suffer any symptoms, including bleeding, anemia, oral ulcers, infection, lung problems (shortness of breath, persistent cough, tiredness). Without consulting a doctor, never stop taking medicines.
EverolimusCiclosporin
Severe
How does the drug interact with Afinitor 5 mg Tablet:
Taking Afinitor 5 mg Tablet with cyclosporine may significantly increases the blood levels of Afinitor 5 mg Tablet.

How to manage the interaction:
Although taking Afinitor 5 mg Tablet and ciclosporin together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience any unusual symptoms contact a doctor immediately. In case you experience any side effects like persistent cough, fever, chills, mouth ulcers, paleness of skin, or unusual bleeding or bruising, or blood in stools or urine, consult a doctor. Do not stop using any medications without talking to a doctor.
EverolimusRifabutin
Severe
How does the drug interact with Afinitor 5 mg Tablet:
Taking Afinitor 5 mg Tablet and Rifabutin may reduce the blood levels of Afinitor 5 mg Tablet, which may make it less effective.

How to manage the interaction:
Co-administration of Afinitor 5 mg Tablet with Rifabutin can result in an interaction, but it can be taken if a doctor has advised it. Do not stop using any medications without a doctor's advice.
EverolimusCeritinib
Severe
How does the drug interact with Afinitor 5 mg Tablet:
Co-administration of Afinitor 5 mg Tablet with ceritinib can raise the blood levels of Afinitor 5 mg Tablet.

How to manage the interaction:
Although there is an interaction between Ceritinib and Afinitor 5 mg Tablet, but it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms like persistent cough, fever, chills, mouth ulcers, paleness, mouth sores, bruising, blood in stools, urine and vomitus, contact a doctor immediately. Do not stop using any medications without talking to a doctor.
EverolimusInfliximab
Severe
How does the drug interact with Afinitor 5 mg Tablet:
When Afinitor 5 mg Tablet and Infliximab are taken together, it can increase the risk or severity of developing serious infections.

How to manage the interaction:
Although taking Afinitor 5 mg Tablet and Infliximab together can cause an interaction, it can be taken if a doctor has suggested it. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, weight loss, and pain or burning when you pee, it's important to contact a doctor right away. Do not discontinue any medications without consulting a doctor.
EverolimusAciclovir
Severe
How does the drug interact with Afinitor 5 mg Tablet:
Coadministration of Aciclovir with Afinitor 5 mg Tablet may increase the risk or severity of kidney injury.

How to manage the interaction:
Taking Aciclovir with Afinitor 5 mg Tablet together can result in an interaction, it can be taken if a doctor has advised it. Contact a doctor immediately if you experience vomiting, irregular urination, sudden weight gain or loss, swelling, breathing difficulty, muscle pains, dizziness, or palpitations. Do not discontinue any medications without consulting a doctor.
Everolimusvalacyclovir
Severe
How does the drug interact with Afinitor 5 mg Tablet:
Co-administration of Afinitor 5 mg Tablet with valacyclovir may increase the risk of kidney problems.

How to manage the interaction:
Although taking Afinitor 5 mg Tablet and valacyclovir together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as nausea, vomiting, loss of appetite, increased urination, weight loss, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not stop using any medications without consulting a doctor.

Drug-Food Interactions

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EVEROLIMUS-5MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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EVEROLIMUS-5MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice

How to manage the interaction:
Taking Afinitor 5 mg Tablet with grapefruit juice can raise blood levels and enhance the effects of Afinitor 5 mg Tablet. Since the co-administration of Afinitor 5 mg Tablet along with grapefruit juice can lead to an interaction, You should not consume grapefruit juice or eat grapefruits while taking Afinitor 5 mg Tablet.

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • KETOCONAZOLE
  • ITRACONAZOLE
  • VORICONAZOLE
  • CLARITHROMYCIN
  • TELITHROMYCIN
  • ERYTHROMYCIN
  • RITONAVIR
  • EFAVIRENZ
  • RAMIPRIL
  • VERAPAMIL
  • DILTIAZEM
  • DRONEDARONE
  • IMATINIB
  • PHENYTOIN
  • CARBAMAZEPINE
  • PHENOBARBITAL
  • FLUCONAZOLE

Habit Forming

No

Special Advise

  • Afinitor 5 mg Tablet should be taken under strict medical supervision. The doctor will regularly monitor your condition while taking Afinitor 5 mg Tablet .
  • Do not have immunizations/vaccinations without a doctor's advice.
  • Avoid contact with people who have recently received live vaccines.

Diet & Lifestyle Advise

  • Avoid smoking and alcohol consumption.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yogurt, apples, peaches, cauliflower, cabbage, broccoli, beans, herbs and spices in your diet.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugar.
  • Get optimal sleep, rest well.
  • Performing yoga and other relaxation techniques may also improve physical and mental health and may reduce your stress levels.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.

Afinitor 5 mg Tablet Substitute

Substitutes safety advice
  • Evermil 5 Tablet 10's

    by AYUR

    463.30per tablet
  • Rolimus 5 Tablet

    by AYUR

    601.63per tablet
  • Everbliss 5mg Tablet

    by Others

    487.73per tablet
  • EVERTOR 5MG TABLET

    by Others

    1621.77per tablet
  • Everbliss 5 Tablet 10's

    by Others

    594.80per tablet
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