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Written By Lakshmithulasi Yarragunta , Pharm-D (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
48 Hrs returnable
COD available

Online payment accepted

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Whats That

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Synonym :

EPIRUBICIN HYDROCHLORIDE

Composition :

EPIRUBICIN-10MG

Manufacturer/Marketer :

Alkem Laboratories Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

Therapeutic Class

ANTINEOPLASTIC

Country of origin

India

Manufacturer/Marketer address

Alkem Laboratories Limited, Devashish Building, Alkem House, Senapati Bapat Road, Lower Parel, Mumbai - 400 013.
Other Info - ALR0002

FAQs

ALRUBICIN 10MG INJECTION 5ML contains Epirubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, thereby destroying the DNA and RNA synthesis.

ALRUBICIN 10MG INJECTION 5ML can disrupt a woman's natural menstrual cycle (period) and inhibit sperm production in men. However, you should not presume that you cannot become pregnant or that you cannot make someone else pregnant. It may also harm your foetus. Use reliable methods of birth control while on treatment with ALRUBICIN 10MG INJECTION 5ML.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Unsafe

Alcohol intake might increase the risk of stomach or intestine bleeding. Alcohol consumption is not recommended.

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Pregnancy

Unsafe

ALRUBICIN 10MG INJECTION 5ML is not recommended for use in pregnancy as it may harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving ALRUBICIN 10MG INJECTION 5ML. Use reliable methods of birth control while on treatment with ALRUBICIN 10MG INJECTION 5ML.

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Breast Feeding

Unsafe

It is not recommended for use in breastfeeding as it may pass into breast milk and harm your infant. Hence, if you are breastfeeding, inform your doctor before receiving ALRUBICIN 10MG INJECTION 5ML. Your doctor may suggest you stop feeding while on treatment with this medicine.

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Driving

Not applicable

ALRUBICIN 10MG INJECTION 5ML does not affect your ability to drive.

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Liver

Caution

ALRUBICIN 10MG INJECTION 5ML should be used with caution in patients with liver impairment. However, this medicine is contraindicated in patients with severe liver disease. If you have a pre-existing or a history of liver disease, inform your doctor. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor. Your doctor may adjust the dose or prescribe a suitable alternative, if necessary, based on your condition.

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Children

Unsafe

ALRUBICIN 10MG INJECTION 5ML is not recommended for use in children, as it is known to cause anthracycline-induced acute manifestations of cardiotoxicity and chronic CHF leading to serious side effects.

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Keep Refrigerated. Do not freeze.

About ALRUBICIN 10MG INJECTION 5ML

ALRUBICIN 10MG INJECTION 5ML is an anti-cancer medicine that is used in conjunction with other drugs to treat breast cancer in people who have had tumor removal surgery. ALRUBICIN 10MG INJECTION 5ML is used as adjuvant chemotherapy in women with axillary lymph nodes with involvement resection of breast cancer (abnormal growth in the cells of the breast).

ALRUBICIN 10MG INJECTION 5ML contains Epirubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, thereby destroying the DNA and RNA synthesis.

ALRUBICIN 10MG INJECTION 5ML may cause certain side effects such as nausea, headache, abdominal pain, loss of appetite, vomiting, dizziness, mouth sores, tiredness, back pain, diarrhoea, and pain at the site of injection. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor. A trained healthcare doctor will administer ALRUBICIN 10MG INJECTION 5ML. So, do not self-administer. Your doctor will decide the dose of the medicine based on your health condition.

ALRUBICIN 10MG INJECTION 5ML should be avoided if you are allergic to it. It is contraindicated in patients having a recent history of myocardial infarction (MI) or heart attack, patients with baseline neutrophil count < 1500 cells/mm3, severe arrhythmias, previous treatment with anthracyclines, and severe hepatic dysfunction. Hence avoid using this medicine under such conditions. Inform your doctor if you have any cardiovascular conditions, liver/kidney disease, or taking any medicines such as cardiotoxic drugs (eg, Thalidomide, doxorubicin, Abiraterone, tamoxifen, letrozole), and cimetidine, as it can cause serious adverse effects. ALRUBICIN 10MG INJECTION 5ML is known to cause embryo-fetal toxicity. Hence it is contraindicated in pregnant or breastfeeding women. ALRUBICIN 10MG INJECTION 5ML is not recommended for children as it is known to cause anthracycline-induced acute manifestations of cardiotoxicity and chronic CHF.

Uses of ALRUBICIN 10MG INJECTION 5ML

Breast Cancer

Medicinal Benefits Mweb

Medicinal Benefits

ALRUBICIN 10MG INJECTION 5ML contains Epirubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, thereby destroying the DNA and RNA synthesis. It is used as adjuvant chemotherapy in women with axillary lymph nodes with involvement resection of breast cancer.

Directions for Use

A trained healthcare professional will administer ALRUBICIN 10MG INJECTION 5ML. Hence, do not self-administer.

Side Effects of ALRUBICIN 10MG INJECTION 5ML

  • Nausea
  • Abdominal pain
  • Vomiting
  • Dizziness
  • Back pain
  • Pain at the site of injection
  • Red discoloration of urine
  • Loss of appetite
  • Mouth sores
  • Tiredness
  • Weight gain
  • Pale skin

Drug Warnings

ALRUBICIN 10MG INJECTION 5ML should be avoided if you are allergic to it. It is contraindicated in patients having a recent history of myocardial infarction (MI) or heart attack, patients with baseline neutrophil count < 1500 cells/mm3, severe arrhythmias, previous treatment with anthracyclines and severe hepatic dysfunction. Hence avoid using this medicine under such conditions. Inform your doctor if you have any cardiovascular conditions, liver/kidney disease, or taking any medicines such as cardiotoxic drugs (e.g., Thalidomide, doxorubicin, Abiraterone, tamoxifen, letrozole), and cimetidine, as it can cause serious adverse effects. ALRUBICIN 10MG INJECTION 5ML is known to cause embryo-fetal toxicity. Hence it is contraindicated in pregnant or breastfeeding women. ALRUBICIN 10MG INJECTION 5ML is not recommended for children as it is known to cause anthracycline-induced acute manifestations of cardiotoxicity and chronic CHF. Do not stop receiving ALRUBICIN 10MG INJECTION 5ML without a doctor’s advice, as it can cause serious health conditions. ALRUBICIN 10MG INJECTION 5ML is known to cause severe life-threatening haematological reactions, tissue necrosis, cardiomyopathy, secondary acute myelogenous leukaemia, and severe myelosuppression in some patients. Hence careful monitoring of the patient is needed while receiving the medicine.

Drug-Drug Interactions

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EpirubicinZiprasidone
Critical
EpirubicinHydroxychloroquine
Severe

Drug-Drug Interactions

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EpirubicinZiprasidone
Critical
How does the drug interact with Alrubicin 10mg Injection 5ml:
Using ziprasidone together with Alrubicin 10mg Injection 5ml can increase the risk of an irregular heart rhythm

How to manage the interaction:
Taking Ziprasidone with Alrubicin 10mg Injection 5ml is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
EpirubicinHydroxychloroquine
Severe
How does the drug interact with Alrubicin 10mg Injection 5ml:
The combined use of Alrubicin 10mg Injection 5ml and Hydroxychloroquine can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of Alrubicin 10mg Injection 5ml and Hydroxychloroquine can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
EpirubicinMoxifloxacin
Severe
How does the drug interact with Alrubicin 10mg Injection 5ml:
Using Moxifloxacin together with Alrubicin 10mg Injection 5ml can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Moxifloxacin with Alrubicin 10mg Injection 5ml together can result in an interaction, but it can be taken if a doctor has advised it. If you experience irregular heart rhythm, vomiting, dizziness, difficulty breathing, or irregular heartbeat call a doctor right away. Do not discontinue any medications without consulting a doctor.
EpirubicinDisopyramide
Severe
How does the drug interact with Alrubicin 10mg Injection 5ml:
The combined use of Efavirenz and Disopyramide can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of Efavirenz and Disopyramide can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
EpirubicinNilotinib
Severe
How does the drug interact with Alrubicin 10mg Injection 5ml:
Coadministration of Alrubicin 10mg Injection 5ml and nilotinib can increase the risk of an irregular heart rhythm. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Alrubicin 10mg Injection 5ml and nilotinib together can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
EpirubicinMifepristone
Severe
How does the drug interact with Alrubicin 10mg Injection 5ml:
Co-administration of Alrubicin 10mg Injection 5ml with mifepristone can increase the risk of irregular heart rhythms. Prolonged treatment with Mifepristone may result in low potassium levels.

How to manage the interaction:
Taking Alrubicin 10mg Injection 5ml with mifepristone together is avoided as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, rapid heartbeat, weakness, tiredness, drowsiness, confusion, painful muscle cramping, nausea, or vomiting, constipation, abdominal cramping, chest pain, and/or swelling in the legs or feet, get medical attention. Do not discontinue any medications without consulting a doctor.
EpirubicinGatifloxacin
Severe
How does the drug interact with Alrubicin 10mg Injection 5ml:
Taking Alrubicin 10mg Injection 5ml with Gatifloxacin can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Alrubicin 10mg Injection 5ml with Gatifloxacin together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
EpirubicinBaricitinib
Severe
How does the drug interact with Alrubicin 10mg Injection 5ml:
Coadministration of baricitinib and Alrubicin 10mg Injection 5ml can raise the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, baricitinib can be taken with Alrubicin 10mg Injection 5ml if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without talking to a doctor.
EpirubicinCeritinib
Severe
How does the drug interact with Alrubicin 10mg Injection 5ml:
Taking Ceritinib with Alrubicin 10mg Injection 5ml can increase the risk of an irregular heart rhythm and other side effects.

How to manage the interaction:
Although taking Ceritinib and Alrubicin 10mg Injection 5ml together can evidently cause an interaction, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
EpirubicinChloroquine
Severe
How does the drug interact with Alrubicin 10mg Injection 5ml:
Using chloroquine together with Alrubicin 10mg Injection 5ml can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although there is a interaction between Chloroquine and Alrubicin 10mg Injection 5ml, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • THALIDOMIDE
  • DOXORUBICIN
  • ABIRATERONE
  • TAMOXIFEN
  • LETROZOLE
  • PACLITAXEL
  • DOCETAXEL
  • CIMETIDINE
  • CILNIDIPINE
  • NIFEDIPINE

Habit Forming

No

Special Advise

  • Avoid having intercourse while on treatment with ALRUBICIN 10MG INJECTION 5ML.
  • Regular monitoring of complete blood count  (CBC) and liver function (LFT) is important while receiving ALRUBICIN 10MG INJECTION 5ML.

Diet & Lifestyle Advise

  • Try to eat more healthy fats, fruits, vegetables and whole-grain foods to give you more energy. 
  • Stay hydrated by drinking plenty of water, as dehydration is often seen in cancers.
  • Taking a stroll in the garden or spending 30 minutes of your time doing some light physical activity can be very useful. However, do not over-exert yourself if you feel too tired. 
  • Avoid smoking and alcohol consumption.
  • Doing meditation and yoga for some time is very effective in helping cancer patients maintain a healthy attitude and body.

ALRUBICIN 10MG INJECTION 5ML Substitute

Substitutes safety advice
  • Adricin 10 Injection 1's

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  • Mapsepicin-10 Injection 1's

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  • Farmorubicin RTU 10mg Injection

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  • Farmorubicin RD 10mg Injection

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    144.94per tablet
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