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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Sunny S , MBBS

Composition :

AMITRIPTYLINE-25MG

Manufacturer/Marketer :

Cryzer Formulation Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

About Amicrez Plus 25 mg Tablet 15'

Amicrez Plus 25 mg Tablet 15' belongs to a group of medicines called 'tricyclic antidepressants' used to treat depression, neuropathic pain, chronic tension-type headache, and migraine in adults. Additionally, Amicrez Plus 25 mg Tablet 15' is also used to treat bedwetting at night in children aged 6 years and above. Depression is a mood disorder that affects a person's daily life described as feelings of sadness, loss, or anger. 

Amicrez Plus 25 mg Tablet 15' contains Amitriptyline that works by affecting certain chemical messengers (serotonin, norepinephrine) in the brain which communicate between brain cells, thereby helping in the regulation of mood and preventing depression. Besides this, Amicrez Plus 25 mg Tablet 15' also the transmission of pain signals, thereby provides relief from neuropathic pain.

You are advised to take Amicrez Plus 25 mg Tablet 15' for as long as your doctor has prescribed it for you depending on your medical condition and response to the treatment. In some cases, you may experience certain common side-effects such as sleepiness, drowsiness, headache, irregular heartbeat, dry mouth, constipation, nausea, weight gain, slurred or slow speech, and congested nose. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.

To treat your condition effectually, continue taking Amicrez Plus 25 mg Tablet 15' for as long as your doctor has prescribed. Do not take Amicrez Plus 25 mg Tablet 15' if you are pregnant or breastfeeding unless prescribed by the doctor. Amicrez Plus 25 mg Tablet 15' causes drowsiness, sleepiness and dizziness, do not drive unless you are alert. Amicrez Plus 25 mg Tablet 15' can be given to children over 6years if prescribed by the doctor for bedwetting. Amicrez Plus 25 mg Tablet 15' should not be given to children for treating depression or neuropathic pain. Avoid consuming alcohol along with Amicrez Plus 25 mg Tablet 15' as it could lead to increased drowsiness and dizziness. Keep your doctor informed about your health condition and medicines to rule out any side-effects.

Uses of Amicrez Plus 25 mg Tablet 15'

Depression

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Directions for Use

Tablet/Capsule: Swallow it as a whole with a glass of water; do not chew, or crush the tablet/capsule.Syrup/Suspension/Drops: Take the prescribed dose by mouth using the measuring cup/dosing syringe/dropper provided by the pack; shake the pack well before each use.

Medicinal Benefits

Amicrez Plus 25 mg Tablet 15' belongs to a group of medicines called tricyclic antidepressants. Amicrez Plus 25 mg Tablet 15' is used to treat depression, neuropathic pain, chronic tension-type headache, and migraine in adults. Amicrez Plus 25 mg Tablet 15' is also used to treat bedwetting at night in children aged 6 years and above. Amicrez Plus 25 mg Tablet 15' works by affecting certain chemical messengers (serotonin and/or norepinephrine) in the brain which communicate between brain cells, thereby helps in regulating mood and treats depression. Amicrez Plus 25 mg Tablet 15' prevents the transmission of pain signals, thereby provides relief from neuropathic pain.

Storage

Keep Amicrez Plus 25 mg Tablet 15' out of reach and sight of children.
Side effects of Amicrez Plus 25 mg Tablet 15'
  • Uncoordinated muscle movements need immediate medical attention.
  • Observe your movements and try to understand and control the particular movement.
  • Regularly do strengthening exercises to improve blood flow throughout the body and avoid involuntary movements.
  • Implement massage techniques to enhance blood flow to organs.
  • Take a balanced diet and quit smoking.
  • Practice yoga and meditation to improve thought processes and reduce uncontrolled and involuntary movements.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
  • Try to practice deep breathing exercises or repeat calming words or phrases.
  • Seek for medical help if aggression occurs frequently, as it can worsen gradually if not attended.
  • You can also try listening to music or relaxing or writing a journal to express the feeling that aggravates to find a solution.
  • Consume controlled amounts of salt to raise sodium levels.
  • Eat fresh fruits like apples, berries, oranges, mangoes, and bananas.
  • Include fresh vegetables like broccoli, sweet potatoes, beets, okra, spinach, peppers, carrots, and edamame.
  • Choose frozen vegetables without added butter or sauce.
  • Drink electrolyte beverages like sports drinks or electrolyte solutions to replenish sodium and other electrolytes.
  • Avoid excessive salt intake, but allow for controlled increases as needed.
  • Monitor and manage underlying health conditions that may contribute to hyponatremia.
  • Quit smoking as smoking impairs erectile function by significantly damaging blood vessels.
  • Maintain a healthy weight as overweight can cause erectile dysfunction.
  • Exercise regularly as physical activity enhances blood flow and overall health, benefiting erectile function.
  • Consume a healthy diet loaded with whole grains, fruits and vegetables.
  • Limit alcohol consumption as excessive alcohol intake can impair erectile function.
  • Manage stress by practicing techniques such as yoga, relaxation exercises or meditation.
  • In case erectile dysfunction is due to psychological factors, consider couple counselling or sex therapy to address relationship and anxiety issues.
  • Openly discuss your concerns with your partner.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.

Drug Warnings

Do not take Amicrez Plus 25 mg Tablet 15' if you are allergic to any of its contents if you recently had a heart attack, or heart problems, are taking other antidepressants like isocarboxazid, phenelzine, selegiline, tranylcypromine or have taken them in the last 14 days, have severe liver disease or if you have taken moclobemide (used to treat depression and social anxiety). Inform your doctor before taking Amicrez Plus 25 mg Tablet 15' if you have heart rhythm problems or hypotension. Consult your doctor immediately if you have suicidal thoughts such as killing or harming yourself. Do not take Amicrez Plus 25 mg Tablet 15' if you are pregnant or breastfeeding unless prescribed. Amicrez Plus 25 mg Tablet 15' causes drowsiness and dizziness, do not drive unless you are alert. Amicrez Plus 25 mg Tablet 15' can be given to children above 6 years if prescribed by the doctor for treating bedwetting. Amicrez Plus 25 mg Tablet 15' should not be given to children for treating depression or neuropathic pain. Avoid consuming alcohol along with Amicrez Plus 25 mg Tablet 15' as it could lead to increased drowsiness and dizziness. Rise slowly from sitting or lying position as Amicrez Plus 25 mg Tablet 15' causes orthostatic hypotension (sudden lowering in blood pressure leading to dizziness on standing).

Drug-Drug Interactions

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AmitriptylineHalofantrine
Critical

Drug-Drug Interactions

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AmitriptylineHalofantrine
Critical
How does the drug interact with Amicrez Plus 25 mg Tablet 15':
Combining Amicrez Plus 25 mg Tablet 15' and Halofantrine may increase the risk of irregular heartbeat.

How to manage the interaction:
Although combining Amicrez Plus 25 mg Tablet 15' with Halofantrine may result in an interaction, it can be used if a doctor recommends it. If you have any heart problems or electrolyte imbalances, you may be susceptible. If you have sudden dizziness, lightheadedness, fainting, or fast or rapid heartbeats during therapy, get emergency medical help. Do not discontinue any medication without consulting a doctor.
How does the drug interact with Amicrez Plus 25 mg Tablet 15':
Combining Amicrez Plus 25 mg Tablet 15' and Pimozide may increase the risk of irregular heartbeat.

How to manage the interaction:
Although combining Amicrez Plus 25 mg Tablet 15' with Pimozide may result in an interaction, it can be used if a doctor recommends it. If you have any heart problems or electrolyte imbalances, you may be susceptible. If you have sudden dizziness, lightheadedness, fainting, or fast or rapid heartbeats during therapy, get emergency medical help. Do not discontinue any medication without consulting a doctor.
How does the drug interact with Amicrez Plus 25 mg Tablet 15':
Combining Furazolidone with Amicrez Plus 25 mg Tablet 15' can increase the risk of serotonin syndrome(increased serotonin hormone).

How to manage the interaction:
Although using Furazolidone and Amicrez Plus 25 mg Tablet 15' together may cause an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have symptoms such as confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Inform a doctor if you have recently taken Amicrez Plus 25 mg Tablet 15'. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Amicrez Plus 25 mg Tablet 15':
Using Amicrez Plus 25 mg Tablet 15' together with Procarbazine can increase the risk of serotonin syndrome (A condition resulting from the accumulation of high levels of serotonin in the body. Serotonin is especially a mood stabilizer).

How to manage the interaction:
Although using Procarbazine and Amicrez Plus 25 mg Tablet 15' together may cause an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have symptoms such as confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Inform a doctor if you have recently taken Amicrez Plus 25 mg Tablet 15'. Do not discontinue any medications without consulting a doctor.
AmitriptylineGrepafloxacin
Critical
How does the drug interact with Amicrez Plus 25 mg Tablet 15':
Combining Amicrez Plus 25 mg Tablet 15' and Grepafloxacin may increase the risk of irregular heartbeat.

How to manage the interaction:
Although combining Amicrez Plus 25 mg Tablet 15' with Grepafloxacin may result in an interaction, it can be used if a doctor recommends it. If you have sudden dizziness, lightheadedness, fainting, or fast or rapid heartbeats during therapy, get emergency medical help. Do not discontinue any medication without consulting a doctor. Note: Grepafloxacin is no longer available in the market. Grepafloxacin should not be combined with any other medications.
AmitriptylineMesoridazine
Critical
How does the drug interact with Amicrez Plus 25 mg Tablet 15':
Coadministration of Amicrez Plus 25 mg Tablet 15' and Mesoridazine may increase the risk of irregular heartbeat.

How to manage the interaction:
Although combining Amicrez Plus 25 mg Tablet 15' with Mesoridazine may result in an interaction, it can be used if a doctor recommends it. If you have any heart problems or electrolyte imbalances, you may be susceptible. If you have sudden dizziness, lightheadedness, fainting, or fast or rapid heartbeats during therapy, get emergency medical help. Do not discontinue any medication without consulting a doctor.
How does the drug interact with Amicrez Plus 25 mg Tablet 15':
Coadministration of Amicrez Plus 25 mg Tablet 15' and Cisapride may increase the risk of irregular heartbeat.

How to manage the interaction:
Although combining Amicrez Plus 25 mg Tablet 15' with Cisapride may result in an interaction, it can be used if a doctor recommends it. If you have any heart problems or electrolyte imbalances, you may be susceptible. If you have sudden dizziness, lightheadedness, fainting, or fast or rapid heartbeats during therapy, get emergency medical help. Do not discontinue any medication without consulting a doctor.
How does the drug interact with Amicrez Plus 25 mg Tablet 15':
Combining Amicrez Plus 25 mg Tablet 15' and Dronedarone may increase the risk of irregular heartbeat.

How to manage the interaction:
Although combining Amicrez Plus 25 mg Tablet 15' with Dronedarone may result in an interaction, it can be used if a doctor recommends it. If you have any heart problems or electrolyte imbalances, you may be susceptible. If you have sudden dizziness, lightheadedness, fainting, or fast or rapid heartbeats during therapy, get emergency medical help. Do not discontinue any medication without consulting a doctor.
How does the drug interact with Amicrez Plus 25 mg Tablet 15':
Amicrez Plus 25 mg Tablet 15' and Thioridazine can enhance each other's effects when used together.

How to manage the interaction:
Although using Amicrez Plus 25 mg Tablet 15' and Thioridazine together can cause an interaction, they can be used if prescribed by a doctor. If you have extreme sleepiness, confusion, anxiety, vomiting, vision problems, feeling hot or cold, sweating, muscle stiffness, fainting, fits, or coma, seek medical help. Do not discontinue any medications without consulting a doctor.
AmitriptylineIsocarboxazid
Critical
How does the drug interact with Amicrez Plus 25 mg Tablet 15':
Combining Isocarboxazid with Amicrez Plus 25 mg Tablet 15' can increase the risk of serotonin syndrome (increase serotonin hormone).

How to manage the interaction:
Although using Isocarboxazid and Amicrez Plus 25 mg Tablet 15' together may cause an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have symptoms such as confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Inform a doctor if you have recently taken Amicrez Plus 25 mg Tablet 15'. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a healthy diet and exercise regularly helps in improving overall health and boosts self-esteem.
  • Regularly attend therapy sessions.
  • Perform meditation and yoga. This helps in relieving stress and provides relaxation.
  • Follow a regular sleep pattern to improve the amount and quality of sleep you get.
  • Include foods rich in omega fatty acids such as fish, nuts, fresh fruits, vegetables and olive oils.
  • Neurotransmitters are made up of amino acids. Amino acid-rich foods such as meat, dairy products, and certain fruits and vegetables help in proper maintenance of neurotransmitters. 
  • Complex carbohydrates help in stimulating serotonin (a feel-good neurotransmitter). These include whole grains, legumes, spinach, broccoli, oranges and pears.
  • Exercising helps in the production of the body’s natural antidepressants. It also helps in relieving stress, improving mood, boosts self-esteem, and provides restful sleep.
  • Avoid smoking and alcohol consumption.
  • Learn about your condition, understand the risk factors and follow the doctor’s treatment plan.

Habit Forming

No

Therapeutic Class

PSYCHOTHERAPEUTICS
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Amicrez Plus 25 mg Tablet 15' as it may cause an increased sedative effect.

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Pregnancy

Caution

Avoid taking Amicrez Plus 25 mg Tablet 15' if you are pregnant unless prescribed by a doctor. Please consult your doctor if you have any concerns regarding this, your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Consult your doctor before taking Amicrez Plus 25 mg Tablet 15'; your doctor will decide whether Amicrez Plus 25 mg Tablet 15' can be taken by breastfeeding mothers or not.

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Driving

Unsafe

Amicrez Plus 25 mg Tablet 15' causes sleepiness, dizziness and drowsiness. Do not drive or operate machinery if you experience these symptoms.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

Amicrez Plus 25 mg Tablet 15' can be given to children above 6 years if prescribed by the doctor for treating bedwetting. Amicrez Plus 25 mg Tablet 15' should not be given to children for treating depression or neuropathic pain.

FAQs

Amicrez Plus 25 mg Tablet 15' works by affecting certain chemical messengers (serotonin and/or norepinephrine) in the brain which communicate between brain cells, thereby helps in regulating mood and treats depression.

Amicrez Plus 25 mg Tablet 15' prevents the transmission of pain signals, thereby provides relief from neuropathic pain.

Amicrez Plus 25 mg Tablet 15' causes sleepiness, drowsiness, and dizziness. Do not drive or operate machinery if you are experiencing these symptoms.

Amicrez Plus 25 mg Tablet 15' causes weight gain due to increased appetite. Eat a healthy diet and exercise regularly to maintain a healthy weight.

Do not discontinue Amicrez Plus 25 mg Tablet 15' without consulting your doctor as it could lead to recurring symptoms. To treat your condition effectually continue taking Amicrez Plus 25 mg Tablet 15' for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Amicrez Plus 25 mg Tablet 15'.

Amicrez Plus 25 mg Tablet 15' may cause decreased sex-drive, problems with erection and orgasm. Consult your doctor if you have any concerns regarding this.

Dry mouth could be a side-effect of Amicrez Plus 25 mg Tablet 15'. Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy might help in stimulating saliva and thereby prevents drying of the mouth.

Yes, orthostatic hypotension could be a side-effect of Amicrez Plus 25 mg Tablet 15'. Orthostatic hypotension is a sudden lowering in blood pressure leading to dizziness on standing. If you experience this, do not try to stand up suddenly or start walking, instead lie down and get up slowly only when you feel better. People taking Amicrez Plus 25 mg Tablet 15' are advised to regularly monitor their blood pressure levels to avoid such unpleasant events.

Country of origin

India

Manufacturer/Marketer address

no.17-1-473, plot no.34, d, 67/1, sri krishna nagar, saidabad, hyderabad, telangana 500059
Other Info - AM44839

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