CEFUROXIME-500MGOther gastroenteritis and colitis of infectious and unspecified origin
How does the disease interact with Arkagen Tab:
Colitis: In some cases the use of Arkagen Tab may cause ranging from mild diarrhea to fatal colitis. Colitis is commonly Clostridioides difficile-associated diarrhea (CDAD). Discontinue therapy if signs of CDAD are confirmed.
How to manage the interaction:
Antibiotics may cause Clostridioides difficile-associated diarrhoea (CDAD), which may range from mild diarrhoea to fatal colitis. Arkagen Tab should be used with caution in patients with a history of gastrointestinal disease, particularly colitis (inflammation of the colon) or pseudomembranous colitis (a severe inflammation of the inner lining of the large intestine). Appropriate fluid and electrolyte management, protein supplementation, antibacterial treatment of C difficile, and surgical evaluation is advised.
CEFUROXIME-500MGChronic kidney disease
How does the disease interact with Arkagen Tab:
Renal dysfunction:
Arkagen Tab is eliminated by the kidney in an unchanged form. Thus the plasma levels of the drug increase and prolongs the half-life. Adjust the doses of Arkagen Tab as necessary.
How to manage the interaction:
The serum concentration may be increased in patients with impaired kidney function as most beta-lactam antibiotics are eliminated by the kidney. Dose adjustment may be necessary for patients with kidney dysfunction. Regular renal function tests are advised during prolonged or high-dose therapy.
CEFUROXIME-500MGDependence on enabling machines and devices, not elsewhere classified
How does the disease interact with Arkagen Tab:
Dialysis : Most of the antibiotics are eliminated by hemodialysis. Therefore, administer Arkagen Tab after dialysis or an additional dosage to be administered.
How to manage the interaction:
Arkagen Tab serum levels may be decreased by hemodialysis and peritoneal dialysis. Supplemental doses should be given at the end of each hemodialysis session.
CEFUROXIME-500MGConvulsions, not elsewhere classified
How does the disease interact with Arkagen Tab:
seizure disorders:
In some patients, seizures were reported with whom renal dysfunction which incase of dosage adjustment was not done. Discontinue Arkagen Tab if seizures are reported.
How to manage the interaction:
Cephalosporin antibiotics may trigger seizures. Arkagen Tab should be discontinued if seizures associated with drug therapy occur.
CEFUROXIME-500MGOther diseases of liver
How does the disease interact with Arkagen Tab:
liver disease: With Arkagen Tab, a transient increase in the AST, ALT, and alkaline phosphatase levels was observed. Use with caution and closely monitor for hepatic function is recommended.
How to manage the interaction:
Caution and monitoring is recommended in patients with liver disease as cases of hepatitis have been reported with the use of certain cephalosporins.
CEFUROXIME-500MGOther diseases of liver
How does the disease interact with Arkagen Tab:
Rarely, cephalosporins use may cause hypoprothrombinemia, with or without bleeding. Monitor for Prothrombin time.
How to manage the interaction:
Cephalosporins may be associated with reduced prothrombin activity/prolonged prothrombin time (blood takes too long to form a clot). Prothrombin time should be monitored in at-risk patients and managed as needed.