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Written By ,
Reviewed By Hari Kumar , MBBS
48 Hrs returnable
COD available

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Whats That

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Composition :

BARICITINIB-4MG

Manufacturer/Marketer :

Lupin Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

Therapeutic Class

IMMUNOMODULATORS

Country of origin

India

Manufacturer/Marketer address

Lupin Ltd, 3rd floor Kalpataru Inspire, Off. W E Highway, Santacruz (East), Mumbai 400 055. India
Other Info - BAR0199

FAQs

Barilup 4 Tablet works by preventing the virus from attaching to the body’s cell receptors and thereby blocking its entry and spread.

If you suffer from Chronic Kidney Disease, please consult with your doctor before using Barilup 4 Tablet and discuss any concerns with them. Barilup 4 Tablet is to be used with caution in those suffering from kidney and liver problems.

Not enough literature exists to ascertain the effects of Barilup 4 Tablet on fertility. However, Barilup 4 Tablet should be absolutely avoided in pregnancy. Please consult your doctor in case of any concerns.

Advanced age, obesity, chronic kidney disease, lung disease, sickle cell disease, neurodevelopmental disorders (for example cerebral palsy) and diseases of metabolism are some risk factors for disease progression.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Caution

It is not recommended to use alcohol with Barilup 4 Tablet . Please consult your doctor if you have any concerns.

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Pregnancy

Unsafe

Barilup 4 Tablet is absolutely contraindicated during pregnancy.

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Breast Feeding

Caution

Not enough studies exist to ascertain the effect of Barilup 4 Tablet on nursing. Barilup 4 Tablet is not recommended to use without contraception during and for at least 1 week after treatment. Please consult your doctor in case of any concerns.

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Driving

Safe if prescribed

Barilup 4 Tablet does not affect your ability to drive.

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Liver

Caution

Exercise caution before using Barilup 4 Tablet in case of established liver disease as it may cause a derangement of liver enzymes. Please consult your doctor to address any concerns.

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Kidney

Caution

Exercise caution before using Barilup 4 Tablet in case of established kidney disease. Please consult your doctor to address any concerns.

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Children

Caution

Not enough studies exist to ascertain the effect of Barilup 4 Tablet in children. Please consult your doctor in case of any concerns.

About Barilup 4 Tablet

Barilup 4 Tablet belongs to the group of immunomodulators. Barilup 4 Tablet is used in the treatment of hospitalised cases of coronavirus disease, an infection caused by COVID-19 and is also used to treat Rheumatoid Arthritis. Rheumatoid arthritis is a chronic inflammatory and autoimmune disorder of the joints. Atopic dermatitis is a skin disease in which the skin becomes red, inflamed and itchy.  Coronavirus disease is an infectious disease caused by SARS-CoV-2. It can range from a mild cold to a serious form of pneumonia

Barilup 4 Tablet contains ‘’Baricitinib.’’ Barilup 4 Tablet works by inhibiting viral entry into body cells, limits viral replication and also controls the release of inflammatory mediators called cytokines.

Take Barilup 4 Tablet as prescribed by the doctor. Barilup 4 Tablet may cause certain common side effects such as throat infection, fatigue and high blood cholesterol. Most of these adverse effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if these side effects persist. 

It is advisable to inform the doctor if you are allergic to Barilup 4 Tablet or any of its components. Keep your doctor informed if you suffer from any medical disorders. Avoid Barilup 4 Tablet in case of a history of thromboembolism, abdominal disorders such as diverticulitis, cancer, liver disease, chronic infections such as tuberculosis, hepatitis B and C and shingles, and any anaemias. Keep your doctor informed if you have recently had any surgery or are scheduled for surgery in the near future. Offer a detailed medical and vaccination history. Discuss any recent vaccinations with the doctor. Inform the doctor if you are on any other JAK-2 inhibitor medicines, painkillers, steroids and/or drugs that affect the immunity and immune system of the body. Consult your doctor if you are planning to get pregnant or are breastfeeding. Avoid Barilup 4 Tablet use with alcohol.

Uses of Barilup 4 Tablet

Rheumatoid Arthritis, Atopic Dermatitis, COVID-19

Medicinal Benefits Mweb

Medicinal Benefits

Barilup 4 Tablet is an immunomodulator used in the treatment of various types of cancers and infections such as Covid-19. Barilup 4 Tablet contains Baricitinib. Baricitinib works by inhibiting the entry of the virus into the body cells. Barilup 4 Tablet targets an enzyme called Janus kinase (JAK-2), which is responsible for the formation of cytokines. Cytokines are inflammatory mediators. Hence, by inhibiting a cytokine-forming enzyme, Baricitinib reduces the level of cytokines in the body, thus relieving signs of inflammation.  In addition, Baricitinib works by reducing viral replication, thus arresting the progress of the disease.

Directions for Use

Take Barilup 4 Tablet with or without food as advised by the doctor. Swallow it as a whole with water; do not crush, break or chew it.

Side Effects of Barilup 4 Tablet

  • Throat infections
  • High blood cholesterol
  • Cold sores
  • Rash
  • Acne

Drug Warnings

It is advisable to inform the doctor if you are allergic to Barilup 4 Tablet or any of its components. Keep your doctor informed if you suffer from any medical disorders. Avoid Barilup 4 Tablet in case of a history of thromboembolism, abdominal disorders such as diverticulitis, cancer, liver disease, chronic infections such as tuberculosis, hepatitis B and C and shingles, and any anaemias. Keep your doctor informed if you have recently had any surgery or are scheduled for surgery in the near future. Offer a detailed medical and vaccination history. Discuss any recent vaccinations with the doctor. Inform the doctor if you are on any other JAK-2 inhibitor medicines, DMARD’s, painkillers, steroids and/or any drugs that affect the immunity and immune system of the body. Consult your doctor if you are planning to get pregnant or are breastfeeding. Avoid Barilup 4 Tablet use with alcohol.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Barilup 4 Tablet:
Co-administration of Barilup 4 Tablet with Cyclosporine can increase the risk of infections as well as some cancers.

How to manage the interaction:
Taking Ciclosporin with Barilup 4 Tablet is not recommended as it can cause an interaction, but it can be taken together if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Barilup 4 Tablet:
Coadministration of Tocilizumab with Barilup 4 Tablet can increase the risk of developing serious infections.

How to manage the interaction:
Co-administration of Tocilizumab with Barilup 4 Tablet can result in an interaction, but it can be taken if your doctor has advised it. However, consult a doctor if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate. Do not stop using any medications without a doctor's advice.
How does the drug interact with Barilup 4 Tablet:
Co-administration of Betamethasone with Barilup 4 Tablet may increase the risk of serious infections.

How to manage the interaction:
Although there is an interaction, Betamethasone can be taken with Barilup 4 Tablet if prescribed by the doctor. Contact the prescriber if you develop signs and symptoms of infection such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning sensation during urination. Do not discontinue the medication without a doctor's advice.
How does the drug interact with Barilup 4 Tablet:
Coadministration of Barilup 4 Tablet and Olaparib can raise the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, Barilup 4 Tablet can be taken with Olaparib if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without talking to a doctor.
How does the drug interact with Barilup 4 Tablet:
Coadministration of Barilup 4 Tablet and adalimumab can raise your risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, Barilup 4 Tablet can be taken with adalimumab if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without talking to a doctor.
How does the drug interact with Barilup 4 Tablet:
Coadministration of Barilup 4 Tablet and chlorambucil can raise the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, Barilup 4 Tablet can be taken with chlorambucil if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscular aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medication without consulting a doctor.
BaricitinibPeginterferon alfa-2a
Severe
How does the drug interact with Barilup 4 Tablet:
Coadministration of Peginterferon alfa-2a with Barilup 4 Tablet can increase the risk of developing serious infections.

How to manage the interaction:
Co-administration of Peginterferon alfa-2a with Barilup 4 Tablet can result in an interaction, but it can be taken if your doctor has advised it. However, consult a doctor if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate. Do not stop using any medications without a doctor's advice.
How does the drug interact with Barilup 4 Tablet:
Coadministration of Clofarabine with Barilup 4 Tablet can increase the risk of developing serious infections.

How to manage the interaction:
Taking Barilup 4 Tablet with Clofarabine together can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Barilup 4 Tablet:
Using Barilup 4 Tablet together with methylprednisolone may increase the risk of serious infections.

How to manage the interaction:
Although there is an interaction, Barilup 4 Tablet can be taken with methylprednisolone if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, severe abdominal pain, nausea, or vomiting, consult a doctor. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Barilup 4 Tablet:
Taking Barilup 4 Tablet and azacitidine can raise the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, Barilup 4 Tablet can be taken with azacitidine if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscular aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medication without consulting a doctor.

Drug-Food Interactions

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BARICITINIB-4MGHigh fat foods
Mild

Drug-Food Interactions

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BARICITINIB-4MGHigh fat foods
Mild
Common Foods to Avoid:
Frozen Meals, Cheese, Red Meat, Potato Chips, Hamburgers, Hot Dogs, Ice Cream

How to manage the interaction:
Coadministration of Barilup 4 Tablet and high-fat meals can decrease the absorption of Barilup 4 Tablet. Avoid fatty food and oily food while being treated with Barilup 4 Tablet.

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • TRAMADOL
  • ABATACEPT
  • METHOTREXATE

Habit Forming

No

Special Advise

  • Discuss contraception with your doctor while taking Barilup 4 Tablet .
  • Use Barilup 4 Tablet with caution in the elderly as they’re more prone to infections.

Diet & Lifestyle Advise

  • Keep a healthy state of mind. Fear is the one of the biggest causes of decreased immunity. See a therapist if you feel the need. 
  • Meditation, music and yoga have also proven very effective in helping with mental health.
  • Keep yourself at a safe distance from people.
  • Always sneeze or cough into your elbow and keep a handkerchief on you.
  • Wash your hands with soap and water and keep yourself clean.
  • Eat more lean meats, healthy fats, fruits, vegetables and whole-grain foods to give you more energy. Load up on Vitamin-C rich citrus fruit for enhanced immunity.
  • Do not forget to take your Vitamin B complex and Vitamin C supplements every day as these are essential for the body and immunity.
  • Steam inhalation for 3-5 minutes every day and salt-water gargle with warm water has been proven very effective in keeping respiratory infections at bay and in promoting health. 
  • Avoid taking Barilup 4 Tablet with alcohol as there may be an interaction.
  • Stay hydrated by drinking plenty of water as dehydration is often seen in pneumonia.
  • Taking a stroll in the garden, or spending 30 minutes of your time doing some light physical activity can be very useful. However, do not over-exert yourself if you feel too tired. Doing weight-bearing exercises can prove very helpful in promoting bone health.
  • Avoid tobacco use as smoking hampers lung health and makes breathing even more difficult.
  • Spend time under the sun (however with proper sunscreen) for quality intake of Vitamin D. Vitamin D is necessary for the absorption of Calcium, which is the most important component of bones and can help with bone and joint pain.

Barilup 4 Tablet Substitute

Always consult your doctor before taking any new medications and supplements

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