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  3. Bortenat 2 mg Injection

Bortenat 2 mg Injection, Pack of 1 INJECTION
Bortenat 2 mg Injection, Pack of 1 INJECTION
Bortenat 2 mg Injection, Pack of 1 INJECTION
Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Sureshvarma D , MPharma
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Whats That

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Composition :

BORTEZOMIB-2MG

Manufacturer/Marketer :

Natco Pharma Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

Therapeutic Class

CHEMOTHERAPY

Country of origin

INDIA

Manufacturer/Marketer address

Natco House, Road No.2, Banjara Hills, Hyderabad-500 034, India
Other Info - BOR0020

Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Sureshvarma D

Reviewed By

Sureshvarma D

MPharma

Last Updated

Jul 8, 2025 | 9:37 AM IST

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FAQs

Bortenat 2 mg Injection contains the active substance bortezomib, also-called ‘proteasome inhibitor. Proteasomes play an important role in controlling cell function and growth. By interfering with their function, thereby it can kill cancer cells.

Bortenat 2 mg Injection is prescribed by a doctor experienced in the use of medications to treat cancer. It is administered by a healthcare professional as an injection into your vein (intravenously or IV) or under your skin (subcutaneously, or SC). Bortenat 2 mg Injection must not be administered into your spinal fluid (intrathecally).

Yes, Bortenat 2 mg Injection can cause low neutrophils levels, a type of white blood cells that help fight infections. If your white blood cells become low, you can be at higher risk for infections. Tell your doctor if you develop a fever or believe you have an infection.

Avoid taking Bortenat 2 mg Injection if you are pregnant because Bortenat 2 mg Injection can cause harmful effects on the unborn baby. Females should follow effective birth control methods during treatment and at least six months after the final dose of Bortenat 2 mg Injection.

Before you receive treatment with Bortenat 2 mg Injection, tell your doctor about all of your medical conditions. You should not receive Bortenat 2 mg Injection if you are allergic to bortezomib or any contents in Bortenat 2 mg Injection.

If not given an inappropriate dose, Bortenat 2 mg Injection can cause toxic effects, although not everyone gets it. So, Bortenat 2 mg Injection is prescribed by a doctor experienced in using medications to treat cancer only.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Caution

You are recommended to avoid alcohol consumption while taking Bortenat 2 mg Injection. It could lead to avoiding unpleasant side effects.

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Pregnancy

Unsafe

Bortenat 2 mg Injection should not be used during pregnancy because it causes harm to the fetus (newborn baby). Both women of childbearing potential and men must use an effective contraception method while taking Bortenat 2 mg Injection and at least six months afterwards. Please discuss with your doctor any concerns regarding this.

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Breast Feeding

Unsafe

Bortenat 2 mg Injection should not be taken during breastfeeding as it passes into the breastmilk and may harm the nursing baby. It is contraindicated in breastfeeding mothers.

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Driving

Caution

Bortenat 2 mg Injection may affect your reactions and your ability to drive. Possible side effects of chemotherapy with Bortenat 2 mg Injection may occur, such as nausea and vomiting. If you are affected by these side effects, you should not drive and/or operate machines that require you to be alert.

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Liver

Caution

If you have a history or evidence of liver-related diseases, inform the doctor before prescribing the Bortenat 2 mg Injection. Your doctor will weigh the benefits and potential risks before prescribing them.

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Kidney

Caution

If you have a history or evidence of kidney-related diseases, inform the doctor before prescribing the Bortenat 2 mg Injection. Your doctor will weigh the benefits and potential risks before prescribing them.

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Children

Unsafe

Bortenat 2 mg Injection should not be used by children below 18 years of age, as efficacy and safety have not been established.

Product Substitutes

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Keep Refrigerated. Do not freeze.Prepaid payment required.

Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/206927s000lbl.pdfhttp://chemocare.com/chemotherapy/drug-info/bortezomib.aspx
  2. https://www.velcade.com/
  3. https://www.medicines.org.uk/emc/files/pil.10551.pdf

About Bortenat 2 mg Injection

Bortenat 2 mg Injection belongs to a group of anti-cancer medicines used to treat adult patients with multiple myeloma and mantle cell lymphoma who have received at least one prior therapy. Multiple myeloma, also known as myeloma, is a type of bone marrow cancer it affects several areas of the body, such as the spine, skull, pelvis, and ribs. Mantle cell lymphoma (MCL) is a rare type of non-Hodgkin lymphoma (NHL). It develops when B-cells (also called B-lymphocytes) become abnormal. B-cells are white blood cells that fight infection.

Bortenat 2 mg Injection contains 'Bortezomibx' that works by interfering with how proteasomes work, which may cause cancer cells to die and may stop cancer from growing and eventually kills them.

Bortenat 2 mg Injection is prescribed by a doctor experienced in the use of medications to treat cancer. It is administered by a healthcare professional as an injection into your vein (intravenously or IV) or under your skin (subcutaneously or SC). Bortenat 2 mg Injection must not be administered into your spinal fluid (intrathecally). You may experience nausea, diarrhoea, thrombocytopenia (a low platelet count), neutropenia (low white blood cell count), peripheral neuropathy (nerves malfunction), fatigue, neuralgia, anaemia, leukopenia, constipation, vomiting, lymphopenia, rash, pyrexia, and anorexia. Most of these side effects of Bortenat 2 mg Injection do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

To treat your condition effectually, continue taking Bortenat 2 mg Injection for as long as your doctor has prescribed. Do not stop the Bortenat 2 mg Injection midway. Talk to your doctor before taking Bortenat 2 mg Injection if you have allergies or if you are suffering from peripheral neuropathy (nerves malfunction), hypotension, cardiac disorders, severe lung problems, pulmonary disorders, posterior reversible encephalopathy syndrome disorders, gastrointestinal disorders, thrombocytopenia (a low platelet count), neutropenia (low white blood cell count), tumour lysis syndrome (metabolic abnormalities that can occur as a complication during the treatment of cancer), hepatic disorders. Avoid taking Bortenat 2 mg Injection if you are pregnant or breastfeeding because this Bortenat 2 mg Injection can cause harmful effects on the unborn baby. Both women and men using this Bortenat 2 mg Injection should use birth control to avoid pregnancy.

Uses of Bortenat 2 mg Injection

Multiple myeloma and Mantle cell lymphoma.

Medicinal Benefits Mweb

Medicinal Benefits

Bortenat 2 mg Injection contains the active substance bortezomib, also-called ‘proteasome inhibitor. Proteasomes play an important role in controlling cell function and growth. By interfering with their function, thereby it can kill cancer cells. Bortenat 2 mg Injection is used to treat multiple myeloma (a cancer of the bone marrow) and mantle cell lymphoma (a type of cancer affecting the lymph nodes) in 18 years or older patients. It can be used alone or together with other medicines.

Directions for Use

Bortenat 2 mg Injection will be administered by a qualified healthcare professional. Kindly do not self-administer.

Side Effects of Bortenat 2 mg Injection

  • Nausea
  • Diarrhoea
  • Thrombocytopenia (low blood platelet count)
  • Neutropenia (too few neutrophils)
  • Peripheral neuropathy (nerves malfunction)
  • Fatigue (overtired)
  • Neuralgia (pain in the head or face)
  • Muscle pain, bone pain
  • Anaemia (low red blood cell Count)
  • Leukopenia (Low White Blood Cell Count)
  • High blood pressure
  • Constipation
  • Dehydration
  • Vomiting
  • Loss of appetite
  • Lymphopenia (Low lymphocytes Count)
  • Rash
  • Pyrexia (raised body temperature)
  • Anorexia (lack or loss of appetite for food)
  • Infections, including pneumonia, respiratory infections, bronchitis, fungal infections, coughing with phlegm, flu-like illness

Drug Warnings

To treat your condition effectually, continue taking Bortenat 2 mg Injection for as long as your doctor has prescribed. Do not stop the Bortenat 2 mg Injection midway. Talk to your doctor before taking Bortenat 2 mg Injection if you have allergies or if you are suffering from peripheral neuropathy (nerves malfunction), hypotension, cardiac disorders, severe lung problems, pulmonary disorders, posterior reversible encephalopathy syndrome disorders, gastrointestinal disorders, thrombocytopenia (a low platelet count), neutropenia (low white blood cell count), tumour lysis syndrome (metabolic abnormalities that can occur as a complication during the treatment of cancer), hepatic disorders. And also, inform your doctor if you have diabetes because this medicine can affect your blood glucose levels. Your doctor may require close monitoring of your blood glucose levels and change your diabetes medicine dose while being treated with Bortenat 2 mg Injection. Avoid taking Bortenat 2 mg Injection if you are pregnant because this Bortenat 2 mg Injection can cause harmful effects on the unborn baby. Both women and men using this Bortenat 2 mg Injection should use birth control to avoid pregnancy and for at least six months following treatment. Do not breastfeed during treatment with Bortenat 2 mg Injection and four months after your final dose of Bortenat 2 mg Injection.

Drug-Drug Interactions

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BortezomibCertolizumab
Severe
BortezomibRifabutin
Severe

Drug-Drug Interactions

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BortezomibCertolizumab
Severe
How does the drug interact with Bortenat 2 mg Injection:
Coadministration of certolizumab and Bortenat 2 mg Injection may increase the risk of infections.

How to manage the interaction:
Although using Bortenat 2 mg Injection and Certolizumab together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience fever, chills, diarrhoea, sore throat, muscle aches, red or irritated skin, or burning during urination. Do not stop taking any medications without consulting a doctor.
BortezomibRifabutin
Severe
How does the drug interact with Bortenat 2 mg Injection:
Coadministration of Bortenat 2 mg Injection and rifabutin may reduce the blood levels of Bortenat 2 mg Injection.

How to manage the interaction:
Although using Bortenat 2 mg Injection and Rifabutin together can possibly result in an interaction, they can be taken together if prescribed by a doctor. Do not stop taking any medications without consulting a doctor.
BortezomibTalimogene laherparepvec
Severe
How does the drug interact with Bortenat 2 mg Injection:
Taking Bortenat 2 mg Injection together with talimogene laherparepvec increases the risk of developing infection.

How to manage the interaction:
Although using Bortenat 2 mg Injection and Talimogene laherparepvec together can possibly result in an interaction, they can be taken together if advised by your doctor. Do not stop taking any medications without consulting a doctor.
BortezomibNatalizumab
Severe
How does the drug interact with Bortenat 2 mg Injection:
Coadministration of Bortenat 2 mg Injection and natalizumab can increase the risk of infections.

How to manage the interaction:
Although using Bortenat 2 mg Injection and natalizumab together can result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience fever, chills, joint pain, or burning during urination. Do not stop taking any medications without consulting a doctor.
BortezomibGolimumab
Severe
How does the drug interact with Bortenat 2 mg Injection:
Coadministration of golimumab and Bortenat 2 mg Injection may increase the risk of infections.

How to manage the interaction:
Although using Bortenat 2 mg Injection and Golimumab together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience fever, chills, diarrhea, sore throat, muscle aches, red or irritated skin, discomfort, or burning during urination. Do not stop taking any medications without consulting a doctor.
BortezomibTofacitinib
Severe
How does the drug interact with Bortenat 2 mg Injection:
Taking tofacitinib and Bortenat 2 mg Injection may increase the risk of infections.

How to manage the interaction:
Although using Bortenat 2 mg Injection and Tofacitinib together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience fever, chills, diarrhea, sore throat, muscle aches, red or irritated skin, or burning during urination. Do not stop taking any medications without consulting a doctor.
BortezomibLomitapide
Severe
How does the drug interact with Bortenat 2 mg Injection:
Coadministration of lomitapide and Bortenat 2 mg Injection can increases the risk of liver problems.

How to manage the interaction:
Although using Bortenat 2 mg Injection and Lomitapide together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience fever, chills, joint pain or swelling, skin rash, itching, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes. Do not stop taking any medications without consulting a doctor.
BortezomibSamarium (153sm) lexidronam
Severe
How does the drug interact with Bortenat 2 mg Injection:
Using samarium (153sm) lexidronam together with Bortenat 2 mg Injection may increase the risk of side effects

How to manage the interaction:
Co-administration of Bortenat 2 mg Injection with Samarium (153sm) lexidronam can possibly result in an interaction; they can be taken if your doctor has advised it. However, consult a doctor if you experience fatigue, dizziness, fever, chills, diarrhea, sore throat, muscle aches, red or inflamed skin, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
BortezomibPrimidone
Severe
How does the drug interact with Bortenat 2 mg Injection:
Coadministration of Bortenat 2 mg Injection and primidone may reduce the blood levels of Bortenat 2 mg Injection, which may make the medication less effective in treating your condition.

How to manage the interaction:
Although using Bortenat 2 mg Injection and Primidone together can possibly result in an interaction, they can be taken together if prescribed by your doctor. Do not discontinue any medications without consulting a doctor.
BortezomibClozapine
Severe
How does the drug interact with Bortenat 2 mg Injection:
Coadministration of clozapine with Bortenat 2 mg Injection may increase the risk of infections.

How to manage the interaction:
Although using Bortenat 2 mg Injection and Clozapine together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience fever, chills, diarrhoea, sore throat, muscle aches, red or irritated skin, or burning during urination. Do not stop taking any medications without consulting a doctor.

Drug-Food Interactions

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BORTEZOMIB-2MGCaffeine containing foods/drinks, Fiber rich foods
Moderate

Drug-Food Interactions

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BORTEZOMIB-2MGCaffeine containing foods/drinks, Fiber rich foods
Moderate
Common Foods to Avoid:
Green Tea, Oranges

How to manage the interaction:
Vitamin C or vitamin-containing foods and green tea diminish the effectiveness of Bortenat 2 mg Injection Avoid or limit the consumption of Vitamin C or vitamin-containing foods and green tea.

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • KETOCONAZOLE
  • RITONAVIR
  • RIFAMPICIN
  • CARBAMAZEPINE
  • PHENYTOIN
  • PHENOBARBITAL

Habit Forming

No

Special Advise

  • Bortenat 2 mg Injection should be taken under strict medical supervision. The doctor will regularly monitor your condition while taking Bortenat 2 mg Injection.
  • Your doctor may get routine blood tests done to monitor your liver function, electrolyte levels, blood cell count in your blood.
  • Avoid unnecessary or prolonged exposure to sunlight and UV light (such as tanning booths) and wear protective clothing, sunglasses, and sunscreen. Bortenat 2 mg Injection may make your skin sensitive to sunlight.

Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs in your diet.
  • Get optimal sleep, and rest well.
  • Performing yoga may also help in improving both physical and mental health.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath, or listening to soothing music.
  • Avoid smoking and alcohol consumption.
  • Avoid fast, fried, processed meats, refined carbs, and added sugars.

Bortenat 2 mg Injection Substitute

Substitutes safety advice

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