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  1. Home
  2. Medicine

  3. Bosutris 500 mg Tablet 30's

Written By Lakshmithulasi Yarragunta , Pharm-D (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
48 Hrs returnable
Know More
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Bosutris 500 mg Tablet 30's, Pack of 1 Tablet
Bosutris 500 mg Tablet 30's, Pack of 1 Tablet
rxMedicinePrescription drug

Whats That

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Composition :

BOSUTINIB-500MG

Manufacturer/Marketer :

Mylan Pharmaceuticals Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

Therapeutic Class

ANTINEOPLASTIC

Country of origin

India

Manufacturer/Marketer address

Mylan Pharmaceuticals Private Limited , Commercial Operations , Prestige Tech Park,Platina-3, 7Th To 12Th Floor, Prestige Tech Park, Kadubesanahalli, Bangalore -560103.
Other Info - BOS0084

Author Details

Lakshmithulasi YarraguntaDoctor badge

Written By

Lakshmithulasi Yarragunta

Pharm-D (PB)

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Aug 20, 2024 | 1:17 PM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

FAQs

Bosutris 500 mg Tablet contains Bosutinib, which works by inhibiting the action of abnormal proteins that cause the multiplication of cancerous cells.

Bosutris 500 mg Tablet is known to cause embryo-fetal toxicity; hence, it is contraindicated for use in pregnancy. A woman needs to have a negative pregnancy test before starting treatment with this medicine. It is better to use effective birth control methods to prevent pregnancy while taking this medicine or at least six months after completion of the treatment.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Unsafe

Avoid alcohol consumption while on treatment with Bosutris 500 mg Tablet to prevent serious adverse effects.

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Pregnancy

Unsafe

Bosutris 500 mg Tablet is not recommended for use in pregnancy as it may harm your fetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before taking Bosutris 500 mg Tablet . Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Caution

Limited data is available on the effect of Bosutris 500 mg Tablet on breastfeeding. Bosutris 500 mg Tablet should be avoided during breastfeeding. Hence, inform your doctor if you are breastfeeding. Your doctor may prescribe an alternative based on the symptoms and health condition.

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Driving

Unsafe

Bosutris 500 mg Tablet may cause dizziness and may make you feel drowsy. Hence, avoid driving or operating machines after taking Bosutris 500 mg Tablet or until you become alert.

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Liver

Caution

Bosutris 500 mg Tablet is known to cause hepatotoxicity. Hence, inform your doctor if you have a pre-existing or a history of liver disease. A dose adjustment may be needed based on your condition.

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Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor before taking Bosutris 500 mg Tablet . Your doctor may reduce the dose of this medicine or prescribe a suitable alternative based on your condition.

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Children

Unsafe

Bosutris 500 mg Tablet is not recommended for use in children below 18 years of age as the safety and efficacy are not established.

Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/203341lbl.pdf
  2. https://go.drugbank.com/drugs/DB06616
  3. https://medlineplus.gov/druginfo/meds/a613005.html
  4. https://pubchem.ncbi.nlm.nih.gov/compound/Bosutinib
  5. https://www.bosulif.com/

About Bosutris 500 mg Tablet

Bosutris 500 mg Tablet is an anti-cancer medicine used in the treatment of Leukemia. Leukemia, also known as blood cancer, is a cancer of blood cells or blood-forming tissues. It causes excessive production of immature white blood cells by the bone marrow and reduces the body’s ability to fight infections. Bosutris 500 mg Tablet is used in the treatment of chronic myelogenous leukemia (CML). This medicine is used in patients with chronic, accelerated, or blast phase Ph+ (Philadelphia chromosome-positive) chronic myelogenous leukemia who are resistant or intolerant to prior therapy.

Bosutris 500 mg Tablet contains Bosutinib, which belongs to the class of kinase inhibitors. It works by inhibiting the action of abnormal proteins that cause the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other parts of the body.

Bosutris 500 mg Tablet may cause certain side effects, such as rash, fatigue, headache, back pain, decreased platelet count, back pain, nausea, vomiting, diarrhea, abdominal pain, loss of appetite, and dizziness. These side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor. Bosutris 500 mg Tablet should be taken as advised by your doctor. Do not take more than the recommended dose of medicine. Your doctor will decide the dose of Bosutris 500 mg Tablet based on the severity of your condition.

Bosutris 500 mg Tablet should be avoided if you are allergic to it or any other components present in it. Let your doctor know about your complete medical history, including current medication, to rule out any side effects/interactions. Before taking this medicine, inform your doctor if you have liver/kidney disease, gastrointestinal toxicity, myelosuppression, fluid retention, and hepatic toxicity, as may cause serious side effects or worsen such conditions. This medicine is known to cause embryo-fetal toxicity. Hence, inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment with Bosutris 500 mg Tablet . Breastfeeding should be discontinued in nursing mothers during the treatment. Bosutris 500 mg Tablet is not recommended for use in children below 18 years of age as the safety and efficacy are not established.

Uses of Bosutris 500 mg Tablet

Philadelphia chromosome-positive chronic myeloid leukemia.

Medicinal Benefits Mweb

Medicinal Benefits

Bosutris 500 mg Tablet contains Bosutinib, which belongs to the class of kinase inhibitors. It works by inhibiting the action of abnormal proteins that cause the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other parts of the body.

Directions for Use

Take Bosutris 500 mg Tablet as advised by your doctor. Do not take more than the prescribed dose of medicine. Swallow the medicine as a whole with a glass of water. Do not chew crush or break the medicine.

Side Effects of Bosutris 500 mg Tablet

  • Nausea
  • Diarrhoea
  • Painful urination
  • Decreased platelet count
  • Fatigue
  • Edema
  • Vomiting
  • Diarrhea
  • Abdominal pain
  • Headache
  • Back pain
  • Cough
  • Dizziness
  • Skin rash

Drug Warnings

Bosutris 500 mg Tablet should be avoided if you are allergic to it or any other components present in it. Let your doctor know about your complete medical history, including current medication, to rule out any side effects/interactions. Before taking, inform your doctor if you have liver/kidney disease, diabetes, cardiac problems, increased blood pressure, gastrointestinal toxicity, myelosuppression, fluid retention, and hepatic toxicity, as the use of Bosutris 500 mg Tablet in these patients may cause serious side effects. This medicine is known to cause embryo-fetal toxicity. Hence, inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment. Breastfeeding should be discontinued in nursing mothers during the treatment. Bosutris 500 mg Tablet is not recommended for use in children below 18 years of age as the safety and efficacy are not established. Avoid alcohol consumption and smoking, as it can lead to serious adverse effects.

Drug-Drug Interactions

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BosutinibYellow fever vaccine
Critical
BosutinibDiltiazem
Severe

Drug-Drug Interactions

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BosutinibYellow fever vaccine
Critical
How does the drug interact with Bosutris 500 mg Tablet:
Combining Yellow fever vaccine with Bosutris 500 mg Tablet can increase the risk of infection.

How to manage the interaction:
Taking Yellow fever vaccine with Bosutris 500 mg Tablet can result in an interaction, but it can be taken if prescribed by a doctor. Do not stop using any medications without consulting a doctor.
BosutinibDiltiazem
Severe
How does the drug interact with Bosutris 500 mg Tablet:
Taking Bosutris 500 mg Tablet with diltiazem can increase the blood levels of Bosutris 500 mg Tablet. This can increase side effects such as nausea, vomiting, abdominal pain, and diarrhea.

How to manage the interaction:
Although there is an interaction between Bosutris 500 mg Tablet and diltiazem, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.
BosutinibAmprenavir
Severe
How does the drug interact with Bosutris 500 mg Tablet:
Taking Bosutris 500 mg Tablet with amprenavir may increase the blood levels of Bosutris 500 mg Tablet, which can raise the risk and severity of side effects.

How to manage the interaction:
Although there is an interaction between Bosutris 500 mg Tablet and Amprenavir, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience abdominal pain, diarrhea, fatigue, dizziness, fever, chills, diarrhea, sore throat, muscle aches, red or inflamed skin, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.
BosutinibBaricitinib
Severe
How does the drug interact with Bosutris 500 mg Tablet:
Coadministration of baricitinib and Bosutris 500 mg Tablet can raise the risk of developing infections.

How to manage the interaction:
Although there is an interaction, baricitinib can be taken with Bosutris 500 mg Tablet if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscular aches, red or irritated skin, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medication without consulting a doctor.
BosutinibSotalol
Severe
How does the drug interact with Bosutris 500 mg Tablet:
Taking Sotalol with Bosutris 500 mg Tablet can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Although there is an interaction between Sotalol and Bosutris 500 mg Tablet, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, or fainting. Do not discontinue any medications without consulting a doctor.
BosutinibTeriflunomide
Severe
How does the drug interact with Bosutris 500 mg Tablet:
Coadministration of Bosutris 500 mg Tablet and Teriflunomide may increase the risk of serious infections and liver problems

How to manage the interaction:
Although there is an interaction between Bosutris 500 mg Tablet and Teriflunomide, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.
BosutinibPanobinostat
Severe
How does the drug interact with Bosutris 500 mg Tablet:
Taking Bosutris 500 mg Tablet and Panobinostat can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Although there is an interaction between Bosutris 500 mg Tablet and panobinostat, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, or fainting. Do not discontinue any medications without consulting a doctor.
BosutinibPrimidone
Severe
How does the drug interact with Bosutris 500 mg Tablet:
Taking Bosutris 500 mg Tablet with primidone can reduce the blood levels of Bosutris 500 mg Tablet, which may make the medication less effective in treating your condition.

How to manage the interaction:
Although taking Primidone and Bosutris 500 mg Tablet together can evidently cause an interaction, it can be taken if your doctor has suggested it. Do not discontinue any medications without consulting a doctor.
BosutinibCrizotinib
Severe
How does the drug interact with Bosutris 500 mg Tablet:
Taking Bosutris 500 mg Tablet with Crizotinib may raise blood levels of Bosutris 500 mg Tablet, increasing the risk of side effects.

How to manage the interaction:
Although there is an interaction between Bosutris 500 mg Tablet and Crizotinib, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fatigue, dizziness, fever, chills, diarrhea, sore throat, muscle aches, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.
BosutinibVoclosporin
Severe
How does the drug interact with Bosutris 500 mg Tablet:
Taking Bosutris 500 mg Tablet and Voclosporin together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Although there is an interaction between Bosutris 500 mg Tablet and Voclosporin, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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BOSUTINIB-500MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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BOSUTINIB-500MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Taking grapefruit or grapefruit juice with Bosutris 500 mg Tablet can increase the blood levels and effects of Bosutris 500 mg Tablet, which may increase the risk of side effects. Avoid the consumption of grapefruit and grapefruit juice.

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • PANTOPRAZOLE
  • ESOMEPRAZOLE
  • RITONAVIR
  • ITRACONAZOLE
  • KETOCONAZOLE
  • CLARITHROMYCIN
  • ERYTHROMYCIN
  • RIFAMPICIN
  • PHENYTOIN
  • PHENOBARBITAL
  • CARBAMAZEPINE

Habit Forming

No

Special Advise

  • Bosutris 500 mg Tablet should be administered only by a trained and experienced oncologist.
  • A blood test should be performed such as LFT and RFT, to check for liver/kidney function.
  • Weekly blood tests should be done during the treatment to check for CBC (Complete blood count).

Diet & Lifestyle Advise

  • After your treatment begins, several dietary adjustments can help you control side effects.
  • Anyone suffering from a chronic illness, including cancer, should consume foods high in protein, healthy fats, whole grains, and vitamins and minerals.
  • Plant-based proteins are among the greatest meals to take during chemotherapy or other cancer treatments. They have the highest concentrations of vitamins and minerals, such as nuts, seeds, beans, and legumes.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.
  • Avoid fast and fried food, processed meats, refined carbs and added sugars.

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