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  3. Brivarise 50 mg Injection 5 ml

Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
48 Hrs returnable
COD available

Online payment accepted

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Whats That

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Manufacturer/Marketer :

Galaxus Pharmaceuticals

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Therapeutic Class

ANTICONVULSANT

Country of origin

India

Manufacturer/Marketer address

Flat No-201, West 2nd Floor, Apurupa Anand Kuteer, Gafoorbagh, Saleem Nagar Colony, Malakpet, Hyderabad - 500036
Other Info - BRI0969

FAQs

Brivarise 50 mg Injection 5 ml contains Brivaracetam, an antiepileptic that attaches itself to specific sites (SV2A) on nerve cell surfaces. This activity may suppress the brain's abnormal activity and prevents the spread of electrical signals that cause seizures.

No, Brivarise 50 mg Injection 5 ml should not be stopped even if you start feeling better. Suddenly stopping the Brivarise 50 mg Injection 5 ml may cause continuous seizures, which can be difficult to control. To treat your condition effectually, continue taking Brivarise 50 mg Injection 5 ml for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Brivarise 50 mg Injection 5 ml; your doctor will gradually reduce the dose to avoid precipitating seizures.

Brivarise 50 mg Injection 5 ml may cause suicidal thoughts such as killing or harming yourself. People taking Brivarise 50 mg Injection 5 ml should be closely monitored for suicidal thoughts or behaviour. Speak with your doctor immediately if you need to.

Pay close attention to any changes in mood, behaviour, thoughts, or feelings, especially if they are sudden.

Disclaimer

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Alcohol

Unsafe

It is unsafe to consume alcohol since it may worsen the side effects like dizziness and sleepiness.

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Pregnancy

Caution

There are no adequate and well-controlled studies on pregnant women. Inform your doctor before receiving the Brivarise 50 mg Injection 5 ml if you are pregnant or planning to become pregnant. Your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

There has been no significant research on using Brivarise 50 mg Injection 5 ml in breastfeeding/nursing moms. So, let your doctor know if you are a nursing mother before taking Brivarise 50 mg Injection 5 ml; your doctor will decide whether Brivarise 50 mg Injection 5 ml can be taken by breastfeeding mothers.

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Driving

Unsafe

Brivarise 50 mg Injection 5 ml may cause somnolence (excess sleepiness) and fatigue (feeling overtired). It impacts your daily activities; hence avoid driving in such situations. Seek medical attention if the symptoms persist longer.

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Liver

Caution

Dose adjustments are recommended for patients with hepatic impairment. So inform your doctor before receiving the Brivarise 50 mg Injection 5 ml if you have a history of liver impairments.

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Kidney

Caution

Brivarise 50 mg Injection 5 ml is recommended not to be used in end-stage renal disease patients undergoing dialysis. Inform your doctor before receiving the Brivarise 50 mg Injection 5 ml if you have a history of kidney diseases/conditions.

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Children

Safe if prescribed

Your doctor will prescribe only if the benefits outweigh the risks.

About Brivarise 50 mg Injection 5 ml

Brivarise 50 mg Injection 5 ml belongs to a group of medications called 'anti-convulsants'. It is used for treating partial-onset seizures (seizures involving only one part of the brain) in people with epilepsy (fits) in patients one month of age and older. Partial-onset seizures are characterized by abnormal electrical activity in only one brain hemisphere. Common symptoms are involuntary muscle contractions, followed by relaxation on one side of the body, uncontrolled head or eye movements, rapid heart rate, and a tingling sensation on the skin.

Brivarise 50 mg Injection 5 ml contains '‘Brivaracetam' that reduces the electrical impulses and subsequent firing of the nerve impulses that cause fits. Thus, Brivarise 50 mg Injection 5 ml decreases the brain's excessive and abnormal nerve activity, thereby controlling seizures.

Brivarise 50 mg Injection 5 ml will be administered by a qualified healthcare professional. In some cases, you may experience certain common side effects such as somnolence (excess sleepiness), dizziness, fatigue (feeling overtired), nausea and vomiting. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

To treat your condition effectually, continue taking Brivarise 50 mg Injection 5 ml for as long as your doctor has prescribed. Brivarise 50 mg Injection 5 ml should be gradually withdrawn, so please do not stop taking Brivarise 50 mg Injection 5 ml without consulting your doctor. Before taking the Brivarise 50 mg Injection 5 ml, let your doctor know about all your medical conditions, sensitivities, and all medications you are using. Inform your doctor if you are pregnant or planning to become pregnant. You should not breastfeed unless the doctor advises. Consult your doctor immediately if you experience suicidal tendencies. It is recommended not to drive or operate machinery as Brivarise 50 mg Injection 5 ml may cause tiredness and fatigue. It is recommended not to take alcoholic beverages while on Brivaracetam therapy.

Uses of Brivarise 50 mg Injection 5 ml

Partial-onset seizures

Medicinal Benefits Mweb

Medicinal Benefits

Brivarise 50 mg Injection 5 ml belongs to a group of medicines called anticonvulsants or anti-epileptics used to control partial-onset seizures in the treatment of epilepsy (fits). Brivarise 50 mg Injection 5 ml consists of ‘Brivaracetam' that works by reducing the electrical impulses and subsequent firing of the nerve impulses that cause fits. Brivarise 50 mg Injection 5 ml decreases the brain's excessive and abnormal nerve activity, thereby helping control seizures.

Directions for Use

Brivarise 50 mg Injection 5 ml will be administered by a qualified healthcare professional. Do not self-administer.

Side Effects of Brivarise 50 mg Injection 5 ml

  • Drowsiness
  • Tiredness
  • Fatigue
  • Asthenia (weakness)
  • Malaise (General discomfort)
  • Hypersomnia (Excessive sleepiness)
  • Sedation
  • Lethargy (a lack of energy)
  • Dizziness
  • Vertigo (Spinning sensation)
  • Balance disorder
  • Ataxia (Impaired coordination)
  • Nystagmus (Involuntary eye movement)
  • Gait disturbance (a manner of walking or moving on foot)
  • Abnormal coordination

Drug Warnings

Before taking the Brivarise 50 mg Injection 5 ml, inform your doctor about all your medical conditions, allergic conditions, and all medications you are using. Inform your doctor if you are pregnant or planning to become pregnant. If you become pregnant while taking Brivarise 50 mg Injection 5 ml, call your doctor. You should not breastfeed unless the doctor advises. Consult your doctor immediately if you experience suicidal tendencies. It is recommended not to drive or operate machinery as Brivarise 50 mg Injection 5 ml may cause tiredness and fatigue. It is recommended not to take alcoholic beverages while on Brivaracetam therapy. Do not stop Brivarise 50 mg Injection 5 ml without first talking to a healthcare provider. Stopping Brivarise 50 mg Injection 5 ml suddenly can cause serious problems. Sometimes, it may lead to seizures that will not stop (status epilepticus).

Drug-Drug Interactions

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BrivaracetamEsketamine
Severe

Drug-Drug Interactions

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How does the drug interact with Brivarise 50 mg Injection 5 ml:
Co-administration of Brivarise 50 mg Injection 5 ml with Ketamine may increase side effects such as drowsiness, difficulty concentrating, confusion, and impairment in thinking, judgment, reaction speed, and motor coordination.

How to manage the interaction:
Although there is a possible interaction between Brivarise 50 mg Injection 5 ml and Ketamine, you can take these medicines together if prescribed by a doctor. If you notice any of these signs - feeling dizzy, sleepy, confused, having trouble focusing, feeling too relaxed, or having trouble breathing - make sure to contact adoctor right away. Do not stop using any medications without talking to a doctor.
BrivaracetamEsketamine
Severe
How does the drug interact with Brivarise 50 mg Injection 5 ml:
Co-administration of Brivarise 50 mg Injection 5 ml with Esketamine may increase side effects such as drowsiness, difficulty concentrating, confusion, and impairment in thinking, judgment, reaction speed, and motor coordination.

How to manage the interaction:
Although there is an interaction, Brivarise 50 mg Injection 5 ml can be taken with Esketamine if prescribed by the doctor. Consult the prescriber if you notice drowsiness, difficulty concentrating, confusion, and impairment in thinking, judgment, reaction speed, and motor coordination. Do not discontinue the medication without consulting a doctor
How does the drug interact with Brivarise 50 mg Injection 5 ml:
Brimonidine may be absorbed into the bloodstream and occasionally produce central nervous system side effects such as dizziness, drowsiness, and difficulty concentrating. Concomitant use of Brivarise 50 mg Injection 5 ml with brimonidine may increase the risk of these side effects.

How to manage the interaction:
Although there is an interaction Brivarise 50 mg Injection 5 ml can be taken with brimonidine if prescribed by the doctor. Consult the prescriber if you notice dizziness, drowsiness, and difficulty concentrating.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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BRIVARACETAM-10MG/MLSymptoms and signs involving emotional state
Moderate
BRIVARACETAM-10MG/MLOther chronic obstructive pulmonary disease
Moderate

Drug-Diseases Interactions

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BRIVARACETAM-10MG/MLSymptoms and signs involving emotional state
Moderate
How does the disease interact with Brivarise 50 mg Injection 5 ml:
Brivarise 50 mg Injection 5 ml which treat epilepsy, have been linked to an elevated risk of suicidal ideas or actions in individuals taking them for any reason. A dosage reduction or therapy termination should be taken into consideration if patients exhibit signs of suicidal ideation or behaviour.

How to manage the interaction:
Anti-epileptic drugs have been associated with an increased risk of suicidal thoughts or behavior. It should be administered with caution in patients with depression or other psychiatric disorders. Consult the doctor if you notice signs and symptoms of depression, any unusual changes in mood or behavior, or the emergence of suicidal thoughts or behavior. If patients have symptoms of suicidal ideation or behavior, a dosage reduction or treatment discontinuation should be considered.
BRIVARACETAM-10MG/MLOther chronic obstructive pulmonary disease
Moderate
How does the disease interact with Brivarise 50 mg Injection 5 ml:
Patients taking Brivarise 50 mg Injection 5 ml have been documented to experience bronchospasm and angioedema, and a hypersensitive reaction to this medication could put patients at danger. Brivarise 50 mg Injection 5 ml should be used with caution in patients who are prone to bronchospasm and angioedema.

How to manage the interaction:
Bronchospasm (tightening of muscles in the airways) and angioedema (swelling) have been reported in patients taking Brivarise 50 mg Injection 5 ml. Caution is advised when using Brivarise 50 mg Injection 5 ml in patients with bronchospasm and angioedema.
BRIVARACETAM-10MG/MLHepatic failure, not elsewhere classified
Moderate
How does the disease interact with Brivarise 50 mg Injection 5 ml:
In the liver, Brivarise 50 mg Injection 5 ml is largely metabolised via hydrolysis. In comparison to matched healthy controls, Brivarise 50 mg Injection 5 ml exposure increased by 50%, 57%, and 59%, respectively, in adult patients with hepatic cirrhosis and Child-Pugh categories A, B, and C. According to the manufacturer's prescription, dosage adjustment is advised for all stages of hepatic impairment due to increases in Brivarise 50 mg Injection 5 ml exposure. When administering this medication to patients with liver illness, caution and close observation are advised.

How to manage the interaction:
Dosage adjustment is recommended for all stages of hepatic impairment. Care and close monitoring is advised when using this medicine in patients with liver disease.
BRIVARACETAM-10MG/MLUnspecified kidney failure
Moderate
How does the disease interact with Brivarise 50 mg Injection 5 ml:
Patients with compromised renal function do not require dose modifications. As there are no data in this patient population, Brivarise 50 mg Injection 5 ml is not advised for use in patients with end-stage renal disease receiving dialysis.

How to manage the interaction:
The use of Brivarise 50 mg Injection 5 ml is not recommended in patients with end-stage renal disease undergoing dialysis as there are no data in this patient population.

Drug-Drug Interactions Checker List

  • CARBAMAZEPINE
  • PHENYTOIN
  • LEVETIRACETAM
  • RIFAMPIN
  • BUPRENORPHINE
  • PROPOXYPHENE
  • ESKETAMINE
  • SODIUM OXYBATE
  • KETAMINE

Habit Forming

Not enough scientific literature available around this hence it is best to consult your physician

Special Advise

  • Pay close attention to any changes in mood, behaviour, thoughts, or feelings, especially if they are sudden.
  • Maintain all scheduled follow-up appointments with your healthcare practitioner.

Diet & Lifestyle Advise

  • A ketogenic diet (low in carbohydrates and high in fats) is recommended for children with epilepsy. This diet helps utilise fat instead of glucose for energy generation.
  • Atkins diet (high fat and controlled carbohydrates) is recommended for adolescents and adults.
  • Exercising regularly helps in maintaining weight and improving overall health. 
  • Rest well, and get plenty of sleep.
  • Avoid smoking and alcohol consumption.
  • Meditation and yoga can help lower stress, decrease pain sensitivity and improves coping skills.
  • Have a seizure response plan, and help those around you know what to do.
  • Prepare your living area; small changes may reduce the risk of physical injury during a seizure.
  • Understand what triggers seizures are and try reducing or avoiding them.
  • Please pay attention to overall health, as it can help reduce seizure activity.
  • Install an alarm or emergency device to get assistance during a seizure attack.

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