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Alcohol
Unsafe
It is unsafe to consume alcohol since it may worsen the side effects like dizziness and sleepiness.
Pregnancy
Caution
There are no adequate and well-controlled studies on pregnant women. Inform your doctor before receiving the Brivup-25 Tablet if you are pregnant or planning to become pregnant. Your doctor will prescribe only if the benefits outweigh the risks.
Breast Feeding
Caution
There has been no significant research on using Brivup-25 Tablet in breastfeeding/nursing moms. So, let your doctor know if you are a nursing mother before taking Brivup-25 Tablet ; your doctor will decide whether Brivup-25 Tablet can be taken by breastfeeding mothers.
Driving
Unsafe
Brivup-25 Tablet may cause somnolence (excess sleepiness) and fatigue (feeling overtired). It impacts your daily activities; hence avoid driving in such situations. Seek medical attention if the symptoms persist longer.
Liver
Caution
Dose adjustments may be needed. So inform your doctor before receiving the Brivup-25 Tablet if you have a history of liver impairments.
Kidney
Caution
Brivup-25 Tablet is not recommended to be used in end-stage renal disease patients undergoing dialysis. Inform your doctor before receiving the Brivup-25 Tablet if you have a history of kidney diseases/conditions.
Children
Safe if prescribed
Your doctor will prescribe only if the benefits outweigh the risks.
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Drug-Drug Interactions
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Co-administration of Brivup-25 Tablet with Ketamine may increase side effects such as drowsiness, difficulty concentrating, confusion, and impairment in thinking, judgment, reaction speed, and motor coordination.
How to manage the interaction:
Although there is a possible interaction between Brivup-25 Tablet and Ketamine, you can take these medicines together if prescribed by a doctor. If you notice any of these signs - feeling dizzy, sleepy, confused, having trouble focusing, feeling too relaxed, or having trouble breathing - make sure to contact adoctor right away. Do not stop using any medications without talking to a doctor.
Co-administration of Brivup-25 Tablet with Esketamine may increase side effects such as drowsiness, difficulty concentrating, confusion, and impairment in thinking, judgment, reaction speed, and motor coordination.
How to manage the interaction:
Although there is an interaction, Brivup-25 Tablet can be taken with Esketamine if prescribed by the doctor. Consult the prescriber if you notice drowsiness, difficulty concentrating, confusion, and impairment in thinking, judgment, reaction speed, and motor coordination. Do not discontinue the medication without consulting a doctor
Brimonidine may be absorbed into the bloodstream and occasionally produce central nervous system side effects such as dizziness, drowsiness, and difficulty concentrating. Concomitant use of Brivup-25 Tablet with brimonidine may increase the risk of these side effects.
How to manage the interaction:
Although there is an interaction Brivup-25 Tablet can be taken with brimonidine if prescribed by the doctor. Consult the prescriber if you notice dizziness, drowsiness, and difficulty concentrating.
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Brivup-25 Tablet which treat epilepsy, have been linked to an elevated risk of suicidal ideas or actions in individuals taking them for any reason. A dosage reduction or therapy termination should be taken into consideration if patients exhibit signs of suicidal ideation or behaviour.
How to manage the interaction:
Anti-epileptic drugs have been associated with an increased risk of suicidal thoughts or behavior. It should be administered with caution in patients with depression or other psychiatric disorders. Consult the doctor if you notice signs and symptoms of depression, any unusual changes in mood or behavior, or the emergence of suicidal thoughts or behavior. If patients have symptoms of suicidal ideation or behavior, a dosage reduction or treatment discontinuation should be considered.
Patients taking Brivup-25 Tablet have been documented to experience bronchospasm and angioedema, and a hypersensitive reaction to this medication could put patients at danger. Brivup-25 Tablet should be used with caution in patients who are prone to bronchospasm and angioedema.
How to manage the interaction:
Bronchospasm (tightening of muscles in the airways) and angioedema (swelling) have been reported in patients taking Brivup-25 Tablet. Caution is advised when using Brivup-25 Tablet in patients with bronchospasm and angioedema.
In the liver, Brivup-25 Tablet is largely metabolised via hydrolysis. In comparison to matched healthy controls, Brivup-25 Tablet exposure increased by 50%, 57%, and 59%, respectively, in adult patients with hepatic cirrhosis and Child-Pugh categories A, B, and C. According to the manufacturer's prescription, dosage adjustment is advised for all stages of hepatic impairment due to increases in Brivup-25 Tablet exposure. When administering this medication to patients with liver illness, caution and close observation are advised.
How to manage the interaction:
Dosage adjustment is recommended for all stages of hepatic impairment. Care and close monitoring is advised when using this medicine in patients with liver disease.
Patients with compromised renal function do not require dose modifications. As there are no data in this patient population, Brivup-25 Tablet is not advised for use in patients with end-stage renal disease receiving dialysis.
How to manage the interaction:
The use of Brivup-25 Tablet is not recommended in patients with end-stage renal disease undergoing dialysis as there are no data in this patient population.
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