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Written By Lakshmithulasi Yarragunta , Pharm-D (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Composition :

CABOZANTINIB-40MG

Manufacturer/Marketer :

Cipla Ltd

Consume Type :

Oral

Expires on or after :

Return Policy :

Not Returnable

Therapeutic Class

[ANTINEOPLASTIC]

Country of origin

INDIA

Manufacturer/Marketer address

Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013
Other Info - CAB0082

FAQs

Cabotres 40 Tablet contains Cabozantinib, which works by stopping the action of a tyrosine kinase enzyme that causes the multiplication of cancerous cells.

Cabotres 40 Tablet may cause thyroid dysfunction, leading to decreased thyroid hormone levels. This effect causes hypothyroidism. So, notify your doctor if you feel extremely tired, colder than others, sudden weight gain/ weight loss, hair loss, or change in voice while using this medicine.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Safe if prescribed

Avoid consumption of alcohol while on treatment with Cabotres 40 Tablet as it may cause serious side effects.

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Pregnancy

Consult your doctor

Cabotres 40 Tablet is not recommended for use in pregnancy as it may cause embryo-fetal toxicity and harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before taking Cabotres 40 Tablet . You should not become pregnant while you are taking Cabotres 40 Tablet for at least four months from the last dose of Cabotres 40 Tablet . Using effective birth control methods while on treatment is suggested.

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Breast Feeding

Consult your doctor

Cabotres 40 Tablet should not be taken if you are breastfeeding as it passes into breast milk and may harm your infant. Avoid nursing your child while on treatment with this medicine and for at least four months from the last dose of medicine.

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Driving

Safe if prescribed

In some cases, Cabotres 40 Tablet may cause dizziness and visual problems. As a result, do not drive, operate machinery, or engage in any activity that requires clear vision until you are satisfied you can drive while on Cabotres 40 Tablet therapy.

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Liver

Consult your doctor

If you have a pre-existing or a history of liver problems, tell your doctor before taking this medicine. Cabotres 40 Tablet is known to cause hepatotoxicity when taken in combination with nivolumab. Hence, this medicine should be taken cautiously in patients with moderate liver impairment. Your doctor may suggest tests to monitor your liver function while on treatment with this medicine.

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Kidney

Consult your doctor

If you have a pre-existing or a history of kidney diseases, inform your doctor before taking Cabotres 40 Tablet . Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Children

Safe if prescribed

Cabotres 40 Tablet is not recommended for use in children as the safety and efficacy are not established.

About Cabotres 40 Tablet

Cabotres 40 Tablet is an anti-cancer medicine used in the treatment of renal cell carcinoma. It is a disease in which cancer cells grow uncontrollably in the kidney and form a tumor. Cabotres 40 Tablet is used in treating advanced renal cell carcinoma as first-line therapy for advanced renal cell carcinoma in combination with nivolumab and hepatocellular carcinoma in patients who have previously been treated with sorafenib.

Cabotres 40 Tablet contains Cabozantinib as an active ingredient, which belongs to the class of medicines known as kinase inhibitors. It works by inhibiting the action of an enzyme (tyrosine kinase) and thus stops the abnormal growth of cancer cells.

Cabotres 40 Tablet may cause certain side effects such as diarrhea, decreased appetite, nausea, vomiting, increased blood pressure, muscle cramps, decreased weight, dizziness, and constipation. Inform your doctor if any of these side effects bother you. Cabotres 40 Tablet should be taken as advised by your doctor.

Avoid taking Cabotres 40 Tablet if you are allergic to it or any other components of it. Before taking Cabotres 40 Tablet , inform your doctor if you have/had liver or kidney disease, gastrointestinal disorders, heart problems, blood or bleeding disorders, open or healing wounds, and a history of recent surgery. This medicine is known to cause embryo-fetal toxicity. Hence, it is not recommended for use in pregnancy and breastfeeding.

Uses of Cabotres 40 Tablet

Renal Cell Carcinoma, Hepatocellular carcinoma.

Medicinal Benefits Mweb

Key Benefits

Cabotres 40 Tablet contains Cabozantinib, which is used in treating advanced renal cell carcinoma and liver cancer. It works by stopping the action of a tyrosine kinase enzyme that causes the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other parts of the body. It also decreases the blood supply to cancer tumors to slow down the growth of the tumor.  In this way, Cabotres 40 Tablet stops the body's production, spread and growth of cancerous cells.

Directions for Use

Take Cabotres 40 Tablet as prescribed by the doctor. It should be taken at least one hour before food or 2 hours after food. Swallow it as a whole with a glass of water. Do not crush, break, or chew the medicine. Avoid taking more than the prescribed dose of medicine.

Side Effects of Cabotres 40 Tablet

  • Nausea
  • Vomiting
  • Diarrhoea
  • Loss of appetite
  • Increased blood pressure
  • Tiredness
  • Chest pain
  • Dizziness
  • Weakness
  • Difficulty speaking
  • Muscle pain
  • Cough
  • Shortness of breath

Drug Warnings

To treat your condition effectually, continue taking Cabotres 40 Tablet for the period that your doctor has prescribed. Caution should be exercised if you have/had liver or kidney disease, any planned surgery, heart disease, blood or bleeding disorders, open/healing of wound, or gastrointestinal disorders. Inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment, as this medicine is known to cause embryo-fetal toxicity. Cabotres 40 Tablet may cause hypertension, thrombotic events, hemorrhagic events, gastrointestinal perforation and fistula, Reversible Posterior Leukoencephalopathy Syndrome (RPLS), hepatotoxicity, severe diarrhoea, Osteonecrosis of the jaw (ONJ), Palmar-Plantar Erythrodysesthesia (PPE), adrenal insufficiency, impaired wound healing, and proteinuria in some patients. Hence, inform your doctor about your complete medication and medical history before taking Cabotres 40 Tablet . Breastfeeding should be discontinued in nursing mothers during the treatment as it passes into breast milk and may cause a possible risk to the infant. Avoid driving and operating machines, as this medicine may cause dizziness. This medicine is not recommended for use in children below 18 years of age as the safety and efficacy are not established.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Cabotres 40 Tablet:
Co-administration of Cabotres 40 Tablet with mifepristone may significantly increase the effect of Cabotres 40 Tablet.

How to manage the interaction:
Taking Cabotres 40 Tablet with mifepristone together can result in an interaction, it can be taken if doctor has advised it. Contact a doctor immediately if you experience symptoms such as nausea, vomiting, diarrhea, loss of appetite, weight loss, mouth sores, abdominal pain, skin rash, unusual bruising or bleeding, delayed wound healing, high blood pressure, dizziness, lightheadedness, fainting, breathing difficulty, heart palpitations, paleness, fatigue, fever, chills, sore throat, muscle aches, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Cabotres 40 Tablet:
Taking Artesunate with Cabotres 40 Tablet may increase blood levels and effects of artesunate and increase the risk of side effects.

How to manage the interaction:
Although taking artesunate with Cabotres 40 Tablet together can result in an interaction, they can be taken if a doctor has prescribed it. Do not discontinue any medication without consulting a doctor.
How does the drug interact with Cabotres 40 Tablet:
Co-administration of Cabotres 40 Tablet with clomipramine can increase the risk of irregular heart rhythms.

How to manage the interaction:
Although taking clomipramine and Cabotres 40 Tablet together can cause an interaction, it can be taken if your doctor has suggested it. However, contact a doctor immediately if you experience any symptoms such as dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Cabotres 40 Tablet:
Taking pazopanib with Cabotres 40 Tablet can increase the risk of irregular heart rhythm.

How to manage the interaction:
Although there is an interaction between Pazopanib and Cabotres 40 Tablet, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Cabotres 40 Tablet:
Taking primaquine and Cabotres 40 Tablet together can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Primaquine and Cabotres 40 Tablet together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult a doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Cabotres 40 Tablet:
Taking Cabotres 40 Tablet together with promethazine can increase the risk of an irregular heart rhythm that may be serious

How to manage the interaction:
Although there is an interaction between promethazine and Cabotres 40 Tablet, you can take these medicines together if prescribed by your doctor. However, contact a doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or an irregular heartbeat. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Cabotres 40 Tablet:
Using Cabotres 40 Tablet with Adenosine can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Adenosine with Cabotres 40 Tablet together can result in an interaction, but it can be taken if your doctor has advised it. If you experience palpitations, shortness of breath, chest discomfort, or dizziness, make sure to contact a doctor right away. Do not stop using any medications without a doctor's advice.
How does the drug interact with Cabotres 40 Tablet:
Co-administration of Cabotres 40 Tablet with Haloperidol can increase the risk of developing irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Cabotres 40 Tablet with Haloperidol can possibly result in an interaction, it can be taken if your doctor has advised it. Contact your doctor immediately if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Cabotres 40 Tablet:
Co-administration of Cabotres 40 Tablet and Diclofenac Diethylamine can increase the risk of severe unusual bleeding.

How to manage the interaction:
Co-administration of Cabotres 40 Tablet and Diclofenac Diethylamine can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, tarry stools, coughing up or vomiting blood, severe headache, and weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Cabotres 40 Tablet:
Taking Venlafaxine with Cabotres 40 Tablet increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Although there is a possible interaction between Venlafaxine and Cabotres 40 Tablet, you can take these medicines together if prescribed by a doctor. However, consult a doctor immediately if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • CLARITHROMYCIN
  • RITONAVIR
  • ITRACONAZOLE
  • KETOCONAZOLE
  • DILTIAZEM
  • ERYTHROMYCIN
  • CARBAMAZEPINE
  • PHENYTOIN
  • PHENOBARBITAL
  • RIFAMPICIN

Habit Forming

No

Special Advise

  • Your doctor may suggest periodic liver function tests, kidney function tests, and urine tests to monitor the function of the liver kidney and the presence of protein in urine due to the use of Cabotres 40 Tablet .
  • Seek medical attention immediately if you have swelling in your lower legs, fast heartbeats, or trouble breathing, as it may be a sign of a heart problem.
  • It is advised to use effective contraceptive methods while using Cabotres 40 Tablet to prevent pregnancy.

Diet & Lifestyle Advise

  • Physical activity helps strengthen muscles, reduces fatigue, helps in weight loss, and gives strength. Gentle activities like 20-30 minutes of walking or swimming would be helpful.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Getting adequate sleep as resting helps improve your health and mental ability and improves attention.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath, or listening to soothing music.
  • Eat food rich in antioxidants such as berries, spinach, etc.
  • Foods containing fibre help in better digestion. These include beans, peas, lentils, whole grains, nuts, and seeds.
  • Avoid smoking and alcohol consumption.
  • Maintain a healthy weight.

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