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  3. CAFIRATE SOLUTION 1.5ML

Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Hari Kumar , MBBS
48 Hrs returnable
COD available

Online payment accepted

rxMedicinePrescription drug

Whats That

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Synonym :

CAFFEINE

Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

Therapeutic Class

ALTERNATIVE MEDICINE

Country of origin

India

Manufacturer/Marketer address

90, Delhi - Jaipur Road, Sector 32, Gurugram, Haryana 122001
Other Info - CAF0019

Author Details

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FAQs

CAFIRATE SOLUTION contains 'Caffeine Citrate', which belongs to the central nervous system (CNS) stimulants class. It works in three different ways. Firstly, it is the adenosine receptor antagonist; secondly, it is a phosphodiesterase inhibitor. And thirdly, it is an active intracellular calcium mobiliser. Collectively Caffeine stimulates the respiratory centre, sensitising it to hypercapnia. Thereby CAFIRATE SOLUTION effectively regulates the mean respiratory rate and tidal volume, improves pulmonary blood flow, decreases carbon dioxide sensitivity and enhances diaphragmatic function and breathing pattern.

No, it is intended to treat primary apnoea of premature newborns/neonates.

The dosage is determined by your baby's weight, medical problems, and responsiveness to therapy. Before determining the dose, it is also necessary to establish the baseline serum caffeine levels in children born to caffeine-consuming mothers.

Disclaimer

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Alcohol

Caution

CAFIRATE SOLUTION is intended to use in premature newborns/neonates.

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Pregnancy

Caution

CAFIRATE SOLUTION is recommended to be used only in infants.

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Breast Feeding

Caution

CAFIRATE SOLUTION is intended for use in newborns/neonates only. If your infant is being treated with this medication, avoid drinking coffee or using any other caffeine-containing products since caffeine passes into breast milk.

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Driving

Caution

CAFIRATE SOLUTION is intended to use in premature newborns/neonates.

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Liver

Caution

CAFIRATE SOLUTION should be used with caution in infants with impaired hepatic or liver function.

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Kidney

Caution

CAFIRATE SOLUTION should be used with caution in infants with impaired renal or kidney function.

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Children

Caution

CAFIRATE SOLUTION is intended to use in premature newborns/neonates.

About CAFIRATE SOLUTION

CAFIRATE SOLUTION belongs to a group of medicines known as methylxanthines. It is used to treat primary apnoea of premature newborns (interrupted breathing in premature babies). Apnea is a condition where breathing interrupts and causes abnormal heart rate and oxygen saturation alterations. It is a common occurrence, particularly in premature infants.

CAFIRATE SOLUTION contains 'Caffeine Citrate', which belongs to the central nervous system (CNS) stimulants class. It works in three different ways. Firstly, it is the adenosine receptor antagonist; secondly, it is a phosphodiesterase inhibitor. And thirdly, it is an active intracellular calcium mobiliser. Collectively Caffeine stimulates the respiratory centre, sensitising it to hypercapnia. Thereby CAFIRATE SOLUTION effectively regulates the mean respiratory rate and tidal volume, improves pulmonary blood flow, decreases carbon dioxide sensitivity and enhances diaphragmatic function and breathing pattern.

CAFIRATE SOLUTION should be used as prescribed by your doctor. Your doctor will determine the suitable dosage based on your infant's medical conditions. In some cases, CAFIRATE SOLUTION can cause side effects like tachycardia (fast heartbeat), arrhythmia (irregular heartbeat) and hyperglycaemia (increased sugar in blood or serum). These side effects are not prevalent and vary from person to person. Consult your doctor if these symptoms continue or worsen. They may be able to recommend strategies to avoid or minimise certain side effects.

Inform your doctor about the complete medical history of your infant. If you are nursing your infant is being treated with this medication, avoid drinking coffee or using any other caffeine-containing products since Caffeine passes into breast milk. This medication should be used with caution in infants with impaired hepatic or renal function. Before fixing the dose, your doctor may assess baseline serum caffeine levels in children born to caffeine-consuming mothers.

Uses of CAFIRATE SOLUTION

Primary apnea of premature newborns/neonates.

Medicinal Benefits Mweb

Medicinal Benefits

CAFIRATE SOLUTION contains 'Caffeine Citrate', which belongs to the central nervous system (CNS) stimulants class. It works in three different ways. Firstly, it is the adenosine receptor antagonist; secondly, it is a phosphodiesterase inhibitor. And thirdly, it is an active intracellular calcium mobiliser. Collectively Caffeine stimulates the respiratory centre, sensitising it to hypercapnia. Thereby CAFIRATE SOLUTION effectively regulates the mean respiratory rate and tidal volume, improves pulmonary blood flow, decreases carbon dioxide sensitivity and enhances diaphragmatic function and breathing pattern.

Directions for Use

CAFIRATE SOLUTION should be used as directed by your doctor.

Side Effects of CAFIRATE SOLUTION

  • Tachycardia (fast heartbeat)
  • Hyperglycaemia (increased sugar in blood or serum)
  • Arrhythmia (irregular heartbeat)

Drug Warnings

Inform your doctor about your infant's medical history. If you are breastfeeding and your infant is being treated with this medication, avoid drinking coffee or using any other caffeine-containing products since caffeine passes into breast milk. CAFIRATE SOLUTION should only be used in a neonatal intensive care unit where adequate patient surveillance and monitoring facilities are available. Treatment should begin under the supervision of a neonatologist with experience in neonatal intensive care. This medication should be used with caution in infants with impaired liver or kidney function.

Drug-Drug Interactions

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CaffeinePhenelzine
Critical
CaffeineLinezolid
Critical

Drug-Drug Interactions

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CaffeinePhenelzine
Critical
How does the drug interact with Cafirate Solution 1.5ml:
Taking these two together can cause your blood pressure to rise, a condition known as a hypertensive crisis.

How to manage the interaction:
Taking Cafirate Solution 1.5ml with Phenelzine is not recommended, please consult your doctor before taking it. They can be taken if your doctor advises it. Do not stop taking any medication without consulting your doctor.
CaffeineLinezolid
Critical
How does the drug interact with Cafirate Solution 1.5ml:
Taking these two together can cause your blood pressure to rise, a condition known as a hypertensive crisis.

How to manage the interaction:
Taking Cafirate Solution 1.5ml with Linezolid is not recommended, please consult your doctor before taking it. It can be taken if your doctor prescribes it. Do not stop taking any medication without consulting your doctor.
CaffeineIsocarboxazid
Critical
How does the drug interact with Cafirate Solution 1.5ml:
Taking these two together can cause your blood pressure to rise, a condition known as a hypertensive crisis.

How to manage the interaction:
Taking Cafirate Solution 1.5ml with Isocarboxazid is not recommended, please consult your doctor before taking it. It can be taken if your doctor prescribes it. Do not stop taking any medication without consulting your doctor.
Critical
How does the drug interact with Cafirate Solution 1.5ml:
Coadministration of tranylcypromine with Cafirate Solution 1.5ml can in cause severe high blood pressure.

How to manage the interaction:
Taking Cafirate Solution 1.5ml with Tranylcypromine is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience headache, confusion, blurred vision, problems with speech or balance, nausea, vomiting, chest pain, convulsions, and sudden numbness or weakness (especially on one side of the body). Do not discontinue any medications without consulting a doctor.
CaffeineDipyridamole
Severe
How does the drug interact with Cafirate Solution 1.5ml:
Concomitant use of Cafirate Solution 1.5ml with dipyridamole may decrease the effects of dipyridamole.

How to manage the interaction:
Although there is an interaction, Cafirate Solution 1.5ml can be taken with dipyridamole if prescribed by the doctor. Avoiding Cafirate Solution 1.5ml for 12 to 24 hours before dipyridamole administration is advised.
CaffeineCocaine
Severe
How does the drug interact with Cafirate Solution 1.5ml:
Coadministration of Cafirate Solution 1.5ml with cocaine can increase the risk of irregular heart rhythm.

How to manage the interaction:
Although there is an interaction, Cafirate Solution 1.5ml can be taken with cocaine if prescribed by the doctor. However, contact your doctor if you experience dizziness, lightheadedness, palpitations, and shortness of breath. Do not discontinue using any medication without contacting a doctor.
CaffeineEsketamine
Severe
How does the drug interact with Cafirate Solution 1.5ml:
Esketamine can cause increase in blood pressure and using it with Cafirate Solution 1.5ml may increase the risk.

How to manage the interaction:
Although there is a possible interaction between Cafirate Solution 1.5ml and Esketamine, it can be taken together if prescribed by your doctor. Do not discontinue using any medications without consulting your doctor.
CaffeineTizanidine
Severe
How does the drug interact with Cafirate Solution 1.5ml:
Coadministration of Cafirate Solution 1.5ml with Tizanidine may increase the blood levels and effects of tizanidine. This may cause excessive blood pressure, especially when rising from a sitting or lying position.

How to manage the interaction:
Although there is an interaction, Cafirate Solution 1.5ml can be taken with tizanidine if prescribed by the doctor. Contact your doctor if you experience dizziness, excessive sweating, or palpitations. Do not stop using any medicine without consulting your doctor.
CaffeineBupropion
Severe
How does the drug interact with Cafirate Solution 1.5ml:
Bupropion and Cafirate Solution 1.5ml can increase blood pressure. Concomitant use may have additive effects.

How to manage the interaction:
Although there is an interaction, Cafirate Solution 1.5ml can be taken with bupropion if prescribed by the doctor. Regular monitoring of blood pressure is advised.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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CAFFEINE CITRATE-20MGComplications and ill-defined descriptions of heart disease
Severe
CAFFEINE CITRATE-20MGEssential (primary) hypertension
Severe

Drug-Diseases Interactions

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CAFFEINE CITRATE-20MGComplications and ill-defined descriptions of heart disease
Severe
How does the disease interact with Cafirate Solution 1.5ml:
Patients with considerable cardiovascular impairment, such as uncompensated heart failure, severe coronary disease, or severe hypertension, should not utilise CNS stimulants.

How to manage the interaction:
It is contraindicated in patients with significant heart problems. Before initiation of therapy, a careful assessment of the the patient's cardiac status should be done.
CAFFEINE CITRATE-20MGEssential (primary) hypertension
Severe
How does the disease interact with Cafirate Solution 1.5ml:
The use of CNS stimulant drugs may be contraindicated in people with severe hypertension since they have been found to raise blood pressure.

How to manage the interaction:
CNS stimulants may increase blood pressure. Therefore, caution should be used when administering to patients with preexisting high blood pressure and other cardiovascular conditions.
CAFFEINE CITRATE-20MGOther diseases of liver
Severe
How does the disease interact with Cafirate Solution 1.5ml:
The liver substantially metabolises CNS stimulants. Patients with compromised hepatic function may see a decrease in their plasma clearance and an extension of their half-life.

How to manage the interaction:
Cafirate Solution 1.5ml should be administered cautiously in patients with moderate to severe liver disease, and the dosage should be adjusted accordingly.
CAFFEINE CITRATE-20MGMental disorder, not otherwise specified
Severe
How does the disease interact with Cafirate Solution 1.5ml:
The use of CNS stimulants can increase symptoms of mental disorder and behaviour disturbance as well as create psychotic or manic symptoms, suicidal ideation, violence, and suicidal behaviour.

How to manage the interaction:
CNS stimulants may cause psychotic or maniac symptoms, suicidal ideation, aggression and can exacerbate symptoms of behavior disturbance and thought disorder. Patients should be monitored closely, specially during treatment initiation and at times of dose changes.
CAFFEINE CITRATE-20MGGastritis and duodenitis
Severe
How does the disease interact with Cafirate Solution 1.5ml:
Peptic acid secretion has been known to be stimulated by methylxanthines. In patients with active peptic ulcer disease, therapy with products containing methylxanthines should be delivered with the utmost caution.

How to manage the interaction:
It should be administered with extreme caution in patients with active peptic ulcer disease.
CAFFEINE CITRATE-20MGOther disorders of kidney and ureter, not elsewhere classified
Moderate
How does the disease interact with Cafirate Solution 1.5ml:
Overall, it is advised to use caution when administering CNS stimulants to patients who have severely compromised renal function because the therapeutic response may be affected by the decreased rate of excretion.

How to manage the interaction:
It should be administered with caution in patients with significantly impaired kidney function. The dosage should be adjusted accordingly.

Habit Forming

No

CAFIRATE SOLUTION Substitute

Substitutes safety advice

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