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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Composition :

ACALABRUTINIB-100MG

Manufacturer/Marketer :

Astra Zeneca Pharma India Ltd

Consume Type :

Oral

Expires on or after :

Return Policy :

Not Returnable

Therapeutic Class

[KINASE INHIBITORS]

Country of origin

Sweden

Manufacturer/Marketer address

Corporate & Registered Office, Block N1, 12Th Floor, Manyata Embassy Business Park, Rachenahalli, Outer Ring Road, 560045, Bangalore
Other Info - CAL2475

FAQs

Calquence 100 mg Capsule contains Acalabrutinib, a tyrosine kinase inhibitor. Tyrosine kinases are enzymes in the body that send signals to cells, directing them to grow and divide. Acalabrutinib blocks these signals to cancer cells. Cancer cells die when their signals are interrupted. This could help to delay the progression of the cancer.

While taking Calquence 100 mg Capsule, make sure you visit your doctor at all the appointments to ensure that treatment works. Regular monitoring of blood and lipid tests and weight checks are required. An effective way of contraception should be used by both men and women while taking the Calquence 100 mg Capsule.

Mantle cell lymphoma (MCL) is diagnosed by taking a biopsy of tumour tissue and examining the cells under a microscope.

You can take the missed dose if you forget to take your acalabrutinib, which is less than 3 hours after your usual time. Then, take the next dose at the regular time. Do not take your missed dose if more than 3 hours have passed. Wait and take the next dose at the regular time. Do not take a double dose to make up for a missing one.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Safe if prescribed

Avoid alcohol consumption while on treatment with Calquence 100 mg Capsule.

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Pregnancy

Consult your doctor

Calquence 100 mg Capsule should not be used during pregnancy. So, inform your doctor if you are pregnant or suspect pregnancy. You or your partner must use a reliable form of contraception to prevent pregnancy while taking these medications.

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Breast Feeding

Consult your doctor

Calquence 100 mg Capsule should not be used in breastfeeding. Discuss with your doctor if you have any concerns.

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Driving

Safe if prescribed

Calquence 100 mg Capsule does not influence the ability to drive or use machines. However, go only if you are alert, as the Calquence 100 mg Capsule may cause tiredness in some people.

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Liver

Consult your doctor

Avoid using Calquence 100 mg Capsule in patients with severe hepatic impairment. The safety of Calquence 100 mg Capsule has not been evaluated in patients with moderate or severe hepatic impairment. So, caution should be exercised while using Calquence 100 mg Capsule in patients with liver impairment. If you have a pre-existing or a history of liver disease, inform your doctor before taking the Calquence 100 mg Capsule. Your doctor will weigh the benefits and potential risks before prescribing Calquence 100 mg Capsule.

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Kidney

Consult your doctor

Caution should be exercised while using Calquence 100 mg Capsule in patients with kidney impairment. If you have a pre-existing or a history of kidney disease, inform your doctor before taking the Calquence 100 mg Capsule. Your doctor will weigh the benefits and potential risks before prescribing Calquence 100 mg Capsule.

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Children

Safe if prescribed

Safety and effectiveness in patients below the age of 18 years have not been established. Hence, use is not recommended.

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Heart

Take Calquence 100 mg Capsule with caution, especially if you have a history of heart diseases/conditions. The dose may be adjusted by your doctor as required.

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Geriatrics

Consult your doctor

Calquence 100 mg Capsule can be safely used in elderly patients with proper monitoring and individualised care.

About Calquence 100 mg Capsule

Calquence 100 mg Capsule is a tyrosine kinase inhibitor or cancer growth inhibitor that is primarily used to treat people with mantle cell lymphoma (MCL) who have had at least one prior treatment for their malignancy (cancer), as well as adults with chronic lymphocytic leukaemia (CLL) or small lymphocytic lymphoma (SLL). Cancer is caused by a genetic mutation that causes our cells to divide uncontrollably and spread into neighbouring tissues.

Calquence 100 mg Capsule contains Acalabrutinib, a tyrosine kinase inhibitor. Tyrosine kinases are enzymes in the body that transmit signals to cells, telling them to grow and divide. Acalabrutinib inhibits these signals to cancer cells. Cells die when their signals are disrupted. This could help to slow the progression of the cancer.

To treat your condition effectually, continue using Calquence 100 mg Capsule for as long as your doctor has prescribed it. The most common adverse reactions are anaemia (lack of blood), neutropenia (low count of neutrophils), upper respiratory tract infection, thrombocytopenia (Low platelet level), headache, diarrhoea, and musculoskeletal pain. You should talk to your doctor if you persistently experience these side effects.

It is recommended not to use if you are hypersensitive to any component present in Calquence 100 mg Capsule and suffer from Severe Hepatic Impairment. Calquence 100 mg Capsule can cause fetal harm when administered to a pregnant woman. It is critical not to become pregnant or get pregnant while undergoing therapy and for several months after the treatment. Using effective contraceptive methods is recommended while on therapy with Calquence 100 mg Capsule. Contact your doctor immediately if you or your partner becomes pregnant while undergoing therapy. Breastfeeding is usually not advised during this treatment. Alcohol should be avoided during treatment with this medicine. Safety and effectiveness in children have not been established.

Uses of Calquence 100 mg Capsule

Mantle cell lymphoma (MCL), chronic lymphocytic leukaemia (CLL) or small lymphocytic lymphoma (SLL)

Medicinal Benefits Mweb

Key Benefits

Calquence 100 mg Capsule is primarily used to treat people with mantle cell lymphoma (MCL) who have had at least one prior treatment for their malignancy, as well as adults with chronic lymphocytic leukaemia (CLL) or small lymphocytic lymphoma (SLL). Calquence 100 mg Capsule contains Acalabrutinib, a tyrosine kinase inhibitor. Tyrosine kinases are enzymes in the body that send signals to cells, directing them to grow and divide. Acalabrutinib blocks these signals to cancer cells. Cancer cells die when their signals are interrupted. This could help to delay the progression of the cancer.

Directions for Use

Calquence 100 mg Capsule should be swallowed as a whole with a glass of water. Do not crush, chew, or break the tablets. The doctor determines the dose and duration based on your health condition.

Side Effects of Calquence 100 mg Capsule

  • Feeling sick (nausea)
  • Being sick (vomiting)
  • Fatigue (
  • Anaemia (lack of blood)
  • Neutropenia (low count of neutrophils)
  • Upper respiratory tract infection
  • Thrombocytopenia (low platelet level)
  • Headache
  • Diarrhea
  • Musculoskeletal pain (myalgia)
  • Abdominal pain
  • Fatigue (tiredness)
  • Bruising
  • Rash
  • Haemorrhage (bleeding)
  • Epistaxis (nosebleed)

Drug Warnings

Before taking the Calquence 100 mg Capsule, inform your doctor about all your medical conditions, sensitivities, and medications you are using. If you are a woman capable of having children, you should use an effective method of contraception during Acalabrutinib treatment and for at least one week after the last dose. If you are a man, you should use a barrier method of contraception to prevent your partner from becoming pregnant while taking Acalabrutinib and for at least one week after the last dose. Unless the doctor suggests, do not use any other medicine, including herbal or vitamin supplements.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Calquence 100 mg Capsule:
Taking Dabigatran etexilate with Calquence 100 mg Capsule can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Dabigatran etexilate with Calquence 100 mg Capsule together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Calquence 100 mg Capsule:
The combined use of Calquence 100 mg Capsule and Diclofenac Diethylamine can increase the risk of unusual bleeding.

How to manage the interaction:
Co-administration of Calquence 100 mg Capsule and Diclofenac Diethylamine can lead to an interaction, but it can be taken if a doctor advises. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, tarry stools, coughing up or vomiting blood, severe headache, or weakness, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Calquence 100 mg Capsule:
Taking Calquence 100 mg Capsule with posaconazole can considerably raise Calquence 100 mg Capsule levels in the blood. This may increase the side effects such as infections, abnormal heart rhythm, and bleeding.

How to manage the interaction:
Although using posaconazole and Calquence 100 mg Capsule together can result in an interaction, they can be taken together if prescribed by your doctor. However, contact your doctor if you experience dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination.
How does the drug interact with Calquence 100 mg Capsule:
Using Calquence 100 mg Capsule together with dalteparin may increase the risk of bleeding.

How to manage the interaction:
Co-administration of Dalteparin with Calquence 100 mg Capsule can possibly result in an interaction, but it can be taken if your doctor has advised it. If you notice any of these signs, it's important to contact your doctor right away: bleeding, serious bleeding, problems, bruising, feeling dizzy or lightheaded, having red or black, sticky stools, a very bad headache, feeling weak, or experiencing bleeding or vomiting. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with Calquence 100 mg Capsule:
Co-administration of Dexlansoprazole may interfere with the absorption of Calquence 100 mg Capsule capsules and reduce its effectiveness.

How to manage the interaction:
Consult your doctor if you are taking dexlansoprazole and Calquence 100 mg Capsule. The doctor may prescribe alternatives that do not interact with Calquence 100 mg Capsule or interact to a lesser extent.
How does the drug interact with Calquence 100 mg Capsule:
Calquence 100 mg Capsule blood levels may be significantly raised by combining itraconazole and Calquence 100 mg Capsule.

How to manage the interaction:
Although there is a possible interaction between Calquence 100 mg Capsule and Itraconazole, they can be taken in case a doctor prescribes it. Consult a doctor if you notice any of the following symptoms: paleness, tiredness, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhoea, sore throat, aches in the muscles, shortness of breath, blood in the phlegm, red or irritated skin, body sores, or pain or burning when urinating. Never stop taking any medications without talking to a doctor.
How does the drug interact with Calquence 100 mg Capsule:
Esomeprazole may interfere with the absorption of Calquence 100 mg Capsule and reduce their efficacy.

How to manage the interaction:
Taking Esomeprazole with Calquence 100 mg Capsule together can result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without talking to your doctor.
How does the drug interact with Calquence 100 mg Capsule:
Taking clopidogrel with Calquence 100 mg Capsule may increase the risk of bleeding.

How to manage the interaction:
There could be a possible interaction between clopidogrel and Calquence 100 mg Capsule, but they can be taken together if your doctor has prescribed them. However, consult your doctor immediately if you experience any unusual bleeding or have other signs of bleeding, like feeling dizzy or lightheaded, red or black, sticky stools, or severe headaches. Do not discontinue any medication without consulting your doctor.
How does the drug interact with Calquence 100 mg Capsule:
Using Calquence 100 mg Capsule together with ketorolac may increase the risk of bleeding.

How to manage the interaction:
Although there is a interaction between Ketorolac and Calquence 100 mg Capsule, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience any unusual bleeding, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Calquence 100 mg Capsule:
Co-administration of Calquence 100 mg Capsule and Diltiazem can significantly increase the blood levels of Calquence 100 mg Capsule.

How to manage the interaction:
Although taking Diltiazem and Calquence 100 mg Capsule together can evidently cause an interaction, it can be taken if your doctor has suggested it. If you notice any symptoms like feeling sick, stomach pain, or unusual bleeding, make sure to call your doctor right away. Do not stop using any medications without first talking to your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Habit Forming

No

Special Advise

  • Keep all of your doctor's and laboratory appointments.
  • Pregnancy testing is recommended prior to starting treatment with Calquence 100 mg Capsule.

Diet & Lifestyle Advise

  • After your treatment begins, several dietary adjustments can help you control side effects.
  • Anyone suffering from a chronic illness, including cancer, should consume foods high in protein, healthy fats, whole grains, and vitamins and minerals.
  • Plant-based proteins are among the greatest meals during chemotherapy or other cancer treatments. They have the highest concentrations of vitamins and minerals, such as nuts, seeds, beans and legumes.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Performing yoga may also help in improving both physical and mental health.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.
  • Avoid fast, fried, processed meats, refined carbs, and added sugars.

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