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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

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Whats That

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Composition :

OLAPARIB-150MG

Manufacturer/Marketer :

Adley Formulations

Consume Type :

ORAL

Return Policy :

Not Returnable

Therapeutic Class

ANTINEOPLASTIC

Country of origin

India

Manufacturer/Marketer address

Adley Formulation, Sco- 42, Sector 12, Panchkula-134112, Haryana, India
Other Info - CAN0759

FAQs

Canrib 150 mg Tablet 60's contains Olaparib, a targeted drug called a PARP inhibitor. PARP is a protein that helps damaged cells to repair themselves. Olaparib stops PARP working. Some cancer cells rely on PARP to keep their DNA healthy. So, the cancer cells die when Olaparib stops PARP from repairing DNA damage.

If you are allergic to Olaparib or any other ingredients in this medication, are breastfeeding, or have too low blood cell counts, you should not use Canrib 150 mg Tablet 60's.

Yes, Canrib 150 mg Tablet 60's can cause low neutrophils levels, a type of white blood cells that help fight infections. If your white blood cells become low, you can be at higher risk for infections. Tell your doctor if you develop a fever or have an infection.

Do not have immunizations/vaccinations without talking to your doctor first. Also, avoid contact with people who recently had immunizations /vaccinations.

Yes, Olaparib was generally a well-tolerated medication. Take Canrib 150 mg Tablet 60's pills exactly as directed by your healthcare provider. Do not change your dose or stop taking Canrib 150 mg Tablet 60's unless your healthcare physician instructs you. If you encounter side symptoms, your healthcare provider may temporarily discontinue your Canrib 150 mg Tablet 60's therapy or adjust your Canrib 150 mg Tablet 60's dose.

Disclaimer

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Alcohol

Caution

Avoid alcohol consumption while on treatment with Canrib 150 mg Tablet 60's.

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Pregnancy

Unsafe

Canrib 150 mg Tablet 60's should not be used during pregnancy because it can harm your fetus (newborn baby). Both women of childbearing potential and men must use an effective contraception method while taking Canrib 150 mg Tablet 60's and at least for six months later treatment. Your doctor will weigh the benefits and risks before prescribing this medicine.

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Breast Feeding

Unsafe

Do not breastfeed during this treatment because the medicine may pass into your milk. Doctors normally advise against breastfeeding throughout this treatment and for one month after the final medication is taken.

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Driving

Caution

Canrib 150 mg Tablet 60's may affect your reactions and your ability to drive. Do not drive and/or operate machines that require your alertness.

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Liver

Caution

In patients with mild or moderate liver impairment, there is no need to alter the initial dose. There is no information available on patients with severe liver impairment.

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Kidney

Caution

In patients with mild or moderate kidney impairment, there is no need to alter the initial dose. There is no information available on patients with severe kidney impairment.

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Children

Caution

The safety and effectiveness of Canrib 150 mg Tablet 60's in pediatric patients have not been established.

About Canrib 150 mg Tablet 60's

Canrib 150 mg Tablet 60's belongs to a group of medicines known as 'anti-cancer' drugs used to treat various cancers, including Ovarian, breast, pancreatic, and prostate. Cancer is a condition where cells in a specific body part grow and reproduce uncontrollably. The cancerous cells can attack and destroy surrounding healthy tissue, including organs.

Canrib 150 mg Tablet 60's contains Olaparib, a targeted drug called a PARP inhibitor. PARP (polyadenosine 5’-diphosphoribose polymerase) is a protein that helps damaged cells repair themselves. Olaparib stops PARP working. Some cancer cells rely on PARP to keep their DNA healthy. So, the cancer cells die when Olaparib stops PARP from repairing DNA damage.

Use this medicine as directed by your doctor. You may sometimes experience shortness of breath (dyspnoea), feeling very tired, pale skin or fast heartbeat, anaemia, feeling sick (nausea), being sick (vomiting), indigestion or heartburn (dyspepsia), loss of appetite, headache, changes in taste of foods (dysgeusia), feeling dizzy, cough and diarrhoea. Most of these side effects may gradually resolve over time. However, if the side effects persist or worsen, consult your doctor.

To treat your condition effectually, continue taking Canrib 150 mg Tablet 60's for as long as your doctor has prescribed. Do not stop using the Canrib 150 mg Tablet 60's midway. Talk to your doctor before taking Canrib 150 mg Tablet 60's if you have severe allergic reactions to Canrib 150 mg Tablet 60's or other medicines or suffer from severe infections, renal dysfunction, hepatic disorders and blood cell counts are too low. Avoid taking Canrib 150 mg Tablet 60's if you are pregnant or breastfeeding because this Canrib 150 mg Tablet 60's can cause harmful effects on the unborn baby. Both women and men using this Canrib 150 mg Tablet 60's should use birth control to avoid pregnancy. While on Canrib 150 mg Tablet 60's treatment, you should avoid eating grapefruit, Seville oranges or consuming grapefruit juice since it can affect how the medicine works.

Uses of Canrib 150 mg Tablet 60's

Cancer (Ovarian cancer, breast cancer, pancreatic cancer, and prostate cancer)

Medicinal Benefits Mweb

Medicinal Benefits

Canrib 150 mg Tablet 60's contains Olaparib, a targeted drug called a PARP inhibitor. PARP is a protein that helps damaged cells to repair themselves. Olaparib stops PARP working. Some cancer cells rely on PARP to keep their DNA healthy. So, the cancer cells die when Olaparib stops PARP from repairing DNA damage. Thus, it treats various cancers, including Ovarian, breast, pancreatic, and prostate. It can be used alone or with other chemotherapy drugs, depending on your type of cancer.

Directions for Use

Swallow it as a whole with water; do not crush or chew it.

Side Effects of Canrib 150 mg Tablet 60's

  • Feeling sick (nausea)
  • Being sick (vomiting)
  • Feeling tired or weak (fatigue)
  • Feeling very tired
  • Indigestion or heartburn (dyspepsia)
  • Loss of appetite
  • Headache
  • Changes in the taste of foods (dysgeusia)
  • Feeling dizzy
  • Cough
  • Shortness of breath (dyspnoea)
  • Diarrhoea
  • Low white blood cell count (leukopenia or neutropenia)
  • Rash
  • Sore mouth (stomatitis)
  • Upper abdominal pain (pain in the stomach area under the ribs)
  • Blood clot in a deep vein, usually in the leg (venous thrombosis)

Drug Warnings

Always take this medicine exactly as your doctor or healthcare professional has told you. To treat your condition effectually, continue taking Canrib 150 mg Tablet 60's for as long as your doctor has prescribed. Do not stop Canrib 150 mg Tablet 60's midway. Talk to your doctor before taking Canrib 150 mg Tablet 60's if you have severe allergic reactions to Canrib 150 mg Tablet 60's or other medicines or suffer from any medical illness. Avoid taking Canrib 150 mg Tablet 60's if you are pregnant or breastfeeding because this Canrib 150 mg Tablet 60's can cause harmful effects on the unborn baby. Both women and men using this Canrib 150 mg Tablet 60's should use birth control to avoid pregnancy. Do not start Canrib 150 mg Tablet 60's unless patients have recovered from haematological damage induced by previous chemotherapy (Grade 1). Check full blood count for cytopenia at baseline and monthly afterwards for clinically significant changes during treatment. For persistent haematological toxicity, discontinue Canrib 150 mg Tablet 60's and monitor blood count weekly until recovery. Do not receive any immunization or vaccination without your doctor's approval while taking the Canrib 150 mg Tablet 60's.

Drug-Drug Interactions

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Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Drug Interactions Checker List

  • AMPRENAVIR
  • DARUNAVIR
  • APREPITANT
  • BCG VACCINE
  • DENGUE VACCINE
  • MUMPS (LIVE ATTENUATED)
  • CIPROFLOXACIN
  • FLUCONAZOLE
  • ITRACONAZOLE

Habit Forming

No

Special Advise

  • Pregnancy testing is recommended for females of reproductive potential prior to initiating treatment with Canrib 150 mg Tablet 60's.
  • Canrib 150 mg Tablet 60's should be taken under strict medical supervision. The doctor will regularly monitor your condition while taking Canrib 150 mg Tablet 60's.
  • Monitor complete blood count for cytopenia at baseline and monthly for clinically significant changes during treatment.
  • Your doctor may get routine blood tests done to monitor your liver function, electrolyte levels, and blood cell count in your blood.
  • Peripheral blood counts should be frequently monitored during Canrib 150 mg Tablet 60's treatment and, when appropriate, until recovery is achieved.
  • Do not donate sperm during treatment with Canrib 150 mg Tablet 60's for three months after your last dose.

Diet & Lifestyle Advise

  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Performing yoga may also help in improving both physical and mental health.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.
  • Avoid fast, fried, processed meats, refined carbs and added sugars.

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