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Written By Lakshmithulasi Yarragunta , Pharm-D (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
48 Hrs returnable
COD available

Online payment accepted

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Whats That

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Composition :

CABOZANTINIB-20MG

Manufacturer/Marketer :

Natco Pharma Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

Therapeutic Class

ANTINEOPLASTIC

Country of origin

India

Manufacturer/Marketer address

Natco House, Road No.2, Banjara Hills, Hyderabad-500 034, India
Other Info - CAZ0029

FAQs

Cazanat 20 Tablet contains Cabozantinib, which works by stopping the action of a tyrosine kinase enzyme that causes the multiplication of cancerous cells.

Cazanat 20 Tablet may cause thyroid dysfunction, leading to decreased thyroid hormone levels. This effect causes hypothyroidism. So, notify your doctor if you feel extremely tired, colder than others, sudden weight gain/ weight loss, hair loss, or change in voice while using this medicine.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Caution

Avoid consumption of alcohol while on treatment with Cazanat 20 Tablet as it may cause serious side effects.

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Pregnancy

Unsafe

Cazanat 20 Tablet is not recommended for use in pregnancy as it may cause embryo-fetal toxicity and harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before taking Cazanat 20 Tablet . You should not become pregnant while you are taking Cazanat 20 Tablet for at least four months from the last dose of Cazanat 20 Tablet . Using effective birth control methods while on treatment is suggested.

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Breast Feeding

Unsafe

Cazanat 20 Tablet should not be taken if you are breastfeeding as it passes into breast milk and may harm your infant. Avoid nursing your child while on treatment with this medicine and for at least four months from the last dose of medicine.

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Driving

Unsafe

In some cases, Cazanat 20 Tablet may cause dizziness and visual problems. As a result, do not drive, operate machinery, or engage in any activity that requires clear vision until you are satisfied you can drive while on Cazanat 20 Tablet therapy.

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Liver

Caution

If you have a pre-existing or a history of liver problems, tell your doctor before taking this medicine. Cazanat 20 Tablet is known to cause hepatotoxicity when taken in combination with nivolumab. Hence, this medicine should be taken cautiously in patients with moderate liver impairment. Your doctor may suggest tests to monitor your liver function while on treatment with this medicine.

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Kidney

Caution

If you have a pre-existing or a history of kidney diseases, inform your doctor before taking Cazanat 20 Tablet . Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Children

Unsafe

Cazanat 20 Tablet is not recommended for use in children as the safety and efficacy are not established.

About Cazanat 20 Tablet

Cazanat 20 Tablet is an anti-cancer medicine used in the treatment of renal cell carcinoma. It is a disease in which cancer cells grow uncontrollably in the kidney and form a tumor. Cazanat 20 Tablet is used in treating advanced renal cell carcinoma as first-line therapy for advanced renal cell carcinoma in combination with nivolumab and hepatocellular carcinoma in patients who have previously been treated with sorafenib.

Cazanat 20 Tablet contains Cabozantinib as an active ingredient, which belongs to the class of medicines known as kinase inhibitors. It works by inhibiting the action of an enzyme (tyrosine kinase) and thus stops the abnormal growth of cancer cells.

Cazanat 20 Tablet may cause certain side effects such as diarrhea, decreased appetite, nausea, vomiting, increased blood pressure, muscle cramps, decreased weight, dizziness, and constipation. Inform your doctor if any of these side effects bother you. Cazanat 20 Tablet should be taken as advised by your doctor.

Avoid taking Cazanat 20 Tablet if you are allergic to it or any other components of it. Before taking Cazanat 20 Tablet , inform your doctor if you have/had liver or kidney disease, gastrointestinal disorders, heart problems, blood or bleeding disorders, open or healing wounds, and a history of recent surgery. This medicine is known to cause embryo-fetal toxicity. Hence, it is not recommended for use in pregnancy and breastfeeding.

Uses of Cazanat 20 Tablet

Renal Cell Carcinoma, Hepatocellular carcinoma.

Medicinal Benefits Mweb

Medicinal Benefits

Cazanat 20 Tablet contains Cabozantinib, which is used in treating advanced renal cell carcinoma and liver cancer. It works by stopping the action of a tyrosine kinase enzyme that causes the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other parts of the body. It also decreases the blood supply to cancer tumors to slow down the growth of the tumor.  In this way, Cazanat 20 Tablet stops the body's production, spread and growth of cancerous cells.

Directions for Use

Take Cazanat 20 Tablet as prescribed by the doctor. It should be taken at least one hour before food or 2 hours after food. Swallow it as a whole with a glass of water. Do not crush, break, or chew the medicine. Avoid taking more than the prescribed dose of medicine.

Side Effects of Cazanat 20 Tablet

  • Nausea
  • Vomiting
  • Diarrhoea
  • Loss of appetite
  • Increased blood pressure
  • Tiredness
  • Chest pain
  • Dizziness
  • Weakness
  • Difficulty speaking
  • Muscle pain
  • Cough
  • Shortness of breath

Drug Warnings

To treat your condition effectually, continue taking Cazanat 20 Tablet for the period that your doctor has prescribed. Caution should be exercised if you have/had liver or kidney disease, any planned surgery, heart disease, blood or bleeding disorders, open/healing of wound, or gastrointestinal disorders. Inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment, as this medicine is known to cause embryo-fetal toxicity. Cazanat 20 Tablet may cause hypertension, thrombotic events, hemorrhagic events, gastrointestinal perforation and fistula, Reversible Posterior Leukoencephalopathy Syndrome (RPLS), hepatotoxicity, severe diarrhoea, Osteonecrosis of the jaw (ONJ), Palmar-Plantar Erythrodysesthesia (PPE), adrenal insufficiency, impaired wound healing, and proteinuria in some patients. Hence, inform your doctor about your complete medication and medical history before taking Cazanat 20 Tablet . Breastfeeding should be discontinued in nursing mothers during the treatment as it passes into breast milk and may cause a possible risk to the infant. Avoid driving and operating machines, as this medicine may cause dizziness. This medicine is not recommended for use in children below 18 years of age as the safety and efficacy are not established.

Drug-Drug Interactions

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CabozantinibGoserelin
Severe

Drug-Drug Interactions

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How does the drug interact with Cazanat 20 Tablet:
Taking Idarubicin and Cazanat 20 Tablet together can increase the chance of a serious abnormal heart rhythm. If you suffer from any cardiac conditions, or electrolyte disturbances (such as magnesium or potassium deficiency brought on by severe or prolonged diarrhea or vomiting), you may be at higher risk.

How to manage the interaction:
Taking Idarubicin and Cazanat 20 Tablet together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
CabozantinibGoserelin
Severe
How does the drug interact with Cazanat 20 Tablet:
Taking Goserelin and Cazanat 20 Tablet can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Goserelin and Cazanat 20 Tablet together can possibly result in an interaction; it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, or a rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Cazanat 20 Tablet:
Coadministration of Nortriptyline with Cazanat 20 Tablet can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Taking Nortriptyline with Cazanat 20 Tablet together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Cazanat 20 Tablet:
Coadministration of Cazanat 20 Tablet and Apixaban co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining Cazanat 20 Tablet and Apixaban may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
How does the drug interact with Cazanat 20 Tablet:
Concomitant use of Alfuzosin with Cazanat 20 Tablet can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Alfuzosin with Cazanat 20 Tablet can result in an interaction, it can be taken if your doctor has advised it. Contact a doctor immediately if you experience signs such as dizziness, difficulty in breathing, or chest pain. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Cazanat 20 Tablet:
Taking Cazanat 20 Tablet together with clopidogrel may increase the risk of bleeding.

How to manage the interaction:
Taking Clopidogrel with Cazanat 20 Tablet together can result in an interaction, but it can be taken if your doctor has advised it. Contact your doctor immediately if you notice symptoms like bleeding, bruising, dizziness, or black stools. Do not stop using any medications without a doctor's advice.
How does the drug interact with Cazanat 20 Tablet:
Taking Dabigatran etexilate with Cazanat 20 Tablet can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Dabigatran etexilate with Cazanat 20 Tablet together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Cazanat 20 Tablet:
Taking Hydroxyzine with Cazanat 20 Tablet increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Co-administration of Hydroxyzine with Cazanat 20 Tablet can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, consult a doctor immediately Do not stop using any medications without a doctor's advice.
How does the drug interact with Cazanat 20 Tablet:
Taking Imipramine and Cazanat 20 Tablet can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Imipramine and Cazanat 20 Tablet together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, or a rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Cazanat 20 Tablet:
Coadministration of amisulpride together with ofloxacin may raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Despite the fact that Ofloxacin and Amisulpride interact, they can be used if prescribed by a doctor. Consult a doctor if you have sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • CLARITHROMYCIN
  • RITONAVIR
  • ITRACONAZOLE
  • KETOCONAZOLE
  • DILTIAZEM
  • ERYTHROMYCIN
  • CARBAMAZEPINE
  • PHENYTOIN
  • PHENOBARBITAL
  • RIFAMPICIN

Habit Forming

No

Special Advise

  • Your doctor may suggest periodic liver function tests, kidney function tests, and urine tests to monitor the function of the liver kidney and the presence of protein in urine due to the use of Cazanat 20 Tablet .
  • Seek medical attention immediately if you have swelling in your lower legs, fast heartbeats, or trouble breathing, as it may be a sign of a heart problem.
  • It is advised to use effective contraceptive methods while using Cazanat 20 Tablet to prevent pregnancy.

Diet & Lifestyle Advise

  • Physical activity helps strengthen muscles, reduces fatigue, helps in weight loss, and gives strength. Gentle activities like 20-30 minutes of walking or swimming would be helpful.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Getting adequate sleep as resting helps improve your health and mental ability and improves attention.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath, or listening to soothing music.
  • Eat food rich in antioxidants such as berries, spinach, etc.
  • Foods containing fibre help in better digestion. These include beans, peas, lentils, whole grains, nuts, and seeds.
  • Avoid smoking and alcohol consumption.
  • Maintain a healthy weight.

Cazanat 20 Tablet Substitute

Always consult your doctor before taking any new medications and supplements

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