CEFUROXIME-125MGOther gastroenteritis and colitis of infectious and unspecified origin
How does the disease interact with Cetil Mint Flav Susp 48g/60ml:
Colitis: In some cases the use of Cetil Mint Flav Susp 48g/60ml may cause ranging from mild diarrhea to fatal colitis. Colitis is commonly Clostridioides difficile-associated diarrhea (CDAD). Discontinue therapy if signs of CDAD are confirmed.
How to manage the interaction:
Antibiotics may cause Clostridioides difficile-associated diarrhoea (CDAD), which may range from mild diarrhoea to fatal colitis. Cetil Mint Flav Susp 48g/60ml should be used with caution in patients with a history of gastrointestinal disease, particularly colitis (inflammation of the colon) or pseudomembranous colitis (a severe inflammation of the inner lining of the large intestine). Appropriate fluid and electrolyte management, protein supplementation, antibacterial treatment of C difficile, and surgical evaluation is advised.
CEFUROXIME-125MGChronic kidney disease
How does the disease interact with Cetil Mint Flav Susp 48g/60ml:
Renal dysfunction:
Cetil Mint Flav Susp 48g/60ml is eliminated by the kidney in an unchanged form. Thus the plasma levels of the drug increase and prolongs the half-life. Adjust the doses of Cetil Mint Flav Susp 48g/60ml as necessary.
How to manage the interaction:
The serum concentration may be increased in patients with impaired kidney function as most beta-lactam antibiotics are eliminated by the kidney. Dose adjustment may be necessary for patients with kidney dysfunction. Regular renal function tests are advised during prolonged or high-dose therapy.
CEFUROXIME-125MGDependence on enabling machines and devices, not elsewhere classified
How does the disease interact with Cetil Mint Flav Susp 48g/60ml:
Dialysis : Most of the antibiotics are eliminated by hemodialysis. Therefore, administer Cetil Mint Flav Susp 48g/60ml after dialysis or an additional dosage to be administered.
How to manage the interaction:
Cetil Mint Flav Susp 48g/60ml serum levels may be decreased by hemodialysis and peritoneal dialysis. Supplemental doses should be given at the end of each hemodialysis session.
CEFUROXIME-125MGConvulsions, not elsewhere classified
How does the disease interact with Cetil Mint Flav Susp 48g/60ml:
seizure disorders:
In some patients, seizures were reported with whom renal dysfunction which incase of dosage adjustment was not done. Discontinue Cetil Mint Flav Susp 48g/60ml if seizures are reported.
How to manage the interaction:
Cephalosporin antibiotics may trigger seizures. Cetil Mint Flav Susp 48g/60ml should be discontinued if seizures associated with drug therapy occur.
CEFUROXIME-125MGOther diseases of liver
How does the disease interact with Cetil Mint Flav Susp 48g/60ml:
liver disease: With Cetil Mint Flav Susp 48g/60ml, a transient increase in the AST, ALT, and alkaline phosphatase levels was observed. Use with caution and closely monitor for hepatic function is recommended.
How to manage the interaction:
Caution and monitoring is recommended in patients with liver disease as cases of hepatitis have been reported with the use of certain cephalosporins.
CEFUROXIME-125MGOther diseases of liver
How does the disease interact with Cetil Mint Flav Susp 48g/60ml:
Rarely, cephalosporins use may cause hypoprothrombinemia, with or without bleeding. Monitor for Prothrombin time.
How to manage the interaction:
Cephalosporins may be associated with reduced prothrombin activity/prolonged prothrombin time (blood takes too long to form a clot). Prothrombin time should be monitored in at-risk patients and managed as needed.