Clisof-CN 1% Lotion 20 ml

How does the disease interact with Clisof-CN 1% Lotion 20 ml:
Almost all antibacterial medications have been associated with reports of Clostridioides difficile-associated diarrhoea (CDAD), formerly known as pseudomembranous colitis. It can vary from mild diarrhoea to deadly colitis.

How to manage the interaction:
Clostridioides difficile-associated diarrhea (CDAD) ranging from mild diarrhoea to colitis has been reported during treatment with antibacterial agents. Therapy should be administered cautiously in patients with history of gastrointestinal disease, particularly colitis and pseudomembranous colitis. Appropriate fluid and electrolyte management, protein supplementation, and antibacterial treatment of C difficile is advised.

How does the disease interact with Clisof-CN 1% Lotion 20 ml:
Benzyl alcohol is frequently used as a preservative in the formulation of multidose vials for parenteral medicines. Manufacturers of pharmaceuticals believe that using them in neonates, especially preterm and underweight newborns, is contraindicated. In low birth weight preterm newborns, the use of benzyl alcohol in bacteriostatic saline intravascular flush and endotracheal tube lavage solutions has been linked to mortality and serious respiratory and metabolic problems.

How to manage the interaction:
Parenteral medications containing benzyl alcohol as a preservative are contraindicated in neonates, particularly premature infants and infants of low birth weight.

How does the disease interact with Clisof-CN 1% Lotion 20 ml:
The liver is the primary site of Clisof-CN 1% Lotion 20 ml metabolism. Patients with significantly impaired hepatic function may have a rise in the blood concentration of Clisof-CN 1% Lotion 20 ml and a prolongation of the half-life. Additionally, the drug's usage may result in abnormal liver enzyme levels and jaundice. Patients with liver problems should receive Clisof-CN 1% Lotion 20 ml therapy with caution. When given every 8 hours, dosage modifications might not be required. However, with high-dose therapy, serum concentrations should be observed, and during prolonged therapy, regular liver function tests should be carried out.

How to manage the interaction:
Clisof-CN 1% Lotion 20 ml is primarily metabolized by the liver. Therapy with Clisof-CN 1% Lotion 20 ml should be administered cautiously in patients with liver disease. Serum concentrations should be monitored during high-dose therapy, and periodic liver function tests should be performed during prolonged therapy.

How does the disease interact with Clisof-CN 1% Lotion 20 ml:
Clisof-CN 1% Lotion 20 ml is partially removed by the kidney. Clisof-CN 1% Lotion 20 ml should be used with caution in individuals with significantly impaired renal function. Dosage changes are probably to be required. Serum Clisof-CN 1% Lotion 20 ml concentrations should be monitored throughout high-dose therapy, and renal function tests should be conducted on a regular basis during extended medication.

How to manage the interaction:
Therapy with Clisof-CN 1% Lotion 20 ml should be administered cautiously in patients with severely impaired renal function. Serum Clisof-CN 1% Lotion 20 ml concentrations should be monitored during high-dose therapy, and periodic renal function tests should be performed during prolonged therapy.

How does the disease interact with Clisof-CN 1% Lotion 20 ml:
Clisof-CN 1% Lotion 20 ml is partially removed by the kidney. Clisof-CN 1% Lotion 20 ml should be used with caution in individuals with significantly impaired renal function. Dosage changes are probably to be required. Serum Clisof-CN 1% Lotion 20 ml concentrations should be monitored throughout high-dose therapy, and renal function tests should be conducted on a regular basis during extended medication.

How to manage the interaction:
Therapy with Clisof-CN 1% Lotion 20 ml should be administered cautiously in patients with severely impaired renal function. Serum Clisof-CN 1% Lotion 20 ml concentrations should be monitored during high-dose therapy, and periodic renal function tests should be performed during prolonged therapy.