CLOMIFENE CITRATE-50MGOther abnormal uterine and vaginal bleeding
How does the disease interact with Clome 50 Tablet:
Abnormal uterine bleeding:
In patients who are not diagnosed with abnormal genital bleeding, Clome 50 Tablet is contraindicated. Evaluate the patients for the presence of neoplastic lesions.
How to manage the interaction:
The use of Clome 50 Tablet is contraindicated in patients with undiagnosed, abnormal genital bleeding.
CLOMIFENE CITRATE-50MGHepatic failure, not elsewhere classified
How does the disease interact with Clome 50 Tablet:
Hepatic dysfunction:
Clome 50 Tablet is contraindicated for patients who have liver failure or a past history of hepatic dysfunction. The Clome 50 Tablet is primarily metabolized in the liver and enters into enterohepatic circulation. Thus, there will be increase in serum concentration and half-life of Clome 50 Tablet.
How to manage the interaction:
The use of Clome 50 Tablet is contraindicated in patients with liver disease or history of hepatic dysfunction.
CLOMIFENE CITRATE-50MGDisorders of endocrine glands in diseases classified elsewhere
How does the disease interact with Clome 50 Tablet:
Pituitary activity:
Clome 50 Tablet is contraindicated for patients who have uncontrolled thyroid or adrenal dysfunction, or who have an organic intracranial lesion such as a pituitary tumour. Clome 50 Tablet interacts with oestrogen receptors in several tissues, including the pituitary, causing a rise in pituitary gonadotropin secretion.
How to manage the interaction:
Clome 50 Tablet is contraindicated in patients with uncontrolled thyroid, adrenal dysfunction or pituitary tumour.
CLOMIFENE CITRATE-50MGOther disorders of adrenal gland
How does the disease interact with Clome 50 Tablet:
Uncontrolled adrenal dysfunction :
Clome 50 Tablet is contraindicated in patients with uncontrolled adrenal function. Adrenal dysfunction can make pregnancy difficult. Clome 50 Tablet therapy may cause changes in steroid production and/or fluid balance.
How to manage the interaction:
The use of Clome 50 Tablet is contraindicated in patients with uncontrolled adrenal function.
CLOMIFENE CITRATE-50MGDisorders of lipoprotein metabolism and other lipidaemias
How does the disease interact with Clome 50 Tablet:
Hyperlipidemia:
Some patients who are on Clome 50 Tablet therapy have reported hypertriglyceridemia. Preexisting hyperlipidemia or a family history of hyperlipidemia, Higher doses of Clome 50 Tablet for a long period are related to an increased risk of hypertriglyceridemia. In this conditions, Monitor plasma triglycerides regular basis and also at base line before initiating the therapy with Clome 50 Tablet.
How to manage the interaction:
Hypertriglyceridemia may occur during Clome 50 Tablet therapy, especially in patients with a family history of hyperlipidemia and use of higher than the recommended dose and/or longer duration of treatment. Periodic monitoring of plasma triglycerides is recommended in patients with preexisting or family history of hyperlipidemia. Pretreatment screening of triglyceride levels is advised in patients initiating Clome 50 Tablet therapy.