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  1. Home
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  3. Combisure 125 mcg Inhaler 120 mdi

Combisure 125 mcg Inhaler 120 mdi, Pack of 1 AEROSOL
Written By Divya L , PharmaD
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
48 Hrs returnable
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Whats That

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Composition :

FLUTICASONE-125MCG + FORMOTEROL-6MCG

Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

INHALATION

Return Policy :

Not Returnable

Expires on or after :

Therapeutic Class

RESPIRATORY STIMULANTS

Country of origin

India

Manufacturer/Marketer address

90, Delhi - Jaipur Road, Sector 32, Gurugram, Haryana 122001
Other Info - COM0318

Author Details

Doctor image

Written By

Divya L

PharmaD

Bayyarapu Mahesh KumarDoctor badge

Reviewed By

Bayyarapu Mahesh Kumar

M Pharmacy

Last Updated

Jul 8, 2025 | 9:32 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

FAQs

COMBISURE 125MCG INHALER is used to treat and prevent respiratory disorders like asthma attacks and chronic obstructive pulmonary diseases (COPD). COMBISURE 125MCG INHALER consists of Formoterol (bronchodilator) and Fluticasone (Fluticasone). Formoterol relaxes the muscles in the airways and increases airflow to the lungs. Fluticasone acts by blocking prostaglandin's production (chemical messengers) that cause inflammation (swelling) of the airways.

COMBISURE 125MCG INHALER should be cautiously administered under doctor's guidance in seizures since bronchodilators like Formoterol can cause central nervous system stimulation that can lead to other adverse conditions. Please consult your doctor before using COMBISURE 125MCG INHALER if you have seizures.

COMBISURE 125MCG INHALER contains bronchodilator (Fluticasone), which can cause a rise in blood glucose levels. Hence therapy with COMBISURE 125MCG INHALER is cautiously administered in patients with diabetes. Please monitor your blood glucose levels regularly and inform your doctor so that the dose can be adjusted accordingly.

Bronchodilator (Formoterol) in COMBISURE 125MCG INHALER may decrease the potassium levels in your body, therefore should be used with caution. Please consult your doctor before taking COMBISURE 125MCG INHALER since low potassium levels can lead to other cardiovascular problems in patients with hypokalaemia.

Take the missed dose as soon as possible. However, if it is time for the next dose, skip the missed dose and go back to your regular dosing schedule.

Formoterol in COMBISURE 125MCG INHALER may cause dry mouth as a temporary side effect in some people. It is not necessary for everyone taking COMBISURE 125MCG INHALER to experience this side effect. However, to avoid such side effects, drink plenty of water, regularly rinse your mouth, practice good oral hygiene and suck on a sugarless candy. However, if the condition persists or worsens, please consult a doctor.

COMBISURE 125MCG INHALER is not recommended for use when you are taking Sotalol or vice versa. Sotalol and COMBISURE 125MCG INHALER have opposing effects in the body. Sotalol may also trigger asthma attacks or worsen your breathing problems by narrowing the airways. Please consult your doctor before using other medicines with COMBISURE 125MCG INHALER.

COMBISURE 125MCG INHALER is not used for sudden breathing problems; your doctor may suggest a rescue inhaler for sudden breathing problems.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Caution

Avoid drinking alcohol while taking this medicine as it can worsen your side effects.

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Pregnancy

Caution

The safety of COMBISURE 125MCG INHALER in pregnant women is unknown. Therefore, it is given to pregnant women only if the doctor thinks benefits outweigh risks.

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Breast Feeding

Caution

It is not known if this drug passes into breast milk. Consult your doctor before breast-feeding.

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Driving

Caution

Do not drive or operate machinery if you experience drowsiness and increased/uneven heart rate while using COMBISURE 125MCG INHALER. This may affect your ability to drive. Seek medical attention if the symptoms persist longer.

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Liver

Caution

COMBISURE 125MCG INHALER should be used with caution in patients with liver diseases. Let your doctor know if you have any history of liver diseases or hepatic impairment. Your doctor will weigh the benefits and potential risks before prescribing COMBISURE 125MCG INHALER.

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Kidney

Caution

COMBISURE 125MCG INHALER should be used with caution in patients with kidney diseases. Let your doctor know if you have any history of kidney diseases. Your doctor will weigh the benefits and potential risks before prescribing COMBISURE 125MCG INHALER.

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Children

Caution

COMBISURE 125MCG INHALER is not recommended for use for children less than five years of age. The dose may have to be adjusted by your doctor depending upon the condition of the child's disease and age.

Product Substitutes

Reference

  1. https://www.drugs.com/mtm/fluticasone-inhalation.html
  2. https://www.drugs.com/mtm/formoterol-inhalation.html
  3. https://www.medicines.org.uk/emc/files/pil.4277.pdf

About COMBISURE 125MCG INHALER

COMBISURE 125MCG INHALER is a respiratory medication, primarily used to treat and prevent asthma and chronic obstructive pulmonary diseases (COPD) like bronchitis (inflammation of the lining of your bronchial tubes) and emphysema (shortness of breath). Asthma is a chronic (long-term) respiratory condition in which airways narrow, swell and produce extra mucus, leading to difficulty breathing. COPD is a group of lung diseases that causes obstructed airflow from the lungs.

COMBISURE 125MCG INHALER is a combination of two medicines, namely: Formoterol (bronchodilator) and Fluticasone (corticosteroids). Formoterol is a long-acting beta-agonist that relaxes the muscles in the airways and increases airflow to the lungs. Formoterol makes breathing easier by widening the airways. Fluticasone acts by blocking prostaglandin's production (chemical messengers) that cause inflammation (swelling) of the airways. Thereby, it provides relief from sneezing, runny or blocked nose and sinus discomfort. It helps to prevent asthma attacks in adults and children.

Your doctor will advise on how often you take COMBISURE 125MCG INHALER based on your medical condition. The common side effects of COMBISURE 125MCG INHALER include nausea, vomiting, respiratory tract infection, headache, sore throat, cough, bone, muscle or joint pain, increased heart rate, chills, tiredness and noisy breathing. Most of these side effects of COMBISURE 125MCG INHALER do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Do not use COMBISURE 125MCG INHALER to treat sudden severe symptoms of asthma or as a rescue inhaler. Brief your medical history if you have heart, liver, kidney diseases, high blood pressure, hypokalaemia (low potassium levels in the blood), aneurysm (swelling of an artery), pheochromocytoma (adrenal gland tumor), hyperadrenocorticism (high levels of cortisol), cataract and glaucoma, chickenpox or measles, immune system problem, seizure (fits), osteoporosis, and diabetes before taking COMBISURE 125MCG INHALER. Please check with your doctor if you are pregnant, currently breastfeeding or taking any other prescribed or non-prescribed medicines. COMBISURE 125MCG INHALER is not recommended for children below five years of age.

Uses of COMBISURE 125MCG INHALER

Asthma, Chronic Obstructive Pulmonary Disease (COPD), Bronchitis and Emphysema.

Medicinal Benefits Mweb

Medicinal Benefits

COMBISURE 125MCG INHALER is used to treat and prevent respiratory disorders like asthma and chronic obstructive pulmonary diseases (COPD). COMBISURE 125MCG INHALER improves pulmonary function and effectively treats and prevents the worsening of emphysema (shortness of breath) and chronic bronchitis (inflammation of the lining of your bronchial tubes). COMBISURE 125MCG INHALER is a combination of Formoterol (bronchodilator) and Fluticasone (corticosteroid). Formoterol relaxes the muscles in the airways and increases airflow to the lungs. It makes breathing easier by widening the airways. Fluticasone acts by blocking prostaglandin's production (chemical messengers) that cause inflammation (swelling) of the airways. Fluticasone has potent vasoconstrictive (narrowing of the blood vessels) and anti-inflammatory activity.

Directions for Use

Please read the instruction leaflet provided with the pack before using COMBISURE 125MCG INHALER.Inhaler: Hold the inhaler with the mouthpiece facing downwards. Form a tight seal by placing your lips around the mouthpiece. Start breathing slowly with your mouth and push down the inhaler once. Remove the inhaler and breathe normally.Rotacap: Rotacap is a capsule with powdered medication which is placed in Rotahaler. Rotahaler is a breath-activated plastic inhalation device which releases the medication when you breathe. Place the rotahaler between your teeth and seal it with your lips. Tilt your head slightly and breathe with your mouth deeply while you press the rotahaler. Remove the device and breathe out normally.Autohaler: Autohaler is a breath-activated device that releases the medication when you inhale. Shake the autohaler well before using. Hold it upright and push the lever up. Place the mouthpiece in your mouth and seal your lips around it. Breathe in slowly and deeply to release the medication from the device. Hold your breath for 10 seconds and breathe out normally. Push the lever down and replace the cap.Capsule: The capsule should not be taken through the mouth. The capsule form contains powdered medication, which is to be inserted into the inhaling device/inhaler. It releases the medicine when you breathe in deeply with your mouth through the inhaler.Rotadisk: Rotadisk is a silver-coloured aluminium foil disk that contains four blisters to place the medication. The medicine is to be inhaled through the mouth from the Rotadisk using a plastic device called Diskhaler.

Side Effects of COMBISURE 125MCG INHALER

  • Nausea
  • Vomiting
  • Respiratory tract infection
  • Headache
  • Sore throat
  • Cough
  • Bone, muscle or joint pain
  • Increased heart rate
  • Chills
  • Tiredness
  • Noisy breathing

Drug Warnings

Do not stop taking this medicine of your own unless advised by your doctor. Please do not use COMBISURE 125MCG INHALER to treat sudden severe symptoms of asthma or as a rescue inhaler. Before taking COMBISURE 125MCG INHALER, let your doctor know if have a history of heart, liver, kidney diseases, high blood pressure, diabetes, and other medical conditions. Special precautions should be taken in patients with a fungal, bacterial, parasitic, or viral infection and tuberculosis since nasal or inhaled corticosteroids like Fluticasone can cause secondary infections. Regular monitoring of potassium levels is recommended while taking COMBISURE 125MCG INHALER as it may cause low potassium levels in the blood. Please let your doctor know if you plan to become pregnant or are already pregnant and a lactating mother. COMBISURE 125MCG INHALER is not recommended for children below five years of age.

Drug-Drug Interactions

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FluticasoneMifepristone
Critical
FluticasoneRitonavir
Severe

Drug-Drug Interactions

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FluticasoneMifepristone
Critical
How does the drug interact with Combisure 125 mcg Inhaler 120 mdi:
Co-administration of Combisure 125 mcg Inhaler 120 mdi with Mifepristone may make Combisure 125 mcg Inhaler 120 mdi less effective as a therapy.

How to manage the interaction:
Taking Combisure 125 mcg Inhaler 120 mdi with Mifepristone is not recommended, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
FluticasoneRitonavir
Severe
How does the drug interact with Combisure 125 mcg Inhaler 120 mdi:
Co-administration of Combisure 125 mcg Inhaler 120 mdi and Ritonavir may increase the blood levels of Combisure 125 mcg Inhaler 120 mdi.

How to manage the interaction:
If you are supposed to take Combisure 125 mcg Inhaler 120 mdi and Ritonavir together, your doctor may adjust the dose or monitor you more frequently to use both medications safely. However, if you experience side effects such as palpitations, swelling, high blood sugar, muscle weakness, acne, depression, thinning skin, easy bruising, stretch marks, bone density loss, cataracts, menstrual irregularities, excessive growth of facial or body hair, and abnormal distribution of body fat, contact a doctor. Do not discontinue the medication without consulting a doctor.
FluticasoneMibefradil
Severe
How does the drug interact with Combisure 125 mcg Inhaler 120 mdi:
Co-administration of Mibefradil may significantly increase the absorption of Combisure 125 mcg Inhaler 120 mdi into the bloodstream.

How to manage the interaction:
Taking Combisure 125 mcg Inhaler 120 mdi with Mibefradil together can possibly result in an interaction, but it can be taken if a doctor has advised it. If you notice any of these symptoms - swelling, weight gain, high blood pressure, high blood sugar, weak muscles, feeling down, acne, thinning skin, easy bruising, irregular periods, too much facial or body hair, unusual fat distribution, infection, injury, or a bad asthma attack - make sure to call a doctor right away. Do not stop using any medications without talking to a doctor.
FluticasoneBoceprevir
Severe
How does the drug interact with Combisure 125 mcg Inhaler 120 mdi:
Co-administration of Boceprevir with Combisure 125 mcg Inhaler 120 mdi may significantly increase the absorption of Combisure 125 mcg Inhaler 120 mdi into the bloodstream.

How to manage the interaction:
Co-administration of Boceprevir and Combisure 125 mcg Inhaler 120 mdi can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like swelling, weight gain, high blood pressure, muscle weakness, depression, acne, thinning skin, stretch marks, easy bruising, bone density loss, menstrual irregularities, excessive growth of facial or body hair, and abnormal distribution of body fat, especially in the face, neck, back, and waist, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
FluticasoneAmprenavir
Severe
How does the drug interact with Combisure 125 mcg Inhaler 120 mdi:
Co-administration of Amprenavir and Combisure 125 mcg Inhaler 120 mdi may significantly increase the absorption of Combisure 125 mcg Inhaler 120 mdi into the blood stream.

How to manage the interaction:
Co-administration of Amprenavir and Combisure 125 mcg Inhaler 120 mdi can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like swelling, weight gain, high blood pressure, muscle weakness, depression, acne, thinning skin, stretch marks, easy bruising, bone density loss, menstrual irregularities, excessive growth of facial or body hair, and abnormal distribution of body fat, especially in the face, neck, back, and waist, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
FluticasoneKetoconazole
Severe
How does the drug interact with Combisure 125 mcg Inhaler 120 mdi:
Co-administration of Ketoconazole and Combisure 125 mcg Inhaler 120 mdi may significantly increase the absorption of Combisure 125 mcg Inhaler 120 mdi into the bloodstream.

How to manage the interaction:
If you are supposed to take Combisure 125 mcg Inhaler 120 mdi and Ketoconazole together, doctor may adjust the dose or monitor you more frequently to use both medications safely. However, if you experience side effects such as weight gain, high blood pressure, swelling, muscle weakness, acne, depression, thinning skin, easy bruising, stretch marks, bone density loss, cataracts, menstrual irregularities, excessive growth of facial or body hair, and abnormal distribution of body fat, especially in the face, neck, back, and waist, contact a doctor. Do not discontinue the medication without consulting a doctor.
FluticasoneConivaptan
Severe
How does the drug interact with Combisure 125 mcg Inhaler 120 mdi:
When Conivaptan is taken with Combisure 125 mcg Inhaler 120 mdi, it can make Conivaptan break down faster in the body.

How to manage the interaction:
Co-administration of Conivaptan and Combisure 125 mcg Inhaler 120 mdi can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like swelling, weight gain, high blood pressure, high blood glucose, muscle weakness, depression, acne, thinning skin, stretch marks, easy bruising, bone density loss, menstrual irregularities, excessive growth of facial or body hair, and abnormal distribution of body fat, especially in the face, neck, back, and waist, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
FluticasoneAtazanavir
Severe
How does the drug interact with Combisure 125 mcg Inhaler 120 mdi:
Co-administration of Atazanavir and Combisure 125 mcg Inhaler 120 mdi may significantly increase the absorption of Combisure 125 mcg Inhaler 120 mdi into the bloodstream.

How to manage the interaction:
Co-administration of Atazanavir and Combisure 125 mcg Inhaler 120 mdi can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like swelling, weight gain, high blood pressure, high blood glucose, muscle weakness, depression, acne, thinning skin, stretch marks, easy bruising, bone density loss, cataracts, menstrual irregularities, excessive growth of facial or body hair, and abnormal distribution of body fat, especially in the face, neck, back, and waist, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
FluticasoneIndinavir
Severe
How does the drug interact with Combisure 125 mcg Inhaler 120 mdi:
Indinavir may increase the absorption of Combisure 125 mcg Inhaler 120 mdi into the bloodstream and increase the risk of side effects.

How to manage the interaction:
If you are supposed to take Combisure 125 mcg Inhaler 120 mdi and Indinavir together, your doctor may adjust the dose or monitor you more frequently to use both medications safely. However, if you experience side effects such as weight gain, high blood pressure, swelling, muscle weakness, acne, depression, thinning skin, easy bruising, stretch marks, bone density loss, cataracts, menstrual irregularities, excessive growth of facial or body hair, and abnormal distribution of body fat, especially in the face, neck, back, and waist, contact your doctor.
FluticasonePosaconazole
Severe
How does the drug interact with Combisure 125 mcg Inhaler 120 mdi:
Co-administration of Combisure 125 mcg Inhaler 120 mdi with posaconazole may increase the level of Combisure 125 mcg Inhaler 120 mdi in the blood and increase the risk of side effects.

How to manage the interaction:
Although there is an interaction between Combisure 125 mcg Inhaler 120 mdi and posaconazole, they can be taken together if prescribed by a doctor. However, if you experience muscle weakness, acne, thinning skin, easy bruising, stretch marks, menstrual irregularities, excessive growth of facial or body hair, and abnormal distribution of body fat, especially in the face, neck, back, and waist, contact a doctor. Do not discontinue the medication without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • FUROSEMIDE
  • BUDESONIDE
  • MOMETASONE
  • BECLOMETASONE
  • VILANTEROL
  • SALMETEROL
  • ALBUTEROL
  • IPRATROPIUM
  • SOTALOL
  • METOPROLOL

Habit Forming

No

Special Advise

  • It is advised to undergo blood examination to keep a check on your potassium levels since COMBISURE 125MCG INHALER can cause low potassium levels in the blood (hypokalaemia).
  • Regularly monitor your blood sugar levels while using COMBISURE 125MCG INHALER since bronchodilators like Formoterol can cause low blood glucose levels.
  • Consult your diabetologist if you have diabetes before using COMBISURE 125MCG INHALER so that your insulin or other diabetic medication can be adjusted accordingly to maintain your blood sugar levels.

Diet & Lifestyle Advise

  • Do meditation, deep breathing, regular exercise and try progressive muscle relaxation techniques to get relief from stress and reduce the risk of an asthma attack.
  • Know your triggers like allergens, such as pollen, dust and food items that make your asthma severe.
  • Quit smoking and avoid passive smoking. Smoking also reduces the effectiveness of the medicine.
  • Eat a healthy diet and exercise regularly to strengthen your breathing muscles and boost your immune system.
  • Learning breathing exercises will help you move more air in and out of your lungs.

COMBISURE 125MCG INHALER Substitute

Substitutes safety advice

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