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  1. Home
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  3. Deferataj 500mg Tablet DT

Prescription drug
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Composition :

DEFERASIROX-500MG

Consume Type :

Oral

Return Policy :

Not Returnable
Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Hari Kumar , MBBS
Deferataj 500mg Tablet DT
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Therapeutic Class

[CHELATING AGENTS]

Country of origin

India
Other Info - DE73408

Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Hari Kumar

Reviewed By

Hari Kumar

MBBS

Last Updated

Jul 8, 2025 | 9:41 AM IST

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FAQs

Deferasirox is the active component in Deferataj 500mg Tablet DT. It's a chelating agent that selectively binds to trivalent iron. It binds extra iron and excretes it in the faeces. As a result, the risk of organ damage is lowered.

No, it is a prescribed drug given by a physician for preventing specific medical conditions. Taking it on your own can cause unwanted side effects.

Take the missed dose as soon as possible. However, skip the missed dose and return to your regular dosing schedule if it is time for the next dose. Do not take a double dose to make up for the dose that you missed.

Deferataj 500mg Tablet DT is safe if used in the dose and duration recommended by your doctor. Take it precisely as directed, and do not skip any dose. Follow your doctor's guidelines carefully and inform your doctor if any of the side effects disturb you.

Hemochromatosis, or iron overload, is a condition in which your body stores too much iron. It can cause severe damage to your body, including to your heart, liver and pancreas.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Safe if prescribed

Consume alcohol along with Deferataj 500mg Tablet DT is not advisable as it may cause unpleasant side effects, or you also may become more sensitive to the effects of alcohol.

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Pregnancy

Consult your doctor

Deferataj 500mg Tablet DT is not usually recommended if you are pregnant. This is because there is not enough information to say whether it's safe. However, your doctor may prescribe it if they think the benefits of the medicine outweigh the risks. Please consult the doctor.

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Breast Feeding

Consult your doctor

Deferataj 500mg Tablet DT is not usually recommended if you are a lactating woman. This is because there is not enough information to say whether it's safe. However, your doctor may prescribe it if they think the benefits of the medicine outweigh the risks.

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Driving

Safe if prescribed

It is not known whether Deferataj 500mg Tablet DT alters the ability to drive, so do not drive or operate machinery if you experience any symptoms that affect your ability to concentrate and react.

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Liver

Consult your doctor

Should exercise caution, and it is advisable to consult a doctor before using it. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Consult your doctor

Should exercise caution, and it is advisable to consult a doctor before using it. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Safe if prescribed

Should be used under the supervision of healthcare provider

Product Substitutes

Reference

  1. https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=207968
  2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/207968s009lbl.pdf

About Deferataj 500mg Tablet DT

Deferataj 500mg Tablet DT belongs to the group of medicines called iron chelators. Deferataj 500mg Tablet DT is indicated for treating chronic iron overload due to blood transfusions (transfusional hemosiderosis) in patients two years older. It can also be indicated for treating chronic iron overload in patients ten years of age and older with non-transfusion-dependent thalassemia (NTDT).

The active ingredient in Deferataj 500mg Tablet DT is deferasirox. It is a trivalent iron selective chelating agent. It binds the excess iron and eliminates it through faeces. The danger of organ damage is reduced as a result.

Deferataj 500mg Tablet DT is available in the form of oral formulations. Please take Deferataj 500mg Tablet DT in the dose and duration prescribed by your doctor based on specific medical conditions. In some cases, you may experience common side effects such as diarrhoea, vomiting, nausea, abdominal pain, skin rashes, and increased serum creatinine. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

To treat your condition effectually, continue using Deferataj 500mg Tablet DT for as long as your doctor has prescribed it. Do not use Deferataj 500mg Tablet DT without a doctor's advice if you have a skin reaction or irritation to any medicine. Consult your doctor before using the Deferataj 500mg Tablet DT if you are pregnant or breastfeeding. Do not use Deferataj 500mg Tablet DT in more than prescribed doses or longer duration as it may cause adverse effects. Keep your doctor informed about your health condition and all the medicines you take before taking Deferataj 500mg Tablet DT to rule out any side effects.

Uses of Deferataj 500mg Tablet DT

Deferataj 500mg Tablet DT is indicated for treating chronic iron overload that occurs due to blood transfusions (transfusional hemosiderosis) in patients two years of age and older. It can also be indicated for treating chronic iron overload in patients ten years of age and older with non-transfusion-dependent thalassemia (NTDT).

Medicinal Benefits Mweb

Key Benefits

Deferasirox is the active component in Deferataj 500mg Tablet DT. It's a chelating agent that selectively binds to trivalent iron. It binds extra iron and excretes it in the faeces. As a result, the risk of organ damage is lowered.

Directions for Use

Tablet/Capsule: Swallow it as a whole with water; do not crush, break or chew it.

Side Effects of Deferataj 500mg Tablet DT

  • Diarrhea
  • Vomiting
  • Nausea
  • Abdominal Pain
  • Skin Rashes
  • Increases in Serum Creatinine

Drug Warnings

Do not take Deferataj 500mg Tablet DT if you are allergic to Deferataj 500mg Tablet DT or its ingredients. Deferataj 500mg Tablet DT is not usually recommended if you are a pregnant or lactating woman; there is not enough information to say whether it's safe. However, your doctor may prescribe it if they think the medicine's benefits outweigh the risks. It is unknown whether Deferataj 500mg Tablet DT alters the ability to drive, so do not drive or operate machinery if you experience any symptoms affecting your ability to concentrate and react. Seek medical attention if the symptoms persist longer. Avoid consuming alcohol along with Deferataj 500mg Tablet DT as it could lead to unpleasant side effects. Should monitor elderly and paediatric patients closely for toxicity.

Drug-Drug Interactions

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DeferasiroxPrasugrel
Severe
DeferasiroxLithium
Severe

Drug-Drug Interactions

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DeferasiroxPrasugrel
Severe
How does the drug interact with Deferataj 500mg Tablet DT:
Using Deferataj 500mg Tablet DT together with Prasugrel may increase the risk of gastrointestinal ulcers.

How to manage the interaction:
Co-administration of Prasugrel with Deferataj 500mg Tablet DT can possibly result in an interaction, but it can be taken if your doctor has advised it. This risk is higher in older people with certain blood disorders or low platelet counts.If you have symptoms like stomach pain, bloating, dizziness, or black stools, it's important to consult a doctor. Do not stop using any medications without a doctor's advice.
DeferasiroxLithium
Severe
How does the drug interact with Deferataj 500mg Tablet DT:
Taking Deferataj 500mg Tablet DT with lithium may increase the risk of kidney problems.

How to manage the interaction:
Although there is a possible interaction between Lithium and Deferataj 500mg Tablet DT, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience nausea, vomiting, loss of hunger, increased or decreased urination, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, palpitations and confusion. Do not discontinue any medications without consulting a doctor.
DeferasiroxPolymyxin b
Severe
How does the drug interact with Deferataj 500mg Tablet DT:
Co-administration of Deferataj 500mg Tablet DT and polymyxin B may increase the risk of kidney problems.

How to manage the interaction:
Although taking polymyxin B and Deferataj 500mg Tablet DT together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, swelling, breathing difficulty, bone pain, muscle pain, dizziness, confusion, or irregular heart rhythm, seek immediate medical attention. Drink plenty of water if you experience diarrhea or vomiting while taking these medications, as dehydration can potentially affect the kidneys. Do not discontinue any medications without a doctor's advice.
DeferasiroxAminophylline
Severe
How does the drug interact with Deferataj 500mg Tablet DT:
Combining Aminophylline with Deferataj 500mg Tablet DT may significantly increase the blood levels of aminophylline.

How to manage the interaction:
Taking Aminophylline with Deferataj 500mg Tablet DT can result in an interaction, it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, diarrhea, loss of appetite, headache, confusion, restlessness, sleeplessness, fits, heart palpitations, or irregular heartbeat contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
DeferasiroxAlendronic acid
Severe
How does the drug interact with Deferataj 500mg Tablet DT:
Co-administration of Alendronic acid (oral form) with Deferataj 500mg Tablet DT may increase the risk of developing gastrointestinal ulcers.

How to manage the interaction:
Although there is a possible interaction between Alendronic acid and Deferataj 500mg Tablet DT, you can take these medicines together if advised by your doctor. However, if you develop severe stomach pain, bloating, sudden dizziness or lightheadedness, vomiting (especially with blood), nausea, loss of appetite, and/or black, tarry stools, contact your doctor immediately. Do not discontinue the medication without consulting a doctor.
DeferasiroxVancomycin
Severe
How does the drug interact with Deferataj 500mg Tablet DT:
Coadministration of Vancomycin with Deferataj 500mg Tablet DT can increase the risk or severity of kidney problems.

How to manage the interaction:
Although taking Vancomycin with Deferataj 500mg Tablet DT may result in an interaction, they can be taken together if prescribed by a doctor. However, contact a doctor immediately if you experience nausea, vomiting, loss of appetite, increased or decreased urination, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medication without consulting a doctor.
DeferasiroxFludrocortisone
Severe
How does the drug interact with Deferataj 500mg Tablet DT:
Using Deferataj 500mg Tablet DT together with fludrocortisone may increase the risk of stomach ulcers and bleeding.

How to manage the interaction:
Co-administration of Fludrocortisone with Deferataj 500mg Tablet DT can possibly result in an interaction, but it can be taken if your doctor has advised it. This risk is higher in older people with certain blood disorders or low platelet counts. If you have symptoms like stomach pain, bloating, dizziness, or black stools, it's important to consult a doctor. Do not stop using any medications without a doctor's advice.
DeferasiroxVoclosporin
Severe
How does the drug interact with Deferataj 500mg Tablet DT:
Deferataj 500mg Tablet DT may cause kidney problems and combining it with voclosporin may increase that risk.

How to manage the interaction:
Although taking voclosporin and Deferataj 500mg Tablet DT together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, or irregular heart rhythm, seek immediate medical attention. Drink plenty of water if you experience diarrhoea or vomiting while taking these medications, as dehydration can potentially affect the kidneys. Do not discontinue any medications without a doctor's advice.
DeferasiroxLeflunomide
Severe
How does the drug interact with Deferataj 500mg Tablet DT:
Leflunomide may cause liver problems and using it with Deferataj 500mg Tablet DT may increase that risk.

How to manage the interaction:
Taking Leflunomide with Deferataj 500mg Tablet DT together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you notice any of these symptoms - fever, joint pain, rash, or any other unusual signs, make sure to contact your doctor right away. Do not discontinue any medications without consulting a doctor.
DeferasiroxZinc chloride
Severe
How does the drug interact with Deferataj 500mg Tablet DT:
Taking zinc acetate with Deferataj 500mg Tablet DT can decrease the blood levels of Deferataj 500mg Tablet DT.

How to manage the interaction:
Although taking Zinc acetate and Deferataj 500mg Tablet DT together can evidently cause an interaction, it can be taken if your doctor has suggested it. Incase of any side effects, consult a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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DEFERASIROX-500MGCaffeine containing foods/drinks
Moderate

Drug-Food Interactions

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DEFERASIROX-500MGCaffeine containing foods/drinks
Moderate
Common Foods to Avoid:
Cocoa, Coffee, Dark Chocolate, Energy Drinks With Caffeine, Green Tea, Kola Nut, Tea, Tiramisu

How to manage the interaction:
The blood levels and effects of caffeine may be enhanced by Deferataj 500mg Tablet DT. Avoid consumption of caffeinated drinks during the treatment with Deferataj 500mg Tablet DT. If you experience any unusual symptoms call a doctor.

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • ALUMINIUM HYDROXIDE
  • REPAGLINIDE
  • THEOPHYLLINE
  • BUSULFAN
  • ASPIRIN
  • CELECOXIB
  • DILTIAZEM
  • PARACETAMOL

Habit Forming

No

Special Advise

  • Monitor blood counts, liver function, and renal function monthly.
  • Monitor serum ferritin monthly to assess the patient’s response to therapy and minimize the risk of over-chelation.

Diet & Lifestyle Advise

  • Choose foods high in nutrients, such as fruits, vegetables, and whole grains.
  • Replace fatty protein sources with lean alternatives and consume modest quantities of healthy fat sources for improved well-being.
  • Create a diet that includes vegetables, fruits, whole grains, legumes, omega-3-rich foods, and lean protein sources.
  • Instead of saturated and trans fats, choose monounsaturated and polyunsaturated fats (fish, nuts, and vegetable oils).
  • Select/prepare foods and beverages with fewer added sugars/caloric sweeteners.
  • Be mindful of salt; consume no more than 2,300 mg each day.
  • Limit or avoid alcohol and caffeine consumption.

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