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  3. Endokine 300 mcg Injection 1 ml

Endokine 300 mcg Injection 1 ml, Pack of 1 INJECTION
Written By Urvashi Bharti , MBBS
Reviewed By Sureshvarma D , MPharma
Non returnable*
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Composition :

FILGRASTIM-300MCG

Manufacturer/Marketer :

Intas Pharmaceuticals Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Endokine 300 mcg Injection 1 ml

Endokine 300 mcg Injection 1 ml belongs to the class of medicine called 'hematopoietic agent' used to treat neutropenia, a lack of certain white blood cells caused by cancer, bone marrow transplant, receiving chemotherapy, bacterial infections or other conditions. Neutropenia is a condition in which the number of neutrophils (a type of white blood cell) in the blood is decreased. White blood cells (neutrophils) protect the body from infections. Without enough neutrophils, the body can not fight off bacteria which increases the risk of many types of infections.

Endokine 300 mcg Injection 1 ml contains ' Filgrastim ' that stimulates the bone marrow (the tissue where new blood cells are made) to produce more white blood cells that help fight infection. Endokine 300 mcg Injection 1 ml is used to improve white blood cells during cancer treatment (chemotherapy), bone marrow transplantation, severe chronic neutropenia (low number of a type of white blood cells), neutropenia in patients with HIV infection, and before stem cell donation.

You are advised to take Endokine 300 mcg Injection 1 ml for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects such as thrombocytopenia (low platelets level), anaemia (low red blood cell), headache, diarrhoea, vomiting, nausea, alopecia (unusual hair loss), tiredness, soreness, swelling of the digestive tract, fever. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

To treat your condition effectually, continue taking Endokine 300 mcg Injection 1 ml for as long as your doctor has prescribed. To avoid recurring symptoms, do not stop it midway. Do not take Endokine 300 mcg Injection 1 ml if you are pregnant or planning for pregnancy. Endokine 300 mcg Injection 1 ml should not be taken by breastfeeding mothers unless prescribed. Endokine 300 mcg Injection 1 ml should be given to children under strict medical supervision. Please tell your doctor before using Endokine 300 mcg Injection 1 ml if you have sickle cell anaemia, as Endokine 300 mcg Injection 1 ml may cause sickle cell crisis and osteoporosis (bone disease). Regular blood tests will be taken to monitor the number of white blood cells in the body. Inform your doctor about your health condition and medicines to rule out unpleasant side effects. Endokine 300 mcg Injection 1 ml is a cold chain medicine, and so it has to be stored in the refrigerator between 2-8 degrees celsius else its efficacy might get lost. Do not store in the freezer or the fridge.

Uses of Endokine 300 mcg Injection 1 ml

Neutropenia (low number of white blood neutropenia cells),  Neutropenia during Chemotherapy,  Neutropenia after Bone marrow transplantation,  Neutropenia in patients with HIV infection,  peripheral blood stem cell mobilisation (to stimulate stem cells to enter the bloodstream to be collected and used in bone marrow transplantation)

Directions for Use

Endokine 300 mcg Injection 1 ml will be administered by a healthcare professional; do not self-administer.

Medicinal Benefits

Endokine 300 mcg Injection 1 ml contains ‘Filgrastim’ is a white blood cell growth factor. It belongs to a group of proteins called cytokines and is very similar to a natural protein (granulocyte-colony stimulating factor) produced by your body. Endokine 300 mcg Injection 1 ml works by stimulating the bone marrow (the tissue where new blood cells are made) to produce more white blood cells that help fight infection. Endokine 300 mcg Injection 1 ml is used to improve white blood cells during cancer treatment (chemotherapy), bone marrow transplantation, severe chronic neutropenia (low number of a type of white blood cells), neutropenia in patients with HIV infection and before stem cell donation.

Storage

Store in a cool and dry place away from sunlight
Side effects of Endokine 300 mcg Injection 1 ml
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Regular exercise, like swimming, walking, and yoga, can help reduce bone pain by strengthening muscles and releasing natural pain relievers.
  • Physical therapy, including stretching, strengthening exercises, TENS (a type of therapy using electrical pulses), and massage, can help ease bone pain and improve movement.
  • Mind-body techniques, like relaxation, meditation, and hypnosis, can reduce pain and help control muscle tension that comes with bone pain.
  • Acupuncture may help reduce bone pain by triggering the release of natural painkillers and easing nerve discomfort.
  • Avoid sitting for long periods; take short walks or stretch regularly.
  • Herbs like turmeric and ginger might help with bone pain.
  • Eat a diet rich in calcium, vitamin D, and protein for strong bones and muscles.
  • Quit smoking and limit alcohol.
  • Eat protein-rich foods like fish, poultry, eggs, and legumes.
  • Include foods with minerals and vitamins essential for hair health.
  • Join a support group to connect with others experiencing hair loss.
  • Openly discuss your feelings about hair loss.
  • Consider covering up with wigs, hats, or scarves.
  • Be patient and avoid seeking miracle cures.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.

Drug Warnings

Do not take Endokine 300 mcg Injection 1 ml if you are allergic to Endokine 300 mcg Injection 1 ml or any of its ingredients it may contain inactive ingredients (such as dry natural rubber/latex in the needle cover on the prefilled syringe), which can cause allergic reactions or other problems. Before starting treatment with Endokine 300 mcg Injection 1 ml, inform your doctor if you have sickle cell anaemia, osteoporosis (bone disease), kidney disease, liver disease, spleen problems, heart problems, and radiation treatment. Endokine 300 mcg Injection 1 ml can cause the spleen to become enlarged, and it could rupture (tear). Inform your doctor right away if you have sudden or severe pain in your left upper stomach spreading up to your shoulder. If you receive chemotherapy or bone marrow transplant, do not use Endokine 300 mcg Injection 1 ml within 24 hours before or 24 hours after you receive chemotherapy or bone marrow transplant.  Do not take Endokine 300 mcg Injection 1 ml if you are pregnant or breastfeeding unless prescribed by the doctor. Endokine 300 mcg Injection 1 ml can be given safely to children only when prescribed. Endokine 300 mcg Injection 1 ml may cause dizziness, so drive only if you are alert. Avoid consuming alcohol along with Endokine 300 mcg Injection 1 ml as it could lead to increased drowsiness. Keep your doctor informed about all the medicines you are taking, including prescription, non-prescription medicines and herbal supplements. 

Drug-Drug Interactions

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FilgrastimBleomycin
Severe
FilgrastimLenalidomide
Severe

Drug-Drug Interactions

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FilgrastimBleomycin
Severe
How does the drug interact with Endokine 300 mcg Injection 1 ml:
Combining Endokine 300 mcg Injection 1 ml with Bleomycin can increase the risk of developing lung disorders.

How to manage the interaction:
There may be a possibility of interaction between Endokine 300 mcg Injection 1 ml and Bleomycin, it can be taken if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
FilgrastimLenalidomide
Severe
How does the drug interact with Endokine 300 mcg Injection 1 ml:
Using Endokine 300 mcg Injection 1 ml together with lenalidomide can reduce the effect of Endokine 300 mcg Injection 1 ml.

How to manage the interaction:
Co-administration of Endokine 300 mcg Injection 1 ml with Lenalidomide can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not discontinue any medications without consulting a doctor.
FilgrastimAzacitidine
Severe
How does the drug interact with Endokine 300 mcg Injection 1 ml:
Coadministration of Endokine 300 mcg Injection 1 ml with Azacitidine can reduce the effects of Endokine 300 mcg Injection 1 ml.

How to manage the interaction:
Although there is an interaction between Endokine 300 mcg Injection 1 ml and azacitidine, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
FilgrastimImatinib
Severe
How does the drug interact with Endokine 300 mcg Injection 1 ml:
Taking Endokine 300 mcg Injection 1 ml together with Imatinib can reduce the effect of Endokine 300 mcg Injection 1 ml.

How to manage the interaction:
There may be a possibility of interaction between Endokine 300 mcg Injection 1 ml and Imatinib, but it can be taken if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
FilgrastimBexarotene
Severe
How does the drug interact with Endokine 300 mcg Injection 1 ml:
Coadministration of Endokine 300 mcg Injection 1 ml with Bexarotene can alter the effect of Endokine 300 mcg Injection 1 ml.

How to manage the interaction:
Although there is an interaction between Endokine 300 mcg Injection 1 ml and bexarotene, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
FilgrastimMercaptopurine
Severe
How does the drug interact with Endokine 300 mcg Injection 1 ml:
Co-administration of Endokine 300 mcg Injection 1 ml together with Mercaptopurine can reduce the effects of Endokine 300 mcg Injection 1 ml.

How to manage the interaction:
Although taking Endokine 300 mcg Injection 1 ml and Mercaptopurine together can cause an interaction, it can be taken if a doctor has suggested it. Do not stop using any medications without a doctor's advice.
FilgrastimBusulfan
Severe
How does the drug interact with Endokine 300 mcg Injection 1 ml:
Coadministration of Endokine 300 mcg Injection 1 ml with Busulfan can reduce the effects of Endokine 300 mcg Injection 1 ml.

How to manage the interaction:
Although there is a possible interaction between Endokine 300 mcg Injection 1 ml and Busulfan, you can take these medicines together if prescribed by your doctor. Do not stop using any medications without talking to your doctor.
FilgrastimMelphalan
Severe
How does the drug interact with Endokine 300 mcg Injection 1 ml:
Co-administration of Endokine 300 mcg Injection 1 ml together with Melphalan can reduce the effect of Endokine 300 mcg Injection 1 ml.

How to manage the interaction:
Although taking Endokine 300 mcg Injection 1 ml and Melphalan together can cause an interaction, it can be taken if a doctor has suggested it. Do not discontinue any medications without consulting a doctor.
FilgrastimPentostatin
Severe
How does the drug interact with Endokine 300 mcg Injection 1 ml:
Using Endokine 300 mcg Injection 1 ml together with pentostatin can reduce the effect of Endokine 300 mcg Injection 1 ml.

How to manage the interaction:
Although there is a possible interaction between Endokine 300 mcg Injection 1 ml and Pentostatin, you can take these medicines together if prescribed by your doctor. Do not stop using any medications without a doctor's advice.
FilgrastimBrentuximab
Severe
How does the drug interact with Endokine 300 mcg Injection 1 ml:
Coadministration of Endokine 300 mcg Injection 1 ml with Brentuximab can decrease the therapeutic effect of Endokine 300 mcg Injection 1 ml.

How to manage the interaction:
Although there is an interaction between Endokine 300 mcg Injection 1 ml and brentuximab, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a well-balanced and healthy diet, as it helps you to recover quickly. A dietitian will help you to create a diet plan based on your health condition. 

  • Avoid eating raw or undercooked food. 

  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.

  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes, and green tea.

  • Limit alcohol consumption and quit smoking. 

Habit Forming

No

Therapeutic Class

HEMATOPOIETIC

Endokine 300 mcg Injection 1 ml Substitute

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Author Details

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Written By

Urvashi Bharti

MBBS

Sureshvarma D

Reviewed By

Sureshvarma D

MPharma

Last Updated

Jul 8, 2025 | 9:34 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Endokine 300 mcg Injection 1 ml contains 'Filgrastim' is a growth factor that stimulates the bone marrow to produce white blood cells. These cells protect the body against infections.

No, Endokine 300 mcg Injection 1 ml is not recommended to patients with spleen disorder. It may cause your spleen to become enlarged, and it could rupture. If you experience pain in the left upper stomach/abdominal area or left shoulder, contact your doctor immediately.

If you are being treated for severe chronic neutropenia for a longer period, Endokine 300 mcg Injection 1 ml may cause blood in your urine (haematuria). Your doctor may regularly test your urine if you experience this side effect or if a protein is found in your urine (proteinuria).

Endokine 300 mcg Injection 1 ml should be used with caution in patients with kidney diseases. Dose adjustments may be necessary. Endokine 300 mcg Injection 1 ml cause breathlessness (dyspnoea), tachycardia & wheeze, and even death. If you have had a history of asthma, the more possibility of these systemic allergic-like reactions. Please inform your doctor.

Endokine 300 mcg Injection 1 ml to be taken with caution, especially if you have had heart problems. The dose may have to be adjusted by your doctor. In some cases, Endokine 300 mcg Injection 1 ml causes inflammation of the aorta (the large blood vessel which transports blood from the heart to the body) symptoms can include fever, abdominal pain, malaise, back pain, and increased inflammatory markers. Tell your doctor if you experience those symptoms. Please inform your doctor before taking Endokine 300 mcg Injection 1 ml.

Yes, Endokine 300 mcg Injection 1 ml may interfere with certain lab tests such as bone imaging and blood tests (elevation in lactate dehydrogenase and alkaline phosphate), possibly causing false test results. Make sure your doctor and laboratory staff know you use Endokine 300 mcg Injection 1 ml.

Drug-Drug Interactions Checker List

  • ALTRETAMINE
  • BUSULFAN
  • CLADRIBINE
  • PROCARBAZINE
  • PEGFILGRASTIM
  • DACARBAZINE
  • GEMTUZUMAB
  • DINUTUXIMAB
  • BEVACIZUMAB
  • ALEMTUZUMAB
  • CARBOPLATIN
  • BENDAMUSTINE

Special Advise

  • Constantly monitors the number of blood cells in your blood, and your bone density level while you are receiving treatment with Endokine 300 mcg Injection 1 ml.

  • Do not take any kind of immunization or vaccination without your doctor's approval while using Endokine 300 mcg Injection 1 ml.

Disease/Condition Glossary

Neutropenia is a condition in which the number of neutrophils (a type of white blood cell) in the blood is decreased. White blood cells (neutrophils) protect the body from infections. Without enough neutrophils, the body can not fight off bacteria which increases the risk of many types of infections. It can be caused by diseases that damage the bone marrow like cancer chemotherapy, HIV or AIDS, infections or deficiencies in vitamins or minerals, such as vitamin B12, folate, or copper, and autoimmune diseases, including Crohn's disease, lupus, and rheumatoid arthritis. Severe chronic neutropenias arise from the failure of the bone marrow to produce adequate numbers of neutrophils that circulate in the blood. It appears that patients with severe chronic neutropenias are at greater risk of developing leukaemia (blood cancer) than are other people.

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