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Written By Urvashi Bharti , MBBS
Reviewed By Sureshvarma D , MPharma
48 Hrs returnable
COD available

Online payment accepted

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Whats That

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Composition :

FILGRASTIM-300MCG

Manufacturer/Marketer :

Intas Pharmaceuticals Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

Therapeutic Class

HEMATOPOIETIC

Country of origin

India

Manufacturer/Marketer address

Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.
Other Info - END0631

Author Details

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FAQs

Endokine 300 mcg Injection 1 ml contains 'Filgrastim' is a growth factor that stimulates the bone marrow to produce white blood cells. These cells protect the body against infections.

No, Endokine 300 mcg Injection 1 ml is not recommended to patients with spleen disorder. It may cause your spleen to become enlarged, and it could rupture. If you experience pain in the left upper stomach/abdominal area or left shoulder, contact your doctor immediately.

If you are being treated for severe chronic neutropenia for a longer period, Endokine 300 mcg Injection 1 ml may cause blood in your urine (haematuria). Your doctor may regularly test your urine if you experience this side effect or if a protein is found in your urine (proteinuria).

Endokine 300 mcg Injection 1 ml should be used with caution in patients with kidney diseases. Dose adjustments may be necessary. Endokine 300 mcg Injection 1 ml cause breathlessness (dyspnoea), tachycardia & wheeze, and even death. If you have had a history of asthma, the more possibility of these systemic allergic-like reactions. Please inform your doctor.

Endokine 300 mcg Injection 1 ml to be taken with caution, especially if you have had heart problems. The dose may have to be adjusted by your doctor. In some cases, Endokine 300 mcg Injection 1 ml causes inflammation of the aorta (the large blood vessel which transports blood from the heart to the body) symptoms can include fever, abdominal pain, malaise, back pain, and increased inflammatory markers. Tell your doctor if you experience those symptoms. Please inform your doctor before taking Endokine 300 mcg Injection 1 ml.

Yes, Endokine 300 mcg Injection 1 ml may interfere with certain lab tests such as bone imaging and blood tests (elevation in lactate dehydrogenase and alkaline phosphate), possibly causing false test results. Make sure your doctor and laboratory staff know you use Endokine 300 mcg Injection 1 ml.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Caution

Avoid alcohol consumption while taking Endokine 300 mcg Injection 1 ml. It could lead to increased dizziness and drowsiness.

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Pregnancy

Caution

It is not known whether this Endokine 300 mcg Injection 1 ml will harm an unborn baby. Inform your doctor if you are pregnant or plan to become pregnant.

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Breast Feeding

Caution

It is unknown whether Endokine 300 mcg Injection 1 ml passes over into the breast milk. Please inform your doctor if you are breastfeeding before taking Endokine 300 mcg Injection 1 ml.

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Driving

Caution

Endokine 300 mcg Injection 1 ml may cause dizziness, drowsiness, and tiredness; do not drive or operate heavy machinery if you feel dizzy.

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Liver

Caution

If you have liver problems, inform your doctor before receiving Endokine 300 mcg Injection 1 ml. Your doctor may adjust the dose based on your condition or prescribe a suitable alternative.

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Kidney

Caution

Endokine 300 mcg Injection 1 ml should be used with caution in patients with kidney diseases. Dose adjustments may be necessary. In some case, Endokine 300 mcg Injection 1 ml cause kidney injury. Inform your doctor immediately if you experience puffiness in your face or ankles, blood in your urine, or brown-coloured urine, or you notice you urinate less than usual.

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Children

Safe if prescribed

Endokine 300 mcg Injection 1 ml is used to treat children who are receiving chemotherapy or who suffer from severe low white blood cell count (neutropenia). The doctor will decide the dose of Endokine 300 mcg Injection 1 ml based on the age, body weight and condition of your child.

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Keep Refrigerated. Do not freeze.

About Endokine 300 mcg Injection 1 ml

Endokine 300 mcg Injection 1 ml belongs to the class of medicine called 'hematopoietic agent' used to treat neutropenia, a lack of certain white blood cells caused by cancer, bone marrow transplant, receiving chemotherapy, bacterial infections or other conditions. Neutropenia is a condition in which the number of neutrophils (a type of white blood cell) in the blood is decreased. White blood cells (neutrophils) protect the body from infections. Without enough neutrophils, the body can not fight off bacteria which increases the risk of many types of infections.

Endokine 300 mcg Injection 1 ml contains ' Filgrastim ' that stimulates the bone marrow (the tissue where new blood cells are made) to produce more white blood cells that help fight infection. Endokine 300 mcg Injection 1 ml is used to improve white blood cells during cancer treatment (chemotherapy), bone marrow transplantation, severe chronic neutropenia (low number of a type of white blood cells), neutropenia in patients with HIV infection, and before stem cell donation.

You are advised to take Endokine 300 mcg Injection 1 ml for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects such as thrombocytopenia (low platelets level), anaemia (low red blood cell), headache, diarrhoea, vomiting, nausea, alopecia (unusual hair loss), tiredness, soreness, swelling of the digestive tract, fever. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

To treat your condition effectually, continue taking Endokine 300 mcg Injection 1 ml for as long as your doctor has prescribed. To avoid recurring symptoms, do not stop it midway. Do not take Endokine 300 mcg Injection 1 ml if you are pregnant or planning for pregnancy. Endokine 300 mcg Injection 1 ml should not be taken by breastfeeding mothers unless prescribed. Endokine 300 mcg Injection 1 ml should be given to children under strict medical supervision. Please tell your doctor before using Endokine 300 mcg Injection 1 ml if you have sickle cell anaemia, as Endokine 300 mcg Injection 1 ml may cause sickle cell crisis and osteoporosis (bone disease). Regular blood tests will be taken to monitor the number of white blood cells in the body. Inform your doctor about your health condition and medicines to rule out unpleasant side effects. Endokine 300 mcg Injection 1 ml is a cold chain medicine, and so it has to be stored in the refrigerator between 2-8 degrees celsius else its efficacy might get lost. Do not store in the freezer or the fridge.

Uses of Endokine 300 mcg Injection 1 ml

Neutropenia (low number of white blood neutropenia cells),  Neutropenia during Chemotherapy,  Neutropenia after Bone marrow transplantation,  Neutropenia in patients with HIV infection,  peripheral blood stem cell mobilisation (to stimulate stem cells to enter the bloodstream to be collected and used in bone marrow transplantation)

Medicinal Benefits Mweb

Medicinal Benefits

Endokine 300 mcg Injection 1 ml contains ‘Filgrastim’ is a white blood cell growth factor. It belongs to a group of proteins called cytokines and is very similar to a natural protein (granulocyte-colony stimulating factor) produced by your body. Endokine 300 mcg Injection 1 ml works by stimulating the bone marrow (the tissue where new blood cells are made) to produce more white blood cells that help fight infection. Endokine 300 mcg Injection 1 ml is used to improve white blood cells during cancer treatment (chemotherapy), bone marrow transplantation, severe chronic neutropenia (low number of a type of white blood cells), neutropenia in patients with HIV infection and before stem cell donation.

Directions for Use

Endokine 300 mcg Injection 1 ml will be administered by a healthcare professional; do not self-administer.

Side Effects of Endokine 300 mcg Injection 1 ml

  • Thrombocytopenia (low platelets level)
  • Anaemia (low red blood cell)
  • Headache
  • Diarrhoea
  • Vomiting
  • Nausea
  • Alopecia (unusual hair loss)
  • Tiredness
  • Soreness and swelling of the digestive tract
  • Fever

Drug Warnings

Do not take Endokine 300 mcg Injection 1 ml if you are allergic to Endokine 300 mcg Injection 1 ml or any of its ingredients it may contain inactive ingredients (such as dry natural rubber/latex in the needle cover on the prefilled syringe), which can cause allergic reactions or other problems. Before starting treatment with Endokine 300 mcg Injection 1 ml, inform your doctor if you have sickle cell anaemia, osteoporosis (bone disease), kidney disease, liver disease, spleen problems, heart problems, and radiation treatment. Endokine 300 mcg Injection 1 ml can cause the spleen to become enlarged, and it could rupture (tear). Inform your doctor right away if you have sudden or severe pain in your left upper stomach spreading up to your shoulder. If you receive chemotherapy or bone marrow transplant, do not use Endokine 300 mcg Injection 1 ml within 24 hours before or 24 hours after you receive chemotherapy or bone marrow transplant.  Do not take Endokine 300 mcg Injection 1 ml if you are pregnant or breastfeeding unless prescribed by the doctor. Endokine 300 mcg Injection 1 ml can be given safely to children only when prescribed. Endokine 300 mcg Injection 1 ml may cause dizziness, so drive only if you are alert. Avoid consuming alcohol along with Endokine 300 mcg Injection 1 ml as it could lead to increased drowsiness. Keep your doctor informed about all the medicines you are taking, including prescription, non-prescription medicines and herbal supplements. 

Drug-Drug Interactions

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FilgrastimBexarotene
Severe
FilgrastimMitomycin
Severe

Drug-Drug Interactions

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FilgrastimBexarotene
Severe
How does the drug interact with Endokine 300 mcg Injection 1 ml:
Coadministration of Endokine 300 mcg Injection 1 ml with Bexarotene can alter the effect of Endokine 300 mcg Injection 1 ml.

How to manage the interaction:
Although there is an interaction between Endokine 300 mcg Injection 1 ml and bexarotene, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
FilgrastimMitomycin
Severe
How does the drug interact with Endokine 300 mcg Injection 1 ml:
Using Endokine 300 mcg Injection 1 ml together with mitomycin reduce the effects of Endokine 300 mcg Injection 1 ml.

How to manage the interaction:
Co-administration of Endokine 300 mcg Injection 1 ml with Mitomycin can result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
FilgrastimLenalidomide
Severe
How does the drug interact with Endokine 300 mcg Injection 1 ml:
Using Endokine 300 mcg Injection 1 ml together with lenalidomide can reduce the effect of Endokine 300 mcg Injection 1 ml.

How to manage the interaction:
Co-administration of Endokine 300 mcg Injection 1 ml with Lenalidomide can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not discontinue any medications without consulting a doctor.
FilgrastimRomidepsin
Severe
How does the drug interact with Endokine 300 mcg Injection 1 ml:
Coadministration of Endokine 300 mcg Injection 1 ml with Romidepsin can reduce the effect of Endokine 300 mcg Injection 1 ml.

How to manage the interaction:
Although there is an interaction between Endokine 300 mcg Injection 1 ml and Romidepsin, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
FilgrastimAzacitidine
Severe
How does the drug interact with Endokine 300 mcg Injection 1 ml:
Coadministration of Endokine 300 mcg Injection 1 ml with Azacitidine can reduce the effects of Endokine 300 mcg Injection 1 ml.

How to manage the interaction:
Although there is an interaction between Endokine 300 mcg Injection 1 ml and azacitidine, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
FilgrastimBrentuximab
Severe
How does the drug interact with Endokine 300 mcg Injection 1 ml:
Coadministration of Endokine 300 mcg Injection 1 ml with Brentuximab can decrease the therapeutic effect of Endokine 300 mcg Injection 1 ml.

How to manage the interaction:
Although there is an interaction between Endokine 300 mcg Injection 1 ml and brentuximab, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
FilgrastimBusulfan
Severe
How does the drug interact with Endokine 300 mcg Injection 1 ml:
Coadministration of Endokine 300 mcg Injection 1 ml with Busulfan can reduce the effects of Endokine 300 mcg Injection 1 ml.

How to manage the interaction:
Although there is a possible interaction between Endokine 300 mcg Injection 1 ml and Busulfan, you can take these medicines together if prescribed by your doctor. Do not stop using any medications without talking to your doctor.
FilgrastimMelphalan
Severe
How does the drug interact with Endokine 300 mcg Injection 1 ml:
Co-administration of Endokine 300 mcg Injection 1 ml together with Melphalan can reduce the effect of Endokine 300 mcg Injection 1 ml.

How to manage the interaction:
Although taking Endokine 300 mcg Injection 1 ml and Melphalan together can cause an interaction, it can be taken if a doctor has suggested it. Do not discontinue any medications without consulting a doctor.
FilgrastimBleomycin
Severe
How does the drug interact with Endokine 300 mcg Injection 1 ml:
Combining Endokine 300 mcg Injection 1 ml with Bleomycin can increase the risk of developing lung disorders.

How to manage the interaction:
There may be a possibility of interaction between Endokine 300 mcg Injection 1 ml and Bleomycin, it can be taken if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
FilgrastimImatinib
Severe
How does the drug interact with Endokine 300 mcg Injection 1 ml:
Taking Endokine 300 mcg Injection 1 ml together with Imatinib can reduce the effect of Endokine 300 mcg Injection 1 ml.

How to manage the interaction:
There may be a possibility of interaction between Endokine 300 mcg Injection 1 ml and Imatinib, but it can be taken if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • ALTRETAMINE
  • BUSULFAN
  • CLADRIBINE
  • PROCARBAZINE
  • PEGFILGRASTIM
  • DACARBAZINE
  • GEMTUZUMAB
  • DINUTUXIMAB
  • BEVACIZUMAB
  • ALEMTUZUMAB
  • CARBOPLATIN
  • BENDAMUSTINE

Habit Forming

No

Special Advise

  • Constantly monitors the number of blood cells in your blood, and your bone density level while you are receiving treatment with Endokine 300 mcg Injection 1 ml.

  • Do not take any kind of immunization or vaccination without your doctor's approval while using Endokine 300 mcg Injection 1 ml.

Diet & Lifestyle Advise

  • Eat a well-balanced and healthy diet, as it helps you to recover quickly. A dietitian will help you to create a diet plan based on your health condition. 

  • Avoid eating raw or undercooked food. 

  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.

  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes, and green tea.

  • Limit alcohol consumption and quit smoking. 

Endokine 300 mcg Injection 1 ml Substitute

Always consult your doctor before taking any new medications and supplements

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