apollo
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Hari Kumar , MBBS
48 Hrs returnable
COD available

Online payment accepted

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Whats That

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Manufacturer/Marketer :

Zydus Healthcare Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

Therapeutic Class

CHEMOTHERAPY

Country of origin

India

Manufacturer/Marketer address

Zydus Tower, Satellite Cross Roads, Ahmedabad – 380015, Gujarat, India.
Other Info - END0101

Author Details

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FAQs

Endoxan Tablet is an alkylating agent that stops the growth and multiplication of cancer cells by damaging their genetic material. Thereby, Endoxan Tablet helps to treat cancer by killing the cancer cells.

Do not stop taking Endoxan Tablet on your own. You are advised to take Endoxan Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Endoxan Tablet .

Endoxan Tablet might interfere with oogenesis (development of ovum) and spermatogenesis (development of sperm) and could impair fertility. Before starting treatment with Endoxan Tablet , talk to your doctor regarding cryopreservation/freezing of eggs/sperm if you consider becoming parents.

Endoxan Tablet might interfere with normal wound healing. Therefore, be cautious while handling sharp objects. Consult your doctor if you notice unusual bleeding, or bruising or if the wounds do not heal properly.

No, it is not safe to father a child while taking Endoxan Tablet . Use effective contraception while taking Endoxan Tablet and for at least four months after treatment. Women of childbearing age taking Endoxan Tablet should use highly effective contraceptives while taking Endoxan Tablet up to 1 year after the treatment.

Endoxan Tablet might cause myelosuppression/bone marrow suppression leading to a decrease in white blood cells. This could lead to an increased risk of infections. Regular blood tests while taking Endoxan Tablet are advised.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Consult your doctor

It is not known if alcohol affects Endoxan Tablet . Please consult your doctor.

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Pregnancy

Unsafe

Cyclophosphamide belongs to pregnancy category D. Endoxan Tablet should not be taken during pregnancy as it might cause fetal harm. Inform your doctor if you are pregnant, think you are pregnant or planning for pregnant.

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Breast Feeding

Unsafe

Endoxan Tablet passes into breastmilk. Avoid breastfeeding while taking Endoxan Tablet .

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Driving

Caution

Endoxan Tablet may cause dizziness. Drive or operate heavy machinery only if you are alert.

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Liver

Caution

Dose adjustment may be needed. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed. Endoxan Tablet should be used with caution in patients with renal impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

Endoxan Tablet should be given to children only if prescribed by a doctor.

About Endoxan Tablet

Endoxan Tablet belongs to the group of anti-cancer medicines used to treat malignant diseases such as lymphoma (Hodgkin’s disease, mixed-cell type lymphoma, lymphocytic lymphoma, histiocytic lymphoma, multiple myeloma, Burkitt’s lymphoma, mycosis fungoide), leukaemia,  nerve tissue cancer, eye cancer, ovarian cancer, soft tissue cancer, bone cancer, and breast cancer. Additionally, Endoxan Tablet is used to treat minimal change nephrotic syndrome (kidney disease) in paediatric patients.
 
Endoxan Tablet contains ‘Cyclophosphamide’, an alkylating agent that stops the growth and multiplication of cancer cells by damaging their genetic material. Thereby, Endoxan Tablet helps to treat cancer by killing the cancer cells.
 
You are advised to take Endoxan Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects, such as fever, nausea, vomiting, diarrhoea, hair loss, low blood cell count, and abdominal pain. Do not be reluctant to talk with your doctor if you experience any of these side effects persistently.
 
Do not take Endoxan Tablet if you are allergic to any of its components; or if you have bladder obstruction or other urination problems. Avoid taking Endoxan Tablet if you are pregnant or breastfeeding. Endoxan Tablet may cause dizziness, so drive only if you are alert. Endoxan Tablet should be given to children only if prescribed by the doctor. Inform your doctor about your health condition and medications to rule out any side effects/interactions.

Uses of Endoxan Tablet

Cancer, nephrotic syndrome (kidney disease)

Medicinal Benefits Mweb

Medicinal Benefits

Endoxan Tablet belongs to the group of anti-cancer medicines used to treat malignant diseases such as Hodgkin’s disease, mixed-cell type lymphoma, lymphocytic lymphoma, histiocytic lymphoma, multiple myeloma(cancer of plasma cells), Burkitt’s lymphoma, leukaemia (blood cancer), neuroblastoma (nerve tissue cancer), retinoblastoma (eye cancer), adenocarcinoma of the ovary (ovarian cancer), mycosis fungoides (T-cell lymphoma), rhabdomyosarcoma (soft tissue cancer), osteosarcoma (bone cancer), and breast carcinoma. Additionally, Endoxan Tablet is used to treat minimal change nephrotic syndrome (kidney disease) in pediatric patients. Endoxan Tablet is an alkylating agent that stops the growth and multiplication of cancer cells by damaging their genetic material. Thereby, Endoxan Tablet helps to treat cancer by killing the cancer cells.

Directions for Use

Tablet/Capsule: Swallow it as a whole with water; do not crush or chew it.Oral liquid: Check the label for directions before use and take the prescribed dose using the dosing syringe or medicine spoon.

Side Effects of Endoxan Tablet

  • Fever
  • Nausea
  • Vomiting
  • Diarrhoea
  • Hair loss
  • Low blood cell count
  • Abdominal pain

Drug Warnings

Do not take Endoxan Tablet if you are allergic to any of its contents; or have urinary flow obstruction, bone marrow suppression, or infections. Talk to your doctor if you have myelosuppression, immunosuppression, infections, diabetes, heart, lung, liver, or kidney problems. Inform your doctor if you are receiving any radiotherapy or chemotherapy. Avoid taking Endoxan Tablet if you are pregnant or breastfeeding. Endoxan Tablet may cause dizziness, so drive only if you are alert. Inform your doctor about your health condition and medications to rule out any side effects/interactions.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Endoxan Tablet:
Co-administration of Nalidixic acid with Endoxan Tablet may cause an increase in the risk of side effects.

How to manage the interaction:
Co-administration of Endoxan Tablet and Nalidixic acid can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like bruising or bleeding, unusual weakness, nausea, stomach pain, low fever, or loss of appetite, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Endoxan Tablet:
Co-administration of Endoxan Tablet and Cidofovir may increase the risk of kidney problems.

How to manage the interaction:
Taking Cyclophosphamine with Cidofovir is not recommended, please consult your doctor before taking it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm contact your doctor immediately. Do not discontinue any medications without consulting a doctor
How does the drug interact with Endoxan Tablet:
The combined use of Cladribine with Endoxan Tablet can increase the risk and severity of side effects.

How to manage the interaction:
Co-administration of Cladribine with Endoxan Tablet can possibly result in an interaction, but it can be taken if a doctor has advised it. If you have any of these symptoms, contact a doctor right away. These symptoms include complications, infection, fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, and pain or burning when you urinate. Do not discontinue any medications without consulting a doctor.
CyclophosphamideVoclosporin
Severe
How does the drug interact with Endoxan Tablet:
Co-administration of Endoxan Tablet with Voclosporin can increase the risk of kidney damage.

How to manage the interaction:
Although there is a possible interaction between Endoxan Tablet and Voclosporin, you can take these medicines together if prescribed by a doctor. It's important to keep an eye on how much you pee. Some other signs to watch out for are feeling sick, throwing up, not wanting to eat, gaining or losing weight suddenly, holding onto fluids, having a fever or chills, having diarrhea or a sore throat, feeling weak or dizzy, being confused, having trouble breathing, feeling pain or a burning sensation when you pee, or having an irregular heartbeat. Do not stop using any medications without talking to a doctor.
How does the drug interact with Endoxan Tablet:
Taking Endoxan Tablet with Thalidomide may increase the risk of blood clots.

How to manage the interaction:
Although there is a possible interaction, Endoxan Tablet can be taken with Thalidomide if prescribed by the doctor. However, consult the doctor if you experience chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, and/or pain, redness, or swelling in an arm or leg. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Endoxan Tablet:
Taking Endoxan Tablet with Tofacitinib may increase the risk of serious infections.

How to manage the interaction:
Although there is a possible interaction, Endoxan Tablet can be taken with Tofacitinib if prescribed by the doctor. Consult the doctor immediately if you develop signs and symptoms of infection such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue the medication without consulting a doctor.
CyclophosphamideRopivacaine
Severe
How does the drug interact with Endoxan Tablet:
Co-administration of Ropivacaine with Endoxan Tablet can cause methemoglobinemia (low levels of oxygen in the blood).

How to manage the interaction:
Although there is a possible interaction between Ropivacaine and Endoxan Tablet, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without talking to a doctor.
How does the drug interact with Endoxan Tablet:
Taking Endoxan Tablet with Leflunomide may increase the risk of serious infections.

How to manage the interaction:
Although there is a possible interaction, Endoxan Tablet can be taken with Leflunomide if prescribed by the doctor. Consult the doctor immediately if you develop signs and symptoms of infection such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue the medication without consulting a doctor.
How does the drug interact with Endoxan Tablet:
Co-administration of Endoxan Tablet with Teriflunomide can increase the risk of side effects.

How to manage the interaction:
Although taking Endoxan Tablet and Teriflunomide together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you notice any symptoms like fever, chills, sore throat, or muscle aches, it's best to contact a doctor right away. Other symptoms to watch out for include diarrhea, shortness of breath, weight loss, or pain during urination. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Endoxan Tablet:
Co-administration of Endoxan Tablet with Busulfan can increase the risk of side effects.

How to manage the interaction:
Although there is an interaction between Busulfan and Endoxan Tablet, they can be taken together if prescribed by a doctor. However, if you experience any vomiting, diarrhea, mouth sores, or stomach pain, contact your doctor immediately. Do not stop using any medications without talking to your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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CYCLOPHOSPHAMIDE-50MGOther diseases of blood and blood-forming organs
Severe
CYCLOPHOSPHAMIDE-50MGObstructive and reflux uropathy
Severe

Drug-Diseases Interactions

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CYCLOPHOSPHAMIDE-50MGOther diseases of blood and blood-forming organs
Severe
How does the disease interact with Endoxan Tablet:
Endoxan Tablet usage can result in severe immunosuppression, bone marrow failure, myelosuppression (leukopenia, neutropenia, thrombocytopenia, and anaemia), and myelosuppression, which can all lead to serious and occasionally deadly infections including sepsis and septic shock. During Endoxan Tablet treatment, complete blood counts must be closely monitored in order to determine whether the dose has to be changed. Patients should not be given Endoxan Tablet if their neutrophil and platelet counts are below 1,500/mm3 and 50,000/mm3, respectively.

How to manage the interaction:
Close monitoring of complete blood count is advised during treatment with Endoxan Tablet. Inform the doctor if you notice any signs or symptoms of bone marrow suppression such as fever, sore throat, local infection, or bleeding.
CYCLOPHOSPHAMIDE-50MGObstructive and reflux uropathy
Severe
How does the disease interact with Endoxan Tablet:
Endoxan Tablet should not be administered to individuals who have any type of urine outflow restriction. Urinary blockage should be ruled out or resolved before therapy is started. During Endoxan Tablet treatment, hemorrhagic cystitis, pyelitis, and hematuria have all been mentioned.

How to manage the interaction:
Therapy with Endoxan Tablet should be administered cautiously in patients with or predisposed to bladder inflammation, including patients with active urinary infections. Urinary sediment should be monitored regularly for presence or erythrocytes and other signs of toxicity.
CYCLOPHOSPHAMIDE-50MGObstructive and reflux uropathy
Severe
How does the disease interact with Endoxan Tablet:
Endoxan Tablet should not be administered to individuals who have any type of urine outflow restriction. Urinary blockage should be ruled out or resolved before therapy is started. During Endoxan Tablet treatment, hemorrhagic cystitis, pyelitis, and hematuria have all been mentioned.

How to manage the interaction:
Therapy with Endoxan Tablet should be administered cautiously in patients with or predisposed to bladder inflammation, including patients with active urinary infections. Urinary sediment should be monitored regularly for presence or erythrocytes and other signs of toxicity.
CYCLOPHOSPHAMIDE-50MGObstructive and reflux uropathy
Severe
How does the disease interact with Endoxan Tablet:
Endoxan Tablet should not be administered to individuals who have any type of urine outflow restriction. Urinary blockage should be ruled out or resolved before therapy is started. During Endoxan Tablet treatment, hemorrhagic cystitis, pyelitis, and hematuria have all been mentioned.

How to manage the interaction:
Therapy with Endoxan Tablet should be administered cautiously in patients with or predisposed to bladder inflammation, including patients with active urinary infections. Urinary sediment should be monitored regularly for presence or erythrocytes and other signs of toxicity.

Drug-Drug Interactions Checker List

  • DOXORUBICIN
  • PACLITAXEL
  • APREPITANT
  • ONDANSETRON
  • ZIDOVUDINE

Habit Forming

No

Special Advise

  • Monitoring of complete blood count while taking Endoxan Tablet is advised.
  • Drink plenty of fluids to prevent urinary problems.
  • If you are due to have any surgery, inform the doctor that you are taking Endoxan Tablet .

Diet & Lifestyle Advise

  • Consume a healthy diet and exercise regularly to maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, herbs, and spices.
  • Avoid fast, fried, processed meats, refined carbs, and added sugar.
  • Get optimal sleep; rest well.
  • Stay protected from the sun. Avoid tanning beds and cover up with clothing, sunscreen, and sunglasses.

Endoxan Tablet Substitute

Always consult your doctor before taking any new medications and supplements

  • Cycloxan Tablet 10's

    by Others

    3.66per tablet
  • Adcyclo 50 Tablet 10's

    by Others

    3.51per tablet
  • Endoxan Tablet 10's

    by Others

    3.83per tablet
  • Eldamide 50mg Tablet

    by Others

    2.03per tablet
  • Cycloglob 50mg Tablet

    by Others

    3.42per tablet

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