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  3. Epnone-T10 Combikit Tablet 20's

Epnone-T10 Combikit Tablet 20's, Pack of 1 TABLET
Epnone-T10 Combikit Tablet 20's, Pack of 1 TABLET
Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
48 Hrs returnable
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COD available

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Whats That

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Composition :

EPLERENONE-25MG + TORSEMIDE-10MG

Manufacturer/Marketer :

Msn Laboratories Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

Therapeutic Class

ANTI- HYPERTENSIVES

Country of origin

INDIA

Manufacturer/Marketer address

MSN Laboratories Pvt.Ltd., MSN House, Plot No: C-24, Industrial Estate, Sanathnagar, Hyderabad - 18 Telangana, INDIA
Other Info - EPN0005

Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 8, 2025 | 9:45 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

FAQs

Epnone-T10 Combikit Tablet works by increasing the amount of urine passed out from the kidneys. It effectively reduces excess fluid levels and treats Oedema (swelling) associated with heart, liver, kidney or lung disease. This reduces the heart's workload and makes the heart more efficient at pumping blood throughout the body. Thus, it also helps lower high blood pressure, reducing the chances of any future heart attack, stroke or angina (chest pain).

Oedema, also known as dropsy, is the medical term for fluid retention in the body. The build-up of fluid causes affected tissue to become swollen. The swelling can occur in one particular part of the body – for example, due to an injury – or it can be more general. This is usually the case with Oedema due to certain health conditions, such as heart failure or kidney failure. If it does not subside, please consult your doctor immediately.

The main side effect of Epnone-T10 Combikit Tablet is peeing (urination) more often than usual. Most people need to pee about 30 minutes after taking Epnone-T10 Combikit Tablet and again within a few hours. Do not take Epnone-T10 Combikit Tablet before going to bed, or you may have to frequently wake up in the night to go for urination.

Yes, Epnone-T10 Combikit Tablet is known to cause dehydration (excessive loss of fluids). The patient may experience dry mouth, decreased urine output, excessive thirst, and hypotension (decreased blood pressure). So, please increase the intake of fluids to avoid excessive dehydration.

Yes, Epnone-T10 Combikit Tablet can cause increased potassium levels (hyperkalemia), especially in patients with kidney problems or if you are taking potassium supplements along with Epnone-T10 Combikit Tablet . Please monitor your electrolyte level regularly to avoid increasing blood potassium levels.

Yes, Epnone-T10 Combikit Tablet may occasionally cause dizziness due to orthostatic hypotension (sudden drop in blood pressure on standing from lying position) or passing out. To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Caution

Avoid consuming alcohol while on treatment with Epnone-T10 Combikit Tablet as it may lead to serious side effects.

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Pregnancy

Caution

Epnone-T10 Combikit Tablet is generally not recommended during pregnancy. Talk to your doctor about the benefits and potential risks of taking this medicine if you're trying to get pregnant or are already pregnant.

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Breast Feeding

Caution

Epnone-T10 Combikit Tablet is generally not advised during breastfeeding. Epnone-T10 Combikit Tablet should be used in breastfeeding mothers only if the benefits outweigh the risks.

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Driving

Caution

It is not advised to drive after taking Epnone-T10 Combikit Tablet because it may cause drowsiness due to orthostatic hypotension (sudden drop in blood pressure on standing from a lying position).

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Liver

Caution

Epnone-T10 Combikit Tablet to be taken with caution, especially if you have a history of Liver diseases/conditions. Your doctor may adjust the dose depending on your current liver conditions.

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Kidney

Caution

Epnone-T10 Combikit Tablet to be taken with caution, especially if you have a history of Kidney diseases/conditions. Your doctor may adjust the dose depending on your current kidney conditions.

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Children

Caution

Epnone-T10 Combikit Tablet is not recommended for children below 12 years of age.

Product Substitutes

Reference

  1. https://www.nhs.uk/medicines/eplerenone/#:~:text=Eplerenone%20is%20a%20blood%20pressure,treat%20a%20condition%20called%20hyperaldosteronism.
  2. https://www.medicines.org.uk/emc/files/pil.1773.pdf
  3. https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021437s013lbl.pdf
  4. https://patient.info/medicine/torasemide-tablets-torem#:~:text=Torasemide%20belongs%20to%20a%20group,high%20blood%20pressure%20(hypertension).
  5. https://www.medicines.org.uk/emc/files/pil.6663.pdf

About Epnone-T10 Combikit Tablet

Epnone-T10 Combikit Tablet belongs to a class of medicine called 'diuretics' (water pills), primarily used to remove excess water from the body. It also maintains the bloodstream's potassium level and prevents hypertension (high blood pressure) due to Oedema (fluid retention). Oedema or fluid overload is associated with pulmonary hypertension (high blood pressure in the lung) or heart failure (irregular heart pumping). Leg swelling is the main characteristic of Oedema, accompanied by shortness of breath, chest pain (angina), abnormal heart rhythms (arrhythmia) and swelling in other hands or abdomen areas.

Epnone-T10 Combikit Tablet is a combination of medications containing Eplerenone and Torsemide, which are prescribed for the treatment of resistant Oedema (fluid overload) associated with pulmonary hypertension (high blood pressure in the lungs), heart failure and hepatic cirrhosis (chronic liver damage). Epnone-T10 Combikit Tablet works by increasing the amount of urine passed out from the kidneys. It effectively reduces excess fluid levels in the body and treats Oedema (swelling) associated with heart, liver, kidney or lung disease. This reduces the heart's workload and makes the heart more efficient at pumping blood throughout the body. Thus, it also helps lower high blood pressure, reducing the chances of any future heart attack, stroke or angina (chest pain).

Take Epnone-T10 Combikit Tablet as prescribed by your doctor. You are advised to take Epnone-T10 Combikit Tablet for as long as your doctor has prescribed it. In some cases, you may experience dehydration, electrolyte disturbances (calcium, magnesium, and sodium), constipation, increased uric acid and itching. Most of these side effects of Epnone-T10 Combikit Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Try not to stop taking Epnone-T10 Combikit Tablet of your own, as doing so may raise your blood pressure, thereby increasing the risk of getting a heart attack and stroke. Inform your doctor if you suffer from any kidney, liver or heart disease. If you are pregnant or breastfeeding, please tell your doctor so that the dosage of Epnone-T10 Combikit Tablet can be prescribed accordingly. Please tell your doctor if you are taking any other medicines or are allergic to Epnone-T10 Combikit Tablet . Reducing the amount of table salt (sodium chloride) in your food often relieves the body's swelling.

Uses of Epnone-T10 Combikit Tablet

Oedema (fluid overload), Hypertension

Medicinal Benefits Mweb

Medicinal Benefits

Epnone-T10 Combikit Tablet is primarily used to remove excess water from the body. It also maintains the bloodstream's potassium level and prevents hypertension (high blood pressure) due to Oedema (fluid retention). Epnone-T10 Combikit Tablet is a combination of medications containing Eplerenone and Torsemide. Both Eplerenone and Torsemide are diuretics and are prescribed for the treatment of resistant Oedema (fluid overload) associated with pulmonary hypertension (high blood pressure in the lungs), heart failure and hepatic cirrhosis (chronic liver damage). Epnone-T10 Combikit Tablet works by increasing the amount of urine passed out from the kidneys. It effectively reduces excess fluid levels in the body and treats Oedema (swelling) associated with heart, liver, kidney or lung disease. This reduces the heart's workload and makes the heart more efficient at pumping blood throughout the body. Thus, it also helps lower high blood pressure, reducing the chances of any future heart attack, stroke or angina (chest pain).

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.Note: It is best to avoid taking this medication within 4 hours of your bedtime to prevent having to get up to urinate.

Side Effects of Epnone-T10 Combikit Tablet

  • Dehydration
  • Electrolyte disturbances (calcium, magnesium, and sodium)
  • Constipation
  • Itching
  • Increased uric acid

Drug Warnings

Epnone-T10 Combikit Tablet should not be given to the people allergic to Epnone-T10 Combikit Tablet , have low blood pressure (less than 90 mm of Hg), have had a heart attack, kidney disease (with creatinine clearance less than 30 mL/min), liver disease, pregnant women, or planning to get pregnant and breastfeeding women. Besides this, it is contraindicated in low blood pressure (hypotension), cardiogenic shock (sudden stopping of blood flow to the heart), and aortic stenosis (heart valve problem). Epnone-T10 Combikit Tablet can pass into breast milk, but its effect on the baby is unknown, so it is better to tell your doctor if you take Epnone-T10 Combikit Tablet and breastfeeding. Dehydration with electrolyte and acid-base disturbances must be corrected before using Epnone-T10 Combikit Tablet . Do not take extra potassium supplements or potassium-rich foods such as bananas and broccoli with Epnone-T10 Combikit Tablet . It may lead to an excessive blood potassium level (hyperkalemia). Please take Epnone-T10 Combikit Tablet at least 4 hours before sleeping to avoid frequent urination at night.

Drug-Drug Interactions

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EplerenonePotassium chloride
Critical
EplerenoneNefazodone
Critical

Drug-Drug Interactions

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EplerenonePotassium chloride
Critical
How does the drug interact with Epnone-T10 Combikit Tablet:
Using Epnone-T10 Combikit Tablet together with Potassium chloride may significantly increase potassium levels in the blood.

How to manage the interaction:
Taking potassium chloride with Epnone-T10 Combikit Tablet is not recommended. You can take these medicines if prescribed by a doctor. Consult a doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or an irregular heartbeat, consult the doctor immediately. It is essential to maintain proper fluid intake while taking these medications. Do not discontinue any medications without a doctor's advice.
EplerenoneNefazodone
Critical
How does the drug interact with Epnone-T10 Combikit Tablet:
Coadministration of Nefazodone with Epnone-T10 Combikit Tablet can increase the levels of Epnone-T10 Combikit Tablet in the body.

How to manage the interaction:
Taking Nefazodone with Epnone-T10 Combikit Tablet together is not recommended as it can result in an interaction, but it can be taken if your doctor has advised it. However, if you notice any symptoms of headaches, irritation, confusion, edema (swelling caused by too much fluid accumulation), weakness, palpitations, or constipation, you should contact a doctor immediately. Do not stop using any medications without a doctor's advice.
EplerenoneSpironolactone
Critical
How does the drug interact with Epnone-T10 Combikit Tablet:
Combining Epnone-T10 Combikit Tablet with Spiranolactone may significantly increase potassium levels in the blood which can lead to kidney issues and irregular heart rhythm.

How to manage the interaction:
Although there is a possible interaction between spironolactone and Epnone-T10 Combikit Tablet, it is not recommended as it can lead to an interaction. You can take these medicines if prescribed by a doctor. Consult a doctor if you experience nausea, vomiting, weakness, confusion, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or an irregular heartbeat. It is essential to maintain proper fluid intake while taking these medications. Do not discontinue any medications without a doctor's advice.
EplerenonePotassium citrate
Critical
How does the drug interact with Epnone-T10 Combikit Tablet:
Taking Epnone-T10 Combikit Tablet with Potassium citrate may significantly increase potassium levels in the blood which can lead to kidney issues, muscle paralysis (loss of muscle function) and irregular heart rhythm.

How to manage the interaction:
Although there is a possible interaction between Potassium citrate and Epnone-T10 Combikit Tablet, you can take these medicines if prescribed by a doctor. Consult a doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or irregular heartbeat. It is essential to maintain proper fluid intake while taking these medications. Do not discontinue any medications without a doctor's advice.
EplerenoneSaquinavir
Critical
How does the drug interact with Epnone-T10 Combikit Tablet:
Co-administration of EPELENONE and SAQUINAVIR may significantly increase the blood levels and side effects of Epnone-T10 Combikit Tablet. This can increase the risk of serious side effects like high blood potassium, which in severe cases can lead to kidney failure, muscle paralysis (loss of muscle function) and irregular heart rhythm.

How to manage the interaction:
Taking saquinavir and Epnone-T10 Combikit Tablet together is not recommended as it can lead to interaction. However, it can be taken if a doctor advises it. If you experience any unusual symptoms like headaches, irritation, confusion, edema (swelling caused by too much fluid accumulation), weakness, palpitations, or constipation, consult a doctor immediately. Do not stop using any medications without the doctor's advice.
EplerenonePotassium iodide
Critical
How does the drug interact with Epnone-T10 Combikit Tablet:
Combining Epnone-T10 Combikit Tablet with Potassium iodide may significantly increase potassium levels in the blood which can lead to kidney issues, muscle paralysis (loss of muscle function) and irregular heart rhythm.

How to manage the interaction:
Although there is a possible interaction between Potassium iodide and Epnone-T10 Combikit Tablet, you can take these medicines if prescribed by a doctor. Consult a doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or irregular heartbeat. It is essential to maintain proper fluid intake while taking these medications. Do not discontinue any medications without a doctor's advice.
EplerenonePosaconazole
Critical
How does the drug interact with Epnone-T10 Combikit Tablet:
Coadministration of posaconazole with Epnone-T10 Combikit Tablet can increase the blood levels of Epnone-T10 Combikit Tablet. This can increase the risk of serious side effects, including hyperkalemia (high blood potassium).

How to manage the interaction:
Although there is an interaction between posaconazole and Epnone-T10 Combikit Tablet, it can be taken if a doctor has advised it. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
EplerenoneClarithromycin
Critical
How does the drug interact with Epnone-T10 Combikit Tablet:
Co-administration of Epnone-T10 Combikit Tablet and Clarithromycin may significantly increase the blood levels and effects of Epnone-T10 Combikit Tablet.This may increase the risk or severity of side effects like high blood potassium which can lead to kidney damage and irregular heart rate.

How to manage the interaction:
Taking Clarithromycin with Epnone-T10 Combikit Tablet is not recommended as it can lead to interaction. However, it can be taken if a doctor advises it. If you experience any unusual symptoms like headaches, irritation, confusion, edema (swelling caused by too much fluid accumulation), weakness, palpitations, or constipation, consult a doctor immediately. Do not stop using any medications without the Doctor's advice.
EplerenoneRitonavir
Critical
How does the drug interact with Epnone-T10 Combikit Tablet:
Co-administration of Epnone-T10 Combikit Tablet and Ritonavir may significantly increase the blood levels of Epnone-T10 Combikit Tablet.

How to manage the interaction:
Taking Ritonavir and Epnone-T10 Combikit Tablet together is not recommended as it can lead to an interaction. However, it can be taken if a doctor advises it. If you experience any unusual symptoms like headaches, irritation, confusion, edema (swelling caused by too much fluid accumulation), weakness, palpitations, or constipation, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
EplerenoneItraconazole
Critical
How does the drug interact with Epnone-T10 Combikit Tablet:
The blood levels and effects of Epnone-T10 Combikit Tablet may be greatly increased when combined with itraconazole.

How to manage the interaction:
Although there is a possible interaction between Epnone-T10 Combikit Tablet and Itraconazole, it is not recommended; they can be taken if prescribed by a doctor. Consult a doctor if you have complications such as hyperkalemia (high blood potassium), which in extreme circumstances can result in kidney problems, muscle paralysis, and an irregular heartbeat. Without first consulting your doctor, never stop taking medicines.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • METOPROLOL
  • RAMIPRIL
  • LOSARTAN
  • ASPIRIN
  • WARFARIN
  • GENTAMICIN
  • CEPHALEXIN
  • CEFTRIAXONE
  • TRIMETHOPRIM
  • LITHIUM
  • DIGOXIN
  • IBUPROFEN
  • ITRACONAZOLE
  • SPIRONOLACTONE
  • AMILORIDE

Habit Forming

No

Special Advise

  • Treatment with Epnone-T10 Combikit Tablet requires regular monitoring of serum potassium, sodium and creatinine levels.
  • Monitor your blood pressure daily, and if there is too much fluctuation, immediately contact your doctor.
  • Regular monitoring of uric acid in patients with gouty arthritis.

Diet & Lifestyle Advise

  • Keep your weight under control with a BMI of 19.5-24.9.
  • Do regular physical activity or exercise for at least 150 minutes per week, or about 30 minutes most days of the week. Doing this can help you lower your raised blood pressure by about 5 mm of Hg.
  • Opt for a diet rich in whole grains, fruits, veggies and low-fat dairy products.
  • Limit sodium chloride (table salt) intake in your daily diet to 2300 mg per day or less than 1500 mg is ideal for most adults.
  • If you take alcohol, only one serving for women and two servings for men is advisable.
  • Quitting smoking is the best strategy to lower the risk of heart disease.
  • Avoid chronic stress, as it can raise your blood pressure. Try to enjoy and spend time with your loved ones to cope with stress and practice mindfulness techniques.
  • Monitor your blood pressure daily, and if there is too much fluctuation, immediately contact your doctor.
  • Try to include heart-healthy omega-3 fatty acids containing food and drinks in your daily diet. You can also use low-fat cooking oil like olive oil, soybean oil, canola oil and coconut oil to lower your elevated blood pressure.

Epnone-T10 Combikit Tablet Substitute

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