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  3. Esdival 250mg Tablet ER

Written By ,
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
48 Hrs returnable
COD available

Online payment accepted

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Whats That

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Composition :

DIVALPROEX-250MG

Manufacturer/Marketer :

Esteem Pharmaceuticals Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Therapeutic Class

ANTICONVULSANT

Country of origin

India
Other Info - ES56808

FAQs

Esdival 250mg Tablet ER decreases the excessive and abnormal nerve activity in the brain. Thereby helps in controlling seizures.

Esdival 250mg Tablet ER helps to treat manic episodes associated with bipolar disorder by increasing the amount of a chemical substance called GABA, this helps in blocking the nerve transmission across the brain and provides a calming effect.

Esdival 250mg Tablet ER limits the transmission of nerve pain, thereby preventing migraine headaches. Migraine is a neurological condition which is characterized by intense headaches.

Esdival 250mg Tablet ER may interact with aspirin and cause abnormal side-effects. So, it is recommended to take any medication along with Esdival 250mg Tablet ER only after consulting a doctor.

Esdival 250mg Tablet ER may improve the symptoms of depression. However, do not use it without consulting a doctor as it may also cause mood disturbances and suicidal thoughts in some patients.

Do not discontinue Esdival 250mg Tablet ER without consulting your doctor. To treat your condition effectually, continue taking Esdival 250mg Tablet ER for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Esdival 250mg Tablet ER; your doctor will gradually reduce the dose to avoid worsening seizures.

Esdival 250mg Tablet ER may cause weight gain due to an increase in appetite. Maintain a healthy weight by following a healthy diet and exercising regularly.

Esdival 250mg Tablet ER may cause thrombocytopenia (low levels of platelets). This might increase the risk of bleeding and bruising. Be cautious while using sharp objects. Consult your doctor if you notice unexplained bleeding or bruising. Regular monitoring of blood count is advised while taking Esdival 250mg Tablet ER.

Topiramate (anticonvulsant) should not be taken along with Esdival 250mg Tablet ER as it may cause hyperammonemia (excess ammonia in the blood), hypothermia (low body temperature) and liver problems.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Esdival 250mg Tablet ER as it may cause increased dizziness.

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Pregnancy

Unsafe

Esdival 250mg Tablet ER belongs to pregnancy category D. Avoid taking Esdival 250mg Tablet ER if you are pregnant as it could lead to serious birth defects. Consult your doctor for further advice.

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Breast Feeding

Caution

Esdival 250mg Tablet ER may pass into breastmilk. Consult your doctor before taking Esdival 250mg Tablet ER if you are breastfeeding.

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Driving

Unsafe

Esdival 250mg Tablet ER causes dizziness and may affect thinking and motor skills. Do not drive or operate machinery.

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Liver

Caution

Esdival 250mg Tablet ER should not be used if you have liver problems or your family has a history of liver problems. Please consult your doctor if you have liver problems or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

Esdival 250mg Tablet ER can be given to children if prescribed by the doctor. The doctor will adjust the dose depending on the child's body weight. Care should be taken in children below two years as they are at a higher risk of liver toxicity.

About Esdival 250mg Tablet ER

Esdival 250mg Tablet ER belongs to a group of medicines called anticonvulsants or anti-epileptics used to treat epilepsy/seizures/fits. Additionally, Esdival 250mg Tablet ER is also used to treat manic episodes associated with bipolar disorder and prevent migraines. Epilepsy is a sudden rush of electricity in the brain. In epilepsy, the brain's electrical rhythms become imbalanced, resulting in recurrent seizures.

Esdival 250mg Tablet ER contains 'Divalproex', which decreases the brain's excessive and abnormal nerve activity. Thereby helping in controlling seizures. Esdival 250mg Tablet ER increases the amount of a chemical substance called GABA; this helps block the nerve transmission across the brain and provides a calming effect. Thereby helping treat bipolar disorder. 

Take Esdival 250mg Tablet ER with or without food. Depending on your medical condition, you are advised to take Esdival 250mg Tablet ER for as long as your doctor has prescribed it for you. In some cases, you may experience certain common side-effects such as abdominal pain, back pain, constipation, diarrhoea, dizziness, nausea, increased appetite, and vomiting. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Please do not stop taking Esdival 250mg Tablet ER without consulting your doctor to avoid worsening seizures. Do not take Esdival 250mg Tablet ER if you are pregnant, as it could cause serious birth defects. If you are of childbearing age, use effective contraception while taking Esdival 250mg Tablet ER. Consult your doctor before taking Esdival 250mg Tablet ER if you are breastfeeding. Avoid driving or operating machinery as Esdival 250mg Tablet ER causes dizziness and may affect thinking and motor skills. Avoid consuming alcohol along with Esdival 250mg Tablet ER as it could lead to increased dizziness. Care should be taken while giving Esdival 250mg Tablet ER to children below two years as there is a higher risk of liver intoxication during the first 6months of treatment. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Esdival 250mg Tablet ER

Epilepsy, bipolar disorder, migraine

Medicinal Benefits Mweb

Medicinal Benefits

Esdival 250mg Tablet ER belongs to a group of medicines called anticonvulsants or anti-epileptics. Esdival 250mg Tablet ER is used to treat epilepsy/seizures/fits. Also, Esdival 250mg Tablet ER is used to treat mood disorders and prevent migraine headaches. Esdival 250mg Tablet ER decreases the excessive and abnormal nerve activity in the brain. Thereby helping in controlling seizures. Esdival 250mg Tablet ER treats mood disorders by increasing the amount of a chemical substance called GABA; this helps block the nerve transmission across the brain and provides a calming effect. Esdival 250mg Tablet ER prevents migraine headaches by limiting the transmission of nerve pain. Esdival 250mg Tablet ER is used alone or in combination to treat simple, complex partial, and complex absence seizures. Esdival 250mg Tablet ER is used in combination to treat multiple seizures, such as absence seizures.

Directions for Use

Tablet/Capsule: Swallow it as a whole with a glass of water; do not chew or crush it.Syrup/Suspension/Drops: Take the prescribed dose by mouth using the measuring cup/dosing syringe/dropper provided by the pack; shake the pack well before each use.Sprinkle capsule: Swallow it as a whole with water or sprinkle the capsule contents on food and consume.

Side Effects of Esdival 250mg Tablet ER

  • Abdominal pain
  • Back pain
  • Constipation
  • Diarrhoea
  • Dizziness
  • Nausea
  • Increased appetite
  • Vomiting
  • Vision problems
  • Weight changes
  • Problems with walking or coordination

Drug Warnings

Do not take Esdival 250mg Tablet ER if you are allergic to any of its contents, have/ had liver problems or urea cycle disorders. Inform your doctor before taking Esdival 250mg Tablet ER if you have pancreatitis, blood problems or multi-organ hypersensitivity. Consult your doctor immediately if you experience suicidal tendencies while taking Esdival 250mg Tablet ER. Esdival 250mg Tablet ER may cause thrombocytopenia (low blood platelets), hyperammonemia (high levels of ammonia in the blood), hypothermia (low body temperature) and liver problems. Please do not stop taking Esdival 250mg Tablet ER without consulting your doctor to avoid worsening of seizures. Do not take Esdival 250mg Tablet ER if you are pregnant, as it could cause serious birth defects. If you are of childbearing age, use effective contraception while taking Esdival 250mg Tablet ER. Consult your doctor before taking Esdival 250mg Tablet ER if you are breastfeeding. Avoid driving or operating machinery as Esdival 250mg Tablet ER causes dizziness and may affect thinking and motor skills. Avoid consuming alcohol along with Esdival 250mg Tablet ER as it could lead to increased dizziness. Care should be taken while giving Esdival 250mg Tablet ER to children below 2 years as there is a higher risk of liver intoxication during the first six months of treatment.

Drug-Drug Interactions

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DivalproexGlycerol phenylbutyrate
Critical

Drug-Drug Interactions

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DivalproexGlycerol phenylbutyrate
Critical
How does the drug interact with Esdival 250mg Tablet ER:
Coadministration of Glycerol phenylbutyrate and Esdival 250mg Tablet ER can increase ammonia levels in the blood.

How to manage the interaction:
Taking Glycerol phenylbutyrate and Esdival 250mg Tablet ER together is generally avoided as it can lead to an interaction, it can be taken when your doctor advises. If you experience any symptoms like sudden dizziness, headaches, vomiting, and visual disturbances, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with Esdival 250mg Tablet ER:
Coadministration of Ertapenem with Esdival 250mg Tablet ER may reduce the blood levels of Esdival 250mg Tablet ER and increase the risk of developing seizures.

How to manage the interaction:
Although there is a possible interaction, ertapenem can be taken with Esdival 250mg Tablet ER if prescribed by the doctor. Consult the doctor if you experience loss of seizure control or changes in behaviour. Do not stop using any medications without talking to your doctor.
DivalproexEsketamine
Severe
How does the drug interact with Esdival 250mg Tablet ER:
Coadministration of Esketamine and Esdival 250mg Tablet ER can increase the side effects of esketamine.

How to manage the interaction:
Although taking Esdival 250mg Tablet ER and Esketamine together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience any symptoms like drowsiness and impaired motor coordination, consult the doctor immediately. Do not stop using any medications without talking to your doctor.
DivalproexBexarotene
Severe
How does the drug interact with Esdival 250mg Tablet ER:
Co-administration of Esdival 250mg Tablet ER and Bexarotene can increase the risk of pancreatitis (inflammation of the pancreas).

How to manage the interaction:
Co-administration of Esdival 250mg Tablet ER and Bexarotene can lead to an interaction, but it can be taken when advised by your doctor. However, if you experience any symptoms like nausea, vomiting, or stomach cramps, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
DivalproexMipomersen
Severe
How does the drug interact with Esdival 250mg Tablet ER:
Co-administration of Esdival 250mg Tablet ER and mipomersen can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Esdival 250mg Tablet ER and mipomersen can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like fever, chills, joint pain, unusual bleeding, weakness, nausea, vomiting, stomach pain, dark urine, pale stools, and yellowing of the skin or eyes, consult the doctor immediately. Avoid alcohol consumption, and Do not stop using any medications without a doctor's advice.
DivalproexLomitapide
Severe
How does the drug interact with Esdival 250mg Tablet ER:
Co-administration of Esdival 250mg Tablet ER and Lomitapide can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Esdival 250mg Tablet ER and lomitapide can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like fever, joint pain, unusual bleeding, weakness, nausea, vomiting, stomach pain, dark urine, pale stools, or yellowing of the skin or eyes, consult the doctor immediately. Do not stop using any medications without the doctor's advice.
How does the drug interact with Esdival 250mg Tablet ER:
Co-administration of Esdival 250mg Tablet ER and Meropenem can reduce the blood levels of Esdival 250mg Tablet ER sodium.

How to manage the interaction:
Co-administration of Esdival 250mg Tablet ER with Meropenem can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Esdival 250mg Tablet ER:
Co-administration of buprenorphine with Esdival 250mg Tablet ER may increase the risk of developing side effects.

How to manage the interaction:
Co-administration of Buprenorphine with Esdival 250mg Tablet ER can result in an interaction, it can be taken when a doctor has advised it. However, if you experience shortness of breath, irregular heart rhythms, nausea, vomiting, and diarrhea contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DivalproexSodium oxybate
Severe
How does the drug interact with Esdival 250mg Tablet ER:
Co-administration of Sodium oxybate and Esdival 250mg Tablet ER can increase the risk of developing side effects.

How to manage the interaction:
Co-administration of Sodium oxybate and Esdival 250mg Tablet ER can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like dizziness, sweating, palpitations, and shortness of breath, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Esdival 250mg Tablet ER:
Coadministration of Ketoconazole and Esdival 250mg Tablet ER may increase the risk of liver damage.

How to manage the interaction:
Although taking Ketoconazole and Esdival 250mg Tablet ER together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you have any of the following symptoms: fever, chills, joint pain, fatigue, nausea, vomiting, stomach pain, dark urine, and yellowing of the skin or eyes, consult a doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • ASPIRIN
  • PREGABALIN
  • TOPIRAMATE
  • PHENOBARBITAL
  • PRIMIDONE
  • PHENYTOIN
  • CARBAMAZEPINE
  • LAMOTRIGINE
  • FELBAMATE
  • ETHOSUXIMIDE
  • ZIDOVUDINE
  • DULOXETINE
  • ESCITALOPRAM
  • AMITRIPTYLINE
  • NORTRIPTYLINE
  • ARIPIPRAZOLE
  • LURASIDONE
  • QUETIAPINE
  • ALPRAZOLAM
  • RIFAMPICIN
  • WARFARIN
  • IMIPENEM
  • MEROPENEM
  • DIAZEPAM

Habit Forming

No

Special Advise

  • Regular monitoring of blood count and coagulation tests are advised while taking Esdival 250mg Tablet ER as it may cause thrombocytopenia (low platelet levels).
  • Esdival 250mg Tablet ER may cause liver toxicity, usually during the first 6months of treatment. Children below two years are at a higher risk. Regular monitoring of liver function tests before treatment and at frequent intervals is advised.
  • Esdival 250mg Tablet ER might alter thyroid function tests and urine ketone tests. Inform the person doing the tests that you are taking Esdival 250mg Tablet ER.

Diet & Lifestyle Advise

  • A ketogenic diet (low in carbohydrates and high in fats) is recommended for children with epilepsy. This diet helps in utilising fat instead of glucose for the generation of energy.
  • Atkins diet (high fay and controlled carbohydrates) is recommended for adolescents and adults.
  • Exercising regularly helps in maintaining weight and improving overall health. 
  • Rest well, get plenty of sleep.
  • Avoid smoking and alcohol consumption.
  • Meditation and yoga can help lower the stress, decrease pain sensitivity and improves coping skills.
  • Have a seizure response plan, help those around you know what to do.
  • Prepare your living area, small changes may reduce the risk of physical injury during a seizure.
  • Understand what triggers seizures and try reducing or avoiding them.
  • Please pay attention to overall health as it can help in reducing seizure activity.
  • Install an alarm or emergency device to get assistance during a seizure attack.

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