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  1. Home
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  3. ESTRAM 140MG CAPSULE

Prescription drug
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ESTRAM 140MG CAPSULE, Pack of 10 CAPSULES
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48 Hrs returnable
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rxMedicinePrescription drug

Composition :

ESTRAMUSTINE-140MG

Manufacturer/Marketer :

United Biotech Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

Therapeutic Class

ANTINEOPLASTIC

Country of origin

India

Manufacturer/Marketer address

FC/B-1 (Extn.), Mohan Co-operative Industrial Estate Mathura Road, New Delhi - 110 044
Other Info - EST0011

Author Details

Lakshmithulasi YarraguntaDoctor badge

Written By

Lakshmithulasi Yarragunta

Pharm-D (PB)

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 8, 2025 | 9:49 AM IST

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FAQs

ESTRAM 140MG CAPSULE contains Estramustine, which belongs to the class of antimicrotubule agents. It works by blocking the replication of DNA (genetic material) in the cancer cells. Hence, this stops the further growth and multiplication of the cancer cells.

No, do not stop taking ESTRAM 140MG CAPSULE without consulting your doctor. It is recommended to take this medicine for the entire prescribed duration, even when symptoms improve or resolve.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Consult your doctor

Interaction of ESTRAM 140MG CAPSULE with alcohol is unknown. It is advisable to consult your doctor if you have concerns.

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Pregnancy

Not applicable

Not intended for women. ESTRAM 140MG CAPSULE has the potential to harm a fetus. If there is a chance that your partner will become pregnant while you are on estramustine, you should utilize effective birth control.

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Breast Feeding

Not applicable

Not intended for women.

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Driving

Unsafe

ESTRAM 140MG CAPSULE may decrease alertness or make you feel sleepy and dizzy. So, do not drive or operate heavy machinery after taking ESTRAM 140MG CAPSULE until your vision improves.

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Liver

Caution

ESTRAM 140MG CAPSULE should be used with caution, especially if you have a history of liver diseases/conditions. Your doctor may adjust the dose based on your condition.

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Kidney

Caution

ESTRAM 140MG CAPSULE should be used with caution, especially if you have a history of kidney diseases/conditions. This medicine causes fluid retention and edema which can be worsened by kidney impairment. Your doctor may adjust the dose based on your condition.

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Children

Not applicable

Intended for use in adult men.

Product Substitutes

Reference

  1. https://go.drugbank.com/drugs/DB01196
  2. https://www.mayoclinic.org/drugs-supplements/estramustine-oral-route/description/drg-20063721
  3. https://medlineplus.gov/druginfo/meds/a608046.html
  4. https://pubmed.ncbi.nlm.nih.gov/7579781/
  5. https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/018045s023lbl.pdf

About ESTRAM 140MG CAPSULE

ESTRAM 140MG CAPSULE is an antineoplastic medicine used in the treatment of prostate cancer. It is used to treat metastatic or progressive prostate cancer (a condition where cancer does not get cured) in men. Prostate cancer is a condition that occurs when the number of prostate gland cells increases abnormally. Symptoms may include difficulty in urinating, pain, numbness, etc.

ESTRAM 140MG CAPSULE contains Estramustine, which belongs to the class of antimicrotubule agents. It works by blocking the replication of DNA (genetic material) in the cancer cells. Hence, this stops the further growth and multiplication of the cancer cells.

ESTRAM 140MG CAPSULE may cause certain side effects such as nausea, dizziness, heartburn, headache, diarrhoea, muscle weakness, joint pain, hot flushes, nausea, vomiting, thirst, flatulence, edema, and GI bleeding. These side effects usually disappear without any medical attention. However, if these side effects persist or worsen, consult your doctor. Take this medicine as advised by your doctor. It should be taken on an empty stomach at least 2 hours before or post meals. Your doctor will decide the dose of the medicine based on the severity of your disease.

ESTRAM 140MG CAPSULE should be avoided if you are allergic to estradiol, nitrogen mustard or any component present in this medicine. Inform your doctor about medications you use to avoid interactions. Inform your doctor if you have any pre-existing or a history of liver/kidney disease, hypocalcemia, thrombophlebitis, fluid retention, coronary artery disease, diabetes, gynecomastia, or impotence before taking ESTRAM 140MG CAPSULE. ESTRAM 140MG CAPSULE is not recommended for use in women and children as this medicine is recommended for men. ESTRAM 140MG CAPSULE is known to cause thrombosis, fatal and nonfatal myocardial infarction, glucose intolerance and elevated blood pressure in some patients. Hence, close monitoring should be done during the treatment. 

Uses of ESTRAM 140MG CAPSULE

Metastatic Prostate Cancer.

Medicinal Benefits Mweb

Medicinal Benefits

ESTRAM 140MG CAPSULE contains Estramustine, which belongs to the class of antimicrotubule agents. It works by blocking the replication of DNA (genetic material) in the cancer cells. Hence, this stops the further growth and multiplication of the cancer cells.

Directions for Use

ESTRAM 140MG CAPSULE should be taken on an empty stomach at least two hours before or after a meal. It is advised not to take more than the recommended dose of medicine. Swallow the medicine as a whole with a glass of water. Do not chew, crush or break the medicine.

Side Effects of ESTRAM 140MG CAPSULE

  • Dizziness
  • Heartburn
  • Headache
  • Diarrhoea
  • Loss of Appetite
  • Nausea
  • Vomiting
  • GI bleeding
  • Thirst
  • Edema

Drug Warnings

ESTRAM 140MG CAPSULE should be avoided if you are allergic to it or either estradiol or nitrogen mustard. Keep a note of all your ongoing medications to avoid interactions. Inform your doctor if you have any pre-existing or a history of liver/kidney disease, hypocalcemia, thrombophlebitis, fluid retention, coronary artery disease, diabetes, Gynecomastia, or impotence before taking ESTRAM 140MG CAPSULE. ESTRAM 140MG CAPSULE is not recommended for use in women and children as the safety and efficacy of this medicine are not established. ESTRAM 140MG CAPSULE is known to cause thrombosis, fatal and nonfatal myocardial infarction, glucose intolerance and elevated blood pressure in some patients. Hence, close monitoring should be done during the entire treatment course. Do not take ESTRAM 140MG CAPSULE with milk or any other dairy products.

Drug-Drug Interactions

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EstramustineLetrozole
Severe
EstramustineTranexamic acid
Severe

Drug-Drug Interactions

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EstramustineLetrozole
Severe
How does the drug interact with Estram 140mg Capsule:
when taken together letrozole's function could be blocked by Estram 140mg Capsule, which would reduce its ability to effectively treat your illness.

How to manage the interaction:
Although taking Letrozole and Estram 140mg Capsule together can possibly result in an interaction, it can be taken if your doctor has prescribed it. Do not discontinue any medications without a doctor's advice.
EstramustineTranexamic acid
Severe
How does the drug interact with Estram 140mg Capsule:
Co-administration of Estram 140mg Capsule with Tranexamic acid can increase the risk of blood clots.

How to manage the interaction:
Taking Estram 140mg Capsule with Tranexamic acid possibly lead to an interaction, however, it can be taken only if a doctor has advised it. If you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, and numbness or weakness on one side of the body contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
EstramustineExemestane
Severe
How does the drug interact with Estram 140mg Capsule:
Co-administration of Exemestane with Estram 140mg Capsule may interfere with exemestane's activity and make it less effective in treating the condition.

How to manage the interaction:
There may be a possibility of interaction between Exemestane and Estram 140mg Capsule, but it can be taken if prescribed by a doctor. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • MAGNESIUM HYDROXIDE
  • ALUMINIUM HYDROXIDE
  • KETOCONAZOLE
  • ITRACONAZOLE

Habit Forming

No

Special Advise

  • ESTRAM 140MG CAPSULE is not recommended for use in patients suffering from severe kidney disease.
  • Regular checkups on your calcium, potassium, blood sugar, and blood pressure levels are advised.

Diet & Lifestyle Advise

  • Try to take vegetables like cauliflower, cabbage, broccoli, spinach and kale. This food slows the growth of prostate cancer and even reduces the risk of prostate cancer.
  • It is advised to consume fewer dairy products as these foods may increase the risk of prostate cancer. 
  • Physical activity helps in strengthening muscles, reduces fatigue, helps in weight loss and gives strength.
  • Maintain a healthy weight by doing regular simple exercises and yoga. 
  • Getting adequate sleep as resting helps improve your health and mental ability and improves attention. 
  • Avoid including red meat high amounts of meat in your diet. When meat is cooked, it may increase the risk of developing prostate cancer.

ESTRAM 140MG CAPSULE Substitute

Substitutes safety advice

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