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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Sureshvarma D , MPharma
48 Hrs returnable
COD available

Online payment accepted

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Whats That

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Manufacturer/Marketer :

Dr Reddy's Laboratories Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

Therapeutic Class

ANTICHOLINERGICS

Country of origin

India

Manufacturer/Marketer address

Dr. Reddy'S Laboratories Ltd., 8-2-337, Road No. 3, Banjara Hills, Hyderabad, Telangana 500034, India
Other Info - EXE0138

Author Details

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FAQs

Exena-S 25/5 Tablet contains Solifenacin and Mirabegron. Solifenacin reduces the undesirable contractions of the bladder, thereby increasing the amount of urine that the bladder can hold. This decreases the urgency for urination. Mirabegron relaxes the muscles of the bladder; this prevents frequent, uncontrolled, or urgent urination. Together, Exena-S 25/5 Tablet helps in treating an overactive bladder.

There is some overlap between the symptoms of both OAB and BPH. OAB occurs due to uncontrolled urinary bladder muscle contractions. The main symptom of OAB is a sudden urge to urinate that's hard to control, which is stressful. On the other hand, BPH occurs due to an enlarged prostate gland, which puts pressure on the urinary bladder, thereby causing pain during urination.

Dry mouth could be a side effect of Exena-S 25/5 Tablet . Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol; drinking water regularly, and chewing sugar-free gum/candy might stimulate saliva and prevent drying of the mouth.

Exena-S 25/5 Tablet might cause hypertension. Therefore, consult your doctor before taking Exena-S 25/5 Tablet if you have high blood pressure.

Constipation could be a side-effect of Exena-S 25/5 Tablet . Eat fibre-rich food and drink plenty of fluids if you experience constipation. Talk to your doctor if you have severe constipation.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Caution

You are recommended to avoid or limit alcohol consumption while taking Exena-S 25/5 Tablet as it may cause increased dizziness.

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Pregnancy

Caution

Limited information is available regarding the usage of Exena-S 25/5 Tablet during pregnancy. Consult your doctor before taking Exena-S 25/5 Tablet if you are pregnant.

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Breast Feeding

Caution

Limited information is available regarding the usage of Exena-S 25/5 Tablet during breastfeeding. Consult your doctor before taking Exena-S 25/5 Tablet if you are breastfeeding.

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Driving

Caution

Exena-S 25/5 Tablet may cause blurred vision and tiredness. Drive or operate machinery only if you are alert.

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Liver

Caution

Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

Exena-S 25/5 Tablet is not recommended for children as safety and effectiveness have not been established.

About Exena-S 25/5 Tablet

Exena-S 25/5 Tablet is a combination medicine used to treat overactive bladder (OAB) with symptoms of urinary incontinence (urine leakage), urgent or frequent urination, increased night-time urination, and dysuria (painful or difficult urination). Overactive bladder is a condition in which there is a problem with bladder function, which causes a sudden urge to urinate that might be difficult to control.
 
Exena-S 25/5 Tablet contains Solifenacin (anti-cholinergic) and Mirabegron (beta-3 adrenergic agonist). Solifenacin reduces the undesirable contractions of the bladder, thereby increasing the amount of urine that the bladder can hold. This decreases the urgency for urination. Mirabegron relaxes the muscles of the bladder; this prevents frequent, uncontrolled, or urgent urination. Together, Exena-S 25/5 Tablet helps in treating overactive bladder.
 
You are advised to take Exena-S 25/5 Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience common side-effects such as dry mouth, constipation, headache, high blood pressure, and vomiting. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
 
Consult your doctor if you are pregnant or breastfeeding. Exena-S 25/5 Tablet is not recommended for children as safety and efficacy have not been established. Exena-S 25/5 Tablet may cause blurred vision, so drive with caution. Avoid or limit alcohol consumption along with Exena-S 25/5 Tablet as it could lead to increased dizziness. Inform your doctor about your health condition and medications before taking Exena-S 25/5 Tablet to rule out any side effects/interactions.

Uses of Exena-S 25/5 Tablet

Overactive bladder syndrome

Medicinal Benefits Mweb

Medicinal Benefits

Exena-S 25/5 Tablet is a combination of two drugs, namely: Solifenacin and Mirabegron. Exena-S 25/5 Tablet is a combination medicine used to treat overactive bladder (OAB) with symptoms of urinary incontinence (urine leakage), urgent or frequent urination, increased night-time urination, dysuria (painful or difficult urination). Solifenacin is an anti-cholinergic that reduces the undesirable contractions of the bladder, thereby increasing the amount of urine that the bladder can hold. This decreases the urgency for urination. Mirabegron is a beta-3 adrenergic agonist which relaxes the muscles of the bladder; this prevents frequent, uncontrolled, or urgent urination. Together, Exena-S 25/5 Tablet helps in treating an overactive bladder.

Directions for Use

Swallow Exena-S 25/5 Tablet as a whole with water; do not chew or break it.

Side Effects of Exena-S 25/5 Tablet

  • Constipation
  • Headache 
  • Dry mouth
  • Blurred vision
  • Vomiting
  • High blood pressure
  • Urinary tract infection

Drug Warnings

Do not take Exena-S 25/5 Tablet if you are allergic to any of its contents. Inform your doctor if you have glaucoma, myasthenia gravis, ulcerative colitis, urinary retention, high blood pressure, angioedema, kidney or liver problems. Consult your doctor if you are pregnant or breastfeeding. Exena-S 25/5 Tablet is not recommended for children. Exena-S 25/5 Tablet may cause blurred vision, so drive with caution. Avoid or limit alcohol consumption with Exena-S 25/5 Tablet as it could lead to increased dizziness. 

Drug-Drug Interactions

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SolifenacinMesoridazine
Critical
SolifenacinPotassium chloride
Critical

Drug-Drug Interactions

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SolifenacinMesoridazine
Critical
How does the drug interact with Exena-S 25/5 Tablet:
Using Mesoridazine together with Exena-S 25/5 Tablet can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Mesoridazine with Exena-S 25/5 Tablet is not recommended, please consult your doctor before taking it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations call a doctor.
SolifenacinPotassium chloride
Critical
How does the drug interact with Exena-S 25/5 Tablet:
Taking Exena-S 25/5 Tablet and Potassium chloride together can increase the risk of stomach ulcers, bleeding, and stomach injury.

How to manage the interaction:
Taking Exena-S 25/5 Tablet with Potassium chloride is not recommended, as it can lead to an interaction, it can be taken if a doctor has prescribed it. However, if you experience severe stomach pain, bloating, sudden lightheadedness or dizziness, nausea, vomiting (especially with blood), decreased hunger, dark, tarry stools, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.
SolifenacinItraconazole
Critical
How does the drug interact with Exena-S 25/5 Tablet:
The blood levels and effects of Exena-S 25/5 Tablet may be greatly increased when combined with itraconazole.

How to manage the interaction:
Exena-S 25/5 Tablet and Itraconazole may interact, however, if recommended by a physician, they are safe to consume. Consult a doctor if you feel sleepy, or uneasy, have an irregular heartbeat, have blurry vision, have trouble urinating, have a dry mouth, a headache, have digestive problems, or have constipation. Without consulting a doctor, never stop taking any medication.
MirabegronEliglustat
Critical
How does the drug interact with Exena-S 25/5 Tablet:
Coadministration of Eliglustat and Exena-S 25/5 Tablet can significantly increase the blood levels of eliglustat. This can increase the risk or severity of side effects.

How to manage the interaction:
Taking Exena-S 25/5 Tablet with Eliglustat is not recommended, it should be taken only when advised by a doctor. You should seek immediate medical help if you develop symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, irregular heart rate, weak pulse, or heart palpitations. Do not discontinue any medications without a doctor's advice.
SolifenacinAmisulpride
Severe
How does the drug interact with Exena-S 25/5 Tablet:
Using amisulpride with Exena-S 25/5 Tablet can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Although taking amisulpride along with Exena-S 25/5 Tablet can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
SolifenacinRitonavir
Severe
How does the drug interact with Exena-S 25/5 Tablet:
Taking Ritonavir and Exena-S 25/5 Tablet may significantly increase the blood levels of Exena-S 25/5 Tablet.

How to manage the interaction:
Although taking Exena-S 25/5 Tablet and Ritonavir together can cause an interaction, it can be taken if your doctor has suggested it. However, consult the doctor immediately if you experience symptoms such as dizziness, irregular heartbeat, blurry vision, difficulty urinating, dry mouth, headache, nausea, vomiting, or constipation. Do not stop using any medications without talking to a doctor.
SolifenacinAtazanavir
Severe
How does the drug interact with Exena-S 25/5 Tablet:
Coadministration of Exena-S 25/5 Tablet with Atazanavir may significantly increase the blood levels of Exena-S 25/5 Tablet.

How to manage the interaction:
There may be a possibility of interaction between Exena-S 25/5 Tablet and Atazanavir, but it can be taken if prescribed by a doctor. If you experience drowsiness, dizziness, irregular heartbeat, blurry vision, difficulty urinating, dry mouth, headache, gastrointestinal upset, or constipation. Do not stop using any medications without talking to a doctor.
SolifenacinHaloperidol
Severe
How does the drug interact with Exena-S 25/5 Tablet:
Co-administration of Exena-S 25/5 Tablet and Haloperidol can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Co-administration of Exena-S 25/5 Tablet and haloperidol can lead to an interaction, but it can be taken if your doctor advises. However, contact your doctor immediately if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhoea, or vomiting. Do not discontinue any medications without consulting a doctor.
SolifenacinCitalopram
Severe
How does the drug interact with Exena-S 25/5 Tablet:
Coadministration of Citalopram with Exena-S 25/5 Tablet can lead to or increase the risk of irregular heart rhythms.

How to manage the interaction:
Taking Citalopram with Exena-S 25/5 Tablet together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor. Do not discontinue any medication without consulting a doctor.
SolifenacinIloperidone
Severe
How does the drug interact with Exena-S 25/5 Tablet:
Coadministration of Iloperidone with Exena-S 25/5 Tablet can lead to or increase the risk of irregular heart rhythms.

How to manage the interaction:
Taking Iloperidone with Exena-S 25/5 Tablet together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • DIPHENHYDRAMINE
  • METOPROLOL
  • ACETAMINOPHEN
  • ALBUTEROL

Habit Forming

No

Diet & Lifestyle Advise

  • Pelvic floor exercises would be helpful in treating bladder spasms.
  • Avoid foods like sugars, carbonated beverages, tea, citrus fruits, tomatoes, spicy foods, chocolate and tea. 
  • Avoid drinking excess alcohol or caffeinated drinks, as they can worsen the symptoms.
  • Maintain a healthy weight, and exercise regularly.
  • Quit smoking.
  • Take 6-8glasses of liquids every day.
  • Avoid processed foods. Instead, choose whole, unprocessed foods.
  • Include fruits, vegetables, and fibre-rich food in your diet.

Exena-S 25/5 Tablet Substitute

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