FOSFOMYCIN-4000MGVascular disorders of intestine
How does the disease interact with Fosfocide 4Gm Inj:
Nearly all antibacterial medications have been associated with Clostridioides difficile-associated diarrhoea (CDAD), formerly known as pseudomembranous colitis, which can range in severity from mild diarrhoea to deadly colitis. Lincomycin and clindamycin are typically to blame. Antibacterial treatment disrupts the colon's normal flora, promoting the growth of C difficile, whose toxins A and B contribute to the emergence of CDAD. When C difficile strains produce hypertoxins, morbidity and death rise; severe infections may not respond to antibiotic therapy and may necessitate colectomy. All individuals who get diarrhoea after taking an antibiotic must be evaluated for CDAD. Careful medical history is required because CDAD has been known to happen more than two months following antibiotic use. Broad-spectrum antibiotics and other medications with potent antibacterial properties should be used in therapy.
How to manage the interaction:
Fosfocide 4Gm Inj should be used with caution in patients with a history of gastrointestinal disease, particularly colitis (inflammation of the large intestine), pseudomembranous colitis (generally characterized by severe, persistent diarrhoea and severe abdominal cramps, and sometimes associated with the passage of blood and mucus).
FOSFOMYCIN-4000MGCare involving dialysis
How does the disease interact with Fosfocide 4Gm Inj:
Hemodialysis removes Fosfocide 4Gm Inj, therefore it needs to be given after treatments.
How to manage the interaction:
As Fosfocide 4Gm Inj is removed by hemodialysis, it should be administered after dialysis sessions.
FOSFOMYCIN-4000MGUnspecified kidney failure
How does the disease interact with Fosfocide 4Gm Inj:
Fosfocide 4Gm Inj is excreted intact in the faeces (18%) and by the kidneys (38%) of healthy adults. In patients with impaired renal function, the excretion of Fosfocide 4Gm Inj is greatly reduced, and the half-life is prolonged. In patients with renal insufficiency, side symptoms (such as diarrhoea, headache, nausea, and vaginitis) may last longer.
How to manage the interaction:
Fosfocide 4Gm Inj should be used with caution in patients with kidney failure. However, if the side effects, such as headache, diarrhoea, nausea, and vaginitis (inflammation or infection of the vagina) worsen, please consult your doctor.