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Alcohol
Caution
The interaction of alcohol with Fosfozyme 3 Powder 8 gm is unknown. However, limit or avoid consumption of alcohol while taking Fosfozyme 3 Powder 8 gm.
Pregnancy
Caution
Fosfozyme 3 Powder 8 gm is a category B pregnancy drug and is given to pregnant women only if the doctor thinks the benefits outweigh the risks. Therefore, please inform your doctor if you are pregnant or planning pregnancy before taking Fosfozyme 3 Powder 8 gm.
Breast Feeding
Caution
Small amounts of Fosfozyme 3 Powder 8 gm are excreted in human milk. Therefore, it is given to breastfeeding mothers only if the doctor thinks the benefits are greater than the risks.
Driving
Caution
Fosfozyme 3 Powder 8 gm may cause dizziness or tiredness in some people. Therefore, avoid driving if you experience any of these symptoms after taking Fosfozyme 3 Powder 8 gm.
Liver
Caution
Limited information is available on the effect of Fosfozyme 3 Powder 8 gm in patients with liver disease. Therefore, inform your doctor if you have any liver diseases/conditions before taking this medicine.
Kidney
Caution
Fosfozyme 3 Powder 8 gm is not recommended if you have severe kidney problems or are undergoing hemodialysis. Inform your doctor if you have any Kidney problems before taking Fosfozyme 3 Powder 8 gm.
Children
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Fosfozyme 3 Powder 8 gm is not recommended for children below 12 years of age as the safety and effectiveness were not established.
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Drug-Drug Interactions
Drug-Drug Interactions
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Co-administration of the Cholera vaccine with Fosfozyme 3 Powder 8 gm may reduce the activity of the Cholera vaccine.
How to manage the interaction:
If you are currently being treated with Fosfozyme 3 Powder 8 gm or have been treated within the last 14 days, inform your doctor before receiving cholera vaccine, live. Avoid receiving cholera vaccine, live until at least 14 days after you complete your antibiotic therapy to ensure adequate vaccine response.
When BCG vaccine is used with Fosfozyme 3 Powder 8 gm, its effectiveness may be reduced.
How to manage the interaction:
Taking Fosfozyme 3 Powder 8 gm with the BCG vaccine can lead to an interaction, please consult a doctor before taking it.
Fosfozyme 3 Powder 8 gm may reduce the effect of balsalazide when taken orally.
How to manage the interaction:
If you are supposed to take Fosfozyme 3 Powder 8 gm and Balsalazide together, your doctor may adjust the dose or monitor you more frequently to use both medications safely.
Drug-Food Interactions
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Drug-Diseases Interactions
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Nearly all antibacterial medications have been associated with Clostridioides difficile-associated diarrhoea (CDAD), formerly known as pseudomembranous colitis, which can range in severity from mild diarrhoea to deadly colitis. Lincomycin and clindamycin are typically to blame. Antibacterial treatment disrupts the colon's normal flora, promoting the growth of C difficile, whose toxins A and B contribute to the emergence of CDAD. When C difficile strains produce hypertoxins, morbidity and death rise; severe infections may not respond to antibiotic therapy and may necessitate colectomy. All individuals who get diarrhoea after taking an antibiotic must be evaluated for CDAD. Careful medical history is required because CDAD has been known to happen more than two months following antibiotic use. Broad-spectrum antibiotics and other medications with potent antibacterial properties should be used in therapy.
How to manage the interaction:
Fosfozyme 3 Powder 8 gm should be used with caution in patients with a history of gastrointestinal disease, particularly colitis (inflammation of the large intestine), pseudomembranous colitis (generally characterized by severe, persistent diarrhoea and severe abdominal cramps, and sometimes associated with the passage of blood and mucus).
Hemodialysis removes Fosfozyme 3 Powder 8 gm, therefore it needs to be given after treatments.
How to manage the interaction:
As Fosfozyme 3 Powder 8 gm is removed by hemodialysis, it should be administered after dialysis sessions.
Fosfozyme 3 Powder 8 gm is excreted intact in the faeces (18%) and by the kidneys (38%) of healthy adults. In patients with impaired renal function, the excretion of Fosfozyme 3 Powder 8 gm is greatly reduced, and the half-life is prolonged. In patients with renal insufficiency, side symptoms (such as diarrhoea, headache, nausea, and vaginitis) may last longer.
How to manage the interaction:
Fosfozyme 3 Powder 8 gm should be used with caution in patients with kidney failure. However, if the side effects, such as headache, diarrhoea, nausea, and vaginitis (inflammation or infection of the vagina) worsen, please consult your doctor.
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