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Written By Divya L , PharmaD
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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About Frumide 40 mg/5 mg Tablet

Frumide 40 mg/5 mg Tablet belongs to the class of 'diuretic drugs or water pills', primarily used to treat hypertension (high blood pressure) and oedema (fluid retention). Hypertension is a medical condition, in which the blood exerts high pressure (force exerted by circulating blood) against blood vessel's walls. This condition makes the heart to work harder in pumping the blood to the whole body. Hypertension can cause severe health complications, including stroke, heart failure, heart attack and kidney failure. Oedema is a condition caused by a build-up of fluid and swelling in the ankles, feet and legs.

Frumide 40 mg/5 mg Tablet prevents the build-up of extra water in the body. This excess water can cause swollen ankles, shortness of breath and tiredness. It iconsists of Furosemide (loop diuretic) and Amiloride (potassium-sparing diuretic). Furosemide inhibits reabsorption of sodium and chloride in the ascending loop of Henle and proximal and distal renal tubules (different parts of the nephron in the kidney). Amiloride inhibits sodium-potassium exchange in the distal tubule of nephron (functional unit of the kidney). Frumide 40 mg/5 mg Tablet helps in clearing the excess fluids in the body in the form of urine.

Your doctor will advise you how often you take Frumide 40 mg/5 mg Tablet based on your medical condition. Like all medicines, Frumide 40 mg/5 mg Tablet can cause side effects, although not everybody gets them. Some common side effects of Frumide 40 mg/5 mg Tablet include dizziness, light-headedness, headache, blurred vision, nausea, vomiting, loss of appetite, stomach/abdominal pain, gas and diarrhoea. Most of these side effects of Frumide 40 mg/5 mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, please reach out to your doctor.

Do not stop taking Frumide 40 mg/5 mg Tablet without consulting your doctor since it may worsen your condition and increase the risk of future heart problems. Inform your doctor if you have any untreated salt/mineral imbalance (high potassium, low sodium level), kidney disease, liver disease, diabetes, dehydration, gout, hearing loss, Addison's disease (adrenal insufficiency), dehydration and lupus (an autoimmune disease of tissues). Please tell your doctor if you are taking any other medicines or have any allergic reactions to Frumide 40 mg/5 mg Tablet. Reducing the amount of table salt (sodium chloride) in your food often relieves the body's swelling. If you are pregnant or breastfeeding, please tell your doctor so that the dosage of Frumide 40 mg/5 mg Tablet can be prescribed accordingly.

Uses of Frumide 40 mg/5 mg Tablet

Hypertension (high blood pressure) and Oedema (fluid retention).

Directions for Use

Swallow Frumide 40 mg/5 mg Tablet as a whole with a glass of water. Do not crush, chew or break it.

Medicinal Benefits

Frumide 40 mg/5 mg Tablet prevents the build-up of extra water in the body and treats hypertension (high blood pressure) and oedema (fluid retention). Frumide 40 mg/5 mg Tablet is a combination of medicine that consists of Furosemide and Amiloride. Furosemide is a 'loop diuretic' that treats high blood pressure, fluid retention (oedema) in people with congestive heart failure, liver disease or nephrotic syndrome (a kidney disease). Amiloride is a 'potassium-sparing diuretic' and treats hypokalemia (low potassium levels in the blood) in people with high blood pressure or congestive heart failure. Frumide 40 mg/5 mg Tablet works by acting on different parts of the kidney to remove extra fluid and certain electrolytes while maintaining the body's potassium balance. Frumide 40 mg/5 mg Tablet clears the excess fluids in the body in the form of urine.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Do not use Frumide 40 mg/5 mg Tablet if you are allergic to Frumide 40 mg/5 mg Tablet or any of its components. Let your doctor know if you have any untreated salt/mineral imbalance (high potassium, low sodium level), kidney disease, liver disease, diabetes, dehydration, gout, hearing loss, Addison's disease (adrenal insufficiency), dehydration and lupus (an autoimmune disease of tissues) before starting Frumide 40 mg/5 mg Tablet. Therapy with loop diuretics should be administered cautiously in patients with diabetes mellitus, glucose intolerance, or a history of hyperglycemia (high glucose levels) since Furosemide affects your blood sugar levels. Pregnant and breastfeeding women should consult a doctor before using Frumide 40 mg/5 mg Tablet. Frumide 40 mg/5 mg Tablet can increase the chances of light-headedness so rise slowly if you are sitting/lying and avoid operating any machine or doing any work that needs mental alertness.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Frumide 40 mg/5 mg Tablet:
Taking Ziprasidone with Frumide 40 mg/5 mg Tablet can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Ziprasidone with Frumide 40 mg/5 mg Tablet is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, weakness, tiredness, drowsiness, confusion, muscle pain, cramps, dizziness, nausea, or vomiting. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Frumide 40 mg/5 mg Tablet:
Coadministration of Frumide 40 mg/5 mg Tablet with Drospirenone may increase potassium levels in the blood.

How to manage the interaction:
Taking Frumide 40 mg/5 mg Tablet with Drospirenone may lead to an interaction but can be taken if prescribed by the doctor. However, consult the doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or a slow or irregular heartbeat. It is advised to reduce intake of potassium-rich foods such as tomatoes, raisins, figs, potatoes, lima beans, bananas, plantains, papayas, pears, cantaloupes, mangoes, and potassium-containing salt substitutes. Do not stop using any medications without talking to a doctor.
How does the drug interact with Frumide 40 mg/5 mg Tablet:
Coadministration of Frumide 40 mg/5 mg Tablet with Spironolactone may increase potassium levels in the blood.

How to manage the interaction:
Taking Frumide 40 mg/5 mg Tablet with Spironolactone is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, consult the doctor if you experience nausea, vomiting, weakness, confusion, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or a slow or irregular heartbeat. It is important to maintain proper fluid intake while taking these medications. Do not stop taking any medication without doctor's advice.
How does the drug interact with Frumide 40 mg/5 mg Tablet:
Taking Frumide 40 mg/5 mg Tablet with Tobramycin can increase the risk of hearing loss and kidney problems.

How to manage the interaction:
Although there is a possible interaction between Tobramycin and Frumide 40 mg/5 mg Tablet, you can take these medicines together if prescribed by your doctor. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Frumide 40 mg/5 mg Tablet:
Co-administration of Frumide 40 mg/5 mg Tablet may interfere with blood glucose control and lower the effectiveness of Glimepiride.

How to manage the interaction:
Although there is a possible interaction, glimepiride can be taken with Frumide 40 mg/5 mg Tablet if prescribed by the doctor. Regular monitoring of blood glucose levels is advised. Do not discontinue the medications without consulting a doctor.
How does the drug interact with Frumide 40 mg/5 mg Tablet:
Coadministration of Streptomycin and Frumide 40 mg/5 mg Tablet may increase the risk or severity of hearing or kidney problems.

How to manage the interaction:
There may be a possibility of interaction between Streptomycin and Frumide 40 mg/5 mg Tablet, but it can be taken if prescribed by a doctor. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, hearing difficulty, swelling, body aches, increased or decreased urination, or memory loss, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Frumide 40 mg/5 mg Tablet:
Concomitant administration of diclofenac and Frumide 40 mg/5 mg Tablet may decrease the therapeutic efficacy of Frumide 40 mg/5 mg Tablet and adversely affect renal function.

How to manage the interaction:
There may be a possible interaction between diclofenac and Frumide 40 mg/5 mg Tablet, but they can be taken together if your doctor has prescribed them. However, consult your doctor immediately if you experience symptoms like nausea, dizziness, irregular heartbeats, altered blood pressure, tingling. Do not stop using any medications without first talking to your doctor.
How does the drug interact with Frumide 40 mg/5 mg Tablet:
Coadministration of Amikacin with Frumide 40 mg/5 mg Tablet can increase the risk of developing kidney disorder and other side effects.

How to manage the interaction:
Although taking amikacin and Frumide 40 mg/5 mg Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience ringing in the ears, irregular urination, muscle cramps, vomiting, or weakness, consult the doctor. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Frumide 40 mg/5 mg Tablet:
Combining Tizanidine and Frumide 40 mg/5 mg Tablet can lower your blood pressure.

How to manage the interaction:
Taking Tizanidine and Frumide 40 mg/5 mg Tablet together can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like headache, dizziness, lightheadedness, fainting, and changes in pulse or heart rate, contact your doctor immediately. Avoid driving or operating hazardous machinery until you know how the medications affect you, use caution when getting up from a sitting or lying position, and do not discontinue any medications without consulting your doctor.
How does the drug interact with Frumide 40 mg/5 mg Tablet:
When Frumide 40 mg/5 mg Tablet is taken with Potassium chloride may increase potassium levels in the blood. (High potassium levels can cause hyperkalemia, which can lead to kidney failure, muscular paralysis, abnormal heart rhythm, and cardiac arrest in extreme cases).

How to manage the interaction:
Although taking Frumide 40 mg/5 mg Tablet and Potassium chloride together may lead to an interaction but can be taken if prescribed by the doctor. However, consult the doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or a slow or irregular heartbeat. It is important to maintain proper fluid intake while taking these medications. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Keep your weight under control with body mass index (BMI) between 19.5 and 24.9.
  • Do regular physical activity or exercise for at least 150 minutes per week, or about 30 minutes most days of the week. Doing this can help you to lower your raised blood pressure by about 5 mm of Hg.
  • Limit sodium chloride intake (table salt) in your daily diet to 2300 mg per day or less than 1500 mg is ideal for most adults.
  • If you are taking alcohol, use only one serving for women and two servings for men.
  • Quit smoking to lower the risk of heart diseases. 
  • Avoid chronic stress as it can raise your blood pressure. Try to enjoy and spent time with your loved ones to cope with stress.
  • Monitor your blood pressure daily and if you notice any fluctuations frequently, please contact your doctor immediately.
  • Try including heart-healthy omega 3 fatty acid-containing foods in your daily diet. You can also use low-fat cooking oils like olive oil, soybean oil, canola oil and coconut oil to lower your elevated blood pressure.

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Therapeutic Class

DIURETIC

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

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FAQs

Frumide 40 mg/5 mg Tablet treats hypertension (high blood pressure) and oedema (fluid retention). Frumide 40 mg/5 mg Tablet consists of diuretic medications: Furosemide and Amiloride. It works by acting on different parts of the kidney to remove extra fluid and certain electrolytes while maintaining the body's potassium balance.

Frumide 40 mg/5 mg Tablet is recommended to use in dose and duration as advised by the doctor. Do not stop taking Frumide 40 mg/5 mg Tablet on your own as it may lead to a sudden rise in blood pressure increasing the risk of heart attack and stroke.

Frumide 40 mg/5 mg Tablet can cause dizziness as one of its side effects. If you feel dizzy, try getting up slowly from a sitting or lying position. If your dizziness is severe or unmanageable, please seek medical advice.

Furosemide in Frumide 40 mg/5 mg Tablet may affect your blood sugar levels. Hence, therapy with loop diuretics should be administered cautiously in patients with diabetes mellitus, glucose intolerance, or a history of hyperglycemia (high glucose levels). Please consult your doctor before taking Frumide 40 mg/5 mg Tablet if you have diabetes.

It is advised to follow a high protein and less fatty diet. Also reduce the intake of table salt in your foods, which plays a significant role in blood pressure and fluid build-up in the body. Furosemide in Frumide 40 mg/5 mg Tablet may reduce the potassium levels in your blood. It is recommended to add potassium-rich foods, such as bananas, orange juice to your diet.

Take the missed dose as soon as possible. However, if it is time for the next dose, skip the missed dose and go back to your regular dosing schedule.

Drug-Drug Interactions Checker List

  • HYDROCHLOROTHIAZIDE
  • FLUTICASONE
  • ALBUTEROL
  • LITHIUM
  • DIGOXIN
  • SOTALOL
  • VALSARTAN
  • RAMIPRIL
  • PREDNISONE
  • IBUPROFEN
  • NAPROXEN
  • MELOXICAM
  • INSULIN GLARGINE
  • TACROLIMUS
  • DROSPIRENONE

Special Advise

  • Monitor your blood pressure regularly and seek medical advice if you notice any drastic fluctuations.
  • Frumide 40 mg/5 mg Tablet may affect patients with hepatic impairment and hence Liver function monitoring and Liver Function Tests are advised to monitor the liver enzyme changes. 
  • Your doctor may advise you to get a regular kidney function test, blood examinations for potassium levels and other electrolytes while using Frumide 40 mg/5 mg Tablet to rule out any renal impairment.

Disease/Condition Glossary

Hypertension: It is a chronic condition when blood pressure is too high. Blood pressure is defined as the amount of blood pumped by the heart and the amount of resistance exerted by the arteries against the blood flow. If the heart pumps more blood, then arteries become narrower and in turn, blood pressure becomes high. If blood pressure becomes uncontrolled, it may lead to serious heart diseases, including stroke and heart attack. Additionally, high blood pressure can also cause brain damage (stroke) and kidney failure. Blood pressure is expressed as systolic and diastolic pressures. Systolic blood pressure represents the contraction and relaxation of the heart. Diastolic pressure is exerted in the blood vessels when the heart beats and is in the resting state. Ideal blood pressure should be between 90/60mmHg and 120/80mmHg. Hypertension is detected when systolic blood pressure is more than 140mmHg and diastolic pressure is higher than 90mmHg. Some of the symptoms of hypertension include headache, nose bleed, vomiting and chest pain. 

Oedema: It is swelling caused by excess fluid trapped in the body's tissues. It can affect any part of the body, preferably more in hands, arms, feet, ankles and legs.

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