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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Sunny S , MBBS

Composition :

LEFLUNOMIDE-0.50MG

Manufacturer/Marketer :

CMG Biotech Pvt Ltd

Consume Type :

Oral

Expires on or after :

Return Policy :

Not Returnable

Therapeutic Class

[ANTIRHEUMATICS]

Country of origin

India

Manufacturer/Marketer address

410, plot no. 4, dda building, swasthya vihar, delhi, 110092
Other Info - GAT0170

Author Details

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FAQs

Gatolef 20 Tablet is a disease-modifying antirheumatic drug (DMARD) which stops DNA (genetic material) of the provoked immune system cells required for its survival. Thereby, helps in treating inflammation, redness, and swelling at the damaged site (especially joint).

Gatolef 20 Tablet may cause diarrhoea. Drink plenty of fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea consult your doctor. Do not take anti-diarrheal medicine on your own.

It might take 4-6 weeks before you notice any benefit. In some cases, it might also take 6 months for you to feel the full effect of Gatolef 20 Tablet. Take Gatolef 20 Tablet for as long as your doctor has prescribed to treat your condition effectually.

Inform your doctor if you have liver disease, kidney disease, weak immune system and serious infections like pneumonia, or tuberculosis (TB).

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Safe if prescribed

You are recommended to avoid alcohol consumption while taking Gatolef 20 Tablet. Alcohol intake, along with Gatolef 20 Tablet, may cause liver disease.

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Pregnancy

Consult your doctor

It is not recommended to take Gatolef 20 Tablet while you are pregnant. Gatolef 20 Tablet may cause serious birth defects.

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Breast Feeding

Consult your doctor

It is not recommended to take Gatolef 20 Tablet while you are breastfeeding. Gatolef 20 Tablet passes into breast milk.

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Driving

Safe if prescribed

Gatolef 20 Tablet may cause dizziness and tiredness; do not drive or operate heavy machinery if you feel dizzy.

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Liver

Consult your doctor

Please consult your doctor if you have liver impairment before taking Gatolef 20 Tablet.

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Kidney

Consult your doctor

Please consult your doctor if you have kidney impairment before taking Gatolef 20 Tablet.

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Children

Safe if prescribed

Gatolef 20 Tablet is not approved for children under the age of 18 years.

About Gatolef 20 Tablet

Gatolef 20 Tablet belongs to the group of medicines called 'anti-rheumatic agents' used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. Rheumatoid arthritis is an auto-immune disease (the body's immune system attacks its tissue) which leads to joint pain and damage. Psoriatic arthritis is a kind of inflammatory arthritis which occurs in patients with psoriasis (red patches of skin with silvery scales). 

Gatolef 20 Tablet contains 'Leflunomide' an isoxazole immunomodulatory agent which works by blocking the formation of genetic material, i.e. DNA required for survival of replicating (dividing) cells of the immune system. As a result, it suppresses the activated immune system to reduce pain, inflammation and swelling. 

Take Gatolef 20 Tablet at the same time every day as prescribed by your doctor. In some cases, Gatolef 20 Tablet may cause common side-effects such as diarrhoea, nausea, stomach pain, indigestion, rash, and hair loss. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Do not take Gatolef 20 Tablet if you are pregnant or planning for pregnancy as Gatolef 20 Tablet may cause serious congenital disabilities. Gatolef 20 Tablet should not be taken by breastfeeding mothers as it passes into breast milk. Gatolef 20 Tablet may cause dizziness, so drive with caution. Avoid consuming alcohol along with Gatolef 20 Tablet as it could lead to increased dizziness and liver damage. Gatolef 20 Tablet may make you more susceptible to infections; consult your doctor if you develop any signs of infections such as fever, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.

Uses of Gatolef 20 Tablet

Rheumatoid arthritis, Psoriatic arthritis

Medicinal Benefits Mweb

Key Benefits

Gatolef 20 Tablet belongs to the group of medicines called anti-rheumatic agents used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. Gatolef 20 Tablet is a disease-modifying antirheumatic drug (DMARDs) which inhibits an enzyme called dihydroorotate dehydrogenase and has antiproliferative activity (suppresses the cell growth). Thereby, helps in treating inflammation, redness, and swelling.

Directions for Use

Take Gatolef 20 Tablet with or without food. Swallow Gatolef 20 Tablet as a whole with water; do not crush or chew it.

Side Effects of Gatolef 20 Tablet

  • Diarrhoea
  • Nausea
  • Stomach pain
  • Indigestion
  • Rash
  • Hair loss

Drug Warnings

Do not take Gatolef 20 Tablet if you are allergic to leflunomide, have severe liverkidney problems, low levels of protein in the blood, immune system problems, bone marrow problems, or serious infections. Gatolef 20 Tablet is not recommended to be used in pregnant women, lactating mothers and people below 18 years of age. Talk to your doctor before taking Gatolef 20 Tablet if you have/had serious infections like interstitial lung disease (inflammation of lungs), tuberculosis (TB), or pneumonia. Gatolef 20 Tablet may cause dizziness, so drive with caution. Gatolef 20 Tablet may make you more susceptible to infections; notify the doctor if you develop infections, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Gatolef 20 Tablet:
Using Gatolef 20 Tablet together with ciclosporin can increase the risk of side effects

How to manage the interaction:
Co-administration of ciclosporin with Gatolef 20 Tablet can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience contact a doctor immediately if you experience symptoms such as serious infection, anemia, bleeding problems, paleness, fatigue, dizziness, bruising, fever, chills, diarrhea, sore throat, muscle aches, or pain during urination. Do not stop using any medications without talking to a doctor.
How does the drug interact with Gatolef 20 Tablet:
Coadministration of Phenytoin and Gatolef 20 Tablet may increase the risk of liver injury.

How to manage the interaction:
Although taking Phenytoin and Gatolef 20 Tablet together can result in an interaction, it can be taken if your doctor has prescribed it. However, if you have any of the following symptoms: fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, fatigue, lack of appetite, nausea, vomiting, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor immediately. Do not discontinue any medication without consulting a doctor.
How does the drug interact with Gatolef 20 Tablet:
Co-administration of divalproex and Gatolef 20 Tablet can increase the risk of liver problems.

How to manage the interaction:
Although there is an interaction between divalproex and Gatolef 20 Tablet, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Gatolef 20 Tablet:
Taking Gatolef 20 Tablet with ramipril can increase the risk of liver problems.

How to manage the interaction:
Although taking Ramipril with Gatolef 20 Tablet can result in an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
LeflunomideBedaquiline
Severe
How does the drug interact with Gatolef 20 Tablet:
Taking bedaquiline with Gatolef 20 Tablet may cause liver problems.

How to manage the interaction:
Although there is an interaction between Gatolef 20 Tablet and Bedaquiline, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
LeflunomideBelinostat
Severe
How does the drug interact with Gatolef 20 Tablet:
Combining Belinostat with Gatolef 20 Tablet can increase the risk of negative side effects.

How to manage the interaction:
Co-administration of Gatolef 20 Tablet with Belinostat can possibly result in an interaction, but it can be taken if your doctor has advised it. If you notice any signs of liver damage, complications, infection, or any other symptoms like fever, chills, diarrhea, sore throat, muscle aches, or shortness of breath, contact your doctor right away. Other symptoms to watch out for include weight loss, pain, joint pain, swelling, bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark-coloured urine, or bleeding. Do not stop using any medications without talking to your doctor.
How does the drug interact with Gatolef 20 Tablet:
Taking Gatolef 20 Tablet with prasterone may increase the risk of liver problems.

How to manage the interaction:
Taking Prasterone with Gatolef 20 Tablet together can result in an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Gatolef 20 Tablet:
When atorvastatin and Gatolef 20 Tablet are taken together it can increase the risk of liver problems.

How to manage the interaction:
Although taking Atorvastatin and Gatolef 20 Tablet together can result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Gatolef 20 Tablet:
Taking Gatolef 20 Tablet with celecoxib affects the liver and may increase the risk of liver problems.

How to manage the interaction:
Although taking celecoxib and Gatolef 20 Tablet together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, weakness, nausea, vomiting, abdominal pain, dark-coloured urine, light-coloured stools, or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Gatolef 20 Tablet:
Coadministration of nicotinamide with Gatolef 20 Tablet can increase the risk or severity of liver problems.

How to manage the interaction:
Although there is an interaction between nicotinamide and Gatolef 20 Tablet, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • IBUPROFEN
  • NAPROXEN
  • ACETAMINOPHEN
  • ASPIRIN
  • DULOXETINE
  • PREDNISONE
  • CELECOXIB
  • AZATHIOPRINE
  • MELOXICAM
  • METHOTREXATE
  • ETANERCEPT
  • ADALIMUMAB
  • ABATACEPT
  • INFLIXIMAB
  • HYDROXYCHLOROQUINE

Habit Forming

No

Special Advise

Regular blood tests to monitor your liver function after starting Gatolef 20 Tablet, and for every 6-8 weeks are advised.

Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep as resting the muscles can help in reducing inflammation and swelling.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Acupuncture, massage and physical therapy may also be helpful.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
  • Avoid smoking and alcohol consumption.

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