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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Hari Kumar , MBBS
48 Hrs returnable
COD available

Online payment accepted

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Whats That

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Composition :

SITAGLIPTIN-100MG

Manufacturer/Marketer :

Eris Life Sciences Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

Therapeutic Class

ANTIDIABETICS

Country of origin

India

Manufacturer/Marketer address

8Th Floor, Commerce House Iv, Prahladnagar, Ahmedabad 380015 Gujarat, India.
Other Info - GLU0835

Author Details

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FAQs

Disclaimer

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Alcohol

Caution

No interaction was found. However, it is advisable not to take or limit alcohol as a precautionary measure.

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Pregnancy

Caution

Glura 100 Tablet is not suggested during pregnancy since there is insufficient evidence on how it may impact a growing infant.

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Breast Feeding

Unsafe

Consult your doctor; there is no substantial research yet on using Glura 100 Tablet in breastfeeding/nursing mothers. Glura 100 Tablet should be used in breastfeeding mothers only if the benefits outweigh the risks.

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Driving

Caution

Glura 100 Tablet should not impair your ability to drive, or operate machinery or tools if your blood sugar levels are stable. When your blood sugar levels drop too low, your concentration suffers. If this occurs, refrain from driving or using equipment or tools until you feel better.

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Liver

Caution

In rare cases, liver enzyme elevations have been reported in the prolonged usage of Glura 100 Tablet . So, if you have or have a history or evidence of any liver-related diseases, please consult the doctor before taking medicine.

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Kidney

Unsafe

Acute renal failure has been reported in the patients taking Glura 100 Tablet . In severe cases, it sometimes requires dialysis. Hence, dosage adjustment can be recommended in patients with moderate or severe kidney disease and patients with kidney failure (ESRD - end-stage renal dialysis).

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Children

Unsafe

The safety and efficacy of Glura 100 Tablet in children have not been established.

About Glura 100 Tablet

Glura 100 Tablet belongs to the class of dipeptidyl peptidase-4 (DPP-4) inhibitors used in treating type 2 diabetes in adults. Glura 100 Tablet is prescribed for the condition of type 2 diabetes when diet and exercise alone cannot control their blood sugar levels. It is the first-line therapy for patients with type 2 diabetes that restores the body's response to insulin. Insulin is the hormone that controls sugar levels in your blood. People with type 2 diabetes either do not produce enough insulin, or the insulin produced cannot perform its function in the body (insulin resistance). Middle-aged or older individuals are most likely to suffer from type 2 diabetes, so it is also known as adult-onset diabetes.

Glura 100 Tablet contains sitagliptin. Glura 100 Tablet work by blocking the action of DPP-4 (an enzyme which destroys the hormone 'Incretin'). The enzyme 'Incretins' helps produce more insulin only when required and reduces blood sugar produced by the liver when not needed.

Glura 100 Tablet should be taken with food or an empty stomach. However, it should be taken at the same time of the day each time for the best results. For better advice, your doctor will decide what dose should be taken, which can change quickly depending on your condition. The most common side effect of Glura 100 Tablet is hypoglycaemia (low blood glucose levels), upper respiratory tract infection, nasopharyngitis (infection of the nose and throat with common cold) and headache.

Glura 100 Tablet should not be used in patients with type 1 diabetes and for treating diabetic ketoacidosis. Glura 100 Tablet should not be stopped even if you feel better without consulting your doctor as the sugar levels change. If you stop taking Glura 100 Tablet abruptly, it may increase your sugar levels which could further increase the risk of eyesight loss (retinopathy), kidney (nephropathy) and nerve damage (neuropathy). Glura 100 Tablet should not be taken if you have severe kidney or liver disease. Please inform your doctor if you have any heart disease or planning to get pregnant or breastfeed. Prolonged intake of Glura 100 Tablet may cause acute pancreatitis (swollen pancreas) and critical kidney problem. Increased risk of hypoglycaemia (low blood sugar level) can occur when Glura 100 Tablet is added to other anti-diabetic agents or insulin therapy. In this case, your doctor may adjust the dose of Glura 100 Tablet . Severe allergic reactions might occur in some patients taking Glura 100 Tablet like anaphylaxis, angioedema (swelling under the skin), and exfoliative skin conditions, including Stevens-Johnson syndrome. The safety and efficacy of Glura 100 Tablet in children under 18 years have not been established, so it should not be given to them. Patients taking digoxin (a heart medicine) with Glura 100 Tablet should be closely monitored as severe drug interaction has been observed.

Uses of Glura 100 Tablet

Type 2 diabetes mellitus

Medicinal Benefits Mweb

Medicinal Benefits

Glura 100 Tablet work by blocking the action of DPP-4 (an enzyme which destroys the hormone ‘Incretin’). The enzyme ‘Incretins’ helps produce more insulin only when required and reduces blood sugar produced by the liver when not needed. Thus, Glura 100 Tablet plays a vital role in controlling blood sugar levels and prevents serious complications of diabetes like eyesight loss (retinopathy), kidney (nephropathy), nerve damage (neuropathy), diabetic foot ulcer and delayed wound healing.

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Side Effects of Glura 100 Tablet

  • Hypoglycaemia (low blood glucose levels)
  • Upper respiratory tract infection
  • Nasopharyngitis (infection of nose and throat with common cold)
  • Headache

Drug Warnings

Tell your doctor before consuming Glura 100 Tablet if you have allergic reactions to sitagliptin, any medications, foods, or any components present in Glura 100 Tablet . Prolonged intake of Glura 100 Tablet may cause acute pancreatitis (swollen pancreas) and critical kidney problem. Increased risk of hypoglycaemia (low blood sugar level) can occur when Glura 100 Tablet is added to other anti-diabetic agents or insulin therapy. In this case, your doctor may adjust the dose of Glura 100 Tablet . Severe allergic reactions might occur in some patients taking Glura 100 Tablet like anaphylaxis, angioedema (swelling under the skin), and exfoliative skin conditions, including Stevens-Johnson syndrome. The safety and efficacy of Glura 100 Tablet in children under 18 years have not been established, so it should not be given to them. Patients taking digoxin (a heart medicine) with Glura 100 Tablet should be closely monitored as severe drug interaction has been observed.

Drug-Drug Interactions

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SitagliptinIvacaftor
Severe

Drug-Drug Interactions

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How does the drug interact with Glura 100 Tablet:
Co-administration of Glura 100 Tablet with Gatifloxacin may sometimes affect blood glucose levels. Both high blood glucose and, less frequently, low blood glucose have been reported.

How to manage the interaction:
Taking Glura 100 Tablet with Gatifloxacin is not recommended as it can lead to a possible interaction, However, it can be taken if advised by the doctor. Consult the prescriber if you experience symptoms such as nervousness, confusion, headache, dizziness, drowsiness, tremors, nausea, hunger, weakness, perspiration, palpitation, rapid heartbeat, increased urination, increased thirst, and increased hunger. Maintaining blood glucose levels is advised. Do not stop using any medications without a doctor's advice.
SitagliptinIvacaftor
Severe
How does the drug interact with Glura 100 Tablet:
When Glura 100 Tablet is taken with Ivacaftor, the amount of Glura 100 Tablet in the blood can go up.

How to manage the interaction:
Taking Glura 100 Tablet with Ivacaftor together can possibly result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
SitagliptinTirzepatide
Moderate
How does the drug interact with Glura 100 Tablet:
As tirzepatide and Glura 100 Tablet both work through similar pathways in the body, it is possible that using them together may result in an increase in side effects.

How to manage the interaction:
It is essential to inform your doctor about all other medications you are taking, including vitamins and herbal supplements. Do not stop using any medications without first talking to your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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SITAGLIPTIN-100MGAcute pancreatitis
Severe
SITAGLIPTIN-100MGChronic kidney disease
Moderate

Drug-Diseases Interactions

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SITAGLIPTIN-100MGAcute pancreatitis
Severe
How does the disease interact with Glura 100 Tablet:
Pancreatitis: Patients using Glura 100 Tablet may cause acute pancreatitis. Use cautiously in patients who have a history of pancreatitis or pancreatic disease are at higher risk. Monitor for pancreatitis symptoms and indications. Discontinue therapy if pancreatitis is suspected.

How to manage the interaction:
Glura 100 Tablet should be used with caution in patients with a history of pancreatitis or pancreatic disease. Patients should be observed for signs and symptoms of pancreatitis during treatment and if pancreatitis is suspected, treatment should be discontinued immediately.
SITAGLIPTIN-100MGChronic kidney disease
Moderate
How does the disease interact with Glura 100 Tablet:
Renal dysfunction: Assess renal function before initiating Glura 100 Tablet therapy. Adjust the dose as per moderate to severe renal insufficiency. Otherwise, observed worsening renal function.

How to manage the interaction:
Dose adjustment may be needed in people with moderate to severe renal insufficiency and end stage renal dysfunction.

Drug-Drug Interactions Checker List

  • BUPROPION
  • CEPHALEXIN
  • CIPROFLOXACIN
  • CIMETIDINE
  • DIGOXIN
  • DOLUTEGRAVIR
  • GLYCOPYRROLATE
  • TOPIRAMATE
  • LAMOTRIGINE
  • RANOLAZINE
  • ALPHA LIPOIC ACID
  • ASPIRIN
  • PROTHIONAMIDE
  • PEGVISOMANT

Habit Forming

No

Diet & Lifestyle Advise

  • Invest at least 150 min of your week in moderate-intensity physical activity or one hour and 15 minutes of high-intensity exercise every week.
  • Losing weight gradually to achieve a healthy body mass index (18.5 to 24.9).
  • Replacing refined carbohydrates-containing foods with whole grain foods and increasing intake of fruits, veggies, and other fibre-enriched foods.
  • Reduce saturated fat intake (or hidden fats) in food like chips, crisps, pastries, biscuits and samosas. Choose omega-3 fatty acid-containing oils for daily cooking. For frying, you can use palm oil, mustard oil, groundnut oil, rice bran oil, and safflower oil.
  • Avoid taking too much stress as it may elevate your blood sugar level. You can adopt stress management techniques like mindfulness to control stress-related blood sugar changes or meditation or yoga.
  • Opt for low-fat dairy products (low-fat yoghurt, fat-free milk and cheese etc.).
  • Keep your blood pressure as normal (140/90) as possible as it reduces the risk of cardiovascular diseases in diabetes patients.

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