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Written By Sureshvarma D , MPharma
Reviewed By Hari Kumar , MBBS
48 Hrs returnable
COD available

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Whats That

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Synonym :

CYCLOSPORIN

Composition :

CICLOSPORIN-50MG

Manufacturer/Marketer :

Intas Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

Therapeutic Class

IMMUNOSUPPRESSANTS

Country of origin

India

Manufacturer/Marketer address

Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.
Other Info - GRA0265

Author Details

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FAQs

Grafotas-50 Capsule acts as an immunosuppressant, which helps in reducing inflammation and prevents joint stiffness, thereby providing relief from rheumatoid arthritis.

If you miss a dose of Grafotas-50 Capsule, take it as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take the scheduled dose. Do not take a double dose to make up for a missed one.

Diarrhoea might be a side-effect of Grafotas-50 Capsule. Drink lots of fluids and eat food rich in fibre if you experience diarrhoea. If you find blood in your stools (tarry stools) or experience excess diarrhoea consult your doctor. Do not take anti-diarrheal medicine on your own.

Yes, using Grafotas-50 Capsule may cause abnormal hair growth, although it does not affect everybody. Consult your doctor if you have any concerns.

Grafotas-50 Capsule is known to decrease the immune system. As a result, it increases your risk of developing cancers, especially of the skin. You should reduce your contact with sunlight and UV light by wearing suitable protective clothing. Sunscreen should be used regularly.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Caution

You are recommended to avoid alcohol consumption while taking Grafotas-50 Capsule. It could lead to increased dizziness and drowsiness.

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Pregnancy

Caution

It is not known whether Grafotas-50 Capsule will harm an unborn baby. Inform your doctor if you are pregnant or plan to become pregnant.

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Breast Feeding

Unsafe

It is not recommended to take Grafotas-50 Capsule while you are breastfeeding. Grafotas-50 Capsule passes into breast milk.

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Driving

Caution

Drive or operate machinery only if you are alert.

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Liver

Caution

Take Grafotas-50 Capsule only if prescribed by the doctor, especially if you are dealing with Liver diseases/conditions, as your doctor may adjust the dose as required.

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Kidney

Caution

Please consult your doctor if you have kidney impairment before taking Grafotas-50 Capsule.

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Children

Unsafe

Grafotas-50 Capsule should not be given to children, as the efficacy and safety have not been established.

About Grafotas-50 Capsule

Grafotas-50 Capsule belongs to the class of medicine called 'immunosuppressant' that helps to reduce the pain/inflammation in rheumatoid arthritis conditions and is also used to treat severe psoriasis. Besides this, it also prevents organ rejection after a kidney, heart, or liver transplant. Rheumatoid arthritis is an autoimmune disease (the body's immune system attacks its tissue) that leads to joint pain and damage. Psoriasis is a long-lasting, inflammatory skin illness. 

Grafotas-50 Capsule contains 'cyclosporine' that works by reducing the function of the cells, causing inflammation, especially in the joint tissues, thereby decreasing pain and inflammation and slowing down the joint damage and disease progression over time. Besides this, after an organ transplant, your body will try to attack the new organ as it sees it as foreign. Grafotas-50 Capsule helps stop your body from rejecting a new organ by suppressing your immune system. 

You are advised to take Grafotas-50 Capsule for as long as your doctor has prescribed it for you, depending on your medical conditions. You may experience headaches, vomiting, nausea, high blood pressure, increased growth of hair, loss of appetite (feeling unwell and upset stomach), kidney disease, and diarrhoea. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

To treat your condition effectually, continue taking Grafotas-50 Capsule for as long as your doctor has prescribed. To avoid recurring symptoms, do not stop it midway. Before taking Grafotas-50 Capsule inform your doctor if you have any allergies, kidney disease, uncontrolled high blood pressure, and any type of cancer. Grafotas-50 Capsule should not be taken by breastfeeding mothers as it passes into breast milk. Inform your doctor about your health condition and medicines to rule out any unpleasant side effects.

Uses of Grafotas-50 Capsule

Rheumatoid arthritis, Immunosuppressant therapy after organ (liver, kidney, and heart) transplant, and psoriasis (a skin disease that causes itchy and dry patches).

Medicinal Benefits Mweb

Medicinal Benefits

Grafotas-50 Capsule belongs to the class of medicine called 'immunosuppressant' that helps to reduce the pain/inflammation in rheumatoid arthritis conditions and is also used to treat severe psoriasis. Besides this, it also prevents organ rejection after a kidney, heart, or liver transplant. Grafotas-50 Capsule contains 'cyclosporine' that works by reducing the function of the cells, causing inflammation, especially in the joint tissues, thereby decreasing pain and inflammation and slowing down the joint damage and disease progression over time. Besides this, after an organ transplant, your body will try to attack the new organ as it sees it as foreign. Grafotas-50 Capsule helps stop your body from rejecting a new organ by suppressing your immune system. 

Directions for Use

Tablet/Capsule: Swallow it as a whole with water; do not crush, break or chew it.Solution/Syrup/Suspension/Drops: Shake the bottle well before use. Take the prescribed dose by mouth using the measuring cup/dosing syringe/dropper provided by the pack.

Side Effects of Grafotas-50 Capsule

  • Headache
  • Vomiting
  • Nausea
  • High blood pressure
  • Increased growth of hair
  • Loss of appetite (feeling unwell and having an upset stomach)
  • Kidney disease
  • Diarrhoea

Drug Warnings

Do not take Grafotas-50 Capsule if you are allergic to any immunosuppressant medicines or Cyclosporine. Let your doctor know if you have liver or kidney problems, high blood pressure, low levels of magnesium, and high levels of potassium. Grafotas-50 Capsule may make you more susceptible to infections; consult your doctor if you develop any signs of severe conditions such as fever, sore throat, breathlessness, jaundice, unexplained bleeding, or bruising. Before taking Grafotas-50 Capsule inform your doctor if you have any type of cancer. Grafotas-50 Capsule should not be taken by breastfeeding mothers as it passes into breast milk. Inform your doctor about your health condition and medicines to rule out any unpleasant side effects.

Drug-Drug Interactions

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CiclosporinPitavastatin
Critical
CiclosporinBosentan
Critical

Drug-Drug Interactions

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CiclosporinPitavastatin
Critical
How does the drug interact with Grafotas-50 Capsule:
Coadministration of pitavastatin with Grafotas-50 Capsule may significantly increase the blood levels of pitavastatin which can increase the risk of side effects such as liver problems and rhabdomyolysis(involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Pitavastatin with Grafotas-50 Capsule is not recommended, as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms like unexpected bruising or bleeding, skin rash, itching, tiredness, nausea, vomiting, yellowing of the skin or eyes, unexplained muscular pain, tenderness, or weakness, fever, dark urine, chills, joint pain, or swelling, consult a doctor. Do not discontinue any medications without a doctor's advice.
CiclosporinBosentan
Critical
How does the drug interact with Grafotas-50 Capsule:
When Bosentan is taken with Cyclosporine, it may increase the risk of side effects.

How to manage the interaction:
Taking Grafotas-50 Capsule with Bosentan is not recommended, but it can be taken if prescribed by the doctor. However, if you experience any symptoms like severe headache, nausea, or an increased heart rate, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
CiclosporinSimvastatin
Critical
How does the drug interact with Grafotas-50 Capsule:
Combining Grafotas-50 Capsule and Simvastatin can increase the blood levels and effects of Simvastatin. This can increase the risk of side effects such as liver damage and rhabdomyolysis(involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Grafotas-50 Capsule and Simvastatin together is not recommended as it can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, weakness, nausea, vomiting, and yellowing of the skin or eyes, contact the doctor immediately. Do not discontinue any medications without consulting your doctor.
CiclosporinBaricitinib
Critical
How does the drug interact with Grafotas-50 Capsule:
Co-administration of Baricitinib with Cyclosporine can increase the risk of infections as well as some cancers.

How to manage the interaction:
Taking Grafotas-50 Capsule with Baricitinib is not recommended as it can cause an interaction, but it can be taken together if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
CiclosporinCidofovir
Critical
How does the drug interact with Grafotas-50 Capsule:
Taking cyclosporine with cidofovir can increase the risk of kidney problems.

How to manage the interaction:
Taking Grafotas-50 Capsule with Cidofovir is not recommended, but can be taken be together if prescribed by a doctor. However, if you experience nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm, contact the doctor immediately. Do not discontinue any medications without consulting a doctor
CiclosporinEverolimus
Severe
How does the drug interact with Grafotas-50 Capsule:
Taking everolimus with cyclosporine may significantly increases the blood levels of everolimus.

How to manage the interaction:
Although taking everolimus and Grafotas-50 Capsule together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience any unusual symptoms contact a doctor immediately. In case you experience any side effects like persistent cough, fever, chills, mouth ulcers, paleness of skin, or unusual bleeding or bruising, or blood in stools or urine, consult a doctor. Do not stop using any medications without talking to a doctor.
CiclosporinVenetoclax
Severe
How does the drug interact with Grafotas-50 Capsule:
Co-administration of venetoclax with Grafotas-50 Capsule may significantly increase the blood levels and effects of venetoclax.

How to manage the interaction:
Although there is a possible interaction between venetoclax and Grafotas-50 Capsule, they can be taken together if your doctor has prescribed them. However, contact your doctor immediately if experience any symptoms such as nausea, paleness, vomiting, diarrhea and weakness. Do not stop using any medications without talking to a doctor.
CiclosporinTriamterene
Severe
How does the drug interact with Grafotas-50 Capsule:
Taking Triamterene with Cyclosporine can increase the risk of hyperkalemia(high levels of potassium in blood).

How to manage the interaction:
Taking Grafotas-50 Capsule with Triamterene together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience slow, fast, or uneven heartbeat, rapid breathing, numbness or tingly feeling, and muscle pain or weakness contact your doctor right away. Do not discontinue any medications without first consulting your doctor.
CiclosporinAmiloride
Severe
How does the drug interact with Grafotas-50 Capsule:
Using Grafotas-50 Capsule with amiloride can result in increased potassium levels in the blood.

How to manage the interaction:
Although taking amiloride and Grafotas-50 Capsule together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult a doctor, if you have symptoms such as a slow, rapid, or irregular heartbeat, rapid breathing, numbness or tingling, or pain in the muscles or weakness. Do not discontinue any medications without a doctor's advice.
CiclosporinItraconazole
Severe
How does the drug interact with Grafotas-50 Capsule:
Taking Grafotas-50 Capsule with itraconazole may significantly raise blood levels of Grafotas-50 Capsule.

How to manage the interaction:
Although there is a interaction between cyclosporine and itraconazole can be used if a doctor prescribes them. However, consult a doctor if you have any of the following symptoms fever, sore throat, unusual bruising or bleeding, increased or reduced urination, nausea, vomiting, diarrhea, stomach discomfort, dizziness, tiredness, headache, shaking, fits, and headache. Never stop taking any medications without talking to a doctor.

Drug-Food Interactions

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CICLOSPORIN-50MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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CICLOSPORIN-50MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Consuming grapefruit and grapefruit juice while taking Grafotas-50 Capsule can increase the effects of Grafotas-50 Capsule. Avoid consuming grapefruit and grapefruit juice while taking Grafotas-50 Capsule.

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • TACROLIMUS
  • AMILORIDE
  • SPIRONOLACTONE
  • ALISKIREN
  • ATORVASTATIN
  • PITAVASTATIN
  • SIMVASTATIN
  • ERYTHROMYCIN
  • AZITHROMYCIN
  • VORICONAZOLE
  • ITRACONAZOLE
  • DILTIAZEM
  • VERAPAMIL
  • DANAZOL
  • ALLOPURINOL
  • COLCHICINE
  • TELAPREVIR

Habit Forming

No

Special Advise

  • Use sunscreen while taking Grafotas-50 Capsule, as it can make your skin more sensitive to sunlight and may cause skin cancer.
  • Long-term use of Grafotas-50 Capsule may increase your risk of developing cancers like blood cancer, skin cancer, and immune system cancer (lymphoma). 

Diet & Lifestyle Advise

  • Physical activity helps strengthen muscles and relieves joint stiffness. Gentle activities like 20-30 minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep, as resting the muscles can help reduce inflammation and swelling.
  • Follow heat or cold therapy, and apply a cold or hot compress on the joints for 15-20 minutes regularly.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath, or listening to soothing music.
  • Acupuncture, massage, and physical therapy may also be helpful.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes, and green tea.
  • Avoid smoking and alcohol consumption.

Grafotas-50 Capsule Substitute

Substitutes safety advice
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    43.20per tablet
  • Cyrin 50mg Capsule

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    49.95per tablet
  • Cyclodac 50 mg Capsule 10's

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    51.60per tablet
  • Cyclodac 50mg Capsule

    by Others

    55.23per tablet
  • Consiral 50 Capsule

    by Others

    46.55per tablet
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