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Grenil Tablet is a combination of drugs namely; Domperidone and Paracetamol. Domperidone is a prokinetic that prevents nausea and vomiting symptoms by blocking certain receptors (like dopamine and serotonin) that stimulate the vomiting centre (chemoreceptor trigger zone - CTZ) located in the brain. It also acts as a prokinetic agent that increases the upper gastrointestinal tract's motility and helps in decreasing the stomach emptying time. Paracetamol is an NSAID that works by blocking the effect of a chemical messenger in your body, known as cyclo-oxygenase (COX) enzymes that make another chemical ‘prostaglandins’(PG). These prostaglandins are produced at injury sites and cause pain and swelling. By blocking the effect of COX enzymes, lesser PGs are produced, which reduces mild to moderate pain and inflammation at the injured or damaged site. Together, used to prevent nausea, vomiting, pain, and fever associated with migraine.
Talk to your doctor if you do not feel better even after taking Grenil Tablet for 14 days. Do not take Grenil Tablet for longer durations unless prescribed by the doctor.
If you or someone else have taken too much of Grenil Tablet , contact your doctor or nearest hospital casualty department.
It is best to avoid alcohol while taking Grenil Tablet as it can make damage to your liver.
Yes, Grenil Tablet can cause dry mouth. In case you feel excessively thirsty, please increase your fluid intake and do frequent mouth rinses.
Alcohol
Caution
Alcohol consumption with Grenil Tablet may cause sleepiness or an irregular heartbeat.
Pregnancy
Caution
The safety of pregnant women is unknown. Therefore, it is given to pregnant women only if the doctor thinks the benefits outweigh the risks.
Breast Feeding
Caution
Grenil Tablet is not usually recommended when breastfeeding, as it passes into breast milk in a small amount. Therefore, it is given to breastfeeding women only if the doctor thinks the benefits outweigh the risks.
Driving
Caution
Drive and operate machinery only if you are alert.
Liver
Caution
Grenil Tablet to be taken with caution, especially if you have had a history of liver disease/condition. The dose may have to be adjusted by your doctor.
Kidney
Caution
Grenil Tablet to be taken with caution, especially if you have had a history of kidney disease/condition. The dose may have to be adjusted by your doctor.
Children
Caution
Grenil Tablet should not be given to children below 5 years of age. Please consult your doctor. Your doctor will weigh the benefits and any potential risks before prescribing it to children.
About Grenil Tablet
Grenil Tablet is a combination medicine used for the symptomatic treatment of migraine, and any medical condition with concomitant nausea/vomiting and fever/pain. Migraine is a neurological condition that can cause severe throbbing pain or a pulsing sensation, usually on one side of the head, eyes, face, and neck. Symptoms may include nausea, vomiting, difficulty speaking, numbness or tingling, and sensitivity to light and sound.
Grenil Tablet is a combination of two drugs, namely: Domperidone and Paracetamol. Domperidone prevents nausea and vomiting symptoms by blocking certain receptors (like dopamine and serotonin) that stimulate the vomiting centre (chemoreceptor trigger zone –CTZ) located in the brain. It also acts as a prokinetic agent that increases the upper gastrointestinal tract's motility and helps in decreasing the stomach emptying time. Paracetamol is an NSAID that works by blocking the effect of a chemical messenger in your body, known as cyclo-oxygenase (COX) enzymes that make another chemical ‘prostaglandins’(PG). These prostaglandins are produced at injury sites and cause pain and swelling. By blocking the effect of COX enzymes, lesser PGs are produced, which reduces mild to moderate pain and inflammation at the injured or damaged site.
Take Grenil Tablet as prescribed. Your doctor will recommend how often you take Grenil Tablet based on your medical condition. Some people may experience some side effects, dry mouth, skin rash, anxiety, diarrhoea, and drowsiness. Most of these side effects of Grenil Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
You can increase the efficacy of Grenil Tablet by taking a small meal or snacks frequently. Do not take Grenil Tablet if you are allergic to Grenil Tablet and other medicines. If you are pregnant or breastfeeding, it is advised to inform your doctor before taking Grenil Tablet . Inform your doctor if you have heart, kidney, and liver disease. Prolonged intake of Grenil Tablet may be associated with an increased risk of heart rhythm disorder (arrhythmia) and cardiac arrest (heart attack). This risk may be more likely in the elderly (those over 60 years old) or taking a higher dose. If you experience heart rhythm disorders like palpitations, trouble in breathing, or loss of consciousness after taking Grenil Tablet , immediately contact your doctor.
Uses of Grenil Tablet
Medicinal Benefits
Grenil Tablet is a combination of two drugs namely; Domperidone and Paracetamol used to treat the vomiting and pain in people with migraines. Domperidone belongs to a class of prokinetic agents that prevents nausea and vomiting symptoms by blocking certain receptors (like dopamine and serotonin) that stimulate the vomiting center (chemoreceptor trigger zone –CTZ) located in the brain. It also acts as a prokinetic agent that increases the upper gastrointestinal tract's motility and helps in decreasing the stomach emptying time. Paracetamol is an NSAID that works by blocking the effect of a chemical messenger in your body, known as cyclo-oxygenase (COX) enzymes that make another chemical ‘prostaglandins’(PG). These prostaglandins are produced at injury sites and cause pain and swelling. By blocking the effect of COX enzymes, lesser PGs are produced, which reduces mild to moderate pain and inflammation at the injured or damaged site. Grenil Tablet together used to prevent nausea, vomiting, pain, and fever associated with migraine.
Directions for Use
Side Effects of Grenil Tablet
Drug Warnings
Do not take Grenil Tablet if you are allergic to any of its contents or any other medicines, have a history of gastrointestinal bleeding, heart disease, liver/ kidney problem. Prolonged intake of Grenil Tablet may be associated with an increased risk of heart rhythm disorder (arrhythmia) and cardiac arrest (heart attack). So, if you experience heart rhythm disorders like palpitations, trouble in breathing, or loss of consciousness after taking Grenil Tablet , immediately contact your doctor. This risk may be more likely in the elderly (those over 60 years old) or taking a higher dose. If you are pregnant or breastfeeding, inform your doctor before using Grenil Tablet . Avoid consumption of alcohol while using Grenil Tablet as it may increase the side effects and make worse your condition. Grenil Tablet should not be given to children below five years of age. The use of Grenil Tablet is safe in children above five years of age if prescribed by the doctor. Do not exceed dose paracetamol more than 4 gm per day as it can damage your liver.
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