Higranil Tablet is a combination medicine used for the symptomatic treatment of migraine, and any medical condition with concomitant nausea/vomiting and fever/pain. Migraine is a neurological condition that can cause severe throbbing pain or a pulsing sensation, usually on one side of the head, eyes, face, and neck. Symptoms may include nausea, vomiting, difficulty speaking, numbness or tingling, and sensitivity to light and sound.

Higranil Tablet is a combination of two drugs, namely: Domperidone and Paracetamol. Domperidone prevents nausea and vomiting symptoms by blocking certain receptors (like dopamine and serotonin) that stimulate the vomiting centre (chemoreceptor trigger zone –CTZ) located in the brain. It also acts as a prokinetic agent that increases the upper gastrointestinal tract's motility and helps in decreasing the stomach emptying time. Paracetamol is an NSAID that works by blocking the effect of a chemical messenger in your body, known as cyclo-oxygenase (COX) enzymes that make another chemical ‘prostaglandins’(PG). These prostaglandins are produced at injury sites and cause pain and swelling. By blocking the effect of COX enzymes, lesser PGs are produced, which reduces mild to moderate pain and inflammation at the injured or damaged site.

Take Higranil Tablet as prescribed. Your doctor will recommend how often you take Higranil Tablet based on your medical condition. Some people may experience some side effects, dry mouth, skin rash, anxiety, diarrhoea, and drowsiness. Most of these side effects of Higranil Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

You can increase the efficacy of Higranil Tablet by taking a small meal or snacks frequently. Do not take Higranil Tablet if you are allergic to Higranil Tablet and other medicines. If you are pregnant or breastfeeding, it is advised to inform your doctor before taking Higranil Tablet. Inform your doctor if you have heart, kidney, and liver disease. Prolonged intake of Higranil Tablet may be associated with an increased risk of heart rhythm disorder (arrhythmia) and cardiac arrest (heart attack). This risk may be more likely in the elderly (those over 60 years old) or taking a higher dose. If you experience heart rhythm disorders like palpitations, trouble in breathing, or loss of consciousness after taking Higranil Tablet, immediately contact your doctor.

Higranil Tablet is a combination of two drugs namely; Domperidone and Paracetamol used to treat the vomiting and pain in people with migraines. Domperidone belongs to a class of prokinetic agents that prevents nausea and vomiting symptoms by blocking certain receptors (like dopamine and serotonin) that stimulate the vomiting center (chemoreceptor trigger zone –CTZ) located in the brain. It also acts as a prokinetic agent that increases the upper gastrointestinal tract's motility and helps in decreasing the stomach emptying time. Paracetamol is an NSAID that works by blocking the effect of a chemical messenger in your body, known as cyclo-oxygenase (COX) enzymes that make another chemical ‘prostaglandins’(PG). These prostaglandins are produced at injury sites and cause pain and swelling. By blocking the effect of COX enzymes, lesser PGs are produced, which reduces mild to moderate pain and inflammation at the injured or damaged site. Higranil Tablet together used to prevent nausea, vomiting, pain, and fever associated with migraine.

Do not take Higranil Tablet if you are allergic to any of its contents or any other medicines, have a history of gastrointestinal bleeding, heart disease, liver/ kidney problem. Prolonged intake of Higranil Tablet may be associated with an increased risk of heart rhythm disorder (arrhythmia) and cardiac arrest (heart attack). So, if you experience heart rhythm disorders like palpitations, trouble in breathing, or loss of consciousness after taking Higranil Tablet, immediately contact your doctor. This risk may be more likely in the elderly (those over 60 years old) or taking a higher dose. If you are pregnant or breastfeeding, inform your doctor before using Higranil Tablet. Avoid consumption of alcohol while using Higranil Tablet as it may increase the side effects and make worse your condition. Higranil Tablet should not be given to children below five years of age. The use of Higranil Tablet is safe in children above five years of age if prescribed by the doctor. Do not exceed dose paracetamol more than 4 gm per day as it can damage your liver.

• Prolonged intake of Higranil Tablet can increase the risk of cardiac arrhythmia (irregular heartbeat), so close monitoring of heartbeat is required.