Ibupyrin 400 mg/333 mg Tablet belongs to a class of painkillers called non-steroidal anti-inflammatory drugs (NSAIDs). It relieves symptoms of muscle pain, arthritis pain, dysmenorrhea (painful periods or menstrual cramps), and dental pain and reduces fever. Pain can be temporary (acute) or long-lasting (chronic). Acute pain is for a short time caused by damage to the tissues of the muscle, bone, or other organs. In contrast, chronic pain lasts for a long duration and is caused due to pathologies like nerve damage, osteoarthritis etc. Besides this, it is also useful for dental pain, which can occur due to damage to the tooth nerve, infection, decay, extraction or injury.

Ibupyrin 400 mg/333 mg Tablet is composed of two medicines, namely Ibuprofen and Paracetamol. Ibuprofen is known to have an analgesic and anti-inflammatory effect for reducing mild to moderate pain. It works by blocking the effect of a chemical known as prostaglandin, responsible for inducing pain and inflammation in our body. Paracetamol acts as a mild analgesic and antipyretic (fever reducer). It lowers the elevated body temperature and mild pain by inhibiting the synthesis of a chemical messenger (prostaglandin) and promoting heat loss (through sweating) that helps reset the hypothalamic thermostat. Together, these two medicines help reduce mild to moderate pain in a shorter duration.

Ibupyrin 400 mg/333 mg Tablet is available in both oral tablet and syrup dosage forms. You should take the syrup form of Ibupyrin 400 mg/333 mg Tablet with food or as your doctor advises. The tablet form of Ibupyrin 400 mg/333 mg Tablet should be swallowed whole with a glass of water. Do not crush, chew or break it. Do not take Ibupyrin 400 mg/333 mg Tablet if your pain lasts more than ten days or your fever lasts more than three days. Do not take a double dose if you missed one dose. Like all medicines, Ibupyrin 400 mg/333 mg Tablet may cause side effects, although not everybody gets them. Stop taking this medicine if you experience symptoms like the tightness of the chest, breathing difficulties, fever, skin rashes, increased heart rate and or in case of any signs of hypersensitivity.

Do not take Ibupyrin 400 mg/333 mg Tablet if you are allergic to painkillers like aspirin, ibuprofen, naproxen, or diclofenac. It is not recommended for use in children, people with liver disease, heart disease or gastric ulcers/bleeding problems. Ibupyrin 400 mg/333 mg Tablet may be associated with a small increase in the risk of heart attack (myocardial infarction). Avoid consumption of alcohol as it may damage your liver and cause increased side effects on taking this drug. Consult your doctor if your pain, inflammation, and fever symptoms do not disappear even after ten days.

Ibupyrin 400 mg/333 mg Tablet comprises Ibuprofen and Paracetamol primarily used to treat mild to moderate pain. Ibupyrin 400 mg/333 mg Tablet is prescribed mainly to treat pain and relieve discomfort caused by conditions like tooth pain, arthritis, period pain and other types of short-term pains. It helps treat pain by blocking the chemical messenger (prostaglandin) in the brain responsible for causing pain. Ibuprofen works by blocking the effect of a chemical known as prostaglandin, responsible for inducing pain and inflammation in our body. On the other hand, Paracetamol lowers the elevated body temperature and mild pain by inhibiting the synthesis of prostaglandin by promoting heat loss (through sweating) that helps reset the hypothalamic thermostat. Paracetamol has the advantage of producing less gastric irritation than other painkillers like aspirin.

Caution is advised in people with underlying sensitivity to aspirin and other pain killers. Ibupyrin 400 mg/333 mg Tablet is contraindicated in children below 12 years of age under 40 kg of weight. If treatment is required for more than three days, consult your doctor. Ibupyrin 400 mg/333 mg Tablet should be taken with caution if you have an allergy to paracetamol, ibuprofen, aspirin, or other pain killers, highly sensitive reactions (asthma, lip/face/throat swelling), existing stomach ulcer or bleeding associated pain killers, blood clotting disorder, heart diseases (like congestive heart failure), kidney disease, peptic ulcer, another active bleeding (like brain stroke bleeding), and severe dehydration (due to vomiting, diarrhoea). Liver damage might occur if taken for a longer duration as it contains paracetamol. The skin should be closely monitored as skin allergic reactions like Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) have been reported with Ibupyrin 400 mg/333 mg Tablet. Blood pressure and cardiovascular (heart) status should be monitored closely during the treatment with Ibupyrin 400 mg/333 mg Tablet, especially in people affected with high blood pressure and who have a history of heart failure.

• Let your doctor know if you are suffering from stomach ulcers as the Ibupyrin 400 mg/333 mg Tablet may enhance the same.