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  1. Home
  2. Medicine

  3. Inemplus Injection

Not for online sale
Inemplus Injection, Pack of 1 Injection
48 Hrs returnable
Know More
COD available

Online payment accepted

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Whats That

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Composition :

CILASTATIN-500MG + IMIPENEM-500MG

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

Therapeutic Class

ANTIBIOTICS

Country of origin

India

Manufacturer/Marketer address

Dr Dadabhai Naoroji Rd, Kala Ghoda, Fort, Mumbai, Maharashtra 400001
Other Info - IN20017

Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Hari Kumar

Reviewed By

Hari Kumar

MBBS

Last Updated

Jul 8, 2025 | 9:38 AM IST

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FAQs

Inemplus Injection is a combination of two drugs, namely: Cilastatin and Imipenem. Cilastatin inhibits the dehydropeptidase enzyme, which causes the breakdown of Imipenem, thereby helps imipenem to stay active for a longer duration. Imipenem prevents the formation of the bacterial protective covering, which is necessary for the survival of the bacteria. Together, Inemplus Injection helps to treat bacterial infections.

Diarrhoea might be a side-effect of Inemplus Injection. Drink lots of fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience prolonged diarrhoea with abdominal pain, consult your doctor. Do not take anti-diarrheal medicine on your own.

Concomitant administration of Probenecid (used to treat gout and hyperuricemia) along with Inemplus Injection is not recommended as it might result in an increase of plasma levels and half-life of Imipenem.

Ganciclovir (anti-viral) should not be co-administered along with Inemplus Injection unless benefits outweigh the risks as generalised seizures have been reported when taken together.

Inemplus Injection may cause changes in urine colour and amount of urine. Do not worry and consult your doctor if you have any concerns regarding this.

Inemplus Injection may rarely cause thrush or candidiasis, which is a fungal infection occurring due to the overgrowth of yeast-like fungus in the mouth or throat. Regularly rinse your mouth with water to prevent the growth of fungus.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Caution

Avoid alcohol consumption as it might cause increased dizziness and sleepiness.

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Pregnancy

Caution

Please consult your doctor if you are pregnant or planning for pregnancy. Your doctor will prescribe Inemplus Injection only if the benefits outweigh the risks.

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Breast Feeding

Caution

Inemplus Injection may pass into breast milk. Please consult your doctor if you are breastfeeding; your doctor will decide if Inemplus Injection can be given to breastfeeding mothers or not.

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Driving

Caution

Inemplus Injection may cause dizziness and sleepiness. Avoid driving or operating machinery unless you are alert.

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Liver

Caution

Dose adjustment may be needed. Please consult your doctor if you have liver impairment/liver disease.

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Kidney

Caution

Dose adjustment may be needed. Please consult your doctor if you have any concerns regarding this or if you have kidney impairment/kidney disease.

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Children

Caution

Inemplus Injection should not be given to children below one year or those who weigh below 30kg with kidney problems. Inemplus Injection is not recommended in paediatric patients with CNS infections due to the risk of seizures.

Product Substitutes

Reference

  1. https://www.medicines.org.uk/emc/files/pil.1515.pdf
  2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/050587s074lbl.pdf
  3. https://www.drugs.com/mtm/imipenem-and-cilastatin.html

About Inemplus Injection

Inemplus Injection is used to treat severe bacterial infections of the lungs, heart, bladder, skin, kidneys, bones, joints, blood, stomach and female reproductive organs. Inemplus Injection may also be used in the management of patients with low white blood cell count who have a fever, which is suspected to be due to bacterial infection. Bacterial infections are caused due to the multiplication of harmful bacteria inside or on the body. Inemplus Injection does not work against infections caused by the virus, including cold and flu. 
 
Inemplus Injection is a combination of two drugs, namely: Cilastatin (dehydropeptidase inhibitor) and Imipenem (antibacterial). Cilastatin inhibits the dehydropeptidase enzyme, which causes the breakdown of Imipenem, thereby helps imipenem to stay active for a longer duration. Imipenem prevents the formation of the bacterial protective covering, which is necessary for the survival of the bacteria. Together, Inemplus Injection helps to treat bacterial infections.
 
Inemplus Injection will be administered by a healthcare professional; do not self-administer. In some cases, Inemplus Injection may cause common side effects such as nausea, vomiting, diarrhoea, swelling, and redness at the site of injection. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
 
Consult your doctor if you are pregnant or breastfeeding. Inemplus Injection may cause dizziness, so drive with caution. Avoid alcohol consumption as it might cause increased dizziness and sleepiness. Inemplus Injection should not be given to children below one year or those who weigh below 30kg with kidney problems. Inemplus Injection is not recommended in paediatric patients with CNS infections due to the risk of seizures. Keep your doctor informed about your health condition and medications to rule out any unpleasant side effects.

Uses of Inemplus Injection

Severe bacterial infections

Medicinal Benefits Mweb

Medicinal Benefits

Inemplus Injection is a combination of two drugs, namely: Cilastatin (dehydropeptidase inhibitor) and Imipenem (antibacterial). Inemplus Injection is used to treat severe bacterial infections of the lungs, heart, bladder, skin, kidneys, bones, joints, blood, stomach, and female reproductive organs. Inemplus Injection may also be used in the management of patients with low white blood cell count who have a fever, which is suspected to be due to bacterial infection. Cilastatin inhibits the dehydropeptidase enzyme, which causes the breakdown of Imipenem, thereby helps imipenem to stay active for a longer duration. Imipenem prevents the formation of the bacterial protective covering, which is necessary for the survival of the bacteria. Together, Inemplus Injection helps to treat bacterial infections. Imipenem is a broad-spectrum antibiotic that is effective against a wide range of aerobic and anaerobic bacteria.

Directions for Use

Inemplus Injection will be administered by a healthcare professional; do not self-administer.

Side Effects of Inemplus Injection

  • Nausea
  • Vomiting
  • Diarrhoea
  • Swelling
  • Redness at the site of injection

Drug Warnings

Do not take Inemplus Injection if you are allergic to any of its components. Inform your doctor if you have an allergy to antibiotics, colitis, gastrointestinal disease, urinary/kidney problems, CNS disorders, seizures/fits, or liver problems. Consult your doctor if you are pregnant or breastfeeding. Avoid alcohol consumption as it might cause increased dizziness and sleepiness. Inemplus Injection should not be given to children below one year or those who weigh below 30kg with kidney problems. Inemplus Injection is not recommended in paediatric patients with CNS infections due to the risk of seizures. Inemplus Injection may cause dizziness and sleepiness, so drive with caution.

Drug-Drug Interactions

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No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • GANCICLOVIR
  • PROBENECID
  • VALPROIC ACID
  • DIVALPROEX SODIUM
  • WARFARIN

Habit Forming

No

Special Advise

  • Inemplus Injection may cause abnormal Coombs, liver, blood, and kidney function tests. Inform the person doing the tests that you are on treatment with Inemplus Injection. 

Diet & Lifestyle Advise

  • Antibiotics can alter the useful bacteria in the stomach, which help in digestion. Therefore, you are advised to take foods rich in probiotics such as yoghurt/curd, kefir, buttermilk, natto and cheese.
  • Eat fibre-rich food like whole grains, beans, lentils, berries, broccoli, peas and bananas.
  • Avoid foods rich in calcium, grapefruit and grapefruit juice as they might hinder the absorption of antibiotics.
  • Avoid/limit the consumption of alcohol and usage of tobacco.

Inemplus Injection Substitute

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