CEFUROXIME-1500MGOther gastroenteritis and colitis of infectious and unspecified origin
How does the disease interact with Injection 1500mg NU Roxim:
Colitis: In some cases the use of Injection 1500mg NU Roxim may cause ranging from mild diarrhea to fatal colitis. Colitis is commonly Clostridioides difficile-associated diarrhea (CDAD). Discontinue therapy if signs of CDAD are confirmed.
How to manage the interaction:
Antibiotics may cause Clostridioides difficile-associated diarrhoea (CDAD), which may range from mild diarrhoea to fatal colitis. Injection 1500mg NU Roxim should be used with caution in patients with a history of gastrointestinal disease, particularly colitis (inflammation of the colon) or pseudomembranous colitis (a severe inflammation of the inner lining of the large intestine). Appropriate fluid and electrolyte management, protein supplementation, antibacterial treatment of C difficile, and surgical evaluation is advised.
CEFUROXIME-1500MGChronic kidney disease
How does the disease interact with Injection 1500mg NU Roxim:
Renal dysfunction:
Injection 1500mg NU Roxim is eliminated by the kidney in an unchanged form. Thus the plasma levels of the drug increase and prolongs the half-life. Adjust the doses of Injection 1500mg NU Roxim as necessary.
How to manage the interaction:
The serum concentration may be increased in patients with impaired kidney function as most beta-lactam antibiotics are eliminated by the kidney. Dose adjustment may be necessary for patients with kidney dysfunction. Regular renal function tests are advised during prolonged or high-dose therapy.
CEFUROXIME-1500MGDependence on enabling machines and devices, not elsewhere classified
How does the disease interact with Injection 1500mg NU Roxim:
Dialysis : Most of the antibiotics are eliminated by hemodialysis. Therefore, administer Injection 1500mg NU Roxim after dialysis or an additional dosage to be administered.
How to manage the interaction:
Injection 1500mg NU Roxim serum levels may be decreased by hemodialysis and peritoneal dialysis. Supplemental doses should be given at the end of each hemodialysis session.
CEFUROXIME-1500MGConvulsions, not elsewhere classified
How does the disease interact with Injection 1500mg NU Roxim:
seizure disorders:
In some patients, seizures were reported with whom renal dysfunction which incase of dosage adjustment was not done. Discontinue Injection 1500mg NU Roxim if seizures are reported.
How to manage the interaction:
Cephalosporin antibiotics may trigger seizures. Injection 1500mg NU Roxim should be discontinued if seizures associated with drug therapy occur.
CEFUROXIME-1500MGOther diseases of liver
How does the disease interact with Injection 1500mg NU Roxim:
liver disease: With Injection 1500mg NU Roxim, a transient increase in the AST, ALT, and alkaline phosphatase levels was observed. Use with caution and closely monitor for hepatic function is recommended.
How to manage the interaction:
Caution and monitoring is recommended in patients with liver disease as cases of hepatitis have been reported with the use of certain cephalosporins.
CEFUROXIME-1500MGOther diseases of liver
How does the disease interact with Injection 1500mg NU Roxim:
Rarely, cephalosporins use may cause hypoprothrombinemia, with or without bleeding. Monitor for Prothrombin time.
How to manage the interaction:
Cephalosporins may be associated with reduced prothrombin activity/prolonged prothrombin time (blood takes too long to form a clot). Prothrombin time should be monitored in at-risk patients and managed as needed.