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  3. IRINOTEL 100MG INJECTION

Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
48 Hrs returnable
COD available

Online payment accepted

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Whats That

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Synonym :

IRINOTECAN HYDROCHLORIDE

Composition :

IRINOTECAN-100MG

Manufacturer/Marketer :

Fresenius Kabi Oncology Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

Therapeutic Class

CHEMOTHERAPY

Country of origin

INDIA

Manufacturer/Marketer address

Fresenius Kabi AG? , Else-Kröner-Straße 1 ? , 61352 Bad Homburg , Germany
Other Info - IRI0004

FAQs

IRINOTEL 100MG INJECTION contains Irinotecan works by blocking an enzyme called topoisomerase I. All cells need this enzyme to divide and grow. Irinotecan blocks this enzyme so the cancer cells can't divide. As a result, Irinotecan inhibits cancer cell division and growth.

IRINOTEL 100MG INJECTION should not be used in patients with pulmonary diseases. So, inform your doctor if you have pulmonary disorders (lung problems).

While taking IRINOTEL 100MG INJECTION, make sure you visit your doctor at all the appointments to ensure that treatment works. Regular monitoring of blood and lipid tests and weight checks are required. An effective way of contraception should be used by both men and women while taking the IRINOTEL 100MG INJECTION.

The live vaccine may not work while on treatment with IRINOTEL 100MG INJECTION. Only have immunizations/vaccinations after talking to your doctor first. Also, avoid contact with people who recently had immunizations /vaccinations.

Irinotecan therapy may lead to Neutropenia (an unusually low number of neutrophil cells). Your doctor will order laboratory testing on a regular basis before and during your treatment.

You should know that this medicine may reduce fertility in both men and women. Discuss the risks of taking an irinotecan injection with your doctor.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Caution

Avoid alcohol consumption while on treatment with IRINOTEL 100MG INJECTION.

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Pregnancy

Unsafe

IRINOTEL 100MG INJECTION should not be used during pregnancy. So, inform your doctor if you are pregnant or suspect pregnancy. You or your partner must use a reliable form of contraception to prevent pregnancy while taking these medications.

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Breast Feeding

Unsafe

IRINOTEL 100MG INJECTION should not be used in breastfeeding. Discuss with your doctor if you have any concerns.

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Driving

Caution

IRINOTEL 100MG INJECTION can make you dizzy or impair your vision, especially in the first 24 hours after taking it. Do not drive or operate machinery until you know how this drug affects you.

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Liver

Caution

IRINOTEL 100MG INJECTION should be used with caution if you have liver disease. Inform your doctor before receiving the IRINOTEL 100MG INJECTION if you have had a liver impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

It is not recommended for use in patients on dialysis. Inform your doctor before receiving the IRINOTEL 100MG INJECTION if you have had a kidney impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Caution

Safety and effectiveness in children have not been established. Hence, use is not recommended.

About IRINOTEL 100MG INJECTION

IRINOTEL 100MG INJECTION belongs to a class of antineoplastic medications or chemotherapy drugs primarily used to manage or treat Colorectal cancer (Cancer that develops in the colon or rectal tissue). Colorectal cancer is a disease in which cells in the colon or rectum grow out of control.

IRINOTEL 100MG INJECTION contains Irinotecan works by blocking an enzyme called topoisomerase I. All cells need this enzyme to divide and grow. Irinotecan blocks this enzyme so the cancer cells can not divide. As a result, Irinotecan inhibits cancer cell division and growth.

IRINOTEL 100MG INJECTION should be administered to patients only in a hospital setting under the supervision of a physician qualified by training and experience to administer cancer chemotherapeutic agents. The most common adverse reactions are nausea, vomiting, abdominal pain, diarrhoea, constipation, anorexia (an eating disorder), Neutropenia (an unusually low number of cells called neutrophils), leukopenia (including lymphocytopenia), anaemia (not having enough healthy red blood cells), asthenia (abnormal weakness), fever, weight loss, alopecia (hair loss). You should talk to your doctor if you persistently experience these side effects.

Avoid using IRINOTEL 100MG INJECTION if you are allergic to it. IRINOTEL 100MG INJECTION can cause fetal harm when administered to a pregnant woman. It is critical not to become pregnant or get pregnant while undergoing therapy and for several months after the treatment. Using effective contraceptive methods is recommended while on treatment with IRINOTEL 100MG INJECTION. Contact your doctor immediately if you or your partner becomes pregnant while undergoing therapy. Breastfeeding is usually not advised during this treatment since it is unknown whether this medication passes into breast milk. Alcohol should be avoided during treatment with this medicine. Safety and effectiveness in children have not been established.

Uses of IRINOTEL 100MG INJECTION

Colorectal cancer

Medicinal Benefits Mweb

Medicinal Benefits

IRINOTEL 100MG INJECTION is an antineoplastic medicine or chemotherapeutic treatment used to control or treat colorectal cancer (colon or rectal cancer). IRINOTEL 100MG INJECTION contains Irinotecan acts by inhibiting an enzyme known as topoisomerase I. This enzyme is required for all cells to divide and flourish. Irinotecan inhibits this enzyme, preventing cancer cells from dividing. As a result, Irinotecan inhibits cancer cell division and growth.

Directions for Use

IRINOTEL 100MG INJECTION should be administered in a hospital setting under the supervision of a physician qualified by training and experience to administer cancer chemotherapeutic agents.

Side Effects of IRINOTEL 100MG INJECTION

  • Nausea
  • Vomiting
  • Abdominal pain
  • Diarrhoea
  • Watery eyes
  • Dizziness
  • Sweating
  • Runny nose
  • Increased saliva
  • Shrinking pupils (black circles in the middle of the eyes)
  • Constipation
  • Anorexia (an eating disorder)
  • Neutropenia (an unusually low number of cells called neutrophils)
  • Leukopenia (including lymphocytopenia)
  • Anaemia (not having enough healthy red blood cells)
  • Asthenia (abnormal weakness)
  • Fever
  • Weight loss
  • Alopecia (hair loss)

Drug Warnings

Before taking the IRINOTEL 100MG INJECTION, let your doctor know about all your medical conditions, sensitivities, and medications you are using. Also, inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Before and during your therapy, your doctor will prescribe laboratory testing on a regular basis. You may also suffer severe diarrhoea (known as ''late diarrhoea'') more than 24 hours after receiving Irinotecan. Your doctor would advise you to take antidiarrheal drugs at regular intervals throughout the day and night. When taking antidiarrheal drugs, always follow your doctor's instructions. During your therapy, your doctor will also inform you which foods to take and which to avoid to reduce diarrhoea. Drink plenty of fluids and strictly adhere to this diet.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Irinotel 100mg Injection:
Using Irinotel 100mg Injection together with ketoconazole can increase the risk of side effects.

How to manage the interaction:
Taking Ketoconazole with Irinotel 100mg Injection is not recommended as it can cause an interaction, but it can be taken if prescribed by the doctor. However, if you experience any symptoms such as paleness, fatigue, dizziness, fainting, unexpected bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, breathing difficulty, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, consult the doctor immediately.
How does the drug interact with Irinotel 100mg Injection:
Taking Irinotel 100mg Injection with Baricitinib can increase the risk of developing serious infections.

How to manage the interaction:
There may be a possibility of interaction between Irinotel 100mg Injection and Baricitinib, but it can be taken if prescribed by a doctor. However, consult a doctor if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate. Do not stop using any medications without a doctor's advice.
How does the drug interact with Irinotel 100mg Injection:
Co-administration of Irinotel 100mg Injection with Clozapine can increase the risk of neutropenia (low white blood count).

How to manage the interaction:
There may be a possibility of interaction between Irinotel 100mg Injection and Clozapine, but it can be taken if prescribed by a doctor. If you experience any symptoms such as fever, chills, diarrhea, sore throat, muscle aches, breathing difficulty, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, it is important to contact a doctor right away. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Irinotel 100mg Injection:
Combining Cladribine with Irinotel 100mg Injection can increase the risk of developing serious infections.

How to manage the interaction:
Although taking Irinotel 100mg Injection and Cladribine together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Irinotel 100mg Injection:
Irinotel 100mg Injection blood levels may be significantly raised by combining itraconazole and Irinotel 100mg Injection.

How to manage the interaction:
Although there is a possible interaction between Irinotel 100mg Injection and Itraconazole, they can be taken in case a doctor prescribes it. Consult a doctor if you notice any of the following symptoms: paleness, tiredness, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhoea, sore throat, aches in the muscles, shortness of breath, blood in the phlegm, red or irritated skin, body sores, or pain or burning when urinating. Never stop taking any medications without talking to a doctor.
IrinotecanEnzalutamide
Severe
How does the drug interact with Irinotel 100mg Injection:
When Enzalutamide is taken with Irinotel 100mg Injection, the blood levels of Irinotel 100mg Injection may be greatly decreased, which might diminish the effectiveness of Irinotel 100mg Injection in curing your cancer.

How to manage the interaction:
Co-administration of Irinotel 100mg Injection with Enzalutamide can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without talking to a doctor.
How does the drug interact with Irinotel 100mg Injection:
Taking Rifabutin and Irinotel 100mg Injection may significantly reduce the blood levels of Irinotel 100mg Injection, which may make the medication less effective.

How to manage the interaction:
Although taking Irinotel 100mg Injection and Rifabutin together can evidently cause an interaction, but it can be taken if your doctor has advised it. However, if you experience any symptoms consult the doctor immediately. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with Irinotel 100mg Injection:
When Clarithromycin is taken with Irinotel 100mg Injection, it can interfere with the normal clearance of Irinotel 100mg Injection from the body. This may increase side effects.

How to manage the interaction:
Although taking Irinotel 100mg Injection and Clarithromycin together can evidently cause an interaction, it can be taken if your doctor has suggested it. If you have any of these symptoms - feeling sick, throwing up, stomach pain, diarrhea, not enough water in your body sores in your mouth, not enough red blood cells, bleeding problems, looking pale, feeling tired, feeling dizzy or passing out, having a fever or chills, a sore throat, muscle pain, trouble breathing, losing weight, feeling pain, or bleeding or bruising - make sure to call your doctor right away. Do not stop using any medications without a doctor's advice.
How does the drug interact with Irinotel 100mg Injection:
Taking thalidomide together with Irinotel 100mg Injection may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking thalidomide and Irinotel 100mg Injection together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Irinotel 100mg Injection:
Taking ceritinib with Irinotel 100mg Injection may increase the risk of infection and other side effects.

How to manage the interaction:
Although taking Irinotel 100mg Injection and Ceritinib together can evidently cause an interaction, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, loose stools, sore throat, muscle aches, shortness of breath, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • CLARITHROMYCIN
  • ERYTHROMYCIN
  • DILTIAZEM
  • ITRACONAZOLE
  • KETOCONAZOLE
  • RITONAVIR

Habit Forming

No

Special Advise

Keep all of your doctor's and laboratory appointments. Your doctor will arrange tests to assess your body's reaction to Irinotecan.

Diet & Lifestyle Advise

  • After your treatment begins, several dietary adjustments can help you control side effects.
  • Anyone suffering from a chronic illness, including cancer, should consume foods high in protein, healthy fats, whole grains, and vitamins and minerals.
  • Plant-based proteins are among the greatest meals during chemotherapy or other cancer treatments. They have the highest concentrations of vitamins and minerals, such as nuts, seeds, beans and legumes.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Performing yoga may also help in improving both physical and mental health.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugars.

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