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  3. Joclab 10 mg Injection 10 ml

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48 Hrs returnable
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Composition :

CLADRIBINE-1MG/ML

Manufacturer/Marketer :

Jodas Expoim Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Therapeutic Class

ANTINEOPLASTIC

Country of origin

India

Manufacturer/Marketer address

Sy No: 1043 & 1048, 3rd Floor, Nsl Centrum Mall, Plot No S-1, K P H B Phase 3, Kukatpally, Hyderabad, Telangana 500072
Other Info - JOC0045

FAQs

Joclab 10 mg Injection 10 ml contains Cladribine, which works by inhibiting the production of genetic material (DNA) in cancer cells by interfering with the ribonucleotide reductase and DNA polymerase enzymes.

It is said that concomitant use of Joclab 10 mg Injection 10 ml along with live vaccines may cause serious adverse effects. Hence, inform your doctor if you have taken any vaccines recently before receiving Joclab 10 mg Injection 10 ml.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Caution

It is not known if alcohol interacts with Joclab 10 mg Injection 10 ml. Please consult the doctor.

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Pregnancy

Unsafe

Joclab 10 mg Injection 10 ml is not recommended for use in pregnancy as it may harm the foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Joclab 10 mg Injection 10 ml. You should not become pregnant while on treatment with Joclab 10 mg Injection 10 ml.

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Breast Feeding

Unsafe

Joclab 10 mg Injection 10 ml is not recommended for use in breastfeeding as it may pass into breast milk and harm your infant. If you are breastfeeding, inform your doctor before receiving Joclab 10 mg Injection 10 ml. Your doctor may suggest you stop feeding while on treatment with this medicine.

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Driving

Not applicable

Joclab 10 mg Injection 10 ml will be administered to hospitalized patients.

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Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before receiving Joclab 10 mg Injection 10 ml. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor before receiving Joclab 10 mg Injection 10 ml. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Children

Consult your doctor

Joclab 10 mg Injection 10 ml is not recommended for use in children as safety and effectiveness have not been established.

About Joclab 10 mg Injection 10 ml

Joclab 10 mg Injection 10 ml belongs to a group of anticancer medicines called purine analogue used in the treatment of hairy cell leukaemia. Leukaemia, also known as blood cancer, is a cancer of blood cells or blood-forming tissues. It causes excessive production of immature white blood cells by the bone marrow and reduces the body’s ability to fight infections. 

Joclab 10 mg Injection 10 ml contains Cladribine, which belongs to the class of purine antimetabolites. It works by inhibiting DNA synthesis (responsible for DNA elongation, synthesis, and repair) in cancer cells by interfering with the ribonucleotide reductase and DNA polymerase enzymes.

Joclab 10 mg Injection 10 ml may cause certain side effects such as insomnia, dizziness, cough, abdominal pain, rash, constipation, fatigue, vomiting, nausea, headache, cough, constipation, weakness, and pain at the site of injection. Most of these side effects of Joclab 10 mg Injection 10 ml do not require medical attention and gradually resolve over time. A trained healthcare professional will administer Joclab 10 mg Injection 10 ml. Hence, do not self-administer.

If you are allergic to Joclab 10 mg Injection 10 ml, inform your doctor and avoid receiving it. Inform your doctor about your complete medical and medication history before starting treatment with Joclab 10 mg Injection 10 ml. Joclab 10 mg Injection 10 ml is contraindicated for pregnant women and breastfeeding women due to serious embryo-fetal toxicity. Hence, consult your doctor if you are pregnant, planning to become pregnant or breastfeeding. Let the doctor know if you have/had kidney or liver disease, hemolytic anaemia, or severe bone marrow suppression before starting the treatment, as it may worsen your condition. Inform your doctor if you have received any vaccination before starting the treatment.

Uses of Joclab 10 mg Injection 10 ml

Hairy cell Leukemia.

Medicinal Benefits Mweb

Medicinal Benefits

Joclab 10 mg Injection 10 ml contains Cladribine, which is used in the treatment of multiple sclerosis. It works by inhibiting DNA synthesis (responsible for DNA elongation, synthesis, and repair) in cancer cells by interfering with the ribonucleotide reductase and DNA polymerase enzymes. Thus, Joclab 10 mg Injection 10 ml stops the multiplication of abnormal cells and causes the death of cancer cells.

Directions for Use

An oncology doctor will administer Joclab 10 mg Injection 10 ml. Self-administration is not recommended.

Side Effects of Joclab 10 mg Injection 10 ml

  • Nausea
  • Abdominal pain
  • Constipation
  • Weakness
  • Injection site reactions
  • Pain at the site of injection
  • Headache
  • Dizziness
  • Insomnia
  • Anxiety
  • Muscle pain
  • Rash

Drug Warnings

If you are allergic to Joclab 10 mg Injection 10 ml, inform your doctor and avoid receiving it. Inform your doctor about your complete medical and medication history before starting treatment with Joclab 10 mg Injection 10 ml. Joclab 10 mg Injection 10 ml is contraindicated for pregnant women and breastfeeding women due to serious embryo-fetal toxicity. Hence, consult your doctor if you are pregnant, planning to become pregnant or breastfeeding. Let the doctor know if you have/had kidney or liver disease, haemolytic anaemia, severe bone marrow suppression, thrombocytopenia (low number of platelets), or neutropenia (low white blood cells) before starting the treatment, as it may worsen your condition. If you are about to receive any vaccinations, inform your doctor beforehand, as it may cause infection.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Joclab 10 mg Injection 10 ml:
Co-administration of Joclab 10 mg Injection 10 ml with Fluticasone can increase the risk of developing serious infections.

How to manage the interaction:
Although taking Fluticasone and Joclab 10 mg Injection 10 ml together can evidently cause an interaction, it can be taken if a doctor has suggested it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Joclab 10 mg Injection 10 ml:
Combining Joclab 10 mg Injection 10 ml with Leflunomide can increase the risk of serious infections.

How to manage the interaction:
Taking Leflunomide with Joclab 10 mg Injection 10 ml together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you experience any complications, infections, fever, chills, diarrhoea, sore throat, muscle aches, difficulty breathing, weight loss, or pain while urinating, it is recommended to contact your doctor right away. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Joclab 10 mg Injection 10 ml:
Taking Joclab 10 mg Injection 10 ml with Carmustine can increase the risk of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between Joclab 10 mg Injection 10 ml and Carmustine, you can take these medicines together if prescribed by your doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Joclab 10 mg Injection 10 ml:
Combining Joclab 10 mg Injection 10 ml with Vincristine can increase the risk and severity of developing serious infections.

How to manage the interaction:
Although taking Joclab 10 mg Injection 10 ml and Vincristine together can cause an interaction, it can be taken if your doctor has suggested it. If you have any of these symptoms, it's important to contact a doctor right away. These symptoms include infection, fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, and pain or burning when you pee. Do not stop using any medications without a doctor's advice.
How does the drug interact with Joclab 10 mg Injection 10 ml:
Combining Joclab 10 mg Injection 10 ml with Fluorouracil can increase the risk of side effects.

How to manage the interaction:
Taking Joclab 10 mg Injection 10 ml with Fluorouracil together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
CladribineOmacetaxine mepesuccinate
Severe
How does the drug interact with Joclab 10 mg Injection 10 ml:
Taking Joclab 10 mg Injection 10 ml together with omacetaxine may increase the risk of infections.

How to manage the interaction:
Taking Joclab 10 mg Injection 10 ml with Omacetaxine mepesuccinate together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms, it's important to contact your doctor right away. These symptoms include complications, infection, fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, and pain or burning when you pee. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Joclab 10 mg Injection 10 ml:
Taking Rucaparib with Joclab 10 mg Injection 10 ml can increase the risk of developing serious infections.

How to manage the interaction:
There may be a possibility of interaction between Joclab 10 mg Injection 10 ml and Rucaparib, but it can be taken if prescribed by a doctor. If you have any of these symptoms, it's important to contact a doctor right away. These symptoms include fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, and pain or burning when you urinate. Do not stop using any medications without a doctor's advice.
How does the drug interact with Joclab 10 mg Injection 10 ml:
Taking Osimertinib with Joclab 10 mg Injection 10 ml can increase the risk of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between Joclab 10 mg Injection 10 ml and Osimertinib, you can take these medicines together if prescribed by your doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Joclab 10 mg Injection 10 ml:
The combined use of Joclab 10 mg Injection 10 ml and valganciclovir can increase the risk of infections.

How to manage the interaction:
Taking Joclab 10 mg Injection 10 ml with Valganciclovir together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms - infection, fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, pain, or burning while urinating - contact your doctor right away. Do not discontinue any medications without consulting your doctor.
CladribinePeginterferon alfa-2b
Severe
How does the drug interact with Joclab 10 mg Injection 10 ml:
Taking Peginterferon alfa-2b with Joclab 10 mg Injection 10 ml can increase the risk of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between Joclab 10 mg Injection 10 ml and Peginterferon alfa-2b, you can take these medicines together if prescribed by your doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Habit Forming

No

Special Advise

Regular blood tests are recommended while receiving Joclab 10 mg Injection 10 ml to monitor any signs of anemia, neutropenia and thrombocytopenia.

Diet & Lifestyle Advise

  • Maintain a balanced diet including fruits and vegetables rich in nutrients and low-fat proteins like lean meats, fish and poultry.
  • Drink plenty of water daily while receiving the medication, as some cancer therapies may cause dehydration.
  • Exercise regularly and maintain a healthy body weight.
  • Regularly wash your hands and avoid contact with people having infections.
  • Quit smoking.

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