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Product Substitutes
Drug-Drug Interactions
Severe
CefuroximeLepirudin
Severe
Drug-Drug Interactions
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Severe
How does the drug interact with Kem 750mg Injection:
Co-administration of Dalteparin and Kem 750mg Injection can increase the blood levels and effects of Dlateparin.
How to manage the interaction:
Taking Kem 750mg Injection with Dalteparin together can possibly result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
Co-administration of Dalteparin and Kem 750mg Injection can increase the blood levels and effects of Dlateparin.
How to manage the interaction:
Taking Kem 750mg Injection with Dalteparin together can possibly result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
CefuroximeLepirudin
Severe
How does the drug interact with Kem 750mg Injection:
The therapeutic efficacy of Lepirudin can be decreased when used in combination with Kem 750mg Injection.
How to manage the interaction:
Although taking Kem 750mg Injection and Lepirudin together can evidently cause an interaction, it can be taken if your doctor has suggested it. Do not stop using any medications without a doctor's advice.
The therapeutic efficacy of Lepirudin can be decreased when used in combination with Kem 750mg Injection.
How to manage the interaction:
Although taking Kem 750mg Injection and Lepirudin together can evidently cause an interaction, it can be taken if your doctor has suggested it. Do not stop using any medications without a doctor's advice.
CefuroximeBCG vaccine
Severe
How does the drug interact with Kem 750mg Injection:
Co-administration of Kem 750mg Injection may reduce the anti-tumor activity of BCG in the bladder.
How to manage the interaction:
Talk to your doctor before receiving BCG if you are currently being treated with Kem 750mg Injection. To ensure adequate response to your treatment, you should not receive BCG until after you complete your antibiotic therapy. Do not discontinue the medication without consulting a doctor.
Co-administration of Kem 750mg Injection may reduce the anti-tumor activity of BCG in the bladder.
How to manage the interaction:
Talk to your doctor before receiving BCG if you are currently being treated with Kem 750mg Injection. To ensure adequate response to your treatment, you should not receive BCG until after you complete your antibiotic therapy. Do not discontinue the medication without consulting a doctor.
Moderate
How does the drug interact with Kem 750mg Injection:
Taking these medications together might make it harder for your body to absorb atazanavir, which could make it less effective.
How to manage the interaction:
vv
Taking these medications together might make it harder for your body to absorb atazanavir, which could make it less effective.
How to manage the interaction:
vv
Drug-Food Interactions
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.
Drug-Food Interactions
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Drug-Diseases Interactions
CEFUROXIME-750MGOther gastroenteritis and colitis of infectious and unspecified origin
Severe
CEFUROXIME-750MGChronic kidney disease
Moderate
Drug-Diseases Interactions
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CEFUROXIME-750MGOther gastroenteritis and colitis of infectious and unspecified origin
Severe
How does the disease interact with Kem 750mg Injection:
Colitis: In some cases the use of Kem 750mg Injection may cause ranging from mild diarrhea to fatal colitis. Colitis is commonly Clostridioides difficile-associated diarrhea (CDAD). Discontinue therapy if signs of CDAD are confirmed.
How to manage the interaction:
Antibiotics may cause Clostridioides difficile-associated diarrhoea (CDAD), which may range from mild diarrhoea to fatal colitis. Kem 750mg Injection should be used with caution in patients with a history of gastrointestinal disease, particularly colitis (inflammation of the colon) or pseudomembranous colitis (a severe inflammation of the inner lining of the large intestine). Appropriate fluid and electrolyte management, protein supplementation, antibacterial treatment of C difficile, and surgical evaluation is advised.
Colitis: In some cases the use of Kem 750mg Injection may cause ranging from mild diarrhea to fatal colitis. Colitis is commonly Clostridioides difficile-associated diarrhea (CDAD). Discontinue therapy if signs of CDAD are confirmed.
How to manage the interaction:
Antibiotics may cause Clostridioides difficile-associated diarrhoea (CDAD), which may range from mild diarrhoea to fatal colitis. Kem 750mg Injection should be used with caution in patients with a history of gastrointestinal disease, particularly colitis (inflammation of the colon) or pseudomembranous colitis (a severe inflammation of the inner lining of the large intestine). Appropriate fluid and electrolyte management, protein supplementation, antibacterial treatment of C difficile, and surgical evaluation is advised.
CEFUROXIME-750MGChronic kidney disease
Moderate
How does the disease interact with Kem 750mg Injection:
Renal dysfunction: Kem 750mg Injection is eliminated by the kidney in an unchanged form. Thus the plasma levels of the drug increase and prolongs the half-life. Adjust the doses of Kem 750mg Injection as necessary.
How to manage the interaction:
The serum concentration may be increased in patients with impaired kidney function as most beta-lactam antibiotics are eliminated by the kidney. Dose adjustment may be necessary for patients with kidney dysfunction. Regular renal function tests are advised during prolonged or high-dose therapy.
Renal dysfunction: Kem 750mg Injection is eliminated by the kidney in an unchanged form. Thus the plasma levels of the drug increase and prolongs the half-life. Adjust the doses of Kem 750mg Injection as necessary.
How to manage the interaction:
The serum concentration may be increased in patients with impaired kidney function as most beta-lactam antibiotics are eliminated by the kidney. Dose adjustment may be necessary for patients with kidney dysfunction. Regular renal function tests are advised during prolonged or high-dose therapy.
CEFUROXIME-750MGDependence on enabling machines and devices, not elsewhere classified
Moderate
How does the disease interact with Kem 750mg Injection:
Dialysis : Most of the antibiotics are eliminated by hemodialysis. Therefore, administer Kem 750mg Injection after dialysis or an additional dosage to be administered.
How to manage the interaction:
Kem 750mg Injection serum levels may be decreased by hemodialysis and peritoneal dialysis. Supplemental doses should be given at the end of each hemodialysis session.
Dialysis : Most of the antibiotics are eliminated by hemodialysis. Therefore, administer Kem 750mg Injection after dialysis or an additional dosage to be administered.
How to manage the interaction:
Kem 750mg Injection serum levels may be decreased by hemodialysis and peritoneal dialysis. Supplemental doses should be given at the end of each hemodialysis session.
CEFUROXIME-750MGConvulsions, not elsewhere classified
Moderate
How does the disease interact with Kem 750mg Injection:
seizure disorders: In some patients, seizures were reported with whom renal dysfunction which incase of dosage adjustment was not done. Discontinue Kem 750mg Injection if seizures are reported.
How to manage the interaction:
Cephalosporin antibiotics may trigger seizures. Kem 750mg Injection should be discontinued if seizures associated with drug therapy occur.
seizure disorders: In some patients, seizures were reported with whom renal dysfunction which incase of dosage adjustment was not done. Discontinue Kem 750mg Injection if seizures are reported.
How to manage the interaction:
Cephalosporin antibiotics may trigger seizures. Kem 750mg Injection should be discontinued if seizures associated with drug therapy occur.
CEFUROXIME-750MGOther diseases of liver
Moderate
How does the disease interact with Kem 750mg Injection:
liver disease: With Kem 750mg Injection, a transient increase in the AST, ALT, and alkaline phosphatase levels was observed. Use with caution and closely monitor for hepatic function is recommended.
How to manage the interaction:
Caution and monitoring is recommended in patients with liver disease as cases of hepatitis have been reported with the use of certain cephalosporins.
liver disease: With Kem 750mg Injection, a transient increase in the AST, ALT, and alkaline phosphatase levels was observed. Use with caution and closely monitor for hepatic function is recommended.
How to manage the interaction:
Caution and monitoring is recommended in patients with liver disease as cases of hepatitis have been reported with the use of certain cephalosporins.
CEFUROXIME-750MGOther diseases of liver
Moderate
How does the disease interact with Kem 750mg Injection:
Rarely, cephalosporins use may cause hypoprothrombinemia, with or without bleeding. Monitor for Prothrombin time.
How to manage the interaction:
Cephalosporins may be associated with reduced prothrombin activity/prolonged prothrombin time (blood takes too long to form a clot). Prothrombin time should be monitored in at-risk patients and managed as needed.
Rarely, cephalosporins use may cause hypoprothrombinemia, with or without bleeding. Monitor for Prothrombin time.
How to manage the interaction:
Cephalosporins may be associated with reduced prothrombin activity/prolonged prothrombin time (blood takes too long to form a clot). Prothrombin time should be monitored in at-risk patients and managed as needed.
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