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  3. Koolistin 4.5miu Injection

Koolistin 4.5miu Injection, Pack of 1 Injection
Koolistin 4.5miu Injection, Pack of 1 Injection
Koolistin 4.5miu Injection, Pack of 1 Injection
Koolistin 4.5miu Injection, Pack of 1 Injection
Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
48 Hrs returnable
Know More
COD available

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Whats That

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Synonym :

COLISTIN

Composition :

COLISTIMETHATE SODIUM-4.5MIU

Manufacturer/Marketer :

Biocon Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

Therapeutic Class

ANTI- BACTERIALS

Country of origin

India

Manufacturer/Marketer address

20th KM, Hosur Road, Electronic City, Bangalore, India - 560 100
Other Info - KOO0033

Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 8, 2025 | 9:47 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

FAQs

Koolistin 4.5miu Injection contains Colistimethate Sodium. Colistimethate Sodium effectively solubilizes the bacterial cell membrane, resulting in bacterial cell death. As a result, Koolistin 4.5miu Injection destroys the bacteria and successfully treats the infection.

Koolistin 4.5miu Injection is contraindicated in people with Hypersensitivity to any component in Koolistin 4.5miu Injection. Besides this, it is also contraindicated to use in people with myasthenia gravis (muscle disorder).

Koolistin 4.5miu Injection contains Colistimethate Sodium. It is an antibiotic medication used when other drugs or therapy are ineffective. Colistimethate Sodium essentially solubilizes the bacterial cell membrane, resulting in bacterial cell death. As a result, Koolistin 4.5miu Injection kills the bacteria and effectively treats the infection. In addition, it can also treat infectious diarrhoea and urinary tract infections.

Do not use anti diarrhoeal until the doctor has prescribed you. You can drink plenty of fluids (electrolytes) to avoid dehydration. Besides this, you can also take prebiotics or probiotics to manage diarrhoea as it may help increase the number of good bacteria in the intestine, which aids indigestion.

After taking an antibiotic, you may need to wait up to three hours to eat or drink dairy products, including milk and butter, yoghurt, and cheese. Grapefruit juice and dietary supplements containing minerals like calcium may also work to dampen the effect of antibiotics.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Caution

Limit alcohol consumption while on treatment with this medicine as it may worsen drowsiness, dizziness or sleepiness.

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Pregnancy

Caution

Koolistin 4.5miu Injection should not be used in pregnancy unless necessary. Hence, inform your doctor if you are pregnant or suspect pregnancy. Your doctor will weigh the benefits and potential risks before prescribing Koolistin 4.5miu Injection.

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Breast Feeding

Caution

Koolistin 4.5miu Injection should not be used in nursing mothers unless necessary. So, inform your doctor if you are a breastfeeding mother. Your doctor will weigh the benefits and potential risks before prescribing Koolistin 4.5miu Injection.

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Driving

Caution

You may have side effects like visual disturbances and dizziness after taking Koolistin 4.5miu Injection that may make you unfit to drive or operate machinery. Hence, do not drive or operate machinery until you are feeling well.

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Liver

Safe if prescribed

Inform your doctor before receiving Koolistin 4.5miu Injection if you have a liver impairment/disorder history. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Kidney

Caution

Caution should be exercised while using Koolistin 4.5miu Injection in patients with severe kidney disease. Inform your doctor before receiving Koolistin 4.5miu Injection if you have a kidney impairment/disorder history. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Children

Consult your doctor

Please consult your doctor. Your doctor will decide the dose of this medicine based on the age and condition of your child.

Product Substitutes

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Keep Refrigerated. Do not freeze.Prepaid payment required.

Reference

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692639/#:~:text=Colistin%20essentially%20solubilizes%20the%20bacterial,resulting%20in%20a%20bactericidal%20effect.
  2. https://www.mims.com/india/drug/info/colistin?type=full&mtype=generic#adverse-reactions
  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241451/#:~:text=In%201959%2C%20the%20US%20FDA,diarrhoea%20and%20urinary%20tract%20infections.

About Koolistin 4.5miu Injection

Koolistin 4.5miu Injection belongs to the class of medications called ‘antibiotics’ used to treat bacterial infections. Bacterial infections are caused by the multiplication of harmful bacteria inside or on the body. These harmful bacteria produce chemicals known as toxins, which can damage tissue and make you sick. Symptoms of bacterial infection vary depending on the organ affected by bacteria.

Koolistin 4.5miu Injection contains Colistimethate Sodium. Colistimethate Sodium effectively solubilizes the bacterial cell membrane, resulting in bacterial cell death. As a result, Koolistin 4.5miu Injection destroys the bacteria and successfully treats the infection.

Koolistin 4.5miu Injection will be administered by a qualified healthcare professional. Sometimes, you may experience common side effects like injection site reactions, renal damage, visual disturbances, GI disturbances, dizziness, nausea, vomiting and muscle weakness. But these side effects are usually in the initial phase and resolve over time. However, if these side effects persist, let your doctor know.

Before receiving Koolistin 4.5miu Injection, let your doctor know about all your medical conditions, sensitivities, and all medications you are using. And also, inform your doctor if you are pregnant, planning pregnancy, or breastfeeding. Koolistin 4.5miu Injection can cause blurred vision and dizziness in some people; if this occurs, do not drive or operate tools or machinery. It is recommended not to consume any alcoholic beverages while on treatment with this medicine.

Uses of Koolistin 4.5miu Injection

Bacterial infections

Medicinal Benefits Mweb

Medicinal Benefits

Koolistin 4.5miu Injection contains Colistimethate Sodium. Colistimethate Sodium, also known as polymyxin E, is an antibiotic medication used as a last-resort treatment for multidrug-resistant Gram-negative infections. Colistimethate Sodium essentially solubilizes the bacterial cell membrane, resulting in bacterial cell death. As a result, Koolistin 4.5miu Injection kills the bacteria and effectively treats the infection. In addition, it can also treat infectious diarrhoea and urinary tract infections.

Directions for Use

Koolistin 4.5miu Injection will be administered by a qualified healthcare professional. Do not self-administer.

Side Effects of Koolistin 4.5miu Injection

  • Superinfection (reinfection)
  • Renal damage
  • Visual disturbances
  • GI disturbances
  • Dizziness
  • Nausea
  • Vomiting
  • Confusion
  • Peripheral neuropathy
  • Respiratory insufficiency
  • Muscle weakness

Drug Warnings

If you are allergic to Koolistin 4.5miu Injection, please inform your physician. Inform your doctor about your medical history and other medications you are currently taking to rule out any potential negative effects. Inform your doctor if you are pregnant, planning to become pregnant, or are breastfeeding before receiving Koolistin 4.5miu Injection. Also, inform your doctor if you have chronic kidney disease, myasthenia gravis (muscle disorder), and porphyria (a blood disorder). Do not abruptly discontinue taking the prescription since this may result in antibiotic resistance, a condition in which bacteria develop resistance to antibiotics.

Drug-Drug Interactions

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ColistinBCG vaccine
Critical
ColistinAmikacin
Severe

Drug-Drug Interactions

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ColistinBCG vaccine
Critical
How does the drug interact with Koolistin 4.5miu Injection:
Coadministration of Koolistin 4.5miu Injection along with BCG vaccine can reduce the treatment outcomes.

How to manage the interaction:
Taking Koolistin 4.5miu Injection with BCG vaccine is avoided as it may lead to an interaction, please consult your doctor before taking it.
ColistinAmikacin
Severe
How does the drug interact with Koolistin 4.5miu Injection:
Coadministration of Koolistin 4.5miu Injection with Amikacin can increase the risk of developing side effects.

How to manage the interaction:
Although there is a possible interaction between Koolistin 4.5miu Injection and Amikacin, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
ColistinSuxamethonium
Severe
How does the drug interact with Koolistin 4.5miu Injection:
Using Suxamethonium together with Koolistin 4.5miu Injection may increase the effects of Suxamethonium.

How to manage the interaction:
Although there is a possible interaction between Koolistin 4.5miu Injection and Suxamethonium, you can take these medicines together if prescribed by your doctor. However, if you experience an upset stomach, Rash Paresthesia (tingling or pricking sensation) Dizziness Slurred speech Vertigo, or Fever, consult a doctor. Do not stop using any medications without a doctor's advice.
ColistinEverolimus
Severe
How does the drug interact with Koolistin 4.5miu Injection:
Coadministration of Koolistin 4.5miu Injection with Everolimus can increase the risk of developing kidney problems.

How to manage the interaction:
Although there is a possible interaction between Koolistin 4.5miu Injection and Everolimus, it can be taken if prescribed by a doctor. However, if you experience vomiting, irregular urination, sudden weight gain or loss, swelling, shortness of breath, or weakness, consult a doctor. Do not discontinue any medications without consulting a doctor.
ColistinAdefovir dipivoxil
Severe
How does the drug interact with Koolistin 4.5miu Injection:
Combining Koolistin 4.5miu Injection with Adefovir dipivoxil may decrease Koolistin 4.5miu Injection's excretion rate, which could result in a higher serum level.

How to manage the interaction:
Although there is a possible interaction between Koolistin 4.5miu Injection and Adefovir dipivoxil, you can take these medicines together if prescribed by your doctor. However, if you experience any irregular urination, swelling, shortness of breath, muscle pain, dizziness, or palpitations call your doctor right away. Do not stop using any medications without a doctor's advice.
ColistinNeomycin
Severe
How does the drug interact with Koolistin 4.5miu Injection:
Combining Koolistin 4.5miu Injection with Neomycin can increase the risk or severity of kidney problems.

How to manage the interaction:
Although there is a possible interaction between Koolistin 4.5miu Injection and Neomycin, you can take these medicines together if prescribed by your doctor. However, if you experience an upset stomach, Rash, Dizziness, or Fever, consult a doctor. Do not stop using any medications without a doctor's advice.
ColistinIohexol
Severe
How does the drug interact with Koolistin 4.5miu Injection:
Combining Koolistin 4.5miu Injection with Iohexol can increase the effect or side effects of Iohexol.

How to manage the interaction:
Although there is a possible interaction between Koolistin 4.5miu Injection and Iohexol, you can take these medicines if prescribed by your doctor. However, if you experience vomiting, loss of appetite, irregular urination, swelling, shortness of breath, muscle cramps, or weakness, consult a doctor. Do not stop using any medications without a doctor's advice.
ColistinGentamicin
Severe
How does the drug interact with Koolistin 4.5miu Injection:
Co-administration of Koolistin 4.5miu Injection with Gentamicin can increase the levels and risk of Koolistin 4.5miu Injection side effects.

How to manage the interaction:
Although there is a possible interaction between Koolistin 4.5miu Injection and Gentamicin, you can take these medicines together if prescribed by your doctor. However, if you experience weight gain or loss suddenly, muscle pain, dizziness, or palpitations, call your doctor right away. Do not stop using any medications without a doctor's advice.
ColistinCisatracurium
Severe
How does the drug interact with Koolistin 4.5miu Injection:
Coadministration of Cisatracurium with Koolistin 4.5miu Injection may increase the risk of side effects of Cisatracurium.

How to manage the interaction:
Although there is a possible interaction of Cisatracurium with Koolistin 4.5miu Injection, it can be taken if prescribed by your doctor. However, if you experience an upset stomach, Rash, Dizziness, Slurred speech, Vertigo, or Fever, consult a doctor. Do not stop using any medications without a doctor's advice.
ColistinTenofovir alafenamide
Severe
How does the drug interact with Koolistin 4.5miu Injection:
Combining Koolistin 4.5miu Injection with Tenofovir alafenamide may increase the risk of kidney problems.

How to manage the interaction:
Although there is a possible interaction between Koolistin 4.5miu Injection and Tenofovir alafenamide, you can take these medicines together if prescribed by your doctor. However, consult a doctor if you experience an upset stomach, rash, dizziness, or fever. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • CYCLOBENZAPRINE
  • METAXALONE
  • AMPHOTERICIN B
  • CAPREOMYCIN
  • VANCOMYCIN

Habit Forming

No

Special Advise

  • Regular blood tests are required to monitor kidney functions while taking Koolistin 4.5miu Injection.
  • A Healthcare professional should always give a Koolistin 4.5miu Injection to a hospital. Never self-administer.

Diet & Lifestyle Advise

  • After taking the full course of Koolistin 4.5miu Injection, probiotics should be taken to restore some of the healthy bacteria in the intestine that may have been killed. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhoea. Certain fermented foods like yoghurt, cheese, sauerkraut and kimchi can restore the intestine's good bacteria stink.
  • Include more fibre-enriched food in your diet, as it can be easily digested by gut bacteria which helps stimulate their growth. Thus fibre foods may help restore healthy gut bacteria after taking a course of antibiotics. Whole grains, like whole-grain bread, and brown rice, should be included in your diet.
  • Avoid taking many calcium-enriched foods and drinks as it might affect the working of Koolistin 4.5miu Injection.
  • Avoid intake of alcoholic beverages with Koolistin 4.5miu Injection as it can make you dehydrated and affect your sleep. This can make it harder for your body to aid the Koolistin 4.5miu Injection in fighting off infections.

Koolistin 4.5miu Injection Substitute

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