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Written By aquibnaseer ,
Reviewed By Sunny S , MBBS
48 Hrs returnable
COD available

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Whats That

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Composition :

CHLOROQUINE-250MG

Manufacturer/Marketer :

Leo Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

Therapeutic Class

ANTI- MALARIALS

Country of origin

India

Manufacturer/Marketer address

LEO Pharma A/S, Industriparken 55, DK-2750 Ballerup, Danmark
Other Info - LEO0021

Author Details

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FAQs

Leoquin EC 250 Tablet works by preventing the formation of the nontoxic heme metabolite hemozoin by the parasite. Due to this, the parasite dies from its own toxic by-products released due to haemoglobin's metabolism.

The use of Leoquin EC 250 Tablet is not allowed in persons who are already taking any antibiotic (azithromycin) as it may cause dangerous effects on the heart.

No such effect has been reported yet. Always consult your doctor for the change of dose regimen or an alternative medicine if needed.

No such harmful interaction has been reported in patients who take this drug under strict doctors' surveillance. However, some patients might experience eye (retina) damage and cause pounding heart, so patient taking Leoquin EC 250 Tablet is advised to consult a doctor and have regular check-ups cyclically.

There may be a risk of hemolysis in patients with G6PD deficiency while using Leoquin EC 250 Tablet . Doctor's consultation is mandatory before you start this medication.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Caution

No serious interaction has been reported between alcohol and Leoquin EC 250 Tablet yet alcohol should be avoided with Leoquin EC 250 Tablet as it aggravates side effects.

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Pregnancy

Caution

Leoquin EC 250 Tablet should be used with caution and can only be used in pregnancy if recommended by the doctor.

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Breast Feeding

Caution

It is not safe to breastfeed while taking Leoquin EC 250 Tablet as this medicine can pass into breast milk. A patient is advised to take this drug only on doctor's consultation.

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Driving

Caution

Leoquin EC 250 Tablet may cause blurred vision, so one should avoid driving or doing any activity that needs mental alertness. A patient is thus advised to take this drug only on doctor's consultation.

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Liver

Caution

Leoquin EC 250 Tablet therapy is unlikely to cause liver injury in normal individuals but can trigger an acute worsening of porphyria in rare cases. Thus doctor's consultation is recommended before taking Leoquin EC 250 Tablet .

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Kidney

Caution

Leoquin EC 250 Tablet administration impairs kidney function in a few cases, so a patient is recommended to consult a doctor before taking Leoquin EC 250 Tablet .

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Children

Safe if prescribed

Leoquin EC 250 Tablet is safe to use in children, yet dose adjustment by a doctor will be done on the basis of age, weight, and severity of the infection.

About Leoquin EC 250 Tablet

Leoquin EC 250 Tablet belongs to the class of medications called 'quinoline' primarily used to treat malaria. Leoquin EC 250 Tablet gives a degree of protection (prophylaxis) against malaria when people travel to areas where malarial cases exist. It is effective against Plasmodium vivax, Plasmodium ovale, and Plasmodium malariae. Leoquin EC 250 Tablet is not effective against Plasmodium falciparum. Besides this, it also treats amoebiasis (intestinal dysentery) and rheumatic disease (arthritis). 

Leoquin EC 250 Tablet contains 'chloroquine' which acts by killing the malarial parasites, i.e. Plasmodium and stops the formation of the nontoxic heme metabolite hemozoin by the parasite. Heme part of the red blood cells is broken by the malarial, causing parasites. Leoquin EC 250 Tablet  prevents the breakdown of heme part and is actually toxic to the parasite. It kills the parasitic form living in red blood cells that resides in the liver.

Leoquin EC 250 Tablet should be taken as prescribed by your doctor. The dose of Leoquin EC 250 Tablet can vary depending upon your condition and the severity of the infection. The common side effects of Leoquin EC 250 Tablet include vomiting, nausea, hair loss and itchy skin. Everyone need not experience the above side effects. In case of any discomfort, speak with a doctor.

Before starting Leoquin EC 250 Tablet , please inform your doctor if you are allergic to chloroquine or have kidney or liver problems. Do not take Leoquin EC 250 Tablet on your own. Leoquin EC 250 Tablet is safe to use during pregnancy and breastfeeding. Prolonged use of Leoquin EC 250 Tablet may have a severe risk on the heart and retina of the eyes leading to pounding heartbeats and permanent vision problems. 

Uses of Leoquin EC 250 Tablet

Malaria, Intestinal amoebiasis, Rheumatoid arthritis

Medicinal Benefits Mweb

Medicinal Benefits

Leoquin EC 250 Tablet falls into a group of medicines known as antimalarials, indicated for treating or preventing malaria. Leoquin EC 250 Tablet contains chloroquine, which belongs to quinoline. It works by preventing the formation of the nontoxic heme metabolite hemozoin by the parasite. Due to this, the parasite dies from its own toxic by-products released due to haemoglobin's metabolism. Leoquin EC 250 Tablet is also indicated for the treatment of rheumatoid arthritis and autoimmune diseases like lupus and intestinal infection caused by amoeba (amoebiasis).

Directions for Use

Tablet/Capsule: Swallow it as a whole with water; do not crush, break or chew it.Syrup/Suspension: Shake the bottle well before use. Take the prescribed dose by mouth using the measuring cup/dosing syringe/dropper provided by the pack.

Side Effects of Leoquin EC 250 Tablet

  • Abnormal heart rhythm
  • Stomach pain
  • Nausea (being sick)
  • Diarrhoea
  • Loss of appetite
  • Headache
  • Skin rash
  • Liver problems

Drug Warnings

Leoquin EC 250 Tablet does not respond well against all malaria strains, so consult with your doctor if you do not respond well to Leoquin EC 250 Tablet . This medicine can affect heart health, especially if a person is taking medications, including the antibiotic azithromycin and anticancer like tamoxifen. An individual must consult with the doctor if they are noticing fast or pounding heartbeats and sudden dizziness. This medicine cannot be used for a long duration as it may cause irreversible damage to the eye that could lead to vision problems. Leoquin EC 250 Tablet cannot be used in persons who have heart disease, heart rhythm disorder, diabetes, a stomach disorder, an allergy to quinine, liver or kidney disease, psoriasis, alcoholism, porphyria (a genetic enzyme disorder that affects the skin or nervous system), a genetic enzyme deficiency called glucose-6-phosphate dehydrogenase (G6PD) deficiency. Consult with your doctor if you are pregnant or breastfeeding as this medicine could only be used if prescribed by the doctor. 

Drug-Drug Interactions

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ChloroquineAurothioglucose
Critical
ChloroquineBepridil
Critical

Drug-Drug Interactions

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ChloroquineAurothioglucose
Critical
How does the drug interact with Leoquin EC 250 Tablet:
Taking Aurothioglucose with Leoquin EC 250 Tablet can cause blood disorders and other severe side effects

How to manage the interaction:
Taking Aurothioglucose with Leoquin EC 250 Tablet is not recommended, as it can cause an interaction, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience unusual symptoms. Do not discontinue any medications without consulting a doctor.
ChloroquineBepridil
Critical
How does the drug interact with Leoquin EC 250 Tablet:
Using Leoquin EC 250 Tablet together with bepridil can increase the risk of an irregular heart rhythm

How to manage the interaction:
Taking Leoquin EC 250 Tablet with Bepridil is not recommended, as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately.
ChloroquineAgalsidase alfa
Critical
How does the drug interact with Leoquin EC 250 Tablet:
When Agalsidase alfa is used with Leoquin EC 250 Tablet, it may decrease the effectiveness of the Agalsidase alfa.

How to manage the interaction:
Taking Agalsidase alfa with Leoquin EC 250 Tablet is not recommended, it can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not stop using any medications without talking to a doctor.
ChloroquinePimozide
Critical
How does the drug interact with Leoquin EC 250 Tablet:
When Pimozide and Leoquin EC 250 Tablet are taken together, it can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Leoquin EC 250 Tablet with Pimozide is not recommended, as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
ChloroquineSparfloxacin
Critical
How does the drug interact with Leoquin EC 250 Tablet:
Using Leoquin EC 250 Tablet together with sparfloxacin can increase the risk of an irregular heart rhythm

How to manage the interaction:
Taking Leoquin EC 250 Tablet with Sparfloxacin is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience unusual symptoms. Do not discontinue any medications without consulting a doctor.
ChloroquinePazopanib
Critical
How does the drug interact with Leoquin EC 250 Tablet:
Taking pazopanib with Leoquin EC 250 Tablet can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Pazopanib with Leoquin EC 250 Tablet is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
ChloroquineTelavancin
Critical
How does the drug interact with Leoquin EC 250 Tablet:
Using Leoquin EC 250 Tablet together with telavancin can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Telavancin with Leoquin EC 250 Tablet is not recommended, as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
ChloroquineCisapride
Critical
How does the drug interact with Leoquin EC 250 Tablet:
Taking Leoquin EC 250 Tablet with Cisapride can increase the risk of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Leoquin EC 250 Tablet with Cisapride is not recommended as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately.
ChloroquineDronedarone
Critical
How does the drug interact with Leoquin EC 250 Tablet:
When Leoquin EC 250 Tablet is taken with Dronedarone, it may increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Leoquin EC 250 Tablet with Dronedarone is not recommended, as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
ChloroquineZiprasidone
Critical
How does the drug interact with Leoquin EC 250 Tablet:
Taking Leoquin EC 250 Tablet with Ziprasidone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Leoquin EC 250 Tablet with Ziprasidone is not recommended, it can be taken together if prescribed by a doctor. However, consult a doctor if you experience dizziness, drowsiness, confusion, and difficulty concentrating. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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CHLOROQUINE-250MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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CHLOROQUINE-250MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Taking grape fruit products while using Leoquin EC 250 Tablet, can increase the risk of irregular heartbeat, which may result in side effects such as sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Avoid grape fruit and its products while taking Leoquin EC 250 Tablet.

Drug-Diseases Interactions

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CHLOROQUINE-250MGDisorders of porphyrin and bilirubin metabolism
Severe
CHLOROQUINE-250MGOther cardiac arrhythmias
Moderate

Drug-Diseases Interactions

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CHLOROQUINE-250MGDisorders of porphyrin and bilirubin metabolism
Severe
How does the disease interact with Leoquin EC 250 Tablet:
Porphyria: In porphyria the use of Leoquin EC 250 Tablet may aggravate this condition. Avoid Leoquin EC 250 Tablet use until it is required.

How to manage the interaction:
If the risks aren't expected to outweigh the possible advantages, Leoquin EC 250 Tablet shouldn't be utilized on these patients.
CHLOROQUINE-250MGOther cardiac arrhythmias
Moderate
How does the disease interact with Leoquin EC 250 Tablet:
Arrhythmias:Leoquin EC 250 Tablet has adverse effect like prolongation of QT interval, ventricular arrhythmias and torsades de pointes. Monitor ECG before initiation and during the therapy.

How to manage the interaction:
If you have sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat while taking these medications, whether they are taken together or separately, you should seek immediate assistance from a doctor. A close monitoring of ECG is required.
CHLOROQUINE-250MGEpilepsy
Moderate
How does the disease interact with Leoquin EC 250 Tablet:
Seizures: Leoquin EC 250 Tablet may cause epileptic seizures in susceptible patients. Administer Leoquin EC 250 Tablet in patients with history of epilepsy.

How to manage the interaction:
In those who are vulnerable, Leoquin EC 250 Tablet may result in epileptic fits. Patients who already have epileptic fits or have a low tolerance for seizures may be at greater risk.
CHLOROQUINE-250MGOther diseases of blood and blood-forming organs
Moderate
How does the disease interact with Leoquin EC 250 Tablet:
Bone marrow suppression: With the use of Leoquin EC 250 Tablet adverse effects such as neutropenia, agranulocytosis, aplastic anemia, and thrombocytopenia. In patients with preexisting bone marrow suppression use cautiously and monitor for complete blood count. Discontinue the Leoquin EC 250 Tablet if any serious blood disorder is suspected.

How to manage the interaction:
It is important to inform your doctor if you have prior conditions like bone marrow suppression, a complete blood picture is advised to be taken if you are on a long term therapy with Leoquin EC 250 Tablet. If you suspect any blood disorders, please inform it to your doctor immediately.
CHLOROQUINE-250MGOther hearing loss
Moderate
How does the disease interact with Leoquin EC 250 Tablet:
Ototoxicity: Rarely, Leoquin EC 250 Tablet was been associated with ototoxicity.The use of Leoquin EC 250 Tablet has been associated rarely with ototoxicity. With long-term, high-dose Leoquin EC 250 Tablet therapy which is irreversible nerve-type deafness may occur. In some patients with preexisting auditory damage, tinnitus, decrease in hearing may occur. Use with caution and discontinue therapy if new auditory defects occur or if hearing loss becomes worse.

How to manage the interaction:
If you any existing hearing damage, do not forget to inform it your doctor, so that a close monitoring can be done during the treatment with Leoquin EC 250 Tablet.
CHLOROQUINE-250MGPsoriasis
Moderate
How does the disease interact with Leoquin EC 250 Tablet:
In psoriasis patients, the Leoquin EC 250 Tablet use may exacerbate severe attack of psoriasis. Do not use Leoquin EC 250 Tablet unless the potential benefits vs risks outweighs.

How to manage the interaction:
It is important to tell your doctor if you have any existing skin conditions like psoriasis. Your doctor may prescribe the medication, if the benefits are more than the risks.
CHLOROQUINE-250MGMyasthenia gravis and other myoneural disorders
Moderate
How does the disease interact with Leoquin EC 250 Tablet:
myasthenia gravis Use of Leoquin EC 250 Tablet may exacerbate new onset of symptoms in patients with previously diagnosed myasthenia gravis. Use cautiously.

How to manage the interaction:
If you are suffering from myasthenia gravis, do not forget to tell it to your doctor. If you are taking Leoquin EC 250 Tablet and experiencing symptoms like muscle weakness or weakness of the arms and legs, drooping of upper eyelid, difficulty speaking, difficulty swallowing, double vision, tiredness, or shortness of breath please inform your doctor.

Drug-Drug Interactions Checker List

  • PHENYLBUTAZONE
  • NEOSTIGMINE
  • PYRIDOSTIGMINE
  • AMPICILLIN
  • CIMETIDINE
  • TAMOXIFEN

Habit Forming

No

Special Advise

Do not take Leoquin EC 250 Tablet if you have had a previous reaction to Leoquin EC 250 Tablet , or if you have certain eye problems involving your retina. Tell your healthcare provider about any problems you may have with your eyes.

Diet & Lifestyle Advise

  • Always take Leoquin EC 250 Tablet with meals for reduced gastric irritation.
  • Adequate nutrition is the key for improvement in malaria induced weakness.
  • It is important to allow the patient to eat regularly in small amounts to tolerate the food. 
  • Increase fluid and protein intake for malaria induced weight loss.
  • Proper rest and mosquito-free premises is important for the patient to recover.

Leoquin EC 250 Tablet Substitute

Always consult your doctor before taking any new medications and supplements

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