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Written By ,
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
Non returnable*
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Manufacturer/Marketer :

Lupin Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Lupiflex 4 Tablet

Lupiflex 4 Tablet belongs to a group of medicines called pain killer/Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) used for the treatment of osteoarthritis, rheumatoid arthritis, gouty arthritis and ankylosing spondylitis, acute pain, chronic low back pain, and muscle spasms. It relieves the pain and relaxes the muscles. Pain is a symptom triggered by the nervous system, causing uncomfortable sensations in the body. Muscle spasm is the sudden involuntary contractions of the muscle, which can be painful and uncomfortable.

Lupiflex 4 Tablet is a combination of two drugs: Ketoprofen (NSAID) and Thiocolchicoside (Muscle relaxant). Ketoprofen blocks the effect of a chemical messenger known as cyclo-oxygenase (COX) enzyme that makes other chemical prostaglandins (PG). By blocking the effect of chemical messenger ketoprofen helps in reducing mild to moderate pain and inflammation at the injured or damaged site. Thiocolchicoside is a muscle relaxant and works on the centres of the spinal cord and brain. This helps relieve muscle stiffness and improves muscle movements, thereby helping relieve pain due to muscle spasms.

Take Lupiflex 4 Tablet as prescribed by your doctor. You are advised to take Lupiflex 4 Tablet for as long as your doctor has prescribed it for you depending on your medical conditions. You may experience nausea, heartburn, indigestion and stomach pain, dizziness, sleepiness, nervousness, diarrhea, ringing in the ear. Most of these side effects of Lupiflex 4 Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Lupiflex 4 Tablet should not be taken if you are known to be allergic to Lupiflex 4 Tablet or any other medicines. Lupiflex 4 Tablet should not be taken in the conditions like kidney or heart disease. If you are pregnant or breastfeeding, please inform your doctor before starting Lupiflex 4 Tablet . Lupiflex 4 Tablet should not be used in children as safety and efficacy have not established. Lupiflex 4 Tablet may cause reduced body movements, drowsiness, sleepiness and dizziness it is advisable to you do not drive unless you are alert.

Uses of Lupiflex 4 Tablet

Osteoarthritis, Rheumatoid arthritis, Gouty arthritis, Ankylosing spondylitis, Acute pain, Chronic low back pain, Muscle spasms.

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Lupiflex 4 Tablet is a combination of two drugs: Ketoprofen (pain killer) and Thiocolchicoside (Muscle relaxant). Lupiflex 4 Tablet is used for the treatment of osteoarthritis, rheumatoid arthritis, gout and ankylosing spondylitis, acute pain, chronic low back pain, and muscle spasms. Ketoprofen blocks the effect of a chemical messenger known as cyclo-oxygenase (COX) enzyme that makes another chemical 'prostaglandin' (PG). These chemicals are produced at injury sites and cause pain and swelling. By blocking the effect of chemicals, ketoprofen helps in reducing mild to moderate pain and inflammation at the injured or damaged site. Thiocolchicoside works on the centers of the spinal cord and brain. This helps relieve muscle stiffness and improves muscle movements, thereby helping relieve pain due to muscle spasms.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Lupiflex 4 Tablet should not be taken if you are known to be allergic to Lupiflex 4 Tablet or any other medicines. Do not take Lupiflex 4 Tablet if you are allergic to any of its contents, if you have stomach ulcers, have suffered bleeding problems, clotting problems, inflammatory bowel disease, severe heart, liver or kidney problems. Lupiflex 4 Tablet can increase your risk of fatal heart attack or stroke. So, if you have had any recent heart surgery, do not take Lupiflex 4 Tablet . Inform your doctor before taking Lupiflex 4 Tablet if you have or had stomach bleeding or ulcers, heart failure, high blood pressure, high cholesterol, kidney or liver impairment. Lupiflex 4 Tablet may cause a visual disturbance in few patients, inform your doctor and discontinue the Lupiflex 4 Tablet immediately if you observe this symptom. This Lupiflex 4 Tablet may increase the potassium level, regular monitoring of potassium level may need. Do not take Lupiflex 4 Tablet if you are pregnant, planning for pregnancy or breastfeeding. If you are pregnant or breastfeeding, please inform your doctor before starting Lupiflex 4 Tablet . Lupiflex 4 Tablet should not be used in children as safety and efficacy have not established. Lupiflex 4 Tablet may cause reduced body movements, drowsiness, sleepiness and dizziness it is advisable to you do not drive unless you are alert.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Lupiflex 4 Tablet:
Coadministration of ketorolac together with Lupiflex 4 Tablet may increase the risk of side effects in the gastrointestinal tract such as inflammation, bleeding and ulcers.

How to manage the interaction:
Taking Ketorolac with Lupiflex 4 Tablet is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience any unusual bleeding, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Lupiflex 4 Tablet:
Coadministration of Lupiflex 4 Tablet and Tenofovir disoproxil can increase the risk of developing kidney problems.

How to manage the interaction:
Taking Lupiflex 4 Tablet and Tenofovir disoproxil together can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, shortness of breath, muscle cramps, dizziness, and irregular heart rhythm, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Lupiflex 4 Tablet:
Using Dasatinib together with Lupiflex 4 Tablet may increase the risk of bleeding.

How to manage the interaction:
Co-administration of Dasatinib with Lupiflex 4 Tablet can result in an interaction, but it can be taken if a doctor has advised it. If you experience symptoms - like bruising, feeling dizzy or lightheaded, having red or black stools, severe headaches contact a doctor right away. Do not stop using any medications without a doctor's advice.
How does the drug interact with Lupiflex 4 Tablet:
Taking Lupiflex 4 Tablet with fondaparinux can increase the risk of bleeding complications.

How to manage the interaction:
Taking Fondaparinux with Lupiflex 4 Tablet together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience bleeding, severe back pain, dizziness, black or red stools, severe headache, weakness, and vomiting contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
How does the drug interact with Lupiflex 4 Tablet:
Taking Human immunoglobulin with Lupiflex 4 Tablet, may raise the risk of kidney problems.

How to manage the interaction:
There may be a possibility of interaction between Human immunoglobulin and Lupiflex 4 Tablet, but it can be taken if prescribed by a doctor. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Lupiflex 4 Tablet:
Coadministration of Lupiflex 4 Tablet and Apixaban co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining Lupiflex 4 Tablet and Apixaban may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
How does the drug interact with Lupiflex 4 Tablet:
Everolimus can cause kidney issues, and taking it with Lupiflex 4 Tablet, can enhance the risk.

How to manage the interaction:
There may be a possibility of interaction between Everolimus and Lupiflex 4 Tablet, but it can be taken if prescribed by a doctor. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not stop using any medications without talking to a doctor.
How does the drug interact with Lupiflex 4 Tablet:
Taking Flurbiprofen with Lupiflex 4 Tablet can increase the risk of side effects.

How to manage the interaction:
Co-administration of Flurbiprofen with Lupiflex 4 Tablet can possibly result in an interaction, but it can be taken if your doctor has advised it. If you're having any of these symptoms like stomach pain, bleeding, or feeling dizzy, it's important to contact your doctor right away. They may be able to recommend other options that won't cause these problems. Remember to reach out to your doctor if you experience any unusual symptoms. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with Lupiflex 4 Tablet:
Taking Lupiflex 4 Tablet with etodolac may raise the risk of gastrointestinal adverse effects (inflammation, bleeding, ulceration, and, in rare cases perforation).

How to manage the interaction:
Co-administration of Etodolac with Lupiflex 4 Tablet can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience any unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, a severe headache, and/or weakness, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Lupiflex 4 Tablet:
Taking Lupiflex 4 Tablet with Glimepiride may increase the risk of hypoglycemia (low blood sugar).

How to manage the interaction:
Although there is a possible interaction, Glimepiride can be taken with Lupiflex 4 Tablet if prescribed by the doctor. Consult the prescriber if you experience symptoms of low blood sugar such as headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat. Do not taking the medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep as resting the muscles can help in reducing inflammation and swelling.
  • Follow heat or cold therapy, apply a cold or hot compress on the joints for 15-20minutes regularly.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listen to soothing music.
  • Acupuncture, massage and physical therapy may also be helpful.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANALGESICS

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Lupiflex 4 Tablet is a combination of two drugs: Ketoprofen and Thiocolchicoside. Ketoprofen blocks the effect of a chemical messenger known as cyclo-oxygenase (COX) enzyme that makes another chemical 'prostaglandin' (PG). These prostaglandins are produced at injury sites and cause pain and swelling. By blocking the effect of chemicals ketoprofen helps in reducing mild to moderate pain and inflammation at the injured or damaged site. Thiocolchicoside is a muscle relaxant that works on the centers of the spinal cord and brain. This helps relieve muscle stiffness and improves muscle movements, thereby helping relieve pain due to muscle spasms. This Lupiflex 4 Tablet is thus better efficient in relieving inflammation and pain.

Lupiflex 4 Tablet is used to reduce and relieve pain and inflammation associated with osteoarthritis, rheumatoid arthritis, gouty arthritis and ankylosing spondylitis. Arthritis is the tenderness and swelling in the joints.

Diarrhea might be a side-effect of Lupiflex 4 Tablet . Drink enough fluids and eat fiber-rich food if you experience diarrhea. If you find blood in stools (tarry stools) or if you experience excess diarrhea consult your doctor. Do not take anti-diarrheal medicine on your own.

Lupiflex 4 Tablet might cause swelling of feet and hands due to fluid retention (edema). While lying down, raise your legs above by putting a pillow below them. Follow a low-salt diet as it might help in reducing fluid build-up.

In some patients, this Lupiflex 4 Tablet may cause a visual disturbance. Immediately discontinue the Lupiflex 4 Tablet in case of visual difficulties and contact your doctor.

Drug-Drug Interactions Checker List

  • WARFARIN
  • KETOROLAC
  • PREDNISOLONE
  • CAPTOPRIL
  • ENALAPRIL
  • GLIMEPIRIDE
  • AMITRIPTYLINE

Special Advise

  • Lupiflex 4 Tablet is not recommended for use in patients with a history of gastrointestinal ulcers or bleeding since it may worsen the patient's condition.
  • Lupiflex 4 Tablet  may cause an impairment of fertility in men and women. Consult your doctor before using Lupiflex 4 Tablet .

Disease/Condition Glossary

Pain: Pain is a symptom triggered by the nervous system, causing uncomfortable sensations in the body. Pain may be dull or sharp, it might be constant or may come and go. The tolerance level of pain might vary from person to person. Pain can be generalized (overall body aches) or localized (affecting a specific area of the body). Pain can be considered a good thing as it helps us know that something is wrong in the body and thereby helps diagnose the condition. The common causes of pain include headache, muscle strain, cramps, cuts, bone fractures, and arthritis.

Osteoarthritis: It is a joint disease in which the two ends of the joints come together due to the breakdown of a protective covering of cartilage. Due to the absence of this protective covering, the joints rub against each other, leading to pain and stiffness. Symptoms include pain, stiffness, inflammation and tenderness.

Rheumatoid arthritis: It is an auto-immune disease (the body's immune system attacks its tissue), leading to joint pain and damage. Symptoms of rheumatoid arthritis include pain, swelling, stiffness, deformities and loss of joint function. 

Ankylosing spondylitis: It causes pain and stiffness in the spine. The pain generally starts in the lower back and can spread to the neck, damaged joints or other body parts. Ankylosing spondylitis includes decreased flexibility which usually leads to hunched-forward posture, pain and back and joints.

Gout: It is caused due to deposits of uric acid crystals in the joints, which leads to pain and inflammation in the joints. Symptoms include pain, swelling and redness in the joints, mostly the big toe.

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