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  1. Home
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  3. Macrozide-750 Tablet 10's

Macrozide-750 Tablet 10's, Pack of 10 TabletS
Macrozide-750 Tablet 10's, Pack of 10 TabletS
Not for online sale
Written By Divya L , PharmaD
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
Non returnable*
Know More
COD available

Online payment accepted

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Whats That

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Composition :

PYRAZINAMIDE-750MG

Manufacturer/Marketer :

Macleods Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

NPPA :

Regulated

About Macrozide-750 Tablet

Macrozide-750 Tablet belongs to the group of medicines called 'anti-tuberculosis' drugs primarily used to treat and prevent tuberculosis. Tuberculosis is an infectious disease that mainly affects the lungs, but it can also spread to other body parts such as kidneys, brain, spine and bone marrow. Macrozide-750 Tablet does not work against infections caused by the virus, such as the common cold and flu.

Macrozide-750 Tablet contains 'Pyrazinamide'. Pyrazinamide is a chemically synthesised bacteriocidal antibiotic. It converts a special enzyme to an active form that inhibits the synthesis of fatty acids; this disrupts the cell membrane and disables energy production necessary for the survival of the TB bacteria.

Your doctor will decide the dose and duration based on the severity of your disease. Common side effects of Macrozide-750 Tablet include muscle/joint pain, nausea, vomiting and loss of appetite. These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.

Let your doctor know if you use any prescription and non-prescription medications you are taking, including other vitamins, before starting Macrozide-750 Tablet . Please tell your doctor if you are allergic to Macrozide-750 Tablet or its components. Inform your doctor beforehand if you have a history of liver or kidney diseases, diabetes, gout, high uric acid level in the blood, alcohol use and are undergoing dialysis. It is essential to let your doctor know if you are pregnant, planning to conceive or are a breastfeeding mother. Avoid consuming alcohol along with Macrozide-750 Tablet as it might lead to liver problems.

Uses of Macrozide-750 Tablet

Tuberculosis (TB).

Directions for Use

Swallow Macrozide-750 Tablet as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Macrozide-750 Tablet contains 'Pyrazinamide', which is used to treat and prevent tuberculosis. Pyrazinamide is a chemically synthesised bacteriocidal antibiotic. It converts a special enzyme to an active form that inhibits the synthesis of fatty acids; this disrupts the cell membrane and disables energy production necessary to survive the TB bacteria. It is usually given in alone or combined with other antitubercular agents to treat tuberculosis.

Storage

Store in a cool and dry place away from sunlight
Side effects of Macrozide-750 Tablet
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the step-by-step strategies to manage the side effects of " Muscle Pain" caused by medication usage:
  • Report to Your Doctor: Inform your doctor about the muscle pain, as they may need to adjust your medication.
  • Stretch Regularly: Gentle stretching can help relieve muscle pain and stiffness.
  • Stay Hydrated: Adequate water intake supports muscle health by removing harmful substances and maintaining proper muscle function.
  • Warm or Cold Compresses: Apply cold or warm compresses to the affected area to reduce pain and inflammation.
  • Rest and Relaxation: Adequate rest helps alleviate muscle strain, while relaxation techniques like deep breathing and meditation can soothe muscle tightness, calm the mind, and promote relief from discomfort.
  • Gentle Exercise: Participate in low-impact activities, such as yoga or short walks, to improve flexibility, reduce muscle tension, and alleviate discomfort.
  • Consult a physician: If your symptoms don't improve or get worse, go to the doctor for help and guidance.
Managing Medication-Triggered malaise (Feeling Unwell): A Step-by-Step Guide:
  • If you experience persistent or severe malaise (a general feeling of discomfort, illness, or unease) after taking medication, seek medical attention immediately.
  • Inform your doctor about the medication you're taking and the symptoms you're experiencing.
  • Your treatment plan may be modified, which may include adjusting the dosage, substituting with an alternative medication, or discontinuing the medication. Additionally, certain lifestyle changes may be recommended to help manage symptoms.
  • To manage malaise symptoms, follow your doctor's advice, such as getting plenty of rest, staying hydrated, and practicing stress-reducing techniques.
  • Track your symptoms regularly and report any changes or concerns to your healthcare provider to ensure the malaise is managed effectively.
  • Painful urination can be reduced by drinking lots of water.
  • Don't hold urine, as it can worsen the pain during urination.
  • Try taking probiotics and eating garlic, which can help reduce painful urination.
  • Sleep well and give enough rest to your body.
  • Take a balanced diet and avoid bladder-irritating foods.
  • Quit smoking and intake of alcohol.
  • Practice yoga and meditation to improve inner strength and stay healthy.

Drug Warnings

Brief your medical history to the doctor if you have any liver or kidney diseases, diabetes, gout, high uric acid level in the blood, lactose intolerance, alcohol use and are undergoing dialysis treatment before starting Macrozide-750 Tablet . Let your doctor know if you are undergoing any vaccinations with live bacterial vaccines (like typhoid vaccine) since Macrozide-750 Tablet may affect vaccine's activity. Please consult your doctor know if you are pregnant, planning to conceive or are a breastfeeding mother before starting Macrozide-750 Tablet . Avoid consuming alcohol along with Macrozide-750 Tablet as it might lead to liver problems. Store Macrozide-750 Tablet below 25°C away from direct sunlight.

Drug-Drug Interactions

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PyrazinamideTeriflunomide
Severe
PyrazinamideKetoconazole
Severe

Drug-Drug Interactions

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PyrazinamideTeriflunomide
Severe
How does the drug interact with Macrozide-750 Tablet:
Co-administration of Teriflunomide with Macrozide-750 Tablet may increase the risk or severity of liver damage.

How to manage the interaction:
Although taking Teriflunomide and Macrozide-750 Tablet together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you have any of these symptoms, it's important to contact your doctor immediately: fever, chills, joint pain, swelling, bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, or bleeding. Do not stop using any medications without a doctor's advice. Do not discontinue the medication without consulting a doctor.
PyrazinamideKetoconazole
Severe
How does the drug interact with Macrozide-750 Tablet:
Co-administration of Ketoconazole with Macrozide-750 Tablet may increase the risk or severity of liver damage.

How to manage the interaction:
Although taking Ketoconazole and Macrozide-750 Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you have any of the following symptoms: fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, fatigue, lack of appetite, nausea, vomiting, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor immediately. Do not discontinue the medication without consulting a doctor.
PyrazinamideRifampicin
Severe
How does the drug interact with Macrozide-750 Tablet:
Taking rifampicin together with Macrozide-750 Tablet can cause liver problems.

How to manage the interaction:
Although there is an interaction between Macrozide-750 Tablet and rifampicin, they can be taken together if prescribed by a doctor. However, if you experience fever, rash, less desire to eat, nausea, vomiting, fatigue, right upper abdominal pain, or dark urine, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
PyrazinamideLeflunomide
Severe
How does the drug interact with Macrozide-750 Tablet:
Co-administration of leflunomide with Macrozide-750 Tablet may increase the risk or severity of liver problems.

How to manage the interaction:
Although taking Leflunomide and Macrozide-750 Tablet together can cause an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
PyrazinamideLomitapide
Severe
How does the drug interact with Macrozide-750 Tablet:
Co-administration of Lomitapide with Macrozide-750 Tablet may increase in the risk or severity of liver problems.

How to manage the interaction:
Although taking Lomitapide and Macrozide-750 Tablet together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you have any of these symptoms, it's important to contact your doctor immediately: fever, chills, joint pain, swelling, bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, or bleeding. Do not stop using any medications without a doctor's advice. Do not discontinue the medication without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Pineapple juice might help soothe the symptoms of cough and cold. It also has anti-inflammatory and mucolytic properties.
  • Foods rich in vitamin C, such as kiwi, broccoli and bell pepper, help improve the immune system.
  • Avoid processed and fried foods.
  • Warm ginger tea or warm soup can help in providing relief from the cough.
  • Avoid foods and drinks, such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine and beer.
  • Quit smoking and avoid alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTI- TUBERCULOSIS

Macrozide-750 Tablet Substitute

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Author Details

Doctor image

Written By

Divya L

PharmaD

Bayyarapu Mahesh KumarDoctor badge

Reviewed By

Bayyarapu Mahesh Kumar

M Pharmacy

Last Updated

Jul 8, 2025 | 9:34 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Macrozide-750 Tablet contains 'Pyrazinamide.' It is bactericidal and works by stopping the growth of Mycobacterium tuberculosis, a bacteria that causes tuberculosis.

Macrozide-750 Tablet is not recommended for use in the medical history of liver or kidney diseases, diabetes, gout, high uric acid level in the blood, alcohol use and undergoing dialysis treatment. Please let your doctor know if you have any other medical problems before starting Macrozide-750 Tablet .

Macrozide-750 Tablet can affect the live vaccines like typhoid vaccine and decrease its effectiveness. Please consult a doctor before you start Macrozide-750 Tablet if you are undergoing any vaccinations.

It is advised to take Macrozide-750 Tablet 30 minutes before food or 2 hours after food. Please consult your doctor for more information.

Macrozide-750 Tablet gets converted in the body to Pyrazinoic acid that blocks the excretion of urates (salt form of uric acid) by the kidneys. Increased blood levels of uric acid (hyperuricemia) causes pain, swelling, redness and stiffness in joints (gout). Hence, Macrozide-750 Tablet should be avoided if you have a history of gout.

Drug-Drug Interactions Checker List

  • PROBENECID
  • SULFINPYRAZONE

Special Advise

  • Let your doctor know that you are taking Macrozide-750 Tablet if you are undergoing any medical tests.
  • Your doctor may advise liver enzymes and uric acid levels tests before you start treatment to make sure you can safely take Macrozide-750 Tablet .
  • It is advised to undergo liver functioning tests to keep a check on your liver function.
  • Use a reliable contraceptive method (such as condoms or a diaphragm) to prevent pregnancy while you are taking Macrozide-750 Tablet as it may make hormonal contraceptives such as the pill less effective.

Disease/Condition Glossary

Tuberculosis (TB): Tuberculosis is an infectious disease that affects the lungs, but it could also spread to other body parts such as kidneys, brain, spine and bone marrow. Tuberculosis is caused by a bacteria named Mycobacterium tuberculosis. It is a contagious disease which can spread to others through small droplets released into the air by a person suffering from tuberculosis. Symptoms include a cough that lasts for a few weeks, pain while coughing or normal breathing, unexplained fatigue, fever, night sweats, and loss of appetite and weight. People who smoke or consume alcohol, and people diagnosed with HIV and immune system problems are more likely at risk of developing active TB.

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