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Written By Divya L , PharmaD
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy

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Whats That

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Composition :

PYRAZINAMIDE-750MG

Manufacturer/Marketer :

Macleods Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

NPPA :

Regulated

Therapeutic Class

ANTI- TUBERCULOSIS

Country of origin

India

Manufacturer/Marketer address

Atlanta Arcade, Marol Church Road, Andheri (East), Mumbai - 400059, INDIA.
Other Info - MAC0037

Author Details

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FAQs

Macrozide-750 Tablet contains 'Pyrazinamide.' It is bactericidal and works by stopping the growth of Mycobacterium tuberculosis, a bacteria that causes tuberculosis.

Macrozide-750 Tablet is not recommended for use in the medical history of liver or kidney diseases, diabetes, gout, high uric acid level in the blood, alcohol use and undergoing dialysis treatment. Please let your doctor know if you have any other medical problems before starting Macrozide-750 Tablet .

Macrozide-750 Tablet can affect the live vaccines like typhoid vaccine and decrease its effectiveness. Please consult a doctor before you start Macrozide-750 Tablet if you are undergoing any vaccinations.

It is advised to take Macrozide-750 Tablet 30 minutes before food or 2 hours after food. Please consult your doctor for more information.

Macrozide-750 Tablet gets converted in the body to Pyrazinoic acid that blocks the excretion of urates (salt form of uric acid) by the kidneys. Increased blood levels of uric acid (hyperuricemia) causes pain, swelling, redness and stiffness in joints (gout). Hence, Macrozide-750 Tablet should be avoided if you have a history of gout.

Disclaimer

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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Macrozide-750 Tablet . Alcohol intake, along with Macrozide-750 Tablet , may cause increased liver damage. Please consult your doctor for more information.

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Pregnancy

Caution

Macrozide-750 Tablet should be used with caution during pregnancy. Please consult your doctor before taking Macrozide-750 Tablet if you are pregnant or planning to conceive.

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Breast Feeding

Caution

Macrozide-750 Tablet is not recommended for use during breastfeeding since it is excreted into the breast milk and may harm a nursing baby. Please consult your doctor if you are a breastfeeding mother.

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Driving

Caution

It is not known if Macrozide-750 Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to drive or operate machinery.

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Liver

Caution

Macrozide-750 Tablet is not recommended in patients with severe liver damage. Please consult your doctor since Macrozide-750 Tablet should be used with caution in patients with liver impairment/liver disease. Regular monitoring of the liver with liver function tests is also advised.

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Kidney

Caution

Please consult your doctor since Macrozide-750 Tablet should be used with caution in patients with kidney impairment/kidney disease. Your doctor may adjust the dosage in case of renal dysfunction.

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Children

Caution

Macrozide-750 Tablet is recommended in children below 12 years of age only after doctor's advice.

About Macrozide-750 Tablet

Macrozide-750 Tablet belongs to the group of medicines called 'anti-tuberculosis' drugs primarily used to treat and prevent tuberculosis. Tuberculosis is an infectious disease that mainly affects the lungs, but it can also spread to other body parts such as kidneys, brain, spine and bone marrow. Macrozide-750 Tablet does not work against infections caused by the virus, such as the common cold and flu.

Macrozide-750 Tablet contains 'Pyrazinamide'. Pyrazinamide is a chemically synthesised bacteriocidal antibiotic. It converts a special enzyme to an active form that inhibits the synthesis of fatty acids; this disrupts the cell membrane and disables energy production necessary for the survival of the TB bacteria.

Your doctor will decide the dose and duration based on the severity of your disease. Common side effects of Macrozide-750 Tablet include muscle/joint pain, nausea, vomiting and loss of appetite. These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.

Let your doctor know if you use any prescription and non-prescription medications you are taking, including other vitamins, before starting Macrozide-750 Tablet . Please tell your doctor if you are allergic to Macrozide-750 Tablet or its components. Inform your doctor beforehand if you have a history of liver or kidney diseases, diabetes, gout, high uric acid level in the blood, alcohol use and are undergoing dialysis. It is essential to let your doctor know if you are pregnant, planning to conceive or are a breastfeeding mother. Avoid consuming alcohol along with Macrozide-750 Tablet as it might lead to liver problems.

Uses of Macrozide-750 Tablet

Tuberculosis (TB).

Medicinal Benefits Mweb

Medicinal Benefits

Macrozide-750 Tablet contains 'Pyrazinamide', which is used to treat and prevent tuberculosis. Pyrazinamide is a chemically synthesised bacteriocidal antibiotic. It converts a special enzyme to an active form that inhibits the synthesis of fatty acids; this disrupts the cell membrane and disables energy production necessary to survive the TB bacteria. It is usually given in alone or combined with other antitubercular agents to treat tuberculosis.

Directions for Use

Swallow Macrozide-750 Tablet as a whole with water; do not crush, break or chew it.

Side Effects of Macrozide-750 Tablet

  • Muscle/joint pain
  • Nausea
  • Vomiting
  • Loss of appetite
  • Hepatitis, liver dysfunction

Drug Warnings

Brief your medical history to the doctor if you have any liver or kidney diseases, diabetes, gout, high uric acid level in the blood, lactose intolerance, alcohol use and are undergoing dialysis treatment before starting Macrozide-750 Tablet . Let your doctor know if you are undergoing any vaccinations with live bacterial vaccines (like typhoid vaccine) since Macrozide-750 Tablet may affect vaccine's activity. Please consult your doctor know if you are pregnant, planning to conceive or are a breastfeeding mother before starting Macrozide-750 Tablet . Avoid consuming alcohol along with Macrozide-750 Tablet as it might lead to liver problems. Store Macrozide-750 Tablet below 25°C away from direct sunlight.

Drug-Drug Interactions

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Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Drug Interactions Checker List

  • PROBENECID
  • SULFINPYRAZONE

Habit Forming

No

Special Advise

  • Let your doctor know that you are taking Macrozide-750 Tablet if you are undergoing any medical tests.
  • Your doctor may advise liver enzymes and uric acid levels tests before you start treatment to make sure you can safely take Macrozide-750 Tablet .
  • It is advised to undergo liver functioning tests to keep a check on your liver function.
  • Use a reliable contraceptive method (such as condoms or a diaphragm) to prevent pregnancy while you are taking Macrozide-750 Tablet as it may make hormonal contraceptives such as the pill less effective.

Diet & Lifestyle Advise

  • Pineapple juice might help soothe the symptoms of cough and cold. It also has anti-inflammatory and mucolytic properties.
  • Foods rich in vitamin C, such as kiwi, broccoli and bell pepper, help improve the immune system.
  • Avoid processed and fried foods.
  • Warm ginger tea or warm soup can help in providing relief from the cough.
  • Avoid foods and drinks, such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine and beer.
  • Quit smoking and avoid alcohol consumption.

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