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Composition :

GENTAMICIN-80MG

Manufacturer/Marketer :

Marc Laboratories Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

Medicinal Benefits Mweb

Medicinal Benefits

Marcogenta 80 Injection is an antibiotic that treats severe/serious bacterial infections. It contains Gentamicin which works by inhibiting bacterial protein synthesis, thus inhibiting bacterial growth. It shows a bacteriostatic effect, which stops bacterial reproduction but doesn't kill them. Marcogenta 80 Injection is useful in treating recurrent infections of kidneys, urinary ducts and bladder, lungs and airways infections during hospitalization, infections of the skin and soft tissues, including burns, and sepsis (blood poisoning by bacteria).

About Marcogenta 80 Injection

Marcogenta 80 Injection belongs to the class of 'antibiotics', primarily used to treat serious bacterial infections. Bacterial infection occurs when harmful bacteria grow in the body and causes illness. It can infect any part of the body and multiply very quickly. 

Marcogenta 80 Injection is composed of Gentamicin, an aminoglycoside antibiotic. It prevents bacteria from synthesising essential proteins required to carry out vital functions. It has broad-spectrum activity against aerobic gram-positive and gram-negative bacteria. 

Marcogenta 80 Injection will be administered by a healthcare professional. Marcogenta 80 Injection may cause a few side effects, although not everybody gets them. Common side effects of Marcogenta 80 Injection include stomach upset, nausea, vomiting, loss of appetite, weight loss, light-headedness, headache, mood changes, joint pain, itching or rash, pain and swelling at the injection site. Most of these side effects do not require medical attention and gradually resolve over time. If these side effects persist longer, please consult your doctor.

Let your doctor know if you have any allergic reactions to medicines, liver/kidney problems, cystic fibrosis (a genetic disorder that affects the digestive and respiratory system), hearing problems, electrolyte imbalance, myasthenia gravis (muscular weakness), or Parkinson's disease before starting Marcogenta 80 Injection . Marcogenta 80 Injection should be used only with a doctor's advice during pregnancy and breastfeeding. Marcogenta 80 Injection may cause light-headedness; in such cases, please do not drive until you are alert. Marcogenta 80 Injection may cause dizziness/vertigo; hence avoid or limit alcohol consumption. 

Drug-Drug Interactions

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GentamicinBacitracin
Severe

Drug-Drug Interactions

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GentamicinBacitracin
Severe
How does the drug interact with Marcogenta 80 Injection 100 ml:
Taking Marcogenta 80 Injection 100 ml with bacitracin may increase the risk of serious side effects such as respiratory depression, kidney problems, and hearing loss.

How to manage the interaction:
Although there is a possible interaction, Marcogenta 80 Injection 100 ml can be taken with bacitracin if prescribed by the doctor. Consult the prescriber if you experience hearing loss, ringing in the ears, vertigo, difficulty breathing, (or) signs and symptoms of kidney damage such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm.
How does the drug interact with Marcogenta 80 Injection 100 ml:
Co-administration of Vecuronium with Marcogenta 80 Injection 100 ml can make the treatment more effective.

How to manage the interaction:
Taking Vecuronium with Marcogenta 80 Injection 100 ml together can possibly result in an interaction, but it can be taken if a doctor has advised it. If you have any of these symptoms - having trouble breathing or feeling like you can't catch your breath for a long time - it's important to call a doctor right away. Do not stop using any medications without a doctor's advice.
How does the drug interact with Marcogenta 80 Injection 100 ml:
Co-administration of Marcogenta 80 Injection 100 ml and Temsirolimus may increase the risk of kidney problems.

How to manage the interaction:
Co-administration of Marcogenta 80 Injection 100 ml with Temsirolimus can possibly result in an interaction, but it can be taken if a doctor has advised it. It's important to keep an eye on how much you pee. If you notice any changes like peeing more or less than usual, it's a good idea to let your doctor know right away. Some signs to watch out for include gaining weight quickly, feeling bloated, having trouble breathing, or feeling sick to your stomach. Other symptoms to be aware of are not feeling hungry, losing weight, swelling, muscle cramps, feeling weak or dizzy, feeling confused, or having an irregular heartbeat. Do not stop using any medications without a doctor's advice.
GentamicinTubocurarine
Severe
How does the drug interact with Marcogenta 80 Injection 100 ml:
Co-administration of Marcogenta 80 Injection 100 ml and Tubocurarine may increase the risk of side effects.

How to manage the interaction:
Co-administration of Marcogenta 80 Injection 100 ml with Tubocurarine can possibly result in an interaction, but it can be taken if a doctor has advised it. If you have any of these symptoms, it's important to contact a doctor right away. These symptoms include having trouble breathing, feeling very weak or unable to breathe, not being able to move your muscles, having problems with your kidneys, having low levels of calcium in your body, or feeling very sick. Do not discontinue any medications without consulting a doctor.
GentamicinPipecuronium bromide
Severe
How does the drug interact with Marcogenta 80 Injection 100 ml:
Co-administration of Pipecuronium bromide with Marcogenta 80 Injection 100 ml may increase the risk or severity of side effects.

How to manage the interaction:
There may be a possibility of interaction between Marcogenta 80 Injection 100 ml and Pipecuronium bromide, but it can be taken if prescribed by a doctor. If you have trouble breathing or feel like you can't breathe at all, it's important to contact your doctor right away. This is especially true if you're having difficulty breathing for a long time. Do not stop using any medications without a doctor's advice.
GentamicinBumetanide
Severe
How does the drug interact with Marcogenta 80 Injection 100 ml:
Taking Marcogenta 80 Injection 100 ml can cause hearing loss, ringing in the ears, vertigo, and kidney problems, and combining it with bumetanide may increase the risk.

How to manage the interaction:
Although there is a possible interaction, Marcogenta 80 Injection 100 ml can be taken with bumetanide if prescribed by the doctor. Consult the doctor if you experience hearing loss, ringing in the ears, vertigo, or kidney problems.
How does the drug interact with Marcogenta 80 Injection 100 ml:
Coadministration of Sirolimus with Marcogenta 80 Injection 100 ml may increase the risk or severity of kidney problems.

How to manage the interaction:
Although there is a possible interaction, Marcogenta 80 Injection 100 ml can be taken with sirolimus if prescribed by the doctor. Consult the doctor if you experience symptoms of kidney damage such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not stop using any medication without consulting your doctor.
GentamicinFoscarnet
Severe
How does the drug interact with Marcogenta 80 Injection 100 ml:
Co-administration of Marcogenta 80 Injection 100 ml with Foscarnet can increase the risk of kidney damage.

How to manage the interaction:
Although taking Marcogenta 80 Injection 100 ml and Foscarnet together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you have any of these symptoms, it's important to contact your doctor right away: seizures, an irregular heart rhythm, feeling sick, swelling, sudden weight gain or loss, severe pain in your upper stomach, strong heartbeats, feeling dizzy, or chest pain. Do not stop using any medications without a doctor's advice.
How does the drug interact with Marcogenta 80 Injection 100 ml:
Taking Marcogenta 80 Injection 100 ml with cidofovir can increase the risk of kidney problems.

How to manage the interaction:
Although taking Marcogenta 80 Injection 100 ml and cidofovir together can possibly cause an interaction, it can be taken if your doctor has suggested it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Marcogenta 80 Injection 100 ml:
Co-administration of Colistin with Marcogenta 80 Injection 100 ml can increase the levels and risk of Colistin side effects.

How to manage the interaction:
Although there is a possible interaction between Colistin and Marcogenta 80 Injection 100 ml, you can take these medicines together if prescribed by your doctor. However, if you experience weight gain or loss suddenly, muscle pain, dizziness, or palpitations, call your doctor right away. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Therapeutic Class

ANTIBIOTICS

FAQs

Marcogenta 80 Injection is an antibiotic that treats bacterial infections. It works by inhibiting bacterial protein synthesis, which retards bacterial growth.

Marcogenta 80 Injection should be used with proper caution and doctor consultation if you have any allergic reactions to medicines, liver/kidney problems, cystic fibrosis, hearing problems, low blood minerals/electrolyte imbalance, myasthenia gravis (muscular weakness), and Parkinson's disease.

Marcogenta 80 Injection can affect the live vaccines like typhoid vaccine and decrease its effectiveness. Please consult a doctor if you are undergoing any vaccinations.

Marcogenta 80 Injection may cause abnormal liver function tests as one of its side effects. It may increase the levels of liver enzymes and blood bilirubin. Please consult your doctor before starting Marcogenta 80 Injection if you have any history of liver problems.

Diarrhoea can be a side-effect of Marcogenta 80 Injection . Clostridium difficile-associated diarrhoea (CDAD) is also reported during usage of antibiotics like Marcogenta 80 Injection . Therefore, when the patient has diarrhoea, undergoing an examination is advised to rule out the chances of CDAD following Marcogenta 80 Injection therapy.

Country of origin

India

Manufacturer/Marketer address

10, H.V.E.S, Building Complex, Kandaswamy Lane, Sultan Bazar Hyderabad-500029, Andhra Pradesh, India
Other Info - MAR0254

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Author Details

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Drug-Diseases Interactions

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GENTAMICIN-80MGOther symptoms and signs involving the digestive system and abdomen
Severe
GENTAMICIN-80MGMyasthenia gravis and other myoneural disorders
Severe

Drug-Diseases Interactions

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GENTAMICIN-80MGOther symptoms and signs involving the digestive system and abdomen
Severe
How does the disease interact with Marcogenta 80 Injection 100 ml:
Adequate hydration is critical for reducing the risk of oto- and nephrotoxicity associated with aminoglycoside usage. Dehydration should preferably be treated before starting therapy. Fluid status should be continuously maintained in patients who are at risk of dehydration, such as those who have severe and/or prolonged diarrhoea or vomiting. If indications of renal irritation appear during therapy, hydration should be increased as directed, followed by a dose reduction if necessary. If urine flow gradually decreases or azotemia worsens, therapy should be discontinued.

How to manage the interaction:
Dehydration should be corrected prior to initiation of therapy. Fluid status should be monitored closely in patients who may be at risk for dehydration, such as those with severe and/or prolonged diarrhea or vomiting. Therapy should be withdrawn if urinary output decreases progressively or azotemia (elevated levels of urea) increases.
GENTAMICIN-80MGMyasthenia gravis and other myoneural disorders
Severe
How does the disease interact with Marcogenta 80 Injection 100 ml:
Aminoglycosides can elicit dose-related neuromuscular blockade and muscle weakness, especially in patients with neuromuscular illness or hypocalcemia, as well as in those undergoing general anaesthesia, neuromuscular blocking medications, or substantial transfusions of citrate-anticoagulated blood. Although neuromuscular blockade caused by aminoglycosides is usually self-limiting, it can occasionally result in respiratory paralysis. The most potent neuromuscular blocking drug in the class is regarded to be neomycin. However, the risk is greatest with large dosages instilled intraperitoneally or intrapleurally, or with fast intravenous administration of parenteral aminoglycosides. In patients with neuromuscular problems (e.g., myasthenia gravis, parkinsonian syndrome, botulism) or hypocalcemia, aminoglycoside therapy should be used with caution. If indications of respiratory paralysis appear during aminoglycoside therapy, the medicine should be stopped and, if necessary, mechanical breathing assistance administered.

How to manage the interaction:
Therapy should be administered cautiously in patients with neuromuscular disorders (e.g., myasthenia gravis, Parkinsonian syndrome, botulism) or hypocalcemia (low calcium levels). The drug should be discontinued and mechanical respiratory assistance provided if needed if signs of respiratory paralysis occur during therapy.
GENTAMICIN-80MGOther disorders of ear, not elsewhere classified
Severe
How does the disease interact with Marcogenta 80 Injection 100 ml:
Aminoglycosides can harm the eighth cranial nerve, causing vestibular and/or auditory toxicity. Dizziness, nystagmus, vertigo, ataxia, tinnitus, and varied degrees of hearing impairment are among the symptoms. Following the discontinuation of the medicine, permanent hearing loss, including whole or partial irreversible bilateral deafness, may occur. Therapy with aminoglycosides, especially if extended (> 10 days), should be used with caution in patients with preexisting vestibular and/or auditory impairment, as it may delay or obfuscate the diagnosis of a drug-induced ototoxic impact. Patients should be adequately hydrated, the usual aminoglycoside dosage should not be exceeded, use with other ototoxic agents should be avoided, and peak and trough serum aminoglycoside concentrations should be determined on a regular basis and dosage adjusted to maintain desired levels.

How to manage the interaction:
Therapy should be administered with caution in patients with ototoxicity. The dosage should be reduced or therapy shoule be withdrawn if signs and symptoms of toxicity develop.
GENTAMICIN-80MGUnspecified kidney failure
Severe
How does the disease interact with Marcogenta 80 Injection 100 ml:
Aminoglycosides have the potential to be ototoxic and nephrotoxic. Damage to the eighth cranial nerve can cause vestibular and/or auditory toxicities such as dizziness, nystagmus, vertigo, ataxia, tinnitus, and varied degrees of hearing impairment. Tubular necrosis, increases in BUN, nonprotein nitrogen, and serum creatinine concentration, decreases in urine specific gravity and creatinine clearance, proteinuria, and cells or casts in the urine are all signs of nephrotoxicity. Rarely, renal electrolyte wasting can cause hypocalcemia, hypomagnesemia, and hypokalemia, which can be accompanied with paresthesia, tetany, disorientation, and positive Chvostek and Trousseau symptoms. Although aminoglycoside-induced nephrotoxicity is often reversible after treatment withdrawal, mortality from uremia has happened on rare occasions. Patients with renal impairment should be treated with caution and at lower doses of aminoglycosides, as they may be at risk.Drug buildup increases the risk of oto- and nephrotoxicity. Patients should be adequately hydrated, the usual aminoglycoside dosage should not be exceeded, use with other neuro- and nephrotoxic agents should be avoided, and peak and trough serum aminoglycoside concentrations should be determined on a regular basis and dosage adjusted to maintain desired levels. If toxicity develops, renal and eighth cranial nerve function should be constantly monitored, and the dosage lowered or therapy discontinued.

How to manage the interaction:
Therapy should be administered cautiously at reduced dosages in patients with kidney impairment. Patients should be adequately hydrated, the dose should not be exceeded, and use with other neuro- and nephrotoxic agents should be avoided to minimize the risk of toxicity.

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