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Written By ,
Reviewed By Sunny S , MBBS
48 Hrs returnable
COD available

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Whats That

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Composition :

IMATINIB-400MG

Manufacturer/Marketer :

Sarabhai Chemicals (India) Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

Therapeutic Class

ANTINEOPLASTIC

Country of origin

India

Manufacturer/Marketer address

Shantisadan, Mirzapur Road, Ahmedabad -380001
Other Info - MAT0091

FAQs

Matinic-400 Tablet contains Imatinib, an anti-cancer medication that works by inhibiting an enzyme responsible for the proliferation of cancer cells and hence induces cell death (apoptosis). As a result, the growth and spread of cancer cells are stopped or slowed down.

Regular monitoring of blood and urine tests and weight checks are required. An effective way of contraception should be used by both men and women while taking Matinic-400 Tablet .

Yes, you might become more sensitive to sunlight while taking Matinic-400 Tablet , so it is important to protect your skin with a high sun protection factor (SPF) while going out, as it can lead to a skin rash if you are not using a strong SPF.

In elderly patients taking Matinic-400 Tablet , the risk of side effects is more. For the elderly, dose adjustment might be required, or your doctor might prescribe any other medication safe for the elderly.

If you are having surgery, including dental surgery, please inform your doctor if you are taking Matinic-400 Tablet as your doctor might stop Matinic-400 Tablet before undergoing surgery.

Matinic-400 Tablet can make you more likely to get infections or may worsen any current infections. Avoid contact with people with infections that may spread to others (such as chickenpox, measles, or flu). Consult your doctor if you have been exposed to an infection or for more details.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Unsafe

Avoid alcohol consumption while taking Matinic-400 Tablet as it may increase drowsiness and lead to unpleasant side effects.

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Pregnancy

Unsafe

Matinic-400 Tablet is a pregnancy category D drug. It should not be used in pregnancy as it is known to cause fetal damage. Also, maintain a gap of 6 months between the last dose of Matinic-400 Tablet and your next pregnancy.

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Breast Feeding

Unsafe

Matinic-400 Tablet is known to pass through breast milk, and it may cause harm to the baby. So, it is advised not to breastfeed while taking Matinic-400 Tablet .

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Driving

Unsafe

Matinic-400 Tablet may cause weakness, dizziness and drowsiness. Do not drive or operate machinery unless you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

The safety and efficacy of Matinic-400 Tablet are not known in children. It should be taken only if prescribed by a doctor.

About Matinic-400 Tablet

Matinic-400 Tablet belongs to a class of drugs known as 'anti-cancer medication', primarily used to treat various types of cancer. It is used to treat cancer of the blood (chronic myeloid leukaemia and acute lymphocytic leukaemia) and gastrointestinal stromal tumour. Cancer is a genetic change in which the cells divide uncontrollably and spread into surrounding tissues. There are more than 100 types of cancer, including blood cancer, lung cancer, breast cancer, etc.

Matinic-400 Tablet contains Imatinib, which is primarily used to treat cancer. It works by inhibiting an enzyme responsible for cancer cell proliferation and induces cell death (apoptosis). As a result, the growth and spread of cancer cells are stopped or slowed down.

You are advised to take Matinic-400 Tablet for as long as your doctor has prescribed it for you, depending upon your medical condition. In some cases, you may experience nausea, vomiting, oedema, fatigue, muscle cramps, musculoskeletal pain, diarrhoea, rash, and abdominal pain. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently. 

Do not take Matinic-400 Tablet if you are allergic to any of its ingredients. While taking Matinic-400 Tablet , you might become more sensitive to sunlight, so it is important to protect your skin with a high sun protection factor (SPF). Regular blood tests are required to monitor liver function and blood cells in the blood while taking Matinic-400 Tablet . Matinic-400 Tablet can cause swelling and water retention, so if you have unexpected rapid weight gain, please consult your doctor. If you ever had a hepatitis B infection, please tell your doctor before starting Matinic-400 Tablet as it can make hepatitis B active again. 

Uses of Matinic-400 Tablet

Cancer

Medicinal Benefits Mweb

Medicinal Benefits

Matinic-400 Tablet belongs to a class of drugs known as 'anti-cancer medication' containing Imatinib, primarily used to treat various cancer types. It is used to treat cancer of the blood (chronic myeloid leukaemia and acute lymphocytic leukaemia) and gastrointestinal stromal tumour. It works by inhibiting an enzyme responsible for cancer cell proliferation and induces cell death (apoptosis). As a result, the growth and spread of cancer cells are stopped or slowed down.

Directions for Use

Swallow the medicine as a whole with a glass of water. Do not crush, chew or break it.

Side Effects of Matinic-400 Tablet

  • Fatigue
  • Nausea
  • Vomiting
  • Diarrhoea
  • Muscle cramp
  • Abdominal pain
  • Musculoskeletal pain
  • Oedema (tissue swelling)
  • Rash

Drug Warnings

Do not take Matinic-400 Tablet if you are allergic to any of its ingredients. Matinic-400 Tablet may cause blurry vision and dizziness, so do not drive or operate any machinery which requires concentration. While taking Matinic-400 Tablet , you might become more sensitive to sunlight, so it is important to protect your skin with a high sun protection factor (SPF) while going out, as it can lead to a skin rash if you are not using a strong SPF. Matinic-400 Tablet can cause leg swelling and water retention (oedema), so if you have unexpected rapid weight gain, please consult your doctor. If you ever had a hepatitis B infection, please tell your doctor before starting Matinic-400 Tablet as it can make hepatitis B active again. Matinic-400 Tablet may make you more susceptible to infections; consult your doctor if you develop any signs of infections, fever, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.

Drug-Drug Interactions

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ImatinibCobimetinib
Critical
ImatinibNaloxegol
Critical

Drug-Drug Interactions

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ImatinibCobimetinib
Critical
How does the drug interact with Matinic-400 Tablet:
When Cobimetinib is taken with Matinic-400 Tablet, it can increase the risk of serious side effects.

How to manage the interaction:
Taking Matinic-400 Tablet with Cobimetinib is not recommended, but can be taken if prescribed by the doctor. However, if you experience any unusual symptoms, consult the doctor.
ImatinibNaloxegol
Critical
How does the drug interact with Matinic-400 Tablet:
Taking Matinic-400 Tablet with Naloxegol may increase the level of naloxegol which may lead to side effects.

How to manage the interaction:
Taking Matinic-400 Tablet with Naloxegol is not recommended, it can be taken if prescribed by your doctor. However, if you experience any unusual symptoms, consult the consult.
ImatinibVenetoclax
Critical
How does the drug interact with Matinic-400 Tablet:
When Venetoclax is taken with Matinic-400 Tablet, Matinic-400 Tablet may increase the level of venetoclax which may lead to side effects.

How to manage the interaction:
Taking Matinic-400 Tablet with Venetoclax is not recommended, it can be taken if prescribed by your doctor. However, if you experience any unusual symptoms, consult the doctor.
ImatinibIvabradine
Critical
How does the drug interact with Matinic-400 Tablet:
Coadministration of Ivabradine with Matinic-400 Tablet can increase the levels of Ivabradine in the body. This increases the risk or severity of side effects.

How to manage the interaction:
Taking Ivabradine with Bosutinib together is generally avoided as it can result in an interaction, it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss. Do not discontinue any medications without consulting a doctor.
ImatinibLomitapide
Critical
How does the drug interact with Matinic-400 Tablet:
When Lomitapide is taken with Matinic-400 Tablet, it can increases levels of lomitapide which may lead to side effects.

How to manage the interaction:
Taking Matinic-400 Tablet with Lomitapide is not recommended, but it can be taken if prescribed by your doctor. However, if you experience any unusual symptoms, consult the doctor.
ImatinibCisapride
Critical
How does the drug interact with Matinic-400 Tablet:
When Matinic-400 Tablet is taken with Cisapride, it can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Matinic-400 Tablet with Cisapride is not recommended, it can be taken if a doctor has prescribed this. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not discontinue the medication without consulting a doctor.
ImatinibEliglustat
Critical
How does the drug interact with Matinic-400 Tablet:
When Matinic-400 Tablet is taken with Eliglustat, Matinic-400 Tablet increases levels of eliglustat which may lead to side effects.

How to manage the interaction:
Taking Matinic-400 Tablet with Eliglustat is not recommended, it can be taken if prescribed by your doctor. However, if you experience any unusual symptoms, consult the doctor.
ImatinibLurasidone
Critical
How does the drug interact with Matinic-400 Tablet:
Using Lurasidone together with Matinic-400 Tablet may result in significantly higher Lurasidone blood levels. This may increase the possibility of negative effects like Parkinson's disease. (It is a brain disorder that produces uncontrollable movements.)

How to manage the interaction:
Taking Lurasidone with Matinic-400 Tablet is not recommended as it leads to an interaction, it can be used if prescribed by a doctor. Consult a doctor if you have any abnormal muscle activity, fits, high blood sugar, high sugars, high cholesterol, heat intolerance or heat stroke, dizziness, lightheadedness, headache, flushing, fainting, or heart palpitations. Do not discontinue any medications without consulting a doctor.
ImatinibFlibanserin
Critical
How does the drug interact with Matinic-400 Tablet:
Taking Matinic-400 Tablet with Flibanserin may increase the level of flibanserin in body leading to side effects.

How to manage the interaction:
Taking Matinic-400 Tablet with Flibanserin is not recommended, but it can be taken if prescribed by your doctor. However, if you experience any unusual symptoms, consult the doctor.
ImatinibDihydroergotamine
Critical
How does the drug interact with Matinic-400 Tablet:
When Dihydroergotamine is taken with Matinic-400 Tablet, it increases levels of dihydroergotamine leading to side effects.

How to manage the interaction:
Taking Matinic-400 Tablet with Dihydroergotamine is not recommended, it can be taken if advised by your doctor. However, if you experience any unusual symptoms, consult the doctor.

Drug-Food Interactions

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IMATINIB-400MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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IMATINIB-400MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Grapefruit or its juice may increase the blood levels of Matinic-400 Tablet which may lead to side effects. Avoid consuming Grapefruit and its juice during treatment with Matinic-400 Tablet.

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • WARFARIN
  • ASPIRIN
  • AMLODIPINE
  • METOPROLOL
  • NIFEDIPINE
  • QUINIDINE
  • ATORVASTATIN
  • LOVASTATIN
  • SIMVASTATIN
  • CYCLOSPORINE
  • ERYTHROMYCIN
  • TELITHROMYCIN
  • ITRACONAZOLE
  • VORICONAZOLE
  • KETOCONAZOLE
  • TRIAZOLAM
  • ALPRAZOLAM
  • ESTAZOLAM
  • PRIMIDONE
  • PHENOBARBITAL
  • PHENYTOIN
  • SAQUINAVIR
  • RITONAVIR
  • SILDENAFIL

Habit Forming

No

Special Advise

  • A regular blood test is required to monitor liver function and blood cells in blood while taking Matinic-400 Tablet .
  • Always take it with food and a full glass of water to prevent nausea.
  • Matinic-400 Tablet can cause swelling and water retention, so if you have unexpected rapid weight gain, please consult your doctor. 
  • While taking Matinic-400 Tablet , you might become more sensitive to sunlight, so it is important to protect your skin with a high sun protection factor (SPF) while going out, as it can lead to a skin rash if you are not using a strong SPF.
  • Do not have immunisations with live vaccines (for mumps, rubella, measles and BCG, yellow fever and shingles or pox chicken) while you’re having treatment and for up to 12 months afterwards. 
  • Contact your doctor immediately if you experience any infection signs, including a temperature above 37.5 C or below 36 C.

Diet & Lifestyle Advise

  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate and high fibre content. Also, eat small and frequent meals for a speedy recovery.
  • Avoid smoking and alcohol consumption. Also, avoid high fat and cholesterol diet.

Matinic-400 Tablet Substitute

Substitutes safety advice
  • Glivec 400 mg Tablet 10's

    by Others

    196.72per tablet
  • Veenat 400 mg Tablet 10's

    by Others

    175.12per tablet
  • Imatib 400 Tablet 10's

    by Others

    171.59per tablet
  • Levin 400 Tablet 10's

    by Others

    143.10per tablet
  • Imat 400 Tablet 10's

    by AYUR

    201.20per tablet
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