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  3. MIFEPRIN KIT TABLET

MIFEPRIN KIT TABLET, Pack of 1 TABLET
Not for online sale
Written By ,
Reviewed By Sunny S , MBBS
Non returnable*
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Composition :

MIFEPRISTONE-200MG + MISOPROSTOL-200MCG

Return Policy :

Not Returnable

About MIFEPRIN KIT TABLET

MIFEPRIN KIT TABLET belongs to a group of gynaecological medications called ‘Abortifacient’ used for the medical termination of the pregnancy before 63 days after the first day of the last menses period. MIFEPRIN KIT TABLET also works in the second trimester of pregnancy.

MIFEPRIN KIT TABLET contains two medicines, namely: Mifepristone and Misoprostol. Mifepristone is an anti-hormone (anti-progestogen) that blocks the effects of the progesterone hormone required in women to continue the pregnancy. On the other hand, Misoprostol is a prostaglandin that increases the womb’s (uterus) contraction and dilates the cervix, thereby expelling the pregnancy. Thus, MIFEPRIN KIT TABLET together cause termination of pregnancy and must be used one after the other for medical abortion.

A medical abortion generally involves 2-3 visits to a doctor or clinic, which includes giving medicines and then confirmation of termination of pregnancy. Following are the schedule involved in medical abortion:

  • Day 1: Medical counselling and examination where doctor instructs to take one tablet of mifepristone (200 mcg)
  • Day 2 to 3: You must return to the hospital/clinic 36 to 48 hours after taking the first dose of mifepristone. Your doctor will tell you about this. The tablet of Misoprostol (800 mcg) will now be given either orally or vaginally.
  • Day 7 to 14: The doctor will confirm and make sure whether the medical abortion has been completed or not. If the abortion is not complete, you might require more follow-up visits.

In some cases, you may experience nausea, uterine cramps, vomiting, diarrhoea, infection following abortion, dizziness, and uterine bleeding. Most of these side effects of MIFEPRIN KIT TABLET subside with time. But if vaginal bleeding does not stop, please visit the doctor immediately, as it requires immediate medical attention.

MIFEPRIN KIT TABLET should not be stopped abruptly without consulting the doctor as it may lead to incomplete abortion. Inform your doctor before starting MIFEPRIN KIT TABLET if you have had an ectopic pregnancy (when the womb grows in the fallopian tube), using an intrauterine device, or you are breastfeeding, any bleeding disorder or heart problem. Do not strenuous activities like running, heavy exercise, or driving to avoid excessive bleeding. The doctor will also check with ultrasound if the absorption is complete as no bleeding does not mean that abortion is complete.

Uses of MIFEPRIN KIT TABLET

Medical abortion

Directions for Use

MIFEPRIN KIT TABLET should be taken in dose and duration as prescribed by your doctor.

Medicinal Benefits

MIFEPRIN KIT TABLET contains Mifepristone and Misoprostol. Mifepristone works by blocking the effect of progesterone (female hormone) needed to maintain a pregnancy. In the absence of progesterone, the lining of the uterus breaks down as it does every month during the menstrual cycle, and the growth of pregnancy is stopped. It takes approximately 24-48 hours for MIFEPRIN KIT TABLET to show effect. Once it starts acting, you will experience uterine bleeding. But no uterine bleeding does not mean that the abortion is complete. On the other hand, the second medicine is Misoprostol, a prostaglandin analogue that helps increase uterine contractions and relaxes the cervix. Thus Together MIFEPRIN KIT TABLET terminates the state of pregnancy. Misoprostol should be taken at least 24-36 hours after taking mifepristone, either orally or vaginally. This is a non-surgical method which is 90% successful.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Do not take MIFEPRIN KIT TABLET if you are allergic to misoprostol and mifepristone, have a heart fitted with an artificial valve, have heart diseases like high blood pressure or high blood cholesterol levels (increased fat in your blood), have asthma, have blood clot problems, have a bleeding disorder, have liver or kidney disease, have anaemia (low haemoglobin) or otherwise malnourished. Taking MIFEPRIN KIT TABLET in these conditions can cause life-threatening conditions in an individual. MIFEPRIN KIT TABLET is known to cause sleepiness, so driving or operating machinery should not be done. If you use contraceptive devices like the intrauterine device (IUD), please remove it before taking MIFEPRIN KIT TABLET. Regular follow-up with the doctor is required for constant monitoring of abortion. If medical termination does not happen or becomes unsuccessful, it should be terminated surgically as it can lead to foetal defects. Your doctor will examine by performing ultrasonography to confirm if the abortion is complete. St John’s Wort (a natural remedy used to treat mild depression) grapefruit juice should not be taken when taking MIFEPRIN KIT TABLET as it is known to interact.

Drug-Drug Interactions

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MifepristoneFluticasone
Critical
MifepristoneMidazolam
Critical

Drug-Drug Interactions

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MifepristoneFluticasone
Critical
How does the drug interact with Mifeprin Kit Tablet:
Co-administration of Fluticasone with Mifeprin Kit Tablet may make Fluticasone less effective as a therapy.

How to manage the interaction:
Taking Fluticasone with Mifeprin Kit Tablet is not recommended, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
MifepristoneMidazolam
Critical
How does the drug interact with Mifeprin Kit Tablet:
Co-administration of Mifeprin Kit Tablet and Midazolam may significantly increase Midazolam blood levels and effects, which increases the risk of side effects.

How to manage the interaction:
Although taking Mifeprin Kit Tablet and Midazolam together may result in an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have excessive or prolonged sleepiness and breathing issues. Do not discontinue any medication without consulting a doctor.
MifepristoneTriamcinolone
Critical
How does the drug interact with Mifeprin Kit Tablet:
Using Mifeprin Kit Tablet with Triamcinolone can significantly reduce the effects of triamcinolone.

How to manage the interaction:
Taking Triamcinolone with Mifeprin Kit Tablet is not recommended but can be taken if prescribed by a doctor. However, if you notice any unusual symptoms contact a doctor. Do not discontinue any medications without consulting a doctor.
MifepristoneSimvastatin
Critical
How does the drug interact with Mifeprin Kit Tablet:
Combining Mifeprin Kit Tablet with Simvastatin can increase the blood levels of simvastatin, which may increase the risk of side effects.

How to manage the interaction:
Taking Simvastatin with Mifeprin Kit Tablet is not recommended, but can be taken if prescribed by the doctor. If you experience any symptoms, contact the doctor immediately. Do not discontinue any medications without consulting a doctor.
MifepristoneDefibrotide
Critical
How does the drug interact with Mifeprin Kit Tablet:
Co-administration of Mifeprin Kit Tablet with Defibrotide can increase the risk and severity of vaginal bleeding in women.

How to manage the interaction:
Taking Mifeprin Kit Tablet with Defibrotide is not recommended, but it can be taken if prescribed by the doctor. However, if you experience excessive, prolonged vaginal bleeding, consult the doctor. Do not stop using any medications without talking to a doctor.
MifepristoneBetamethasone
Critical
How does the drug interact with Mifeprin Kit Tablet:
Co-administration of Betamethasone with Mifeprin Kit Tablet may significantly reduce the effect of Betamethasone which may be less effective as a therapy.

How to manage the interaction:
Taking betamethasone with Mifeprin Kit Tablet together can result in an interaction, it can be taken if a doctor has advised it. Contact a doctor immediately if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
MifepristoneBudesonide
Critical
How does the drug interact with Mifeprin Kit Tablet:
Using Mifeprin Kit Tablet together with budesonide may significantly reduce the effects of budesonide.

How to manage the interaction:
Taking Budesonide with Mifeprin Kit Tablet is not recommended as it can cause an interaction, but it can be taken if prescribed by the doctor. Do not stop using any medications without talking to a doctor.
MifepristoneRanolazine
Critical
How does the drug interact with Mifeprin Kit Tablet:
When Mifeprin Kit Tablet is taken with Ranolazine, may cause an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Phenylbutazone with Ranolazine can lead to an interaction. They can be taken together if advised by a doctor. However, contact a doctor if you experience any symptoms such as dizziness, lightheadedness, fainting, or fast or pounding heartbeats. Do not stop taking any medications without consulting a doctor.
MifepristoneFludrocortisone
Critical
How does the drug interact with Mifeprin Kit Tablet:
When Fludrocortisone is taken with Mifeprin Kit Tablet, it can increase the risk of side effects.

How to manage the interaction:
Taking Mifeprin Kit Tablet with Fludrocortisone is not recommended, but it can be taken if prescribed by the doctor. Do not stop using any medication without consulting a doctor.
MifepristoneApixaban
Critical
How does the drug interact with Mifeprin Kit Tablet:
Mifeprin Kit Tablet and Apixaban co-administration have been associated with more severe vaginal bleeding in women.

How to manage the interaction:
Taking Apixaban with Mifeprin Kit Tablet together is not generally recommended as it may lead to an interaction, but it can be taken if prescribed by a doctor. However, if you experience persistent, excessive bleeding, consult the doctor. Without consulting a doctor, never stop taking any medication.

Drug-Food Interactions

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MIFEPRISTONE-200MG+MISOPROSTOL-200MCGFruit juices, Fruits
Moderate

Drug-Food Interactions

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MIFEPRISTONE-200MG+MISOPROSTOL-200MCGFruit juices, Fruits
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Consumption of grapefruit or grapefruit juice along with Mifeprin Kit Tablet may cause the medication's blood levels to rise to unwanted levels and raise the chance of adverse effects. Avoid taking grapefruit or grapefruit juice along with Mifeprin Kit Tablet as this can raise the chance of adverse effects. However, consult a doctor if you experience headache, dizziness, fatigue, nausea, vomiting, cramping, diarrhea, hypokalemia (low blood potassium), fluid retention, swelling, and high blood pressure.

Diet & Lifestyle Advise

  • Keep your weight under control with body mass index (BMI) 19.5-24.9.
  • Opt for a diet rich in whole grains, fruits, veggies, and low-fat dairy products.
  • Quitting smoking and not drinking alcohol is the best strategy to lower the risk of any complication.
  • Avoid chronic stress and physical exercise like running as it might increase vaginal bleeding.
  • Monitor your blood pressure daily and if there is too much fluctuation, then immediately contact your doctor.
  • Get an ultrasound done to check if the abortion is done completely to avoid any unwanted complications.
  • Try to include heart-healthy omega 3 fatty acid containing food drinks in your daily diet. You can also use low-fat cooking oil like olive oil, soybean oil, canola oil, and coconut oil to lower your elevated blood pressure.

Habit Forming

No

Therapeutic Class

ABORTIFACIENT, CERVICAL RIPENING AGENTS

MIFEPRIN KIT TABLET Substitute

Substitutes safety advice

Product Substitutes

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

MIFEPRIN KIT TABLET contains Mifepristone and Misoprostol. Mifepristone works by blocking the effect of progesterone (female hormone), which is needed to sustain a pregnancy. In the absence of progesterone, the lining of the uterus breaks down as it does every month during the menstrual cycle, and the growth of pregnancy is stopped. Misoprostol is a prostaglandin analogue that helps increase uterine contractions and relaxes the cervix. Misoprostol should be taken 24-36 hours after taking mifepristone, either orally or vaginally.

No, MIFEPRIN KIT TABLET should be taken in the dose and duration as advised by the doctor. Taking it in more than the recommended dose might cause unpleasant side effects like excessive uterine or vaginal bleeding.

No, MIFEPRIN KIT TABLET is not known to affect any future chances of pregnancy. MIFEPRIN KIT TABLET is used for medical abortion of early or unwanted pregnancy.

After taking MIFEPRIN KIT TABLET, you may or may not experience vaginal bleeding, which does not indicate complete abortion. Your doctor will examine with the performing ultrasonography to confirm if the abortion is complete.

Do not take MIFEPRIN KIT TABLET, if you have a heart fitted with an artificial valve, heart diseases like high blood pressure or high blood cholesterol levels (increased fat in your blood), have asthma, have blood clot problems, have a bleeding disorder, have liver or kidney disease, have anaemia (low haemoglobin) or otherwise malnourished. Taking MIFEPRIN KIT TABLET in these conditions can cause life-threatening conditions in an individual.

Drug-Drug Interactions Checker List

  • DEXAMETHASONE
  • KETOCONAZOLE
  • ITRACONAZOLE
  • ERYTHROMYCIN
  • RIFAMPICIN
  • PHENYTOIN
  • PHENOBARBITAL
  • CARBAMAZEPINE
  • CYCLOSPORINE
  • TACROLIMUS
  • SIROLIMUS
  • ERGOTAMINE

Special Advise

  • Get an ultrasound to check whether medical abortion is done completely to avoid unwanted complications.
  • Monitor your blood pressure daily and if there is too much fluctuation, then immediately contact your doctor.
  • There might be a possibility of becoming pregnant again immediately after the pregnancy termination is complete. It would be best if you started using contraceptives for at least ten days of taking the mifepristone tablet. It is better to discuss contraceptive options with your doctor.
  • If you are (Rh factor negative), the use of MIFEPRIN KIT TABLET requires special measures which are taken to prevent Rhesus (Rh) factor sensitisation. So, if you are Rhesus negative, let your doctor know about this before using MIFEPRIN KIT TABLET.

Disease/Condition Glossary

Medical abortion: It is a procedure in which medicine is used to terminate a pregnancy. It is effectively causing abortion if performed in the first 70 days of pregnancy. Vagina bleeding occurs, and if it does not stop, please inform your doctor as it might require medical supervision. Having a medical abortion is a very emotional decision. You should be mentally prepared for all the risks a surgical absorption could lead to, like incomplete abortion, heavy and prolonged bleeding (may last up to 30 days), fever, digestive system discomfort fever. Also, if the medication does not work, it can lead to an unwanted ongoing pregnancy, leading to fetal defects. So, to avoid any complications, keep in regular touch with your doctor and do as advised.

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