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Written By ,
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
Non returnable*
COD available

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Manufacturer/Marketer :

Aarohi Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

About Naprohi-D 250 Tablet 10's

Naprohi-D 250 Tablet 10's belongs to the group of medications called analgesics. It treats migraine headaches. Besides this, it can also be used to reduce pain in rheumatoid arthritis, gout and dysmenorrhea (menstrual pain). Migraine is a condition characterized by intense headaches. Pain is a symptom that occurs due to various underlying conditions.

Naprohi-D 250 Tablet 10's is a combination of two drugs: Naproxen and Domperidone. Naproxen works by blocking the action of the cyclo-oxygenase (COX) enzyme in the body that produces certain chemical substances such as prostaglandins that cause pain and swelling. Domperidone is an antiemetic agent which prevents nausea and vomiting symptoms by blocking certain receptors (like dopamine and serotonin) that stimulate the vomiting centre (chemoreceptor trigger zone – CTZ) located in the brain.

Take Naprohi-D 250 Tablet 10's as prescribed by your doctor. You are advised to take Naprohi-D 250 Tablet 10's for as long as your doctor has prescribed it for you based on your medical condition. Common side-effects of Naprohi-D 250 Tablet 10's are dryness of the mouth, abdominal pain, constipation, drowsiness, dizziness, visual disturbances, hearing problems and headache. Consult your doctor if you feel any discomfort.

Before taking the Naprohi-D 250 Tablet 10's, let your doctor know about all your allergic or hypersensitivity reactions to medicines or food. If you are pregnant or breastfeeding, please tell your doctor so that your doctor will weigh the benefits and any potential risks before prescribing it to you. Also, inform the doctor if you have a history of heart rhythm problems or ulcers due to pain killers. Patients with age above 65 years, pre-existing cardiac diseases such as heart failure, hypertension or stroke, gastrointestinal bleeding (due to pain killers), gastric ulcers, respiratory diseases such as asthma, liver diseases, kidney diseases or bleeding disorders should use Naprohi-D 250 Tablet 10's only when prescribed by a doctor.

Uses of Naprohi-D 250 Tablet 10's

Migraine headache, Pain associated with conditions like rheumatoid arthritis, gout and dysmenorrhea (menstrual pain).

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Naprohi-D 250 Tablet 10's is a combination of naproxen and domperidone. Naproxen is an anti-inflammatory (reduce inflammation) and analgesic (reduce pain) agent. It inhibits the synthesis of prostaglandins, which are inflammatory mediators, thereby reducing pain and inflammation. Domperidone acts by enhancing gastric peristalsis (movements) to empty stomach. Easy movement of food through the stomach helps in relieving nausea and vomiting. It blocks the dopamine receptors present at the chemoreceptor trigger zone (responsible for regulating nausea and vomiting).

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Inform your doctor if you are taking any of the anticoagulants (warfarin), other NSAIDs (ibuprofen, ketorolac), corticosteroids (prednisolone), antidepressants (citalopram, fluoxetine, paroxetine, duloxetine, venlafaxine), or any other dietary or herbal supplements. Long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs) (other than aspirin) such as naproxen may increase the risk of heart attack or stroke and stomach ulcers. The risk of developing ulcers is higher if you have a history of ulcers, have bleeding disorders, older in age, alcoholic or have multiple diseases. The risk of having a heart attack increases if you smoke, or you or your family has a history of heart failure, stroke, or hypertension. Call for medical help immediately, if you experience chest pain, shortness of breath, blood in the stool or dark stools, heartburn, or any other abnormal signs.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Naprohi-D 250 Tablet:
Coadministration of Ketorolac with Naprohi-D 250 Tablet can increase the risk or severity of gastric bleeding and ulceration.

How to manage the interaction:
Taking Ketorolac with Naprohi-D 250 Tablet together is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, other signs of bleeding, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
How does the drug interact with Naprohi-D 250 Tablet:
Co-administration of Naprohi-D 250 Tablet with Meloxicam can increase the risk or severity of gastric bleeding, ulceration, and rarely, perforation leading to serious blood loss.

How to manage the interaction:
Taking Meloxicam with Naprohi-D 250 Tablet is not advised as it can possibly result in an interaction, it can be taken if your doctor has advised it. You should seek immediate medical attention if you experience any unusual bleeding or bruising or have other signs and symptoms of bleeding such as dizziness; lightheadedness; red or black, tarry stools; coughing up or vomiting fresh or dried blood that looks like coffee grounds; severe headache; and weakness.
How does the drug interact with Naprohi-D 250 Tablet:
Taking cidofovir with Naprohi-D 250 Tablet may increase the risk or severity of kidney problems

How to manage the interaction:
Taking Naprohi-D 250 Tablet with Cidofovir is generally avoided as it can possibly result in an interaction. You should seek immediate medical attention if you develop signs and symptoms such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm.
DomperidoneNefazodone
Severe
How does the drug interact with Naprohi-D 250 Tablet:
Coadministration of Naprohi-D 250 Tablet with Nefazodone can increase the blood levels of Naprohi-D 250 Tablet.

How to manage the interaction:
There may be a possibility of interaction between Naprohi-D 250 Tablet and Nefazodone, but it can be taken if prescribed by a doctor. In case you experience any side effects like swelling of the ankles or feet, unusual tiredness, redness, changes in menstrual ability, contact a doctor. It is recommended to do this to ensure your heart stays healthy. Do not stop using any medications without talking to a doctor.
DomperidoneToremifene
Severe
How does the drug interact with Naprohi-D 250 Tablet:
Coadministration of Naprohi-D 250 Tablet with Toremifene can Increase the risk of irregular heart rhythm.

How to manage the interaction:
Although taking Naprohi-D 250 Tablet and Toremifene together can cause an interaction, it can be taken if your doctor has suggested it. If you experience lightheadedness, tiredness, increased heart rate, consult a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Naprohi-D 250 Tablet:
Coadministration of Naprohi-D 250 Tablet with Clarithromycin can increase the risk of side effects.

How to manage the interaction:
There may be a possibility of interaction between Naprohi-D 250 Tablet and Clarithromycin, but it can be taken if prescribed by a doctor. Do not stop using any medications without talking to a doctor.
DomperidoneMethadone
Severe
How does the drug interact with Naprohi-D 250 Tablet:
Coadministration of Naprohi-D 250 Tablet with Methadone can Increase the risk of irregular heart rhythm.

How to manage the interaction:
Although taking Naprohi-D 250 Tablet and Methadone together can cause an interaction, it can be taken if your doctor has suggested it. If you experience lightheadedness, tiredness, increased heart rate, consult a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Naprohi-D 250 Tablet:
Coadministration of Naprohi-D 250 Tablet with Ritonavir can increase the blood levels of Naprohi-D 250 Tablet.

How to manage the interaction:
There may be a possibility of interaction between Naprohi-D 250 Tablet and Ritonavir, but it can be taken if prescribed by a doctor. In case you experience any side effects like swelling of the ankles or feet, unusual tiredness, redness, changes in menstrual ability, contact a doctor. It is recommended to do this to ensure your heart stays healthy. Do not stop using any medications without talking to a doctor.
How does the drug interact with Naprohi-D 250 Tablet:
Coadministration of Naprohi-D 250 Tablet with Ketoconazole can Increase the risk of irregular heart rhythm.

How to manage the interaction:
Although taking Naprohi-D 250 Tablet and Ketoconazole together can cause an interaction, it can be taken if a doctor has suggested it. If you experience lightheadedness, tiredness, increased heart rate, consult a doctor. Do not discontinue any medications without consulting a doctor.
DomperidoneBepridil
Severe
How does the drug interact with Naprohi-D 250 Tablet:
Co-administration of Domeperidone and Bepridil can increase the risk of irregular heart rhythm.

How to manage the interaction:
Although taking Naprohi-D 250 Tablet and Bepridil together can cause an interaction, it can be taken if your doctor has suggested it. If you experience lightheadedness, tiredness, increased heart rate, consult a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Drink plenty of fluids to avoid gastrointestinal problems.
  • Avoid triggers that can increase your migraine headache.
  • Take enough rest.
  • Acupuncture, massage and physical therapy may also be helpful.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listen to soothing music.
  • Avoid smoking and alcohol consumption.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Get adequate sleep as resting the muscles can help in reducing inflammation and swelling.

Habit Forming

No

Therapeutic Class

ANALGESICS

Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Naproxen works by inhibiting the cyclo-oxygenase (COX) enzyme in the body, which creates chemical compounds such as prostaglandins, which induce pain and swelling. Domperidone is an antiemetic that blocks certain receptors (such as dopamine and serotonin) that stimulate the brain's vomiting centre (chemoreceptor trigger zone - CTZ).

Naprohi-D 250 Tablet 10's cannot permanently cure migraine. It can provide relief from pain and headache.

Naprohi-D 250 Tablet 10's on prolonged or frequent use can cause liver or kidney problems. Therefore, it should be only used for a duration as prescribed by the doctor.

Arthritis is a chronic condition of joints with pain and inflammation. Naprohi-D 250 Tablet 10's does not cure arthritis but relieves symptoms of arthritis-like joint pain, swelling and stiffness.

Yes, Naprohi-D 250 Tablet 10's may increase the risk of heart problems such as heart attack and stroke, especially when used in high doses or for a prolonged duration. It is advised to inform your doctor if you have any of these conditions or have a history of heart problems or stroke before taking the Naprohi-D 250 Tablet 10's.

Dry mouth may be caused by Domperidone in Naprohi-D 250 Tablet 10's. Chew a sugar-free sweet or sugar-free gum.

Drug-Drug Interactions Checker List

  • WARFARIN
  • KETOROLAC
  • PREDNISOLONE
  • RAMIPRIL
  • AMLODIPINE
  • AMIKACIN
  • ATORVASTATIN
  • CITALOPRAM
  • FLUOXETINE

Special Advise

  • Your doctor may monitor liver function and kidney function if you are taking Naprohi-D 250 Tablet 10's for long-term.
  • Taking meals at the same time every day and sufficient sleep might help in avoiding migraine attacks. You are recommended to avoid loud music, noisy place, extreme temperatures and bright light. Also, avoid consumption of chocolates, cheese, processed food, smoking and alcohol.

Disease/Condition Glossary

Migraine: Migraine is a condition characterized by intense headaches. It also causes nausea, vomiting, sensitivity to light and sound and difficulty speaking. Bright lights, strong smells, certain foods, loud sounds, stress and hormonal changes act as triggers for migraine. These triggers lead to acute attacks. Acute migraine attacks result in throbbing headaches and pain in the eyes, face or neck.

Pain: Pain is a widely used term used to describe unpleasant feelings or discomfort. It ranges from mild to severe. The severity of the pain depends on the underlying condition.

Rheumatoid arthritis: Rheumatoid arthritis is an auto-immune disease (the body's immune system attacks its tissue) which leads to joint pain and damage. Symptoms of rheumatoid arthritis include pain, swelling, stiffness, deformities and loss of joint function.

Gout: Gout is an inflammatory condition in which uric acid deposits and crystallizes in the joints. It is characterized by acute, severe, and recurring pain attacks, especially at night, redness and swelling in the affected joints.

Dysmenorrhea: Dysmenorrhea refers to abdominal cramps/pain and an unpleasant sensory/emotional experience associated with irregular periods. It occurs just before or during menses. Menstrual cramps that cause throbbing pain in the lower belly during periods may vary from mild to severe. Some of the common symptoms of menstrual cramps include an aching pain in your belly (sometimes severe), a feeling of pressure in your belly, pain in your hips, lower back, and inner thighs.

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