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Naproxen works by inhibiting the cyclo-oxygenase (COX) enzyme in the body, which creates chemical compounds such as prostaglandins, which induce pain and swelling. Domperidone is an antiemetic that blocks certain receptors (such as dopamine and serotonin) that stimulate the brain's vomiting centre (chemoreceptor trigger zone - CTZ).
Napsav-D 500 Tablet cannot permanently cure migraine. It can provide relief from pain and headache.
Napsav-D 500 Tablet on prolonged or frequent use can cause liver or kidney problems. Therefore, it should be only used for a duration as prescribed by the doctor.
Arthritis is a chronic condition of joints with pain and inflammation. Napsav-D 500 Tablet does not cure arthritis but relieves symptoms of arthritis-like joint pain, swelling and stiffness.
Yes, Napsav-D 500 Tablet may increase the risk of heart problems such as heart attack and stroke, especially when used in high doses or for a prolonged duration. It is advised to inform your doctor if you have any of these conditions or have a history of heart problems or stroke before taking the Napsav-D 500 Tablet .
Dry mouth may be caused by Domperidone in Napsav-D 500 Tablet . Chew a sugar-free sweet or sugar-free gum.
Alcohol
Caution
It is advised not to take alcohol as Napsav-D 500 Tablet can cause dizziness or drowsiness.
Pregnancy
Caution
Napsav-D 500 Tablet should be used in pregnant women only if clinically needed, and the benefits outweigh the risks.
Breast Feeding
Caution
Napsav-D 500 Tablet should be used in breastfeeding mothers only if the benefits outweigh the risks.
Driving
Unsafe
It is unsafe to drive after taking Napsav-D 500 Tablet as it impacts your ability to drive or operate machinery.
Liver
Caution
Limited information was available for the use of Napsav-D 500 Tablet in patients suffering from liver impairment. Please consult your doctor if you have any concerns regarding using Napsav-D 500 Tablet in patients with liver impairment. Your doctor will prescribe only if the benefits outweigh the risks.
Kidney
Caution
Limited information was available for the use of Napsav-D 500 Tablet in patients suffering from kidney impairment. Please consult your doctor if you have any concerns regarding using Napsav-D 500 Tablet in patients with kidney impairment. Your doctor will prescribe only if the benefits outweigh the risks.
Children
Caution
Napsav-D 500 Tablet should be used in children below 12 years of age only when prescribed by a child specialist.
Product Substitutes
About Napsav-D 500 Tablet
Napsav-D 500 Tablet belongs to the group of medications called analgesics. It treats migraine headaches. Besides this, it can also be used to reduce pain in rheumatoid arthritis, gout and dysmenorrhea (menstrual pain). Migraine is a condition characterized by intense headaches. Pain is a symptom that occurs due to various underlying conditions.
Napsav-D 500 Tablet is a combination of two drugs: Naproxen and Domperidone. Naproxen works by blocking the action of the cyclo-oxygenase (COX) enzyme in the body that produces certain chemical substances such as prostaglandins that cause pain and swelling. Domperidone is an antiemetic agent which prevents nausea and vomiting symptoms by blocking certain receptors (like dopamine and serotonin) that stimulate the vomiting centre (chemoreceptor trigger zone – CTZ) located in the brain.
Take Napsav-D 500 Tablet as prescribed by your doctor. You are advised to take Napsav-D 500 Tablet for as long as your doctor has prescribed it for you based on your medical condition. Common side-effects of Napsav-D 500 Tablet are dryness of the mouth, abdominal pain, constipation, drowsiness, dizziness, visual disturbances, hearing problems and headache. Consult your doctor if you feel any discomfort.
Before taking the Napsav-D 500 Tablet , let your doctor know about all your allergic or hypersensitivity reactions to medicines or food. If you are pregnant or breastfeeding, please tell your doctor so that your doctor will weigh the benefits and any potential risks before prescribing it to you. Also, inform the doctor if you have a history of heart rhythm problems or ulcers due to pain killers. Patients with age above 65 years, pre-existing cardiac diseases such as heart failure, hypertension or stroke, gastrointestinal bleeding (due to pain killers), gastric ulcers, respiratory diseases such as asthma, liver diseases, kidney diseases or bleeding disorders should use Napsav-D 500 Tablet only when prescribed by a doctor.
Uses of Napsav-D 500 Tablet
Medicinal Benefits
Napsav-D 500 Tablet is a combination of naproxen and domperidone. Naproxen is an anti-inflammatory (reduce inflammation) and analgesic (reduce pain) agent. It inhibits the synthesis of prostaglandins, which are inflammatory mediators, thereby reducing pain and inflammation. Domperidone acts by enhancing gastric peristalsis (movements) to empty stomach. Easy movement of food through the stomach helps in relieving nausea and vomiting. It blocks the dopamine receptors present at the chemoreceptor trigger zone (responsible for regulating nausea and vomiting).
Directions for Use
Side Effects of Napsav-D 500 Tablet
Drug Warnings
Inform your doctor if you are taking any of the anticoagulants (warfarin), other NSAIDs (ibuprofen, ketorolac), corticosteroids (prednisolone), antidepressants (citalopram, fluoxetine, paroxetine, duloxetine, venlafaxine), or any other dietary or herbal supplements. Long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs) (other than aspirin) such as naproxen may increase the risk of heart attack or stroke and stomach ulcers. The risk of developing ulcers is higher if you have a history of ulcers, have bleeding disorders, older in age, alcoholic or have multiple diseases. The risk of having a heart attack increases if you smoke, or you or your family has a history of heart failure, stroke, or hypertension. Call for medical help immediately, if you experience chest pain, shortness of breath, blood in the stool or dark stools, heartburn, or any other abnormal signs.
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